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P37145

- THRC_METGL

UniProt

P37145 - THRC_METGL

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Protein

Threonine synthase

Gene
thrC
Organism
Methylobacillus glycogenes
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity.

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. threonine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
OrganismiMethylobacillus glycogenes
Taxonomic identifieri406 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Threonine synthasePRO_0000185635Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei120 – 1201N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiP37145.

Structurei

3D structure databases

ProteinModelPortaliP37145.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.90.1380.10. 1 hit.
InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37145-1 [UniParc]FASTAAdd to Basket

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MKYISTRGQS PALSFSEILL GGLAPDGGLY LPEQYPQFSA DALSAMRGMN    50
YRDLAFTILS RLIDDIPADD LRIIVDKTYR ADVYAYARPG QDAEDITPTY 100
KLEDDLYLLS LSNGPTLAFK DMAMQLLGNL FEYVLAQKGE TTNILGATSG 150
DTGSAAEYAM RGKQGVKVFM LSPHQKMSRF QTAQMFSLQD DNIFNIAVKG 200
VFDDCQDIVK AVSNDHAFKA KNKIGAVNSI NWARVAAQVV YYFKGYFAVT 250
ADNAQQVSFA VPSGNFGNVC AGHIARMMGL PIAKLVVATN ENDVLDEFFK 300
TGVYRPRGSA NTYHTSSPSM DISKASNFER FVFDLVGRDA AKVRELWGKV 350
DAGGSFDLND GGWFAKVADY GFVSGSSNHA NRMQTIKATH ERYGVTIDTH 400
TADGLKVALE HREAGTPMLV LETALPAKFE DAIVEALGHK PERPHSLEGL 450
ESLPQRFEVM EADAAVIKQF IVEHI 475
Length:475
Mass (Da):52,115
Last modified:October 1, 1994 - v1
Checksum:i2520D44EAA16E831
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14071 Genomic DNA. Translation: BAA40416.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14071 Genomic DNA. Translation: BAA40416.1 .

3D structure databases

ProteinModelPortali P37145.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P37145.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00065 .

Family and domain databases

Gene3Di 3.90.1380.10. 1 hit.
InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00260. thrC. 1 hit.
PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and nucleotide sequences of the homoserine dehydrogenase genes (hom) and the threonine synthase genes (thrC) of the Gram-negative obligate methylotroph Methylobacillus glycogenes."
    Motoyama H., Maki K., Anazawa H., Ishino S., Teshiba S.
    Appl. Environ. Microbiol. 60:111-119(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 21371 / JCM 2853.

Entry informationi

Entry nameiTHRC_METGL
AccessioniPrimary (citable) accession number: P37145
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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