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P37145

- THRC_METGL

UniProt

P37145 - THRC_METGL

Protein

Threonine synthase

Gene

thrC

Organism
Methylobacillus glycogenes
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

    Catalytic activityi

    O-phospho-L-homoserine + H2O = L-threonine + phosphate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. threonine synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00050; UER00065.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine synthase (EC:4.2.3.1)
    Short name:
    TS
    Gene namesi
    Name:thrC
    OrganismiMethylobacillus glycogenes
    Taxonomic identifieri406 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 475475Threonine synthasePRO_0000185635Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei120 – 1201N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiP37145.

    Structurei

    3D structure databases

    ProteinModelPortaliP37145.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the threonine synthase family.Curated

    Family and domain databases

    Gene3Di3.90.1380.10. 1 hit.
    InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00260. thrC. 1 hit.
    PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37145-1 [UniParc]FASTAAdd to Basket

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    MKYISTRGQS PALSFSEILL GGLAPDGGLY LPEQYPQFSA DALSAMRGMN    50
    YRDLAFTILS RLIDDIPADD LRIIVDKTYR ADVYAYARPG QDAEDITPTY 100
    KLEDDLYLLS LSNGPTLAFK DMAMQLLGNL FEYVLAQKGE TTNILGATSG 150
    DTGSAAEYAM RGKQGVKVFM LSPHQKMSRF QTAQMFSLQD DNIFNIAVKG 200
    VFDDCQDIVK AVSNDHAFKA KNKIGAVNSI NWARVAAQVV YYFKGYFAVT 250
    ADNAQQVSFA VPSGNFGNVC AGHIARMMGL PIAKLVVATN ENDVLDEFFK 300
    TGVYRPRGSA NTYHTSSPSM DISKASNFER FVFDLVGRDA AKVRELWGKV 350
    DAGGSFDLND GGWFAKVADY GFVSGSSNHA NRMQTIKATH ERYGVTIDTH 400
    TADGLKVALE HREAGTPMLV LETALPAKFE DAIVEALGHK PERPHSLEGL 450
    ESLPQRFEVM EADAAVIKQF IVEHI 475
    Length:475
    Mass (Da):52,115
    Last modified:October 1, 1994 - v1
    Checksum:i2520D44EAA16E831
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14071 Genomic DNA. Translation: BAA40416.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14071 Genomic DNA. Translation: BAA40416.1 .

    3D structure databases

    ProteinModelPortali P37145.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P37145.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00065 .

    Family and domain databases

    Gene3Di 3.90.1380.10. 1 hit.
    InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00260. thrC. 1 hit.
    PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and nucleotide sequences of the homoserine dehydrogenase genes (hom) and the threonine synthase genes (thrC) of the Gram-negative obligate methylotroph Methylobacillus glycogenes."
      Motoyama H., Maki K., Anazawa H., Ishino S., Teshiba S.
      Appl. Environ. Microbiol. 60:111-119(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 21371 / JCM 2853.

    Entry informationi

    Entry nameiTHRC_METGL
    AccessioniPrimary (citable) accession number: P37145
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3