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Protein

Carbohydrate diacid regulator

Gene

cdaR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization.

GO - Molecular functioni

  • transcription factor activity, sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG12335-MONOMER.
ECOL316407:JW5013-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbohydrate diacid regulator
Alternative name(s):
Sugar diacid regulator
Gene namesi
Name:cdaR
Synonyms:sdaR, yaeG
Ordered Locus Names:b0162, JW5013
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12335. cdaR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Carbohydrate diacid regulatorPRO_0000165944Add
BLAST

Proteomic databases

PaxDbiP37047.

Interactioni

Protein-protein interaction databases

BioGridi4260992. 4 interactions.
DIPiDIP-9258N.
STRINGi511145.b0162.

Structurei

3D structure databases

ProteinModelPortaliP37047.
SMRiP37047. Positions 326-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CdaR family.Curated

Phylogenomic databases

eggNOGiENOG4108IXP. Bacteria.
COG3835. LUCA.
HOGENOMiHOG000271795.
InParanoidiP37047.
KOiK02647.
OMAiNTRHEGA.
OrthoDBiEOG6B3623.
PhylomeDBiP37047.

Family and domain databases

InterProiIPR008599. Diacid_rec.
IPR025736. PucR_C-HTH_dom.
[Graphical view]
PfamiPF05651. Diacid_rec. 1 hit.
PF13556. HTH_30. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37047-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGWHLDTKM AQDIVARTMR IIDTNINVMD ARGRIIGSGD RERIGELHEG
60 70 80 90 100
ALLVLSQGRV VDIDDAVARH LHGVRQGINL PLRLEGEIVG VIGLTGEPEN
110 120 130 140 150
LRKYGELVCM TAEMMLEQSR LMHLLAQDSR LREELVMNLI QAEENTPALT
160 170 180 190 200
EWAQRLGIDL NQPRVVAIVE VDSGQLGVDS AMAELQQLQN ALTTPERNNL
210 220 230 240 250
VAIVSLTEMV VLKPALNSFG RWDAEDHRKR VEQLITRMKE YGQLRFRVSL
260 270 280 290 300
GNYFTGPGSI ARSYRTAKTT MVVGKQRMPE SRCYFYQDLM LPVLLDSLRG
310 320 330 340 350
DWQANELARP LARLKTMDNN GLLRRTLAAW FRHNVQPLAT SKALFIHRNT
360 370 380
LEYRLNRISE LTGLDLGNFD DRLLLYVALQ LDEER
Length:385
Mass (Da):43,687
Last modified:December 15, 1998 - v2
Checksum:i5FD4EEFB33C44DBB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti292 – 2921P → S in strain: JA176; unable to grow on galactarate, glucarate and glycerate.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA. Translation: AAB08592.1.
U00096 Genomic DNA. Translation: AAC73273.2.
AP009048 Genomic DNA. Translation: BAB96739.2.
PIRiB64740.
RefSeqiNP_414704.4. NC_000913.3.
WP_000929443.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73273; AAC73273; b0162.
BAB96739; BAB96739; BAB96739.
GeneIDi944860.
KEGGiecj:JW5013.
eco:b0162.
PATRICi32115433. VBIEscCol129921_0168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA. Translation: AAB08592.1.
U00096 Genomic DNA. Translation: AAC73273.2.
AP009048 Genomic DNA. Translation: BAB96739.2.
PIRiB64740.
RefSeqiNP_414704.4. NC_000913.3.
WP_000929443.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP37047.
SMRiP37047. Positions 326-358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260992. 4 interactions.
DIPiDIP-9258N.
STRINGi511145.b0162.

Proteomic databases

PaxDbiP37047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73273; AAC73273; b0162.
BAB96739; BAB96739; BAB96739.
GeneIDi944860.
KEGGiecj:JW5013.
eco:b0162.
PATRICi32115433. VBIEscCol129921_0168.

Organism-specific databases

EchoBASEiEB2239.
EcoGeneiEG12335. cdaR.

Phylogenomic databases

eggNOGiENOG4108IXP. Bacteria.
COG3835. LUCA.
HOGENOMiHOG000271795.
InParanoidiP37047.
KOiK02647.
OMAiNTRHEGA.
OrthoDBiEOG6B3623.
PhylomeDBiP37047.

Enzyme and pathway databases

BioCyciEcoCyc:EG12335-MONOMER.
ECOL316407:JW5013-MONOMER.

Miscellaneous databases

PROiP37047.

Family and domain databases

InterProiIPR008599. Diacid_rec.
IPR025736. PucR_C-HTH_dom.
[Graphical view]
PfamiPF05651. Diacid_rec. 1 hit.
PF13556. HTH_30. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region."
    Fujita N., Mori H., Yura T., Ishihama A.
    Nucleic Acids Res. 22:1637-1639(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "A common regulator for the operons encoding the enzymes involved in D-galactarate, D-glucarate, and D-glycerate utilization in Escherichia coli."
    Monterrubio R., Baldoma L., Obradors N., Aguilar J., Badia J.
    J. Bacteriol. 182:2672-2674(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: K12 / MC4100 / ATCC 35695 / DSM 6574 and K12 / MC4100 / JA176.

Entry informationi

Entry nameiCDAR_ECOLI
AccessioniPrimary (citable) accession number: P37047
Secondary accession number(s): Q8KJQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 15, 1998
Last modified: January 20, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.