Reviewed, UniProtKB/Swiss-Prot P37088 (SCNNA_HUMAN)

Names and origin

Protein names

Recommended name:
    Amiloride-sensitive sodium channel subunit alpha
Alternative name(s):
    Epithelial Na(+) channel subunit alpha
    Alpha-ENaC
    SCNEA
    Nonvoltage-gated sodium channel 1 subunit alpha
    Alpha-NaCH

Gene names

Name:	SCNN1A
Synonyms:	SCNN1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	669 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Subunit structure	Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. Ref.10 Ref.11 Ref.12 Ref.13
Subcellular location	Apical cell membrane; Multi-pass membrane protein. Note: Apical membrane of epithelial cells.
Tissue specificity	Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart. Ref.9
Induction	By aldosterone. Ref.8
Post-translational modification	Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation By similarity.
Involvement in disease	Defects in SCNN1A are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350]. PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss. Ref.15 Ref.17
Sequence similarities	Belongs to the amiloride-sensitive sodium channel family.

Ontologies

Keywords
Biological process	Ion transport Sensory transduction Sodium transport Taste Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Domain	Transmembrane
Ligand	Sodium
Molecular function	Ionic channel Sodium channel
PTM	Glycoprotein Ubl conjugation
Gene Ontology (GO)
Biological process	excretion Traceable author statement. Source: ProtInc response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of taste Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Traceable author statement. Source: ProtInc
Cellular component	apical plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	WW domain binding Inferred from physical interaction. Source: UniProtKB sodium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P37088-1)

Also known as: Alpha ENAC1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P37088-2)

Also known as: Alpha ENAC2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGMARGSLTRVPGVMGEGTQGPELSLDPDPCSPQSTPGLMKGNKLEEQDPRPLQPIPGLM

Isoform 3 (identifier: P37088-3)

Also known as: Alpha ENACx;

The sequence of this isoform differs from the canonical sequence as follows:
     229-245: CNQNKSDCFYQTYSSGV → ELLSLPPPDVWKLLYFG
     246-669: Missing.

Note: Does not give rise to amiloride-sensitive ion current.

Isoform 4 (identifier: P37088-4)

Also known as: Alpha ENAC-19;

The sequence of this isoform differs from the canonical sequence as follows:
     327-345: Missing.

Note: Amiloride-sensitive ion current is nearly abolished.

Isoform 5 (identifier: P37088-5)

Also known as: Alpha ENAC+22;

The sequence of this isoform differs from the canonical sequence as follows:
     454-454: G → GQVRSLTPVIPALWEAEAGGSRG

Note: Does not give rise to amiloride-sensitive ion current.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 669	669	Amiloride-sensitive sodium channel subunit alpha		PRO_0000181261
Regions
	Topological domain	1 – 85	85	Cytoplasmic Potential
	Transmembrane	86 – 106	21	Potential
	Topological domain	107 – 562	456	Extracellular Potential
	Transmembrane	563 – 583	21	Potential
	Topological domain	584 – 669	86	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	232	1	N-linked (GlcNAc...) Potential
	Glycosylation	293	1	N-linked (GlcNAc...) Potential
	Glycosylation	312	1	N-linked (GlcNAc...) Potential
	Glycosylation	397	1	N-linked (GlcNAc...) Potential
	Glycosylation	511	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1	1	M → MGMARGSLTRVPGVMGEGTQ GPELSLDPDPCSPQSTPGLM KGNKLEEQDPRPLQPIPGLM in isoform 2.		VSP_007719
	Alternative sequence	229 – 245	17	CNQNK…YSSGV → ELLSLPPPDVWKLLYFG in isoform 3.		VSP_007720
	Alternative sequence	246 – 669	424	Missing in isoform 3.		VSP_007721
	Alternative sequence	327 – 345	19	Missing in isoform 4.		VSP_007722
	Alternative sequence	454	1	G → GQVRSLTPVIPALWEAEAGG SRG in isoform 5.		VSP_007723
	Natural variant	327	1	G → C in PHA1. Ref.17		VAR_026518
	Natural variant	402	1	P → H: dbSNP rs13306616.		VAR_052035
	Natural variant	493	1	W → R Rare polymorphism. dbSNP rs5742912. Ref.15		VAR_015833
	Natural variant	562	1	S → L in PHA1. Ref.15		VAR_015834
	Natural variant	618	1	C → F: dbSNP rs3741913.		VAR_022142
	Natural variant	663	1	T → A: dbSNP rs2228576. Ref.6 Ref.14 Ref.16		VAR_015835

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Alpha ENAC1) [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 2CCF342E7DF32E72	FASTA	669	75,704
	10 20 30 40 50 60 MEGNKLEEQD SSPPQSTPGL MKGNKREEQG LGPEPAAPQQ PTAEEEALIE FHRSYRELFE 70 80 90 100 110 120 FFCNNTTIHG AIRLVCSQHN RMKTAFWAVL WLCTFGMMYW QFGLLFGEYF SYPVSLNINL 130 140 150 160 170 180 NSDKLVFPAV TICTLNPYRY PEIKEELEEL DRITEQTLFD LYKYSSFTTL VAGSRSRRDL 190 200 210 220 230 240 RGTLPHPLQR LRVPPPPHGA RRARSVASSL RDNNPQVDWK DWKIGFQLCN QNKSDCFYQT 250 260 270 280 290 300 YSSGVDAVRE WYRFHYINIL SRLPETLPSL EEDTLGNFIF ACRFNQVSCN QANYSHFHHP 310 320 330 340 350 360 MYGNCYTFND KNNSNLWMSS MPGINNGLSL MLRAEQNDFI PLLSTVTGAR VMVHGQDEPA 370 380 390 400 410 420 FMDDGGFNLR PGVETSISMR KETLDRLGGD YGDCTKNGSD VPVENLYPSK YTQQVCIHSC 430 440 450 460 470 480 FQESMIKECG CAYIFYPRPQ NVEYCDYRKH SSWGYCYYKL QVDFSSDHLG CFTKCRKPCS 490 500 510 520 530 540 VTSYQLSAGY SRWPSVTSQE WVFQMLSRQN NYTVNNKRNG VAKVNIFFKE LNYKTNSESP 550 560 570 580 590 600 SVTMVTLLSN LGSQWSLWFG SSVLSVVEMA ELVFDLLVIM FLMLLRRFRS RYWSPGRGGR 610 620 630 640 650 660 GAQEVASTLA SSPPSHFCPH PMSLSLSQPG PAPSPALTAP PPAYATLGPR PSPGGSAGAS SSTCPLGGP
	Isoform 2 (Alpha ENAC2). Checksum: 206613374DFB1800	FASTA	728	81,856
	10 20 30 40 50 60 MGMARGSLTR VPGVMGEGTQ GPELSLDPDP CSPQSTPGLM KGNKLEEQDP RPLQPIPGLM 70 80 90 100 110 120 EGNKLEEQDS SPPQSTPGLM KGNKREEQGL GPEPAAPQQP TAEEEALIEF HRSYRELFEF 130 140 150 160 170 180 FCNNTTIHGA IRLVCSQHNR MKTAFWAVLW LCTFGMMYWQ FGLLFGEYFS YPVSLNINLN 190 200 210 220 230 240 SDKLVFPAVT ICTLNPYRYP EIKEELEELD RITEQTLFDL YKYSSFTTLV AGSRSRRDLR 250 260 270 280 290 300 GTLPHPLQRL RVPPPPHGAR RARSVASSLR DNNPQVDWKD WKIGFQLCNQ NKSDCFYQTY 310 320 330 340 350 360 SSGVDAVREW YRFHYINILS RLPETLPSLE EDTLGNFIFA CRFNQVSCNQ ANYSHFHHPM 370 380 390 400 410 420 YGNCYTFNDK NNSNLWMSSM PGINNGLSLM LRAEQNDFIP LLSTVTGARV MVHGQDEPAF 430 440 450 460 470 480 MDDGGFNLRP GVETSISMRK ETLDRLGGDY GDCTKNGSDV PVENLYPSKY TQQVCIHSCF 490 500 510 520 530 540 QESMIKECGC AYIFYPRPQN VEYCDYRKHS SWGYCYYKLQ VDFSSDHLGC FTKCRKPCSV 550 560 570 580 590 600 TSYQLSAGYS RWPSVTSQEW VFQMLSRQNN YTVNNKRNGV AKVNIFFKEL NYKTNSESPS 610 620 630 640 650 660 VTMVTLLSNL GSQWSLWFGS SVLSVVEMAE LVFDLLVIMF LMLLRRFRSR YWSPGRGGRG 670 680 690 700 710 720 AQEVASTLAS SPPSHFCPHP MSLSLSQPGP APSPALTAPP PAYATLGPRP SPGGSAGASS STCPLGGP
	Isoform 3 (Alpha ENACx). Checksum: FFDC0622FFA37329	FASTA	245	28,328
	10 20 30 40 50 60 MEGNKLEEQD SSPPQSTPGL MKGNKREEQG LGPEPAAPQQ PTAEEEALIE FHRSYRELFE 70 80 90 100 110 120 FFCNNTTIHG AIRLVCSQHN RMKTAFWAVL WLCTFGMMYW QFGLLFGEYF SYPVSLNINL 130 140 150 160 170 180 NSDKLVFPAV TICTLNPYRY PEIKEELEEL DRITEQTLFD LYKYSSFTTL VAGSRSRRDL 190 200 210 220 230 240 RGTLPHPLQR LRVPPPPHGA RRARSVASSL RDNNPQVDWK DWKIGFQLEL LSLPPPDVWK LLYFG
	Isoform 4 (Alpha ENAC-19). Checksum: 5866D42CCAF6F8B4	FASTA	650	73,603
	10 20 30 40 50 60 MEGNKLEEQD SSPPQSTPGL MKGNKREEQG LGPEPAAPQQ PTAEEEALIE FHRSYRELFE 70 80 90 100 110 120 FFCNNTTIHG AIRLVCSQHN RMKTAFWAVL WLCTFGMMYW QFGLLFGEYF SYPVSLNINL 130 140 150 160 170 180 NSDKLVFPAV TICTLNPYRY PEIKEELEEL DRITEQTLFD LYKYSSFTTL VAGSRSRRDL 190 200 210 220 230 240 RGTLPHPLQR LRVPPPPHGA RRARSVASSL RDNNPQVDWK DWKIGFQLCN QNKSDCFYQT 250 260 270 280 290 300 YSSGVDAVRE WYRFHYINIL SRLPETLPSL EEDTLGNFIF ACRFNQVSCN QANYSHFHHP 310 320 330 340 350 360 MYGNCYTFND KNNSNLWMSS MPGINNVTGA RVMVHGQDEP AFMDDGGFNL RPGVETSISM 370 380 390 400 410 420 RKETLDRLGG DYGDCTKNGS DVPVENLYPS KYTQQVCIHS CFQESMIKEC GCAYIFYPRP 430 440 450 460 470 480 QNVEYCDYRK HSSWGYCYYK LQVDFSSDHL GCFTKCRKPC SVTSYQLSAG YSRWPSVTSQ 490 500 510 520 530 540 EWVFQMLSRQ NNYTVNNKRN GVAKVNIFFK ELNYKTNSES PSVTMVTLLS NLGSQWSLWF 550 560 570 580 590 600 GSSVLSVVEM AELVFDLLVI MFLMLLRRFR SRYWSPGRGG RGAQEVASTL ASSPPSHFCP 610 620 630 640 650 HPMSLSLSQP GPAPSPALTA PPPAYATLGP RPSPGGSAGA SSSTCPLGGP
	Isoform 5 (Alpha ENAC+22). Checksum: 07B981FBE74AE30B	FASTA	691	77,980
	10 20 30 40 50 60 MEGNKLEEQD SSPPQSTPGL MKGNKREEQG LGPEPAAPQQ PTAEEEALIE FHRSYRELFE 70 80 90 100 110 120 FFCNNTTIHG AIRLVCSQHN RMKTAFWAVL WLCTFGMMYW QFGLLFGEYF SYPVSLNINL 130 140 150 160 170 180 NSDKLVFPAV TICTLNPYRY PEIKEELEEL DRITEQTLFD LYKYSSFTTL VAGSRSRRDL 190 200 210 220 230 240 RGTLPHPLQR LRVPPPPHGA RRARSVASSL RDNNPQVDWK DWKIGFQLCN QNKSDCFYQT 250 260 270 280 290 300 YSSGVDAVRE WYRFHYINIL SRLPETLPSL EEDTLGNFIF ACRFNQVSCN QANYSHFHHP 310 320 330 340 350 360 MYGNCYTFND KNNSNLWMSS MPGINNGLSL MLRAEQNDFI PLLSTVTGAR VMVHGQDEPA 370 380 390 400 410 420 FMDDGGFNLR PGVETSISMR KETLDRLGGD YGDCTKNGSD VPVENLYPSK YTQQVCIHSC 430 440 450 460 470 480 FQESMIKECG CAYIFYPRPQ NVEYCDYRKH SSWGQVRSLT PVIPALWEAE AGGSRGYCYY 490 500 510 520 530 540 KLQVDFSSDH LGCFTKCRKP CSVTSYQLSA GYSRWPSVTS QEWVFQMLSR QNNYTVNNKR 550 560 570 580 590 600 NGVAKVNIFF KELNYKTNSE SPSVTMVTLL SNLGSQWSLW FGSSVLSVVE MAELVFDLLV 610 620 630 640 650 660 IMFLMLLRRF RSRYWSPGRG GRGAQEVAST LASSPPSHFC PHPMSLSLSQ PGPAPSPALT 670 680 690 APPPAYATLG PRPSPGGSAG ASSSTCPLGG P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The lung amiloride-sensitive Na+ channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning." Voilley N., Lingueglia E., Champigny G., Mattei M.-G., Waldmann R., Lazdunski M., Barbry P. Proc. Natl. Acad. Sci. U.S.A. 91:247-251(1994) [PubMed: 8278374] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Lung.
[2]	"Cloning, expression, and tissue distribution of a human amiloride-sensitive Na+ channel." McDonald F.J., Snyder P.M., McCray P.B. Jr., Welsh M.J. Am. J. Physiol. 266:L728-L734(1994) [PubMed: 8023962] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Kidney.
[3]	"Structural organisation of the gene encoding the alpha-subunit of the human amiloride-sensitive epithelial sodium channel." Ludwig M., Bolkenius U., Wickert L., Marynen P., Bidlingmaier F. Hum. Genet. 102:576-581(1998) [PubMed: 9654208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Hormonal regulation and genomic organization of the human amiloride-sensitive epithelial sodium channel alpha subunit gene." Chow Y.H., Wang Y., Plumb J., O'Brodovich H., Hu J. Pediatr. Res. 46:208-214(1999) [PubMed: 10447117] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Upregulated expression of ENaC in human CF nasal epithelium." Bangel N., Dahlhoff C., Sobczak K., Weber W.M., Kusche-Vihrog K. J. Cyst. Fibros. 7:197-205(2008) [PubMed: 17766193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-663. Tissue: Nasal epithelium.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-663. Tissue: Colon and Lung.
[7]	"5' heterogeneity in epithelial sodium channel alpha-subunit mRNA leads to distinct NH2-terminal variant proteins." Thomas C.P., Auerbach S.D., Stokes J.B., Volk K.A. Am. J. Physiol. 274:C1312-C1323(1998) [PubMed: 9612219] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-50, ALTERNATIVE SPLICING (ISOFORMS 1 AND 2). Tissue: Kidney.
[8]	"The alpha-subunit of the epithelial sodium channel is an aldosterone-induced transcript in mammalian collecting ducts, and this transcriptional response is mediated via distinct cis-elements in the 5'-flanking region of the gene." Mick V.E., Itani O.A., Loftus R.W., Husted R.F., Schmidt T.J., Thomas C.P. Mol. Endocrinol. 15:575-588(2001) [PubMed: 11266509] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-50 (ISOFORMS 1 AND 2), INDUCTION. Tissue: Placenta.
[9]	"Cloning and functional studies of splice variants of the alpha-subunit of the amiloride-sensitive Na+ channel." Tucker J.K., Tamba K., Lee Y.-J., Shen L.-L., Warnock D.G., Oh Y. Am. J. Physiol. 274:C1081-C1089(1998) [PubMed: 9575806] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 3; 4 AND 5), TISSUE SPECIFICITY.
[10]	"Identification of novel human WW domain-containing proteins by cloning of ligand targets." Pirozzi G., McConnell S.J., Uveges A.J., Carter J.M., Sparks A.B., Kay B.K., Fowlkes D.M. J. Biol. Chem. 272:14611-14616(1997) [PubMed: 9169421] [Abstract] Cited for: INTERACTION WITH WWP1 AND WWP2.
[11]	"The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel." Harvey K.F., Dinudom A., Cook D.I., Kumar S. J. Biol. Chem. 276:8597-8601(2001) [PubMed: 11244092] [Abstract] Cited for: INTERACTION WITH NEDD4 AND NEDD4L.
[12]	"Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel." McDonald F.J., Western A.H., McNeil J.D., Thomas B.C., Olson D.R., Snyder P.M. Am. J. Physiol. 283:F431-F436(2002) [PubMed: 12167593] [Abstract] Cited for: INTERACTION WITH NEDD4 AND WWP2.
[13]	"Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel." Snyder P.M., Olson D.R., Thomas B.C. J. Biol. Chem. 277:5-8(2002) [PubMed: 11696533] [Abstract] Cited for: INTERACTION WITH NEDD4 AND NEDD4L.
[14]	"Polymorphisms of amiloride-sensitive sodium channel subunits in five sporadic cases of pseudohypoaldosteronism: do they have pathologic potential?" Arai K., Zachman K., Shibasaki T., Chrousos G.P. J. Clin. Endocrinol. Metab. 84:2434-2437(1999) [PubMed: 10404817] [Abstract] Cited for: VARIANT ALA-663.
[15]	"Lung symptoms in pseudohypoaldosteronism type 1 are associated with deficiency of the alpha-subunit of the epithelial sodium channel." Schaedel C., Marthinsen L., Kristoffersson A.-C., Kornfalt R., Nilsson K.O., Orlenius B., Holmberg L. J. Pediatr. 135:739-745(1999) [PubMed: 10586178] [Abstract] Cited for: VARIANT PHA1 LEU-562, VARIANT ARG-493.
[16]	"Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel alpha-, beta-, and gamma-subunit genes." Saxena A., Hanukoglu I., Saxena D., Thompson R.J., Gardiner R.M., Hanukoglu A. J. Clin. Endocrinol. Metab. 87:3344-3350(2002) [PubMed: 12107247] [Abstract] Cited for: VARIANT ALA-663.
[17]	"Novel mutations in epithelial sodium channel (ENaC) subunit genes and phenotypic expression of multisystem pseudohypoaldosteronism." Edelheit O., Hanukoglu I., Gizewska M., Kandemir N., Tenenbaum-Rakover Y., Yurdakoek M., Zajaczek S., Hanukoglu A. Clin. Endocrinol. (Oxf.) 62:547-553(2005) [PubMed: 15853823] [Abstract] Cited for: VARIANT PHA1 CYS-327.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBLGenBankDDBJ	X76180 mRNA. Translation: CAA53773.1. L29007 Genomic DNA. Translation: AAA21813.1. Z92978 , Z92979, Z92980, Z92981 Genomic DNA. Translation: CAB07505.1. AF060913 , AF060910, AF060911, AF060912 Genomic DNA. Translation: AAD28355.1. DQ402522 mRNA. Translation: ABD72218.1. BC006526 mRNA. Translation: AAH06526.2. Different initiation. BC062613 mRNA. Translation: AAH62613.1. U81961 Genomic DNA. Translation: AAC31773.1. U81961 Genomic DNA. Translation: AAC31774.1.
IPI	IPI00019931. IPI00334114. IPI00334115. IPI00334116. IPI00334117.
PIR	A49585.
RefSeq	NP_001029.1.
UniGene	Hs.279594 Hs.591047
3D structure databases
ModBase	Search...
Protein family/group databases
TCDB	1.A.6.1.1. epithelial Na+ channel (ENaC) family.
PTM databases
PhosphoSite	P37088.
Proteomic databases
PRIDE	P37088.
Genome annotation databases
Ensembl	ENSG00000111319. Homo sapiens. [Contig view]
GeneID	6337.
KEGG	hsa:6337.
Organism-specific databases
GeneCards	GC12M006326.
H-InvDB	HIX0010361.
HGNC	HGNC:10599. SCNN1A.
HPA	HPA012743. HPA012939.
MIM	264350. phenotype. 600228. gene.
Orphanet	171876. Generalized pseudohypoaldosteronism type I. 756. Pseudohypoaldosteronism, type 1.
PharmGKB	PA305.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P37088.
OMA	P37088. CNQANYS.
Gene expression databases
ArrayExpress	P37088.
Bgee	P37088.
CleanEx	HS_SCNN1A.
GermOnline	ENSG00000111319. Homo sapiens.
Family and domain databases
InterPro	IPR004724. EnaC. IPR001873. Na+channel_ASC. [Graphical view]
PANTHER	PTHR11690. Na+channel_ASC. 1 hit.
Pfam	PF00858. ASC. 1 hit. [Graphical view]
PRINTS	PR01078. AMINACHANNEL.
TIGRFAMs	TIGR00859. ENaC. 1 hit.
PROSITE	PS01206. ASC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00594. Amiloride. DB00384. Triamterene.
NextBio	24608.
SOURCE	Search...

Entry information

Entry name

SCNNA_HUMAN

Accession

Primary (citable) accession number: P37088
Secondary accession number(s): A5X2U9 , O43271, Q6GSQ6, Q9UM64

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	June 16, 2009
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)