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Protein

N-acetylmuramoyl-L-alanine amidase CwlM

Gene

cwlM

Organism
Bacillus licheniformis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes the cell wall of M.luteus more efficiently than that of B.licheniformis and B.subtilis. The C-terminal region, including the repeats, determines substrate specificity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCell wall biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase CwlM (EC:3.5.1.28)
Alternative name(s):
Autolysin
Cell wall hydrolase
Gene namesi
Name:cwlM
OrganismiBacillus licheniformis
Taxonomic identifieri1402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Subcellular locationi

  • Secreted Curated
  • Note: Accumulates in cells as inclusion bodies. May be secreted by a mechanism different from the normal export system.

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001644201 – 253N-acetylmuramoyl-L-alanine amidase CwlMAdd BLAST253

Structurei

3D structure databases

ProteinModelPortaliP37134
SMRiP37134
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 253SPORAdd BLAST75
Repeati184 – 2191Add BLAST36
Repeati220 – 2532Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni184 – 2532 X 35 AA approximate tandem repeatsAdd BLAST70

Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

CDDicd02696 MurNAc-LAA, 1 hit
Gene3Di3.30.70.1070, 1 hit
InterProiView protein in InterPro
IPR002508 MurNAc-LAA_cat
IPR007730 SPOR-like_dom
IPR036680 SPOR-like_sf
PfamiView protein in Pfam
PF01520 Amidase_3, 1 hit
PF05036 SPOR, 1 hit
SMARTiView protein in SMART
SM00646 Ami_3, 1 hit
SUPFAMiSSF110997 SSF110997, 1 hit
PROSITEiView protein in PROSITE
PS51724 SPOR, 1 hit

Sequencei

Sequence statusi: Complete.

P37134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKIFIDPGH GGSDTGASAN GLQEKQLTLQ TALALRNMLL NEYQNVSVLL
60 70 80 90 100
SRTSDQTVSL TQRTNAANSW GADYFLSIHM NAGGGTGFED YIYPGVGAPT
110 120 130 140 150
TTYRDIMHEE ILKVVDFRDR GKKTANFHVL RETAMPALLT ENGFVDNTND
160 170 180 190 200
AEKLKSSAFI QSIARGHANG LARAFNLSKN AAALYKVQIA AFRTKANADS
210 220 230 240 250
LAAQAEAKGF DALVIYRDSL YKVQIGAFSS KENAEALVQQ AKNAEFDTFI

YQE
Length:253
Mass (Da):27,600
Last modified:October 1, 1994 - v1
Checksum:i28E86E017B68D768
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62116 Genomic DNA Translation: CAA44026.1
PIRiS23572

Similar proteinsi

Entry informationi

Entry nameiCWLM_BACLI
AccessioniPrimary (citable) accession number: P37134
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health