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P37171 (HPRT_RHOCB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hypoxanthine-guanine phosphoribosyltransferase

Short name=HGPRT
Short name=HGPRTase
EC=2.4.2.8
Gene names
Name:hpt
Ordered Locus Names:RCAP_rcc01790
OrganismRhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) [Complete proteome] [HAMAP]
Taxonomic identifier272942 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Protein attributes

Sequence length182 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.

GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactor

Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
Nucleotide-binding
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processIMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionguanine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

hypoxanthine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 182182Hypoxanthine-guanine phosphoribosyltransferase
PRO_0000139611

Regions

Nucleotide binding101 – 11010IMP By similarity
Nucleotide binding160 – 1612IMP By similarity

Sites

Active site1051Proton acceptor By similarity
Metal binding1611Magnesium By similarity
Binding site1331IMP By similarity
Binding site1551IMP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P37171 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 890A60FCE67C0E05

FASTA18220,323
        10         20         30         40         50         60 
MSQSGYVIDQ MISAKAIAAR VEALGAEITE AFKDTDRLVV VGLLRGSFVF IADLIREIGV 

        70         80         90        100        110        120 
PCEVDFLEAS SYGNETTSTR EVRVLKDLRG IIGGRDVLVV EDIIDTGHTI SKVMEMLRAR 

       130        140        150        160        170        180 
APRRIECCAM LDKPSRREVD VKARWTGFEI PDEFVVGYGL DYAQNHRNLP FIGTVRFTDP 


QK 

« Hide

References

« Hide 'large scale' references
[1]"A bacterial homolog to HPRT."
Beckman D.L., Kranz R.G.
Biochim. Biophys. Acta 1129:112-114(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC BAA-309 / NBRC 16581 / SB1003.
[2]"Complete genome sequence of the photosynthetic purple nonsulfur bacterium Rhodobacter capsulatus SB 1003."
Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V., Haselkorn R.
J. Bacteriol. 192:3545-3546(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-309 / NBRC 16581 / SB1003.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60977 Genomic DNA. Translation: CAA43293.1.
CP001312 Genomic DNA. Translation: ADE85535.1.
PIRS19720.
RefSeqYP_003577942.1. NC_014034.1.

3D structure databases

ProteinModelPortalP37171.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADE85535; ADE85535; RCAP_rcc01790.
GeneID9004613.
KEGGrcp:RCAP_rcc01790.
PATRIC35503726. VBIRhoCap134200_1821.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000236520.
KOK00760.
OMAMRADFTG.

Enzyme and pathway databases

BioCycRCAP272942:GJIY-1815-MONOMER.
UniPathwayUPA00591; UER00648.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
InterProIPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01203. HGPRTase. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHPRT_RHOCB
AccessionPrimary (citable) accession number: P37171
Secondary accession number(s): D5AU96
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways