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P37171

- HPRT_RHOCB

UniProt

P37171 - HPRT_RHOCB

Protein

Hypoxanthine-guanine phosphoribosyltransferase

Gene

hpt

Organism
Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
    GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei105 – 1051Proton acceptorBy similarity
    Binding sitei133 – 1331IMPBy similarity
    Binding sitei155 – 1551IMP; via carbonyl oxygenBy similarity
    Metal bindingi161 – 1611MagnesiumBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi101 – 11010IMPBy similarity
    Nucleotide bindingi160 – 1612IMPBy similarity

    GO - Molecular functioni

    1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
    2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW
    4. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. IMP salvage Source: UniProtKB-UniPathway
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Keywords - Ligandi

    Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRCAP272942:GJIY-1815-MONOMER.
    UniPathwayiUPA00591; UER00648.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hypoxanthine-guanine phosphoribosyltransferase (EC:2.4.2.8)
    Short name:
    HGPRT
    Short name:
    HGPRTase
    Gene namesi
    Name:hpt
    Ordered Locus Names:RCAP_rcc01790
    OrganismiRhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
    Taxonomic identifieri272942 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000002361: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 182182Hypoxanthine-guanine phosphoribosyltransferasePRO_0000139611Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP37171.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000236520.
    KOiK00760.
    OMAiMRADFTG.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    InterProiIPR005904. Hxn_phspho_trans.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01203. HGPRTase. 1 hit.
    PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37171-1 [UniParc]FASTAAdd to Basket

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    MSQSGYVIDQ MISAKAIAAR VEALGAEITE AFKDTDRLVV VGLLRGSFVF    50
    IADLIREIGV PCEVDFLEAS SYGNETTSTR EVRVLKDLRG IIGGRDVLVV 100
    EDIIDTGHTI SKVMEMLRAR APRRIECCAM LDKPSRREVD VKARWTGFEI 150
    PDEFVVGYGL DYAQNHRNLP FIGTVRFTDP QK 182
    Length:182
    Mass (Da):20,323
    Last modified:October 1, 1994 - v1
    Checksum:i890A60FCE67C0E05
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60977 Genomic DNA. Translation: CAA43293.1.
    CP001312 Genomic DNA. Translation: ADE85535.1.
    PIRiS19720.
    RefSeqiYP_003577942.1. NC_014034.1.

    Genome annotation databases

    EnsemblBacteriaiADE85535; ADE85535; RCAP_rcc01790.
    GeneIDi9004613.
    KEGGircp:RCAP_rcc01790.
    PATRICi35503726. VBIRhoCap134200_1821.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60977 Genomic DNA. Translation: CAA43293.1 .
    CP001312 Genomic DNA. Translation: ADE85535.1 .
    PIRi S19720.
    RefSeqi YP_003577942.1. NC_014034.1.

    3D structure databases

    ProteinModelPortali P37171.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE85535 ; ADE85535 ; RCAP_rcc01790 .
    GeneIDi 9004613.
    KEGGi rcp:RCAP_rcc01790.
    PATRICi 35503726. VBIRhoCap134200_1821.

    Phylogenomic databases

    HOGENOMi HOG000236520.
    KOi K00760.
    OMAi MRADFTG.

    Enzyme and pathway databases

    UniPathwayi UPA00591 ; UER00648 .
    BioCyci RCAP272942:GJIY-1815-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    InterProi IPR005904. Hxn_phspho_trans.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01203. HGPRTase. 1 hit.
    PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC BAA-309 / NBRC 16581 / SB1003.
    2. "Complete genome sequence of the photosynthetic purple nonsulfur bacterium Rhodobacter capsulatus SB 1003."
      Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V., Haselkorn R.
      J. Bacteriol. 192:3545-3546(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-309 / NBRC 16581 / SB1003.

    Entry informationi

    Entry nameiHPRT_RHOCB
    AccessioniPrimary (citable) accession number: P37171
    Secondary accession number(s): D5AU96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3