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Protein

UPF0716 protein FxsA

Gene

fxsA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Overexpression alleviates the exclusion of phage T7 in cells harboring the F plasmid.

Enzyme and pathway databases

BioCyciEcoCyc:G7832-MONOMER.
ECOL316407:JW4100-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0716 protein FxsA
Alternative name(s):
Suppressor of F exclusion of phage T7
Gene namesi
Name:fxsA
Synonyms:yjeG
Ordered Locus Names:b4140, JW4100
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12382. fxsA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 78PeriplasmicSequence analysisAdd BLAST41
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 158CytoplasmicSequence analysisAdd BLAST59

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873941 – 158UPF0716 protein FxsAAdd BLAST158

Proteomic databases

PaxDbiP37147.
PRIDEiP37147.

Interactioni

Protein-protein interaction databases

BioGridi4262196. 11 interactors.
IntActiP37147. 3 interactors.
STRINGi511145.b4140.

Structurei

3D structure databases

ProteinModelPortaliP37147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0716 (FxsA) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108YH1. Bacteria.
COG3030. LUCA.
HOGENOMiHOG000272432.
InParanoidiP37147.
KOiK07113.
OMAiQGIQTLM.

Family and domain databases

InterProiIPR007313. FxsA.
[Graphical view]
PfamiPF04186. FxsA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWLPFIAIF LYVYIEISIF IQVAHVLGVL LTLVLVIFTS VIGMSLVRNQ
60 70 80 90 100
GFKNFVLMQQ KMAAGENPAA EMIKSVSLII AGLLLLLPGF FTDFLGLLLL
110 120 130 140 150
LPPVQKHLTV KLMPHLRFSR MPGGGFSAGT GGGNTFDGEY QRKDDERDRL

DHKDDRQD
Length:158
Mass (Da):17,692
Last modified:February 1, 1995 - v2
Checksum:iDB2338BFE146076D
GO

Sequence cautioni

The sequence AAA97039 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA27700 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78484 Genomic DNA. Translation: AAB36686.1.
U14003 Genomic DNA. Translation: AAA97039.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77100.2.
AP009048 Genomic DNA. Translation: BAE78142.1.
X04066 Genomic DNA. Translation: CAA27700.1. Different initiation.
PIRiS56368.
RefSeqiNP_418564.2. NC_000913.3.
WP_001267448.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77100; AAC77100; b4140.
BAE78142; BAE78142; BAE78142.
GeneIDi948657.
KEGGiecj:JW4100.
eco:b4140.
PATRICi32123849. VBIEscCol129921_4272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78484 Genomic DNA. Translation: AAB36686.1.
U14003 Genomic DNA. Translation: AAA97039.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77100.2.
AP009048 Genomic DNA. Translation: BAE78142.1.
X04066 Genomic DNA. Translation: CAA27700.1. Different initiation.
PIRiS56368.
RefSeqiNP_418564.2. NC_000913.3.
WP_001267448.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP37147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262196. 11 interactors.
IntActiP37147. 3 interactors.
STRINGi511145.b4140.

Proteomic databases

PaxDbiP37147.
PRIDEiP37147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77100; AAC77100; b4140.
BAE78142; BAE78142; BAE78142.
GeneIDi948657.
KEGGiecj:JW4100.
eco:b4140.
PATRICi32123849. VBIEscCol129921_4272.

Organism-specific databases

EchoBASEiEB2284.
EcoGeneiEG12382. fxsA.

Phylogenomic databases

eggNOGiENOG4108YH1. Bacteria.
COG3030. LUCA.
HOGENOMiHOG000272432.
InParanoidiP37147.
KOiK07113.
OMAiQGIQTLM.

Enzyme and pathway databases

BioCyciEcoCyc:G7832-MONOMER.
ECOL316407:JW4100-MONOMER.

Miscellaneous databases

PROiP37147.

Family and domain databases

InterProiIPR007313. FxsA.
[Graphical view]
PfamiPF04186. FxsA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFXSA_ECOLI
AccessioniPrimary (citable) accession number: P37147
Secondary accession number(s): P76797, Q2M6G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.