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P37145 (THRC_METGL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Threonine synthase

Short name=TS
EC=4.2.3.1
Gene names
Name:thrC
OrganismMethylobacillus glycogenes
Taxonomic identifier406 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus

Protein attributes

Sequence length475 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity.

Catalytic activity

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.

Sequence similarities

Belongs to the threonine synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   LigandPyridoxal phosphate
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionpyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

threonine synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 475475Threonine synthase
PRO_0000185635

Amino acid modifications

Modified residue1201N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P37145 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 2520D44EAA16E831

FASTA47552,115
        10         20         30         40         50         60 
MKYISTRGQS PALSFSEILL GGLAPDGGLY LPEQYPQFSA DALSAMRGMN YRDLAFTILS 

        70         80         90        100        110        120 
RLIDDIPADD LRIIVDKTYR ADVYAYARPG QDAEDITPTY KLEDDLYLLS LSNGPTLAFK 

       130        140        150        160        170        180 
DMAMQLLGNL FEYVLAQKGE TTNILGATSG DTGSAAEYAM RGKQGVKVFM LSPHQKMSRF 

       190        200        210        220        230        240 
QTAQMFSLQD DNIFNIAVKG VFDDCQDIVK AVSNDHAFKA KNKIGAVNSI NWARVAAQVV 

       250        260        270        280        290        300 
YYFKGYFAVT ADNAQQVSFA VPSGNFGNVC AGHIARMMGL PIAKLVVATN ENDVLDEFFK 

       310        320        330        340        350        360 
TGVYRPRGSA NTYHTSSPSM DISKASNFER FVFDLVGRDA AKVRELWGKV DAGGSFDLND 

       370        380        390        400        410        420 
GGWFAKVADY GFVSGSSNHA NRMQTIKATH ERYGVTIDTH TADGLKVALE HREAGTPMLV 

       430        440        450        460        470 
LETALPAKFE DAIVEALGHK PERPHSLEGL ESLPQRFEVM EADAAVIKQF IVEHI 

« Hide

References

[1]"Cloning and nucleotide sequences of the homoserine dehydrogenase genes (hom) and the threonine synthase genes (thrC) of the Gram-negative obligate methylotroph Methylobacillus glycogenes."
Motoyama H., Maki K., Anazawa H., Ishino S., Teshiba S.
Appl. Environ. Microbiol. 60:111-119(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 21371 / JCM 2853.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D14071 Genomic DNA. Translation: BAA40416.1.

3D structure databases

ProteinModelPortalP37145.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP37145.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00050; UER00065.

Family and domain databases

Gene3D3.90.1380.10. 1 hit.
InterProIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamPF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view]
SUPFAMSSF53686. SSF53686. 1 hit.
TIGRFAMsTIGR00260. thrC. 1 hit.
PROSITEPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHRC_METGL
AccessionPrimary (citable) accession number: P37145
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways