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Protein

Signal recognition particle 54 kDa protein 1

Gene

SRP-54A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi108 – 115GTPBy similarity8
Nucleotide bindingi190 – 194GTPBy similarity5
Nucleotide bindingi248 – 251GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-1799339 SRP-dependent cotranslational protein targeting to membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle 54 kDa protein 1
Short name:
SRP54
Gene namesi
Name:SRP-54A
Synonyms:SRP-54
Ordered Locus Names:At1g15310
ORF Names:F9L1.25
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G15310
TAIRilocus:2037803 AT1G15310

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Signal recognition particle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012041 – 479Signal recognition particle 54 kDa protein 1Add BLAST479

Proteomic databases

PaxDbiP37106
PRIDEiP37106

Expressioni

Gene expression databases

ExpressionAtlasiP37106 baseline and differential
GenevisibleiP37106 AT

Interactioni

Subunit structurei

Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

Protein-protein interaction databases

BioGridi23340, 1 interactor
DIPiDIP-59002N
IntActiP37106, 2 interactors
MINTiP37106
STRINGi3702.AT1G15310.1

Structurei

3D structure databases

ProteinModelPortaliP37106
SMRiP37106
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 295G-domainAdd BLAST295
Regioni296 – 479M-domainAdd BLAST184

Domaini

Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.

Sequence similaritiesi

Belongs to the GTP-binding SRP family. SRP54 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0780 Eukaryota
COG0541 LUCA
HOGENOMiHOG000036165
InParanoidiP37106
KOiK03106
OMAiRFEKENC
OrthoDBiEOG09360AIV
PhylomeDBiP37106

Family and domain databases

Gene3Di1.10.260.30, 1 hit
HAMAPiMF_00306 SRP54, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR036891 Signal_recog_part_SRP54_M_sf
IPR013822 Signal_recog_particl_SRP54_hlx
IPR004125 Signal_recog_particle_SRP54_M
IPR036225 SRP/SRP_N
IPR022941 SRP54
IPR006325 SRP54_euk
IPR000897 SRP54_GTPase_dom
PANTHERiPTHR11564 PTHR11564, 1 hit
PfamiView protein in Pfam
PF00448 SRP54, 1 hit
PF02881 SRP54_N, 1 hit
PF02978 SRP_SPB, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00962 SRP54, 1 hit
SM00963 SRP54_N, 1 hit
SUPFAMiSSF47364 SSF47364, 1 hit
SSF47446 SSF47446, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01425 SRP54_euk, 1 hit
PROSITEiView protein in PROSITE
PS00300 SRP54, 1 hit

Sequencei

Sequence statusi: Complete.

P37106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLAELGGRI TRAIQQMNNV TIIDEKVLND FLNEITRALL QSDVSFGLVE
60 70 80 90 100
KMQTNIKKIV NLDDLAAGHN KRLIIEQAIF KELCRMLDPG KPAFAPKKAK
110 120 130 140 150
PSVVMFVGLQ GAGKTTTCTK YAYYHQKKGY KAALVCADTF RAGAFDQLKQ
160 170 180 190 200
NATKAKIPFY GSYTESDPVK IAVEGVDRFK KEKCDLIIVD TSGRHKQAAS
210 220 230 240 250
LFEEMRQVAE ATEPDLVIFV MDSSIGQAAF EQAEAFKETV SVGAVIITKM
260 270 280 290 300
DGHAKGGGAL SAVAATKSPV IFIGTGEHMD EFEVFDVKPF VSRLLGKGDW
310 320 330 340 350
SGLVDKLQEV VPKDLQNELV ENLSQGNFTL RSMYDQFQCS LRIPLNQLFS
360 370 380 390 400
MLPGISAEMM PKGHGEESRV KMKRYMTMMD SMTNKELDSP NPKIFNESRI
410 420 430 440 450
MRIARGSGRL VREVMEMLEE YKRIAKTMKG IKIPKNGDMS KVIPPQMLKQ
460 470
MGGMSGLQSL MKQMGSAKDM MGMFGGGGK
Length:479
Mass (Da):53,007
Last modified:October 1, 1994 - v1
Checksum:iDA4C0634420F486E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19997 Unassigned DNA Translation: AAA19728.1
AC007591 Genomic DNA Translation: AAD39659.1
CP002684 Genomic DNA Translation: AEE29301.1
AF344329 mRNA Translation: AAK06880.1
AY086187 mRNA Translation: AAM64266.1
PIRiS42550
RefSeqiNP_563970.1, NM_101400.4
UniGeneiAt.24597

Genome annotation databases

EnsemblPlantsiAT1G15310.1; AT1G15310.1; AT1G15310
GeneIDi838100
GrameneiAT1G15310.1; AT1G15310.1; AT1G15310
KEGGiath:AT1G15310

Similar proteinsi

Entry informationi

Entry nameiSR541_ARATH
AccessioniPrimary (citable) accession number: P37106
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 25, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health