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P37134

- CWLM_BACLI

UniProt

P37134 - CWLM_BACLI

Protein

N-acetylmuramoyl-L-alanine amidase CwlM

Gene

cwlM

Organism
Bacillus licheniformis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    • Comment

    Functioni

    Hydrolyzes the cell wall of M.luteus more efficiently than that of B.licheniformis and B.subtilis. The C-terminal region, including the repeats, determines substrate specificity.

    Catalytic activityi

    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Cell wall biogenesis/degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetylmuramoyl-L-alanine amidase CwlM (EC:3.5.1.28)
    Alternative name(s):
    Autolysin
    Cell wall hydrolase
    Gene namesi
    Name:cwlM
    OrganismiBacillus licheniformis
    Taxonomic identifieri1402 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

    Subcellular locationi

    Secreted Curated
    Note: Accumulates in cells as inclusion bodies. May be secreted by a mechanism different from the normal export system.

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 253253N-acetylmuramoyl-L-alanine amidase CwlMPRO_0000164420Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP37134.
    SMRiP37134. Positions 180-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini179 – 25375SPORAdd
    BLAST
    Repeati184 – 219361Add
    BLAST
    Repeati220 – 253342Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni184 – 253702 X 35 AA approximate tandem repeatsAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SPOR domain.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di3.30.70.1070. 1 hit.
    3.40.630.40. 1 hit.
    InterProiIPR002508. CW_Hdrlase/autolysin_cat.
    IPR007730. Sporulation-related_dom.
    [Graphical view]
    PfamiPF01520. Amidase_3. 1 hit.
    PF05036. SPOR. 1 hit.
    [Graphical view]
    SMARTiSM00646. Ami_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF110997. SSF110997. 1 hit.
    PROSITEiPS51724. SPOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37134-1 [UniParc]FASTAAdd to Basket

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    MVKIFIDPGH GGSDTGASAN GLQEKQLTLQ TALALRNMLL NEYQNVSVLL    50
    SRTSDQTVSL TQRTNAANSW GADYFLSIHM NAGGGTGFED YIYPGVGAPT 100
    TTYRDIMHEE ILKVVDFRDR GKKTANFHVL RETAMPALLT ENGFVDNTND 150
    AEKLKSSAFI QSIARGHANG LARAFNLSKN AAALYKVQIA AFRTKANADS 200
    LAAQAEAKGF DALVIYRDSL YKVQIGAFSS KENAEALVQQ AKNAEFDTFI 250
    YQE 253
    Length:253
    Mass (Da):27,600
    Last modified:October 1, 1994 - v1
    Checksum:i28E86E017B68D768
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62116 Genomic DNA. Translation: CAA44026.1.
    PIRiS23572.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62116 Genomic DNA. Translation: CAA44026.1 .
    PIRi S23572.

    3D structure databases

    ProteinModelPortali P37134.
    SMRi P37134. Positions 180-253.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.70.1070. 1 hit.
    3.40.630.40. 1 hit.
    InterProi IPR002508. CW_Hdrlase/autolysin_cat.
    IPR007730. Sporulation-related_dom.
    [Graphical view ]
    Pfami PF01520. Amidase_3. 1 hit.
    PF05036. SPOR. 1 hit.
    [Graphical view ]
    SMARTi SM00646. Ami_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110997. SSF110997. 1 hit.
    PROSITEi PS51724. SPOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic structure, isolation and characterization of a Bacillus licheniformis cell wall hydrolase."
      Kuroda A., Sugimoto Y., Funahashi T., Sekiguchi J.
      Mol. Gen. Genet. 234:129-137(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FD0120.

    Entry informationi

    Entry nameiCWLM_BACLI
    AccessioniPrimary (citable) accession number: P37134
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3