Reviewed, UniProtKB/Swiss-Prot P37144 (DHON_METGL)

Names and origin

Protein names

Recommended name:
    Homoserine dehydrogenase
      Short name=HDH
    EC=1.1.1.3

Gene names

Name:

hom

Organism

Methylobacillus glycogenes

Taxonomic identifier

406 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Methylophilales › Methylophilaceae › Methylobacillus

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.
Sequence similarities	Belongs to the homoserine dehydrogenase family. Contains 1 ACT domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis Isoleucine biosynthesis Methionine biosynthesis Threonine biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 412	412	Homoserine dehydrogenase
Regions
	Domain	329 – 404	76	ACT
	Nucleotide binding	9 – 16	8	NADP By similarity
Sites
	Active site	205	1	Proton donor Potential
	Binding site	105	1	NADP By similarity
	Binding site	190	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P37144-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 613A1B7FDECEF4AA	FASTA	412	44,818
	10 20 30 40 50 60 MKPINVGLLG IGTVGGGTYT VLTRNQEEIA RRAGRPIAIT RVADRNLELA RQVTGGKIDV 70 80 90 100 110 120 TDDAFAIVSD PAIDIVVELI GGYTVARELV LKAIENGKHV VTANKALIAC MAMKFLPLRR 130 140 150 160 170 180 KKASSSLLKL PLLVVSPLFK AVREGLAANR IEWIAGIING TTNFILSEMR EKGLAFADVL 190 200 210 220 230 240 KEAQRLGYAE ADPTFDVEGI DAAHKLMILA AMLWLFVHSL CRGITKLDAV DITKRTDKGV 250 260 270 280 290 300 ELRVHPTLIP EKRLICQCEW RNECCAGQGR CCWPTLYYGA GAGAEPTASA VADLVDGTDR 310 320 330 340 350 360 GISCPHLAFQ PDRLVDLPIL PIGEISSAYY LRLRAVDKPG VLADVTRILG DRQISIDAMI 370 380 390 400 410 QKEPQEGEDQ ADIIILTHVT VEKNMDDAIA AIEALPAISG KVTRLRMEEL SR

References

[1]

"Cloning and nucleotide sequences of the homoserine dehydrogenase genes (hom) and the threonine synthase genes (thrC) of the Gram-negative obligate methylotroph Methylobacillus glycogenes." Motoyama H., Maki K., Anazawa H., Ishino S., Teshiba S. Appl. Environ. Microbiol. 60:111-119(1994) [PubMed: 8117070] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 21371 / JCM 2853.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D14071 Genomic DNA. Translation: BAA40415.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR002912. ACT_bd. IPR005106. Asp/hSer_DHase_NAD-bd. IPR016204. hSer_DHase. IPR001342. hSer_DHase_cat. [Graphical view]
Pfam	PF01842. ACT. 1 hit. PF00742. Homoserine_dh. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view]
PIRSF	PIRSF000098. Homoser_dehydrog. 1 hit.
PROSITE	PS01042. HOMOSER_DHGENASE. 1 hit. [Graphical view]
ProDom	P37144. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

DHON_METGL

Accession

Primary (citable) accession number: P37144

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	July 22, 2008
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)