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Protein

Lysozyme X

Gene

LysX

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food. May be involved in the clearance of bacteria from the larval gut before metamorphosis.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51PROSITE-ProRule annotation1
Active sitei69PROSITE-ProRule annotation1

GO - Molecular functioni

  • lysozyme activity Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.
R-DME-6803157. Antimicrobial peptides.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme X (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase X
Gene namesi
Name:LysX
ORF Names:CG9120
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0004431. LysX.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001851620 – 142Lysozyme XAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 140PROSITE-ProRule annotation
Disulfide bondi46 ↔ 130PROSITE-ProRule annotation
Disulfide bondi81 ↔ 97PROSITE-ProRule annotation
Disulfide bondi93 ↔ 111PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP37161.
PRIDEiP37161.

Expressioni

Tissue specificityi

Found in the midgut.

Developmental stagei

Rises dramatically in the late third instar, then decreases gradually during the pupal stages. Low expression is found in adults.

Gene expression databases

BgeeiFBgn0004431.
ExpressionAtlasiP37161. differential.
GenevisibleiP37161. DM.

Interactioni

Protein-protein interaction databases

BioGridi63669. 1 interactor.
DIPiDIP-24095N.
MINTiMINT-1674138.
STRINGi7227.FBpp0072533.

Structurei

3D structure databases

ProteinModelPortaliP37161.
SMRiP37161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXGD. Eukaryota.
ENOG4111QHM. LUCA.
GeneTreeiENSGT00550000074398.
InParanoidiP37161.
KOiK01185.
OMAiPKGMSAW.
OrthoDBiEOG091G0R9V.
PhylomeDBiP37161.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiView protein in InterPro
IPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom_sf.
PfamiView protein in Pfam
PF00062. Lys. 1 hit.
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiView protein in SMART
SM00263. LYZ1. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiView protein in PROSITE
PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALLGICVL ALVTPAVLGR TMDRCSLARE MANMGVSRDQ LSKWACIAEH
60 70 80 90 100
ESSYRTGVVG PPNTDGSNDY GIFQINDMYW CQPSSGKFSH NGCDVSCNAL
110 120 130 140
LTDDIKSSVR CALKVLGQQG WSAWSTWHYC SGYLPPIDDC FV
Length:142
Mass (Da):15,591
Last modified:December 1, 2000 - v2
Checksum:i2A48035364B995BC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti6G → T in strain: G140. 1 Publication1
Natural varianti78M → L in strain: Canton-S, G02, G130 and G140. 1 Publication1
Natural varianti94D → G in strain: G130 and G140. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM412869 Genomic DNA. Translation: CAL85492.1.
AM412870 Genomic DNA. Translation: CAL85493.1.
AM412871 Genomic DNA. Translation: CAL85494.1.
AM412872 Genomic DNA. Translation: CAL85495.1.
AE014296 Genomic DNA. Translation: AAF47445.1.
AY119081 mRNA. Translation: AAM50941.1.
Z22224 mRNA. Translation: CAA80226.1.
PIRiS41580.
RefSeqiNP_523881.1. NM_079157.2.
UniGeneiDm.19201.

Genome annotation databases

EnsemblMetazoaiFBtr0072637; FBpp0072533; FBgn0004431.
GeneIDi38122.
KEGGidme:Dmel_CG9120.

Similar proteinsi

Entry informationi

Entry nameiLYSX_DROME
AccessioniPrimary (citable) accession number: P37161
Secondary accession number(s): A4V9W9
, A4V9X0, A4V9X1, A4V9X2, Q9W0K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: December 1, 2000
Last modified: November 22, 2017
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families