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Protein

Type II secretion system protein E

Gene

epsE

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi264 – 2718ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVCHO:VC2732-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type II secretion system protein E
Short name:
T2SS protein E
Alternative name(s):
Cholera toxin secretion protein EpsE
General secretion pathway protein E
Type II traffic warden ATPase
Gene namesi
Name:epsE
Ordered Locus Names:VC_2732
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Type II secretion system protein EPRO_0000207290Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC2732.

Structurei

Secondary structure

1
503
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi19 – 257Combined sources
Beta strandi27 – 315Combined sources
Beta strandi33 – 353Combined sources
Beta strandi38 – 425Combined sources
Helixi48 – 5811Combined sources
Beta strandi62 – 665Combined sources
Helixi69 – 7911Combined sources
Helixi101 – 1066Combined sources
Helixi122 – 13716Combined sources
Beta strandi140 – 1478Combined sources
Beta strandi150 – 1578Combined sources
Beta strandi160 – 1656Combined sources
Helixi169 – 1713Combined sources
Helixi172 – 18211Combined sources
Beta strandi194 – 1996Combined sources
Beta strandi207 – 2148Combined sources
Beta strandi221 – 2244Combined sources
Turni229 – 2324Combined sources
Helixi236 – 2383Combined sources
Helixi243 – 25311Combined sources
Beta strandi255 – 2639Combined sources
Helixi270 – 28112Combined sources
Beta strandi288 – 2947Combined sources
Beta strandi300 – 3067Combined sources
Helixi309 – 3113Combined sources
Helixi315 – 3228Combined sources
Helixi323 – 3253Combined sources
Beta strandi328 – 3336Combined sources
Helixi338 – 34912Combined sources
Beta strandi353 – 3586Combined sources
Beta strandi361 – 3633Combined sources
Helixi364 – 37310Combined sources
Helixi377 – 3837Combined sources
Beta strandi384 – 39613Combined sources
Turni398 – 4003Combined sources
Beta strandi402 – 4054Combined sources
Helixi408 – 4114Combined sources
Beta strandi423 – 4264Combined sources
Beta strandi431 – 4333Combined sources
Beta strandi435 – 44915Combined sources
Helixi452 – 4598Combined sources
Helixi464 – 4729Combined sources
Helixi478 – 48710Combined sources
Helixi493 – 4986Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1P9RX-ray2.50A91-498[»]
1P9WX-ray2.70A91-498[»]
2BH1X-ray2.40X/Y1-96[»]
4KSRX-ray4.20A/B/C100-503[»]
4KSSX-ray7.58A/B/C/D/E/F100-503[»]
ProteinModelPortaliP37093.
SMRiP37093. Positions 14-81, 98-498.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37093.

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP E family.Curated

Phylogenomic databases

eggNOGiENOG4107QHF. Bacteria.
COG2804. LUCA.
KOiK02454.
OMAiTMIHRQA.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013369. T2SS_GspE.
IPR001482. T2SS_protein-E.
[Graphical view]
PfamiPF00437. T2SSE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02533. type_II_gspE. 1 hit.
PROSITEiPS00662. T2SP_E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEMVISPAE RQSIRRLPFS FANRFKLVLD WNEDFSQASI YYLAPLSMEA
60 70 80 90 100
LVETKRVVKH AFQLIELSQA EFESKLTQVY QRDSSEARQL MEDIGADSDD
110 120 130 140 150
FFSLAEELPQ NEDLLESEDD APIIKLINAM LGEAIKEGAS DIHIETFEKT
160 170 180 190 200
LSIRFRVDGV LREVLAPSRK LSSLLVSRVK VMAKLDIAEK RVPQDGRISL
210 220 230 240 250
RIGGRAVDVR VSTMPSSHGE RVVMRLLDKN ATRLDLHSLG MTAHNHDNFR
260 270 280 290 300
RLIKRPHGII LVTGPTGSGK STTLYAGLQE LNSSERNILT VEDPIEFDID
310 320 330 340 350
GIGQTQVNPR VDMTFARGLR AILRQDPDVV MVGEIRDLET AQIAVQASLT
360 370 380 390 400
GHLVMSTLHT NTAVGAVTRL RDMGIEPFLI SSSLLGVLAQ RLVRTLCPDC
410 420 430 440 450
KEPYEADKEQ RKLFDSKKKE PLILYRATGC PKCNHKGYRG RTGIHELLLV
460 470 480 490 500
DDALQELIHS EAGEQAMEKH IRATTPSIRD DGLDKVRQGI TSLEEVMRVT

KES
Length:503
Mass (Da):56,359
Last modified:October 1, 1994 - v1
Checksum:i3FEF661307BB962B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96172 Genomic DNA. Translation: AAA27518.1.
L33796 Genomic DNA. Translation: AAA58786.1.
AE003852 Genomic DNA. Translation: AAF95872.1.
PIRiJU0147.
RefSeqiNP_232359.1. NC_002505.1.
WP_000138174.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95872; AAF95872; VC_2732.
GeneIDi2614895.
KEGGivch:VC2732.
PATRICi20084482. VBIVibCho83274_2607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96172 Genomic DNA. Translation: AAA27518.1.
L33796 Genomic DNA. Translation: AAA58786.1.
AE003852 Genomic DNA. Translation: AAF95872.1.
PIRiJU0147.
RefSeqiNP_232359.1. NC_002505.1.
WP_000138174.1. NC_002505.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1P9RX-ray2.50A91-498[»]
1P9WX-ray2.70A91-498[»]
2BH1X-ray2.40X/Y1-96[»]
4KSRX-ray4.20A/B/C100-503[»]
4KSSX-ray7.58A/B/C/D/E/F100-503[»]
ProteinModelPortaliP37093.
SMRiP37093. Positions 14-81, 98-498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC2732.

Protocols and materials databases

DNASUi2614895.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF95872; AAF95872; VC_2732.
GeneIDi2614895.
KEGGivch:VC2732.
PATRICi20084482. VBIVibCho83274_2607.

Phylogenomic databases

eggNOGiENOG4107QHF. Bacteria.
COG2804. LUCA.
KOiK02454.
OMAiTMIHRQA.

Enzyme and pathway databases

BioCyciVCHO:VC2732-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP37093.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013369. T2SS_GspE.
IPR001482. T2SS_protein-E.
[Graphical view]
PfamiPF00437. T2SSE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02533. type_II_gspE. 1 hit.
PROSITEiPS00662. T2SP_E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSPE_VIBCH
AccessioniPrimary (citable) accession number: P37093
Secondary accession number(s): Q9JPZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.