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Protein

Phosphodiesterase YaeI

Gene

yaeI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Shows phosphodiesterase activity, hydrolyzing phosphodiester bond in the artificial chromogenic substrate bis-p-nitrophenyl phosphate (bis-pNPP).1 Publication

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi56Divalent metal cation 1By similarity1
Metal bindingi58Divalent metal cation 1By similarity1
Metal bindingi88Divalent metal cation 1By similarity1
Metal bindingi88Divalent metal cation 2By similarity1
Metal bindingi120Divalent metal cation 2By similarity1
Metal bindingi209Divalent metal cation 2By similarity1
Metal bindingi211Divalent metal cation 1By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12337-MONOMER.
ECOL316407:JW5014-MONOMER.
BRENDAi3.1.4.1. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphodiesterase YaeI (EC:3.1.4.-)
Gene namesi
Name:yaeI
Ordered Locus Names:b0164, JW5014
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12337. yaeI.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001728491 – 270Phosphodiesterase YaeIAdd BLAST270

Proteomic databases

PaxDbiP37049.
PRIDEiP37049.

Interactioni

Protein-protein interaction databases

BioGridi4260646. 2 interactors.
STRINGi511145.b0164.

Structurei

3D structure databases

ProteinModelPortaliP37049.
SMRiP37049.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallophosphoesterase superfamily.Curated

Phylogenomic databases

eggNOGiENOG4105DIN. Bacteria.
COG1408. LUCA.
HOGENOMiHOG000260481.
InParanoidiP37049.
KOiK07098.
OMAiPLITPPY.
PhylomeDBiP37049.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

P37049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISRRRFLQA TAATIATSSG FGYMHYCEPG WFELIRHRLA FFKDNAAPFK
60 70 80 90 100
ILFLADLHYS RFVPLSLISD AIALGIEQKP DLILLGGDYV LFDMSLNFSA
110 120 130 140 150
FSDVLSPLAE CAPTFACFGN HDRPVGTEKN HLIGETLKSA GITVLFNQAT
160 170 180 190 200
VIATPNRQFE LVGTGDLWAG QCKPPPASEA NLPRLVLAHN PDSKEVMRDE
210 220 230 240 250
PWDLMLCGHT HGGQLRVPLV GEPFAPVEDK RYVAGLNAFG ERHIYTTRGV
260 270
GSLYGLRLNC RPEVTMLELV
Length:270
Mass (Da):29,863
Last modified:April 27, 2001 - v2
Checksum:i6A075D0C09E5CAE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA. Translation: AAB08594.1.
U00096 Genomic DNA. Translation: AAC73275.2.
AP009048 Genomic DNA. Translation: BAB96741.2.
PIRiD64740.
RefSeqiNP_414706.2. NC_000913.3.
WP_000625631.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73275; AAC73275; b0164.
BAB96741; BAB96741; BAB96741.
GeneIDi945002.
KEGGiecj:JW5014.
eco:b0164.
PATRICi32115437. VBIEscCol129921_0170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA. Translation: AAB08594.1.
U00096 Genomic DNA. Translation: AAC73275.2.
AP009048 Genomic DNA. Translation: BAB96741.2.
PIRiD64740.
RefSeqiNP_414706.2. NC_000913.3.
WP_000625631.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP37049.
SMRiP37049.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260646. 2 interactors.
STRINGi511145.b0164.

Proteomic databases

PaxDbiP37049.
PRIDEiP37049.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73275; AAC73275; b0164.
BAB96741; BAB96741; BAB96741.
GeneIDi945002.
KEGGiecj:JW5014.
eco:b0164.
PATRICi32115437. VBIEscCol129921_0170.

Organism-specific databases

EchoBASEiEB2241.
EcoGeneiEG12337. yaeI.

Phylogenomic databases

eggNOGiENOG4105DIN. Bacteria.
COG1408. LUCA.
HOGENOMiHOG000260481.
InParanoidiP37049.
KOiK07098.
OMAiPLITPPY.
PhylomeDBiP37049.

Enzyme and pathway databases

BioCyciEcoCyc:EG12337-MONOMER.
ECOL316407:JW5014-MONOMER.
BRENDAi3.1.4.1. 2026.

Miscellaneous databases

PROiP37049.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYAEI_ECOLI
AccessioniPrimary (citable) accession number: P37049
Secondary accession number(s): P75666, Q8KJP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 27, 2001
Last modified: November 30, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.