Reviewed, UniProtKB/Swiss-Prot P37145 (THRC_METGL)

Names and origin

Protein names

Recommended name:
    Threonine synthase
    EC=4.2.3.1

Gene names

Name:

thrC

Organism

Methylobacillus glycogenes

Taxonomic identifier

406 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Methylophilales › Methylophilaceae › Methylobacillus

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	O-phospho-L-homoserine + H2O = L-threonine + phosphate.
Cofactor	Pyridoxal phosphate.
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.
Sequence similarities	Belongs to the serine/threonine dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro threonine synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 475	475	Threonine synthase		PRO_0000185635
Amino acid modifications
	Modified residue	120	1	N6-(pyridoxal phosphate)lysine Probable

Sequences

	Sequence		Length	Mass (Da)
	P37145-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 2520D44EAA16E831	FASTA	475	52,115
	10 20 30 40 50 60 MKYISTRGQS PALSFSEILL GGLAPDGGLY LPEQYPQFSA DALSAMRGMN YRDLAFTILS 70 80 90 100 110 120 RLIDDIPADD LRIIVDKTYR ADVYAYARPG QDAEDITPTY KLEDDLYLLS LSNGPTLAFK 130 140 150 160 170 180 DMAMQLLGNL FEYVLAQKGE TTNILGATSG DTGSAAEYAM RGKQGVKVFM LSPHQKMSRF 190 200 210 220 230 240 QTAQMFSLQD DNIFNIAVKG VFDDCQDIVK AVSNDHAFKA KNKIGAVNSI NWARVAAQVV 250 260 270 280 290 300 YYFKGYFAVT ADNAQQVSFA VPSGNFGNVC AGHIARMMGL PIAKLVVATN ENDVLDEFFK 310 320 330 340 350 360 TGVYRPRGSA NTYHTSSPSM DISKASNFER FVFDLVGRDA AKVRELWGKV DAGGSFDLND 370 380 390 400 410 420 GGWFAKVADY GFVSGSSNHA NRMQTIKATH ERYGVTIDTH TADGLKVALE HREAGTPMLV 430 440 450 460 470 LETALPAKFE DAIVEALGHK PERPHSLEGL ESLPQRFEVM EADAAVIKQF IVEHI

References

[1]

"Cloning and nucleotide sequences of the homoserine dehydrogenase genes (hom) and the threonine synthase genes (thrC) of the Gram-negative obligate methylotroph Methylobacillus glycogenes." Motoyama H., Maki K., Anazawa H., Ishino S., Teshiba S. Appl. Environ. Microbiol. 60:111-119(1994) [PubMed: 8117070] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 21371 / JCM 2853.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D14071 Genomic DNA. Translation: BAA40416.1.
3D structure databases
HSSP	HSSP built from PDB template 1KL7 based on UniProtKB P16120.
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.2.3.1. 20727.
Family and domain databases
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. IPR004450. Thr_synthase. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
TIGRFAMs	TIGR00260. thrC. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THRC_METGL

Accession

Primary (citable) accession number: P37145

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)