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P37172

- ACVR1_MOUSE

UniProt

P37172 - ACVR1_MOUSE

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Protein
Activin receptor type-1
Gene
Acvr1, Acvrlk2, Tgfb1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved in left-right pattern formation during embryogenesis.1 Publication

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei235 – 2351ATP By similarity
Active sitei336 – 3361Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi214 – 2229ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. activin binding Source: MGI
  3. activin receptor activity, type I Source: MGI
  4. growth factor binding Source: MGI
  5. metal ion binding Source: UniProtKB-KW
  6. receptor signaling protein serine/threonine kinase activity Source: Ensembl
  7. transforming growth factor beta binding Source: MGI
  8. transforming growth factor beta receptor activity, type I Source: MGI

GO - Biological processi

  1. BMP signaling pathway Source: Ensembl
  2. G1/S transition of mitotic cell cycle Source: Ensembl
  3. acute inflammatory response Source: UniProtKB
  4. atrial septum primum morphogenesis Source: Ensembl
  5. cardiac muscle cell fate commitment Source: Ensembl
  6. cellular response to glucocorticoid stimulus Source: Ensembl
  7. determination of left/right symmetry Source: MGI
  8. embryonic heart tube morphogenesis Source: Ensembl
  9. endocardial cushion cell fate commitment Source: Ensembl
  10. gastrulation Source: MGI
  11. gastrulation with mouth forming second Source: MGI
  12. germ cell development Source: MGI
  13. heart development Source: MGI
  14. in utero embryonic development Source: MGI
  15. mesoderm development Source: MGI
  16. mesoderm formation Source: MGI
  17. mitral valve morphogenesis Source: Ensembl
  18. negative regulation of activin receptor signaling pathway Source: Ensembl
  19. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  20. neural crest cell migration Source: MGI
  21. pathway-restricted SMAD protein phosphorylation Source: Ensembl
  22. patterning of blood vessels Source: MGI
  23. peptidyl-threonine phosphorylation Source: Ensembl
  24. pharyngeal system development Source: MGI
  25. positive regulation of bone mineralization Source: Ensembl
  26. positive regulation of determination of dorsal identity Source: Ensembl
  27. positive regulation of osteoblast differentiation Source: Ensembl
  28. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  29. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  30. regulation of skeletal muscle tissue development Source: Ensembl
  31. smooth muscle cell differentiation Source: MGI
  32. transforming growth factor beta receptor signaling pathway Source: MGI
  33. urogenital system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-1 (EC:2.7.11.30)
Alternative name(s):
Activin receptor type I
Short name:
ACTR-I
Serine/threonine-protein kinase receptor R1
Short name:
SKR1
TGF-B superfamily receptor type I
Short name:
TSR-I
TSK-7L
Gene namesi
Name:Acvr1
Synonyms:Acvrlk2, Tgfb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:87911. Acvr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 123103Extracellular Reviewed prediction
Add
BLAST
Transmembranei124 – 14623Helical; Reviewed prediction
Add
BLAST
Topological domaini147 – 509363Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. activin receptor complex Source: Ensembl
  2. apical part of cell Source: MGI
  3. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 By similarity
Add
BLAST
Chaini21 – 509489Activin receptor type-1
PRO_0000024395Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction
Modified residuei501 – 5011Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP37172.
PRIDEiP37172.

PTM databases

PhosphoSiteiP37172.

Expressioni

Tissue specificityi

Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.

Developmental stagei

Highly expressed in the node and midline and weakly expressed in E8.5 embryos and in the lateral plate mesoderm.1 Publication

Gene expression databases

ArrayExpressiP37172.
BgeeiP37172.
CleanExiMM_ACVR1.
MM_TGFB1.
GenevestigatoriP37172.

Interactioni

Subunit structurei

Interacts with FKBP1A. Interacts with FCHO1 By similarity.

Protein-protein interaction databases

BioGridi197953. 3 interactions.
DIPiDIP-5798N.
MINTiMINT-1341279.

Structurei

3D structure databases

ProteinModelPortaliP37172.
SMRiP37172. Positions 158-499.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini178 – 20730GS
Add
BLAST
Domaini208 – 502295Protein kinase
Add
BLAST

Sequence similaritiesi

Contains 1 GS domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00730000110868.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiP37172.
KOiK04675.
OMAiVCEGMSC.
OrthoDBiEOG7Q8CN3.
PhylomeDBiP37172.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37172-1 [UniParc]FASTAAdd to Basket

« Hide

MVDGVMILPV LMMMAFPSPS VEDEKPKVNQ KLYMCVCEGL SCGNEDHCEG    50
QQCFSSLSIN DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN 100
RNITAQLPTK GKSFPGTQNF HLEVGLIILS VVFAVCLLAC ILGVALRKFK 150
RRNQERLNPR DVEYGTIEGL ITTNVGDSTL AELLDHSCTS GSGSGLPFLV 200
QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR DEKSWFRETE 250
LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 300
DTVSCLRIVL SIASGLAHLH IEIFGTQGKS AIAHRDLKSK NILVKKNGQC 350
CIADLGLAVM HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK 400
RVDIWAFGLV LWEVARRMVS NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV 450
DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ NPSARLTALR IKKTLTKIDN 500
SLDKLKTDC 509
Length:509
Mass (Da):57,226
Last modified:October 17, 2006 - v2
Checksum:i05BCFC22C5740028
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271K → E in BAE29239. 1 Publication
Sequence conflicti27 – 271K → E in BAE29286. 1 Publication
Sequence conflicti60 – 601N → Y in AAA40495. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15436 mRNA. Translation: AAA40495.1.
AF332087 mRNA. Translation: AAK56115.1.
AF332088 mRNA. Translation: AAK56116.1.
AK150014 mRNA. Translation: BAE29239.1.
AK150075 mRNA. Translation: BAE29286.1.
BC058718 mRNA. Translation: AAH58718.1.
CCDSiCCDS16050.1.
PIRiA37489. I59576.
RefSeqiNP_001103674.1. NM_001110204.1.
NP_001103675.1. NM_001110205.1.
NP_031420.2. NM_007394.3.
XP_006497685.1. XM_006497622.1.
UniGeneiMm.689.

Genome annotation databases

EnsembliENSMUST00000056376; ENSMUSP00000056784; ENSMUSG00000026836.
ENSMUST00000090935; ENSMUSP00000088453; ENSMUSG00000026836.
ENSMUST00000112599; ENSMUSP00000108218; ENSMUSG00000026836.
ENSMUST00000112601; ENSMUSP00000108220; ENSMUSG00000026836.
GeneIDi11477.
KEGGimmu:11477.
UCSCiuc008jss.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15436 mRNA. Translation: AAA40495.1 .
AF332087 mRNA. Translation: AAK56115.1 .
AF332088 mRNA. Translation: AAK56116.1 .
AK150014 mRNA. Translation: BAE29239.1 .
AK150075 mRNA. Translation: BAE29286.1 .
BC058718 mRNA. Translation: AAH58718.1 .
CCDSi CCDS16050.1.
PIRi A37489. I59576.
RefSeqi NP_001103674.1. NM_001110204.1.
NP_001103675.1. NM_001110205.1.
NP_031420.2. NM_007394.3.
XP_006497685.1. XM_006497622.1.
UniGenei Mm.689.

3D structure databases

ProteinModelPortali P37172.
SMRi P37172. Positions 158-499.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 197953. 3 interactions.
DIPi DIP-5798N.
MINTi MINT-1341279.

PTM databases

PhosphoSitei P37172.

Proteomic databases

PaxDbi P37172.
PRIDEi P37172.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000056376 ; ENSMUSP00000056784 ; ENSMUSG00000026836 .
ENSMUST00000090935 ; ENSMUSP00000088453 ; ENSMUSG00000026836 .
ENSMUST00000112599 ; ENSMUSP00000108218 ; ENSMUSG00000026836 .
ENSMUST00000112601 ; ENSMUSP00000108220 ; ENSMUSG00000026836 .
GeneIDi 11477.
KEGGi mmu:11477.
UCSCi uc008jss.1. mouse.

Organism-specific databases

CTDi 90.
MGIi MGI:87911. Acvr1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00730000110868.
HOGENOMi HOG000230587.
HOVERGENi HBG054502.
InParanoidi P37172.
KOi K04675.
OMAi VCEGMSC.
OrthoDBi EOG7Q8CN3.
PhylomeDBi P37172.
TreeFami TF314724.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 3474.

Miscellaneous databases

ChiTaRSi ACVR1. mouse.
NextBioi 278820.
PROi P37172.
SOURCEi Search...

Gene expression databases

ArrayExpressi P37172.
Bgeei P37172.
CleanExi MM_ACVR1.
MM_TGFB1.
Genevestigatori P37172.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
PRINTSi PR00653. ACTIVIN2R.
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor."
    Ebner R., Chen H., Shum L., Lawler S., Lee A.L., Zioncheck T.F., Lopez A.R., Derynck R.
    Science 260:1344-1348(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary gland.
  2. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
    Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
    Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ILS and ISS.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  5. "BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo."
    Kishigami S., Yoshikawa S., Castranio T., Okazaki K., Furuta Y., Mishina Y.
    Dev. Biol. 276:185-193(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, FUNCTION.

Entry informationi

Entry nameiACVR1_MOUSE
AccessioniPrimary (citable) accession number: P37172
Secondary accession number(s): Q3UDH5, Q91VF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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