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P37073

- GUB_BREBE

UniProt

P37073 - GUB_BREBE

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Protein

Beta-glucanase

Gene

bglBB

Organism
Brevibacillus brevis (Bacillus brevis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Hydrolyzes B-glucans containing mixed beta-1,3 and beta-1,4 linkages.

Catalytic activityi

Hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3)- and (1->4)-bonds.

Temperature dependencei

Optimum temperature is 65-70 degrees Celsius. Thermostable.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei142 – 1421NucleophilePROSITE-ProRule annotation
Active sitei146 – 1461Proton donorPROSITE-ProRule annotation

GO - Molecular functioni

  1. licheninase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH16. Glycoside Hydrolase Family 16.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucanase (EC:3.2.1.73)
Alternative name(s):
1,3-1,4-beta-D-glucan 4-glucanohydrolase
Endo-beta-1,3-1,4 glucanase
Lichenase
Gene namesi
Name:bglBB
OrganismiBrevibacillus brevis (Bacillus brevis)
Taxonomic identifieri1393 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 259228Beta-glucanasePRO_0000011787Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP37073.
SMRiP37073. Positions 37-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 16 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008264. Beta_glucanase.
IPR013320. ConA-like_dom.
IPR000757. Glyco_hydro_16.
IPR008263. Glycoside_hydrolase_16_AS.
[Graphical view]
PfamiPF00722. Glyco_hydro_16. 1 hit.
[Graphical view]
PRINTSiPR00737. GLHYDRLASE16.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS01034. GLYCOSYL_HYDROL_F16. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37073-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKSKYLVFI SVFSLLFGVF VVGFSHQGVK AEEERPMGTA FYESFDAFDD
60 70 80 90 100
ERWSKAGVWT NGQMFNATWY PEQVTADGLM RLTIAKKTTS ARNYKAGELR
110 120 130 140 150
TNDFYHYGLF EVSMKPAKVE GTVSSFFTYT GEWDWDGDPW DEIDIEFLGK
160 170 180 190 200
DTTRIQFNYF TNGVGGNEFY YDLGFDASES FNTYAFEWRE DSITWYVNGE
210 220 230 240 250
AVHTATENIP QTPQKIMMNL WPGVGVDGWT GVFDGDNTPV YSYYDWVRYT

PLQNYQIHQ
Length:259
Mass (Da):29,960
Last modified:June 1, 1994 - v1
Checksum:iA63C09F281FF5D13
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84339 Genomic DNA. Translation: AAA22265.1.
PIRiA48378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84339 Genomic DNA. Translation: AAA22265.1 .
PIRi A48378.

3D structure databases

ProteinModelPortali P37073.
SMRi P37073. Positions 37-253.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH16. Glycoside Hydrolase Family 16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008264. Beta_glucanase.
IPR013320. ConA-like_dom.
IPR000757. Glyco_hydro_16.
IPR008263. Glycoside_hydrolase_16_AS.
[Graphical view ]
Pfami PF00722. Glyco_hydro_16. 1 hit.
[Graphical view ]
PRINTSi PR00737. GLHYDRLASE16.
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS01034. GLYCOSYL_HYDROL_F16. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization, cloning and sequencing of a thermostable endo-(1,3-1,4) beta-glucanase-encoding gene from an alkalophilic Bacillus brevis."
    Louw M.E., Reid S.J., Watson T.G.
    Appl. Microbiol. Biotechnol. 38:507-513(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Alk36.

Entry informationi

Entry nameiGUB_BREBE
AccessioniPrimary (citable) accession number: P37073
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Beta-glucanases of Bacillus have a substrate range similar to lichenase of germinating barley.

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3