Reviewed, UniProtKB/Swiss-Prot P37141 (GPX3_BOVIN)

Names and origin

Protein names

Recommended name:
    Glutathione peroxidase 3
    EC=1.11.1.9
Alternative name(s):
    GSHPx-3
      Short name=GPx-3
    Plasma glutathione peroxidase
    GSHPx-P

Gene names

Name:

GPX3

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Catalytic activity	2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
Subunit structure	Homotetramer.
Subcellular location	Secreted.
Tissue specificity	Secreted in plasma.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Selenocysteine
Domain	Signal
Ligand	Selenium
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	protein homotetramerization Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	extracellular space Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	glutathione peroxidase activity Inferred from sequence or structural similarity. Source: UniProtKB selenium binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 226	202	Glutathione peroxidase 3		PRO_0000013061
Sites
	Active site	73	1
Amino acid modifications
	Non-standard residue	73	1	Selenocysteine
Experimental info
	Sequence conflict	169	1	L → H in AAI49267. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P37141-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 6357FCED08507923	FASTA	226	25,663
	10 20 30 40 50 60 MARLFRASCL LSLLLAGFIP PSQGQEKSKT DCHAGVGGTI YEYGALTIDG EEYIPFKQYA 70 80 90 100 110 120 GKYILFVNVA SYUGLTGQYV ELNALQEELE PFGLVILGFP CNQFGKQEPG ENSEILATLK 130 140 150 160 170 180 YVRPGGGFTP NFQLFEKGDV NGEKEQKFYT FLKNSCPPTS ELLGSPDRLF WEPMKVHDIR 190 200 210 220 WNFEKFLVGP DGIPIMRWYH RTTVNSVKMD ILTYMRRRAV WEAKGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the bovine plasma selenium-dependent glutathione peroxidase (GP) cDNA from the ocular ciliary epithelium: expression of the plasma and cellular forms within the mammalian eye." Martin-Alonso J.M., Ghosh S., Coca-Prados M. J. Biochem. 114:284-291(1993) [PubMed: 8262911] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Eye.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L10325 mRNA. Translation: AAA16579.2. BC149266 mRNA. Translation: AAI49267.1.
PIR	JX0280.
RefSeq	NP_776502.1.
UniGene	Bt.12916
3D structure databases
HSSP	HSSP built from PDB template 1GP1 based on UniProtKB P00435.
ModBase	Search...
Protein family/group databases
PeroxiBase	3636. BtGPx03.
Genome annotation databases
Ensembl	ENSBTAG00000012665. Bos taurus. [Contig view]
GeneID	281210.
KEGG	bta:281210.
Phylogenomic databases
HOVERGEN	P37141.
Family and domain databases
InterPro	IPR000889. Glut_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

GPX3_BOVIN

Accession

Primary (citable) accession number: P37141
Secondary accession number(s): A6QPD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	February 26, 2008
Last modified:	July 22, 2008
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)