P37083 (PTRD_KLEPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sorbose permease IID component

Alternative name(s):
EIID-Sor
PTS system sorbose-specific EIID component

Gene names

Name:

sorM

Organism

Klebsiella pneumoniae

Taxonomic identifier

573 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in sorbose transport.
Subcellular location	Cell inner membrane; Multi-pass membrane protein Probable.
Domain	The EIID domain, with its homologous EIIC domain, forms the PTS system translocation channel and contains part of its specific substrate-binding site.
Sequence similarities	Contains 1 PTS EIID domain.

Ontologies

Keywords
Biological process	Phosphotransferase system Sugar transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Gene Ontology (GO)
Biological_process	phosphoenolpyruvate-dependent sugar phosphotransferase system Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Sorbose permease IID component		PRO_0000186664
Regions
	Transmembrane	61 – 81	21	Helical; Potential
	Transmembrane	99 – 119	21	Helical; Potential
	Transmembrane	126 – 146	21	Helical; Potential
	Transmembrane	186 – 206	21	Helical; Potential
	Transmembrane	226 – 246	21	Helical; Potential
	Transmembrane	253 – 273	21	Helical; Potential
	Domain	4 – 273	270	PTS EIID

Sequences

	Sequence		Length	Mass (Da)
	P37083 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 91C2E415ACBDE960	FASTA	274	29,196
	10 20 30 40 50 60 MEQKKITQGD LVSMFLRSNL QQASFNFERI HGLGFCYDMI PAIKRLYPLK ADQVAALKRH 70 80 90 100 110 120 LVFFNTTPAV CGPVIAVTAA MEEARANGAA IDDGAINGIK VGLMGPLAGV GDPLVWGTLR 130 140 150 160 170 180 PITAALGASL ALSGNILGPL LFFFIFNAVR LAMKWYGLQL GFRKGVNIVS DMGGNLLQKL 190 200 210 220 230 240 TEGASILGLF VMGVLVTKWT TINVPLVVSQ TPGADGATVT MTVQNILDQL CPGLLALGLT 250 260 270 LLMVRLLNKK VNPVWLIFAL FGLGIIGNAL GFLS

References

[1]	"Sequence of the sor-operon for L-sorbose utilization from Klebsiella pneumoniae KAY2026." Wehmeier U.F., Lengeler J.W. Biochim. Biophys. Acta 1208:348-351(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 1033-5P14 / KAY2026.
[2]	"Molecular analysis of the phosphoenolpyruvate-dependent L-sorbose: phosphotransferase system from Klebsiella pneumoniae and of its multidomain structure." Wehmeier U.F., Wohrl B.M., Lengeler J.W. Mol. Gen. Genet. 246:610-618(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X66059 Genomic DNA. Translation: CAA46860.1.
PIR	S50190.
3D structure databases
ModBase	Search...
Protein family/group databases
TCDB	4.A.6.1.3. PTS mannose-fructose-sorbose (Man) family.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004704. PTS_IID_comp. IPR018405. PTS_IID_comp_subgr. [Graphical view]
Pfam	PF03613. EIID-AGA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00828. EIID-AGA. 1 hit.
PROSITE	PS51108. PTS_EIID. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTRD_KLEPN

Accession

Primary (citable) accession number: P37083

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program