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Protein

Lysozyme S

Gene

LysS

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51PROSITE-ProRule annotation1
Active sitei69PROSITE-ProRule annotation1

GO - Molecular functioni

  • lysozyme activity Source: FlyBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-5653890. Lactose synthesis.
R-DME-6798695. Neutrophil degranulation.
R-DME-6803157. Antimicrobial peptides.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme S (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase S
Gene namesi
Name:LysS
ORF Names:CG1165
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0004430. LysS.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001851520 – 140Lysozyme SAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 139PROSITE-ProRule annotation
Disulfide bondi46 ↔ 129PROSITE-ProRule annotation
Disulfide bondi81 ↔ 96PROSITE-ProRule annotation
Disulfide bondi92 ↔ 110PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP37160.
PRIDEiP37160.

Expressioni

Tissue specificityi

Found in the midgut, especially the epithelium of the gastric caeca.

Developmental stagei

Expressed only during the larval stage, the highest level is reached during the third larval instar.

Gene expression databases

BgeeiFBgn0004430.
GenevisibleiP37160. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0072527.

Structurei

3D structure databases

ProteinModelPortaliP37160.
SMRiP37160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXGD. Eukaryota.
ENOG4111QHM. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000263860.
InParanoidiP37160.
KOiK01185.
OMAiSQQGWGA.
OrthoDBiEOG091G0R9V.
PhylomeDBiP37160.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAFFALVLL AIAAPALAGR TLDRCSLARE MADLGVPRDQ LDKWTCIAQH
60 70 80 90 100
ESDYRTWVVG PANSDGSNDY GIFQINDLYW CQADGRFSYN ECGLSCNALL
110 120 130 140
TDDITNSVRC AQKVLSQQGW SAWAVWHYCS GWLPSIDECF
Length:140
Mass (Da):15,652
Last modified:December 1, 2000 - v2
Checksum:iACD139CC656EF8FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11 – 16AIAAPA → PLPLC in CAA80230 (PubMed:8159165).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22228 Genomic DNA. Translation: CAA80230.1.
AE014296 Genomic DNA. Translation: AAF47453.1.
AY119049 mRNA. Translation: AAM50909.1.
PIRiS41579.
RefSeqiNP_476829.1. NM_057481.4.
UniGeneiDm.14478.

Genome annotation databases

EnsemblMetazoaiFBtr0072631; FBpp0072527; FBgn0004430.
GeneIDi38130.
KEGGidme:Dmel_CG1165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22228 Genomic DNA. Translation: CAA80230.1.
AE014296 Genomic DNA. Translation: AAF47453.1.
AY119049 mRNA. Translation: AAM50909.1.
PIRiS41579.
RefSeqiNP_476829.1. NM_057481.4.
UniGeneiDm.14478.

3D structure databases

ProteinModelPortaliP37160.
SMRiP37160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0072527.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Proteomic databases

PaxDbiP37160.
PRIDEiP37160.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072631; FBpp0072527; FBgn0004430.
GeneIDi38130.
KEGGidme:Dmel_CG1165.

Organism-specific databases

CTDi38130.
FlyBaseiFBgn0004430. LysS.

Phylogenomic databases

eggNOGiENOG410IXGD. Eukaryota.
ENOG4111QHM. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000263860.
InParanoidiP37160.
KOiK01185.
OMAiSQQGWGA.
OrthoDBiEOG091G0R9V.
PhylomeDBiP37160.

Enzyme and pathway databases

ReactomeiR-DME-5653890. Lactose synthesis.
R-DME-6798695. Neutrophil degranulation.
R-DME-6803157. Antimicrobial peptides.

Miscellaneous databases

GenomeRNAii38130.
PROiP37160.

Gene expression databases

BgeeiFBgn0004430.
GenevisibleiP37160. DM.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYSS_DROME
AccessioniPrimary (citable) accession number: P37160
Secondary accession number(s): Q9W0J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.