Reviewed,
UniProtKB/Swiss-Prot P37143 (DHOM_METGL)
Last modified
November 24, 2009.
Version 48.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Homoserine dehydrogenase Short name=HDH EC=1.1.1.3 | ||
| Gene names |
| ||
| Organism | Methylobacillus glycogenes | ||
| Taxonomic identifier | 406 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Methylophilales › Methylophilaceae › Methylobacillus |
Protein attributes
| Sequence length | 435 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H. |
| Pathway | Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5. |
| Sequence similarities | Belongs to the homoserine dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Branched-chain amino acid biosynthesis Isoleucine biosynthesis Methionine biosynthesis Threonine biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | isoleucine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW methionine biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW threonine biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | NADP or NADPH binding Inferred from electronic annotation. Source: InterPro homoserine dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 435 | 435 | Homoserine dehydrogenase | PRO_0000066698 | |||||
Regions | |||||||||
| Nucleotide binding | 9 – 16 | 8 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 204 | 1 | Proton donor Potential | ||||||
| Binding site | 105 | 1 | NADP By similarity | ||||||
| Binding site | 190 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Cloning and nucleotide sequences of the homoserine dehydrogenase genes (hom) and the threonine synthase genes (thrC) of the Gram-negative obligate methylotroph Methylobacillus glycogenes." Motoyama H., Maki K., Anazawa H., Ishino S., Teshiba S. Appl. Environ. Microbiol. 60:111-119(1994) [PubMed: 8117070] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 21276. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D14070 Genomic DNA. Translation: BAA40414.1. |
3D structure databases | |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.3. 20727. |
Family and domain databases | |
| InterPro | IPR005106. Asp/hSer_DH_NAD-bd. IPR001342. Homoserine_dehydrogenase_cat. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Pfam | PF00742. Homoserine_dh. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view] |
| PROSITE | PS01042. HOMOSER_DHGENASE. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DHOM_METGL | ||||||||
| Accession | Primary (citable) accession number: P37143 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


