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Protein

Signal recognition particle 54 kDa protein 1

Gene

SRP-54A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi108 – 115GTPBy similarity8
Nucleotide bindingi190 – 194GTPBy similarity5
Nucleotide bindingi248 – 251GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

GTP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

ReactomeiR-ATH-1799339. SRP-dependent cotranslational protein targeting to membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle 54 kDa protein 1
Short name:
SRP54
Gene namesi
Name:SRP-54A
Synonyms:SRP-54
Ordered Locus Names:At1g15310
ORF Names:F9L1.25
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G15310.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: TAIR
  • signal recognition particle, endoplasmic reticulum targeting Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Signal recognition particle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012041 – 479Signal recognition particle 54 kDa protein 1Add BLAST479

Proteomic databases

PaxDbiP37106.
PRIDEiP37106.

Expressioni

Gene expression databases

ExpressionAtlasiP37106. baseline and differential.
GenevisibleiP37106. AT.

Interactioni

Subunit structurei

Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

Protein-protein interaction databases

DIPiDIP-59002N.
IntActiP37106. 1 interactor.
MINTiMINT-7992984.
STRINGi3702.AT1G15310.1.

Structurei

3D structure databases

ProteinModelPortaliP37106.
SMRiP37106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 295G-domainAdd BLAST295
Regioni296 – 479M-domainAdd BLAST184

Domaini

Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.

Sequence similaritiesi

Belongs to the GTP-binding SRP family. SRP54 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0780. Eukaryota.
COG0541. LUCA.
HOGENOMiHOG000036165.
InParanoidiP37106.
KOiK03106.
OMAiDSMTNKE.
OrthoDBiEOG09360AIV.
PhylomeDBiP37106.

Family and domain databases

Gene3Di1.10.260.30. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00306. SRP54. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR004125. Signal_recog_particle_SRP54_M.
IPR022941. SRP54.
IPR006325. SRP54_euk.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
PF02978. SRP_SPB. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF47446. SSF47446. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01425. SRP54_euk. 1 hit.
PROSITEiPS00300. SRP54. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLAELGGRI TRAIQQMNNV TIIDEKVLND FLNEITRALL QSDVSFGLVE
60 70 80 90 100
KMQTNIKKIV NLDDLAAGHN KRLIIEQAIF KELCRMLDPG KPAFAPKKAK
110 120 130 140 150
PSVVMFVGLQ GAGKTTTCTK YAYYHQKKGY KAALVCADTF RAGAFDQLKQ
160 170 180 190 200
NATKAKIPFY GSYTESDPVK IAVEGVDRFK KEKCDLIIVD TSGRHKQAAS
210 220 230 240 250
LFEEMRQVAE ATEPDLVIFV MDSSIGQAAF EQAEAFKETV SVGAVIITKM
260 270 280 290 300
DGHAKGGGAL SAVAATKSPV IFIGTGEHMD EFEVFDVKPF VSRLLGKGDW
310 320 330 340 350
SGLVDKLQEV VPKDLQNELV ENLSQGNFTL RSMYDQFQCS LRIPLNQLFS
360 370 380 390 400
MLPGISAEMM PKGHGEESRV KMKRYMTMMD SMTNKELDSP NPKIFNESRI
410 420 430 440 450
MRIARGSGRL VREVMEMLEE YKRIAKTMKG IKIPKNGDMS KVIPPQMLKQ
460 470
MGGMSGLQSL MKQMGSAKDM MGMFGGGGK
Length:479
Mass (Da):53,007
Last modified:October 1, 1994 - v1
Checksum:iDA4C0634420F486E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19997 Unassigned DNA. Translation: AAA19728.1.
AC007591 Genomic DNA. Translation: AAD39659.1.
CP002684 Genomic DNA. Translation: AEE29301.1.
AF344329 mRNA. Translation: AAK06880.1.
AY086187 mRNA. Translation: AAM64266.1.
PIRiS42550.
RefSeqiNP_563970.1. NM_101400.4.
UniGeneiAt.24597.

Genome annotation databases

EnsemblPlantsiAT1G15310.1; AT1G15310.1; AT1G15310.
GeneIDi838100.
GrameneiAT1G15310.1; AT1G15310.1; AT1G15310.
KEGGiath:AT1G15310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19997 Unassigned DNA. Translation: AAA19728.1.
AC007591 Genomic DNA. Translation: AAD39659.1.
CP002684 Genomic DNA. Translation: AEE29301.1.
AF344329 mRNA. Translation: AAK06880.1.
AY086187 mRNA. Translation: AAM64266.1.
PIRiS42550.
RefSeqiNP_563970.1. NM_101400.4.
UniGeneiAt.24597.

3D structure databases

ProteinModelPortaliP37106.
SMRiP37106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59002N.
IntActiP37106. 1 interactor.
MINTiMINT-7992984.
STRINGi3702.AT1G15310.1.

Proteomic databases

PaxDbiP37106.
PRIDEiP37106.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G15310.1; AT1G15310.1; AT1G15310.
GeneIDi838100.
GrameneiAT1G15310.1; AT1G15310.1; AT1G15310.
KEGGiath:AT1G15310.

Organism-specific databases

TAIRiAT1G15310.

Phylogenomic databases

eggNOGiKOG0780. Eukaryota.
COG0541. LUCA.
HOGENOMiHOG000036165.
InParanoidiP37106.
KOiK03106.
OMAiDSMTNKE.
OrthoDBiEOG09360AIV.
PhylomeDBiP37106.

Enzyme and pathway databases

ReactomeiR-ATH-1799339. SRP-dependent cotranslational protein targeting to membrane.

Miscellaneous databases

PROiP37106.

Gene expression databases

ExpressionAtlasiP37106. baseline and differential.
GenevisibleiP37106. AT.

Family and domain databases

Gene3Di1.10.260.30. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00306. SRP54. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR004125. Signal_recog_particle_SRP54_M.
IPR022941. SRP54.
IPR006325. SRP54_euk.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
PF02978. SRP_SPB. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF47446. SSF47446. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01425. SRP54_euk. 1 hit.
PROSITEiPS00300. SRP54. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSR541_ARATH
AccessioniPrimary (citable) accession number: P37106
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.