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P37172

- ACVR1_MOUSE

UniProt

P37172 - ACVR1_MOUSE

Protein

Activin receptor type-1

Gene

Acvr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved in left-right pattern formation during embryogenesis.1 Publication

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei235 – 2351ATPPROSITE-ProRule annotation
    Active sitei336 – 3361Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi214 – 2229ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. activin binding Source: MGI
    2. activin receptor activity, type I Source: MGI
    3. ATP binding Source: UniProtKB-KW
    4. growth factor binding Source: MGI
    5. metal ion binding Source: UniProtKB-KW
    6. receptor signaling protein serine/threonine kinase activity Source: Ensembl
    7. transforming growth factor beta binding Source: MGI
    8. transforming growth factor beta receptor activity, type I Source: MGI

    GO - Biological processi

    1. acute inflammatory response Source: UniProtKB
    2. atrial septum primum morphogenesis Source: Ensembl
    3. BMP signaling pathway Source: Ensembl
    4. cardiac muscle cell fate commitment Source: Ensembl
    5. cellular response to glucocorticoid stimulus Source: Ensembl
    6. determination of left/right symmetry Source: MGI
    7. embryonic heart tube morphogenesis Source: Ensembl
    8. endocardial cushion cell fate commitment Source: Ensembl
    9. G1/S transition of mitotic cell cycle Source: Ensembl
    10. gastrulation Source: MGI
    11. gastrulation with mouth forming second Source: MGI
    12. germ cell development Source: MGI
    13. heart development Source: MGI
    14. in utero embryonic development Source: MGI
    15. mesoderm development Source: MGI
    16. mesoderm formation Source: MGI
    17. mitral valve morphogenesis Source: Ensembl
    18. negative regulation of activin receptor signaling pathway Source: Ensembl
    19. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    20. neural crest cell migration Source: MGI
    21. pathway-restricted SMAD protein phosphorylation Source: Ensembl
    22. patterning of blood vessels Source: MGI
    23. peptidyl-threonine phosphorylation Source: Ensembl
    24. pharyngeal system development Source: MGI
    25. positive regulation of bone mineralization Source: Ensembl
    26. positive regulation of determination of dorsal identity Source: Ensembl
    27. positive regulation of osteoblast differentiation Source: Ensembl
    28. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    29. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    30. regulation of skeletal muscle tissue development Source: Ensembl
    31. smooth muscle cell differentiation Source: MGI
    32. transforming growth factor beta receptor signaling pathway Source: MGI
    33. urogenital system development Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activin receptor type-1 (EC:2.7.11.30)
    Alternative name(s):
    Activin receptor type I
    Short name:
    ACTR-I
    Serine/threonine-protein kinase receptor R1
    Short name:
    SKR1
    TGF-B superfamily receptor type I
    Short name:
    TSR-I
    TSK-7L
    Gene namesi
    Name:Acvr1
    Synonyms:Acvrlk2, Tgfb1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:87911. Acvr1.

    Subcellular locationi

    GO - Cellular componenti

    1. activin receptor complex Source: Ensembl
    2. apical part of cell Source: MGI
    3. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 509489Activin receptor type-1PRO_0000024395Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Modified residuei501 – 5011PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP37172.
    PRIDEiP37172.

    PTM databases

    PhosphoSiteiP37172.

    Expressioni

    Tissue specificityi

    Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.

    Developmental stagei

    Highly expressed in the node and midline and weakly expressed in E8.5 embryos and in the lateral plate mesoderm.1 Publication

    Gene expression databases

    ArrayExpressiP37172.
    BgeeiP37172.
    CleanExiMM_ACVR1.
    MM_TGFB1.
    GenevestigatoriP37172.

    Interactioni

    Subunit structurei

    Interacts with FKBP1A. Interacts with FCHO1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi197953. 3 interactions.
    DIPiDIP-5798N.
    MINTiMINT-1341279.

    Structurei

    3D structure databases

    ProteinModelPortaliP37172.
    SMRiP37172. Positions 158-499.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 123103ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini147 – 509363CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei124 – 14623HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini178 – 20730GSPROSITE-ProRule annotationAdd
    BLAST
    Domaini208 – 502295Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GS domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00730000110868.
    HOGENOMiHOG000230587.
    HOVERGENiHBG054502.
    InParanoidiP37172.
    KOiK04675.
    OMAiVCEGMSC.
    OrthoDBiEOG7Q8CN3.
    PhylomeDBiP37172.
    TreeFamiTF314724.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    PRINTSiPR00653. ACTIVIN2R.
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P37172-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDGVMILPV LMMMAFPSPS VEDEKPKVNQ KLYMCVCEGL SCGNEDHCEG    50
    QQCFSSLSIN DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN 100
    RNITAQLPTK GKSFPGTQNF HLEVGLIILS VVFAVCLLAC ILGVALRKFK 150
    RRNQERLNPR DVEYGTIEGL ITTNVGDSTL AELLDHSCTS GSGSGLPFLV 200
    QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR DEKSWFRETE 250
    LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 300
    DTVSCLRIVL SIASGLAHLH IEIFGTQGKS AIAHRDLKSK NILVKKNGQC 350
    CIADLGLAVM HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK 400
    RVDIWAFGLV LWEVARRMVS NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV 450
    DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ NPSARLTALR IKKTLTKIDN 500
    SLDKLKTDC 509
    Length:509
    Mass (Da):57,226
    Last modified:October 17, 2006 - v2
    Checksum:i05BCFC22C5740028
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271K → E in BAE29239. (PubMed:16141072)Curated
    Sequence conflicti27 – 271K → E in BAE29286. (PubMed:16141072)Curated
    Sequence conflicti60 – 601N → Y in AAA40495. (PubMed:8388127)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L15436 mRNA. Translation: AAA40495.1.
    AF332087 mRNA. Translation: AAK56115.1.
    AF332088 mRNA. Translation: AAK56116.1.
    AK150014 mRNA. Translation: BAE29239.1.
    AK150075 mRNA. Translation: BAE29286.1.
    BC058718 mRNA. Translation: AAH58718.1.
    CCDSiCCDS16050.1.
    PIRiA37489. I59576.
    RefSeqiNP_001103674.1. NM_001110204.1.
    NP_001103675.1. NM_001110205.1.
    NP_031420.2. NM_007394.3.
    XP_006497685.1. XM_006497622.1.
    UniGeneiMm.689.

    Genome annotation databases

    EnsembliENSMUST00000056376; ENSMUSP00000056784; ENSMUSG00000026836.
    ENSMUST00000090935; ENSMUSP00000088453; ENSMUSG00000026836.
    ENSMUST00000112599; ENSMUSP00000108218; ENSMUSG00000026836.
    ENSMUST00000112601; ENSMUSP00000108220; ENSMUSG00000026836.
    GeneIDi11477.
    KEGGimmu:11477.
    UCSCiuc008jss.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L15436 mRNA. Translation: AAA40495.1 .
    AF332087 mRNA. Translation: AAK56115.1 .
    AF332088 mRNA. Translation: AAK56116.1 .
    AK150014 mRNA. Translation: BAE29239.1 .
    AK150075 mRNA. Translation: BAE29286.1 .
    BC058718 mRNA. Translation: AAH58718.1 .
    CCDSi CCDS16050.1.
    PIRi A37489. I59576.
    RefSeqi NP_001103674.1. NM_001110204.1.
    NP_001103675.1. NM_001110205.1.
    NP_031420.2. NM_007394.3.
    XP_006497685.1. XM_006497622.1.
    UniGenei Mm.689.

    3D structure databases

    ProteinModelPortali P37172.
    SMRi P37172. Positions 158-499.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 197953. 3 interactions.
    DIPi DIP-5798N.
    MINTi MINT-1341279.

    PTM databases

    PhosphoSitei P37172.

    Proteomic databases

    PaxDbi P37172.
    PRIDEi P37172.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000056376 ; ENSMUSP00000056784 ; ENSMUSG00000026836 .
    ENSMUST00000090935 ; ENSMUSP00000088453 ; ENSMUSG00000026836 .
    ENSMUST00000112599 ; ENSMUSP00000108218 ; ENSMUSG00000026836 .
    ENSMUST00000112601 ; ENSMUSP00000108220 ; ENSMUSG00000026836 .
    GeneIDi 11477.
    KEGGi mmu:11477.
    UCSCi uc008jss.1. mouse.

    Organism-specific databases

    CTDi 90.
    MGIi MGI:87911. Acvr1.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00730000110868.
    HOGENOMi HOG000230587.
    HOVERGENi HBG054502.
    InParanoidi P37172.
    KOi K04675.
    OMAi VCEGMSC.
    OrthoDBi EOG7Q8CN3.
    PhylomeDBi P37172.
    TreeFami TF314724.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 3474.

    Miscellaneous databases

    ChiTaRSi ACVR1. mouse.
    NextBioi 278820.
    PROi P37172.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P37172.
    Bgeei P37172.
    CleanExi MM_ACVR1.
    MM_TGFB1.
    Genevestigatori P37172.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    PRINTSi PR00653. ACTIVIN2R.
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor."
      Ebner R., Chen H., Shum L., Lawler S., Lee A.L., Zioncheck T.F., Lopez A.R., Derynck R.
      Science 260:1344-1348(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Mammary gland.
    2. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
      Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
      Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ILS and ISS.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    5. "BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo."
      Kishigami S., Yoshikawa S., Castranio T., Okazaki K., Furuta Y., Mishina Y.
      Dev. Biol. 276:185-193(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE, FUNCTION.

    Entry informationi

    Entry nameiACVR1_MOUSE
    AccessioniPrimary (citable) accession number: P37172
    Secondary accession number(s): Q3UDH5, Q91VF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 141 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3