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Protein

Type II secretion system protein E

Gene

epsE

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi264 – 271ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVCHO:VC2732-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type II secretion system protein E
Short name:
T2SS protein E
Alternative name(s):
Cholera toxin secretion protein EpsE
General secretion pathway protein E
Type II traffic warden ATPase
Gene namesi
Name:epsE
Ordered Locus Names:VC_2732
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002072901 – 503Type II secretion system protein EAdd BLAST503

Interactioni

Protein-protein interaction databases

STRINGi243277.VC2732.

Structurei

Secondary structure

1503
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi19 – 25Combined sources7
Beta strandi27 – 31Combined sources5
Beta strandi33 – 35Combined sources3
Beta strandi38 – 42Combined sources5
Helixi48 – 58Combined sources11
Beta strandi62 – 66Combined sources5
Helixi69 – 79Combined sources11
Helixi101 – 106Combined sources6
Helixi122 – 137Combined sources16
Beta strandi140 – 147Combined sources8
Beta strandi150 – 157Combined sources8
Beta strandi160 – 165Combined sources6
Helixi169 – 171Combined sources3
Helixi172 – 182Combined sources11
Beta strandi194 – 199Combined sources6
Beta strandi207 – 214Combined sources8
Beta strandi221 – 224Combined sources4
Turni229 – 232Combined sources4
Helixi236 – 238Combined sources3
Helixi243 – 253Combined sources11
Beta strandi255 – 263Combined sources9
Helixi270 – 281Combined sources12
Beta strandi288 – 294Combined sources7
Beta strandi300 – 306Combined sources7
Helixi309 – 311Combined sources3
Helixi315 – 322Combined sources8
Helixi323 – 325Combined sources3
Beta strandi328 – 333Combined sources6
Helixi338 – 349Combined sources12
Beta strandi353 – 358Combined sources6
Beta strandi361 – 363Combined sources3
Helixi364 – 373Combined sources10
Helixi377 – 383Combined sources7
Beta strandi384 – 396Combined sources13
Turni398 – 400Combined sources3
Beta strandi402 – 405Combined sources4
Helixi408 – 411Combined sources4
Beta strandi423 – 426Combined sources4
Beta strandi431 – 433Combined sources3
Beta strandi435 – 449Combined sources15
Helixi452 – 459Combined sources8
Helixi464 – 472Combined sources9
Helixi478 – 487Combined sources10
Helixi493 – 498Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P9RX-ray2.50A91-498[»]
1P9WX-ray2.70A91-498[»]
2BH1X-ray2.40X/Y1-96[»]
4KSRX-ray4.20A/B/C100-503[»]
4KSSX-ray7.58A/B/C/D/E/F100-503[»]
ProteinModelPortaliP37093.
SMRiP37093.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37093.

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP E family.Curated

Phylogenomic databases

eggNOGiENOG4107QHF. Bacteria.
COG2804. LUCA.
KOiK02454.
OMAiTMIHRQA.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013369. T2SS_GspE.
IPR001482. T2SS_protein-E.
[Graphical view]
PfamiPF00437. T2SSE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02533. type_II_gspE. 1 hit.
PROSITEiPS00662. T2SP_E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEMVISPAE RQSIRRLPFS FANRFKLVLD WNEDFSQASI YYLAPLSMEA
60 70 80 90 100
LVETKRVVKH AFQLIELSQA EFESKLTQVY QRDSSEARQL MEDIGADSDD
110 120 130 140 150
FFSLAEELPQ NEDLLESEDD APIIKLINAM LGEAIKEGAS DIHIETFEKT
160 170 180 190 200
LSIRFRVDGV LREVLAPSRK LSSLLVSRVK VMAKLDIAEK RVPQDGRISL
210 220 230 240 250
RIGGRAVDVR VSTMPSSHGE RVVMRLLDKN ATRLDLHSLG MTAHNHDNFR
260 270 280 290 300
RLIKRPHGII LVTGPTGSGK STTLYAGLQE LNSSERNILT VEDPIEFDID
310 320 330 340 350
GIGQTQVNPR VDMTFARGLR AILRQDPDVV MVGEIRDLET AQIAVQASLT
360 370 380 390 400
GHLVMSTLHT NTAVGAVTRL RDMGIEPFLI SSSLLGVLAQ RLVRTLCPDC
410 420 430 440 450
KEPYEADKEQ RKLFDSKKKE PLILYRATGC PKCNHKGYRG RTGIHELLLV
460 470 480 490 500
DDALQELIHS EAGEQAMEKH IRATTPSIRD DGLDKVRQGI TSLEEVMRVT

KES
Length:503
Mass (Da):56,359
Last modified:October 1, 1994 - v1
Checksum:i3FEF661307BB962B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96172 Genomic DNA. Translation: AAA27518.1.
L33796 Genomic DNA. Translation: AAA58786.1.
AE003852 Genomic DNA. Translation: AAF95872.1.
PIRiJU0147.
RefSeqiNP_232359.1. NC_002505.1.
WP_000138174.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95872; AAF95872; VC_2732.
GeneIDi2614895.
KEGGivch:VC2732.
PATRICi20084482. VBIVibCho83274_2607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96172 Genomic DNA. Translation: AAA27518.1.
L33796 Genomic DNA. Translation: AAA58786.1.
AE003852 Genomic DNA. Translation: AAF95872.1.
PIRiJU0147.
RefSeqiNP_232359.1. NC_002505.1.
WP_000138174.1. NC_002505.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P9RX-ray2.50A91-498[»]
1P9WX-ray2.70A91-498[»]
2BH1X-ray2.40X/Y1-96[»]
4KSRX-ray4.20A/B/C100-503[»]
4KSSX-ray7.58A/B/C/D/E/F100-503[»]
ProteinModelPortaliP37093.
SMRiP37093.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC2732.

Protocols and materials databases

DNASUi2614895.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF95872; AAF95872; VC_2732.
GeneIDi2614895.
KEGGivch:VC2732.
PATRICi20084482. VBIVibCho83274_2607.

Phylogenomic databases

eggNOGiENOG4107QHF. Bacteria.
COG2804. LUCA.
KOiK02454.
OMAiTMIHRQA.

Enzyme and pathway databases

BioCyciVCHO:VC2732-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP37093.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013369. T2SS_GspE.
IPR001482. T2SS_protein-E.
[Graphical view]
PfamiPF00437. T2SSE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02533. type_II_gspE. 1 hit.
PROSITEiPS00662. T2SP_E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSPE_VIBCH
AccessioniPrimary (citable) accession number: P37093
Secondary accession number(s): Q9JPZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.