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P37161

- LYSX_DROME

UniProt

P37161 - LYSX_DROME

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Protein

Lysozyme X

Gene

LysX

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food. May be involved in the clearance of bacteria from the larval gut before metamorphosis.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511PROSITE-ProRule annotation
Active sitei69 – 691PROSITE-ProRule annotation

GO - Molecular functioni

  1. lysozyme activity Source: FlyBase

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiREACT_180705. Amyloids.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme X (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase X
Gene namesi
Name:LysX
ORF Names:CG9120
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0004431. LysX.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 142123Lysozyme XPRO_0000018516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 140PROSITE-ProRule annotation
Disulfide bondi46 ↔ 130PROSITE-ProRule annotation
Disulfide bondi81 ↔ 97PROSITE-ProRule annotation
Disulfide bondi93 ↔ 111PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP37161.
PRIDEiP37161.

Expressioni

Tissue specificityi

Found in the midgut.

Developmental stagei

Rises dramatically in the late third instar, then decreases gradually during the pupal stages. Low expression is found in adults.

Gene expression databases

BgeeiP37161.

Interactioni

Protein-protein interaction databases

BioGridi63669. 1 interaction.
DIPiDIP-24095N.
MINTiMINT-1674138.
STRINGi7227.FBpp0072533.

Structurei

3D structure databases

ProteinModelPortaliP37161.
SMRiP37161. Positions 20-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG281116.
GeneTreeiENSGT00550000074398.
InParanoidiP37161.
KOiK01185.
OMAiQGMDGYR.
OrthoDBiEOG7BW0M5.
PhylomeDBiP37161.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37161-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRALLGICVL ALVTPAVLGR TMDRCSLARE MANMGVSRDQ LSKWACIAEH
60 70 80 90 100
ESSYRTGVVG PPNTDGSNDY GIFQINDMYW CQPSSGKFSH NGCDVSCNAL
110 120 130 140
LTDDIKSSVR CALKVLGQQG WSAWSTWHYC SGYLPPIDDC FV
Length:142
Mass (Da):15,591
Last modified:December 1, 2000 - v2
Checksum:i2A48035364B995BC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61G → T in strain: G140. 1 Publication
Natural varianti78 – 781M → L in strain: Canton-S, G02, G130 and G140. 1 Publication
Natural varianti94 – 941D → G in strain: G130 and G140. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM412869 Genomic DNA. Translation: CAL85492.1.
AM412870 Genomic DNA. Translation: CAL85493.1.
AM412871 Genomic DNA. Translation: CAL85494.1.
AM412872 Genomic DNA. Translation: CAL85495.1.
AE014296 Genomic DNA. Translation: AAF47445.1.
AY119081 mRNA. Translation: AAM50941.1.
Z22224 mRNA. Translation: CAA80226.1.
PIRiS41580.
RefSeqiNP_523881.1. NM_079157.2.
UniGeneiDm.19201.

Genome annotation databases

EnsemblMetazoaiFBtr0072637; FBpp0072533; FBgn0004431.
GeneIDi38122.
KEGGidme:Dmel_CG9120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM412869 Genomic DNA. Translation: CAL85492.1 .
AM412870 Genomic DNA. Translation: CAL85493.1 .
AM412871 Genomic DNA. Translation: CAL85494.1 .
AM412872 Genomic DNA. Translation: CAL85495.1 .
AE014296 Genomic DNA. Translation: AAF47445.1 .
AY119081 mRNA. Translation: AAM50941.1 .
Z22224 mRNA. Translation: CAA80226.1 .
PIRi S41580.
RefSeqi NP_523881.1. NM_079157.2.
UniGenei Dm.19201.

3D structure databases

ProteinModelPortali P37161.
SMRi P37161. Positions 20-141.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 63669. 1 interaction.
DIPi DIP-24095N.
MINTi MINT-1674138.
STRINGi 7227.FBpp0072533.

Protein family/group databases

CAZyi GH22. Glycoside Hydrolase Family 22.

Proteomic databases

PaxDbi P37161.
PRIDEi P37161.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0072637 ; FBpp0072533 ; FBgn0004431 .
GeneIDi 38122.
KEGGi dme:Dmel_CG9120.

Organism-specific databases

CTDi 38122.
FlyBasei FBgn0004431. LysX.

Phylogenomic databases

eggNOGi NOG281116.
GeneTreei ENSGT00550000074398.
InParanoidi P37161.
KOi K01185.
OMAi QGMDGYR.
OrthoDBi EOG7BW0M5.
PhylomeDBi P37161.

Enzyme and pathway databases

Reactomei REACT_180705. Amyloids.

Miscellaneous databases

GenomeRNAii 38122.
NextBioi 807080.

Gene expression databases

Bgeei P37161.

Family and domain databases

InterProi IPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view ]
Pfami PF00062. Lys. 1 hit.
[Graphical view ]
PRINTSi PR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTi SM00263. LYZ1. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
PROSITEi PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A screen for immunity genes evolving under positive selection in Drosophila."
    Jiggins F.M., Kim K.W.
    J. Evol. Biol. 20:965-970(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-6; LEU-78 AND GLY-94.
    Strain: G02, G130, G140 and G28.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Larva and Pupae.
  5. "The lysozyme locus in Drosophila melanogaster: an expanded gene family adapted for expression in the digestive tract."
    Daffre S., Kylsten P., Samakovlis C., Hultmark D.
    Mol. Gen. Genet. 242:152-162(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 62-142.
    Strain: Canton-S.

Entry informationi

Entry nameiLYSX_DROME
AccessioniPrimary (citable) accession number: P37161
Secondary accession number(s): A4V9W9
, A4V9X0, A4V9X1, A4V9X2, Q9W0K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: December 1, 2000
Last modified: October 1, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3