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Reviewed, UniProtKB/Swiss-Prot P37145 (THRC_METGL)

Last modified June 16, 2009. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Threonine synthase
    EC=4.2.3.1
Gene names
Name: thrC
OrganismMethylobacillus glycogenes
Taxonomic identifier406 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus

Protein attributes

Sequence length475 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactor

Pyridoxal phosphate.

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.

Sequence similarities

Belongs to the serine/threonine dehydratase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 475475Threonine synthase
PRO_0000185635

Amino acid modifications

Modified residue1201N6-(pyridoxal phosphate)lysine Probable

Sequences

Sequence LengthMass (Da)Tools
P37145-1 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 2520D44EAA16E831

FASTA47552,115
        10         20         30         40         50         60 
MKYISTRGQS PALSFSEILL GGLAPDGGLY LPEQYPQFSA DALSAMRGMN YRDLAFTILS 

        70         80         90        100        110        120 
RLIDDIPADD LRIIVDKTYR ADVYAYARPG QDAEDITPTY KLEDDLYLLS LSNGPTLAFK 

       130        140        150        160        170        180 
DMAMQLLGNL FEYVLAQKGE TTNILGATSG DTGSAAEYAM RGKQGVKVFM LSPHQKMSRF 

       190        200        210        220        230        240 
QTAQMFSLQD DNIFNIAVKG VFDDCQDIVK AVSNDHAFKA KNKIGAVNSI NWARVAAQVV 

       250        260        270        280        290        300 
YYFKGYFAVT ADNAQQVSFA VPSGNFGNVC AGHIARMMGL PIAKLVVATN ENDVLDEFFK 

       310        320        330        340        350        360 
TGVYRPRGSA NTYHTSSPSM DISKASNFER FVFDLVGRDA AKVRELWGKV DAGGSFDLND 

       370        380        390        400        410        420 
GGWFAKVADY GFVSGSSNHA NRMQTIKATH ERYGVTIDTH TADGLKVALE HREAGTPMLV 

       430        440        450        460        470 
LETALPAKFE DAIVEALGHK PERPHSLEGL ESLPQRFEVM EADAAVIKQF IVEHI 

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References

[1]"Cloning and nucleotide sequences of the homoserine dehydrogenase genes (hom) and the threonine synthase genes (thrC) of the Gram-negative obligate methylotroph Methylobacillus glycogenes."
Motoyama H., Maki K., Anazawa H., Ishino S., Teshiba S.
Appl. Environ. Microbiol. 60:111-119(1994) [PubMed: 8117070] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 21371 / JCM 2853.

Cross-references

Sequence databases

D14071 Genomic DNA. Translation: BAA40416.1.

3D structure databases

HSSPHSSP built from PDB template 1KL7 based on UniProtKB P16120.
ModBaseSearch...

Enzyme and pathway databases

BRENDA4.2.3.1. 20727.

Family and domain databases

InterProIPR001926. PyrdxlP-dep_enz_bsu.
IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR004450. Thr_synthase.
[Graphical view]
PfamPF00291. PALP. 1 hit.
[Graphical view]
TIGRFAMsTIGR00260. thrC. 1 hit.
PROSITEPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHRC_METGL
AccessionPrimary (citable) accession number: P37145
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents