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Protein

Lysozyme X

Gene

LysX

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food. May be involved in the clearance of bacteria from the larval gut before metamorphosis.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51PROSITE-ProRule annotation1
Active sitei69PROSITE-ProRule annotation1

GO - Molecular functioni

  • lysozyme activity Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-6798695 Neutrophil degranulation
R-DME-6803157 Antimicrobial peptides

Protein family/group databases

CAZyiGH22 Glycoside Hydrolase Family 22

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme X (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase X
Gene namesi
Name:LysX
ORF Names:CG9120
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0004431 LysX

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001851620 – 142Lysozyme XAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 140PROSITE-ProRule annotation
Disulfide bondi46 ↔ 130PROSITE-ProRule annotation
Disulfide bondi81 ↔ 97PROSITE-ProRule annotation
Disulfide bondi93 ↔ 111PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP37161
PRIDEiP37161

Expressioni

Tissue specificityi

Found in the midgut.

Developmental stagei

Rises dramatically in the late third instar, then decreases gradually during the pupal stages. Low expression is found in adults.

Gene expression databases

BgeeiFBgn0004431
ExpressionAtlasiP37161 baseline and differential
GenevisibleiP37161 DM

Interactioni

Protein-protein interaction databases

BioGridi63669, 1 interactor
DIPiDIP-24095N
STRINGi7227.FBpp0072533

Structurei

3D structure databases

ProteinModelPortaliP37161
SMRiP37161
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXGD Eukaryota
ENOG4111QHM LUCA
GeneTreeiENSGT00550000074398
InParanoidiP37161
KOiK01185
OMAiSKWACIA
OrthoDBiEOG091G0R9V
PhylomeDBiP37161

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000974 Glyco_hydro_22_lys
IPR023346 Lysozyme-like_dom_sf
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00137 LYSOZYME
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALLGICVL ALVTPAVLGR TMDRCSLARE MANMGVSRDQ LSKWACIAEH
60 70 80 90 100
ESSYRTGVVG PPNTDGSNDY GIFQINDMYW CQPSSGKFSH NGCDVSCNAL
110 120 130 140
LTDDIKSSVR CALKVLGQQG WSAWSTWHYC SGYLPPIDDC FV
Length:142
Mass (Da):15,591
Last modified:December 1, 2000 - v2
Checksum:i2A48035364B995BC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti6G → T in strain: G140. 1 Publication1
Natural varianti78M → L in strain: Canton-S, G02, G130 and G140. 1 Publication1
Natural varianti94D → G in strain: G130 and G140. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM412869 Genomic DNA Translation: CAL85492.1
AM412870 Genomic DNA Translation: CAL85493.1
AM412871 Genomic DNA Translation: CAL85494.1
AM412872 Genomic DNA Translation: CAL85495.1
AE014296 Genomic DNA Translation: AAF47445.1
AY119081 mRNA Translation: AAM50941.1
Z22224 mRNA Translation: CAA80226.1
PIRiS41580
RefSeqiNP_523881.1, NM_079157.2
UniGeneiDm.19201

Genome annotation databases

EnsemblMetazoaiFBtr0072637; FBpp0072533; FBgn0004431
GeneIDi38122
KEGGidme:Dmel_CG9120

Similar proteinsi

Entry informationi

Entry nameiLYSX_DROME
AccessioniPrimary (citable) accession number: P37161
Secondary accession number(s): A4V9W9
, A4V9X0, A4V9X1, A4V9X2, Q9W0K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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