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Protein

Progonadoliberin-1

Gene

GNRH1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates the secretion of gonadotropins.

GO - Molecular functioni

  • gonadotropin hormone-releasing hormone activity Source: UniProtKB
  • gonadotropin-releasing hormone receptor binding Source: Roslin

GO - Biological processi

  • luteinizing hormone secretion Source: AgBase
  • multicellular organism development Source: UniProtKB
  • negative regulation of neuron migration Source: Ensembl
  • positive regulation of luteinizing hormone secretion Source: AgBase
  • regulation of gene expression Source: Ensembl
  • regulation of hormone biosynthetic process Source: AgBase
  • regulation of ovarian follicle development Source: Ensembl
  • regulation of testosterone secretion Source: AgBase
  • reproduction Source: Roslin
  • response to alkaloid Source: AgBase
  • response to ethanol Source: Ensembl
  • response to serotonin Source: AgBase
  • response to steroid hormone Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-GGA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Progonadoliberin-1
Alternative name(s):
Progonadoliberin I
Cleaved into the following 2 chains:
Alternative name(s):
Gonadoliberin I
Gonadotropin-releasing hormone I
Short name:
GnRH-I
Luliberin I
Luteinizing hormone-releasing hormone I
Short name:
LH-RH I
Alternative name(s):
GnRH-associated peptide I
Gene namesi
Name:GNRH1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 22

Subcellular locationi

GO - Cellular componenti

  • axon Source: AgBase
  • extracellular region Source: UniProtKB
  • perikaryon Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 232 PublicationsAdd BLAST23
ChainiPRO_000001241924 – 92Progonadoliberin-1Add BLAST69
PeptideiPRO_000001242024 – 33Gonadoliberin-110
PeptideiPRO_000001242137 – 92GnRH-associated peptide 1Add BLAST56

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acid1
Modified residuei33Glycine amide1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP37042.

Expressioni

Gene expression databases

BgeeiENSGALG00000000277.
ExpressionAtlasiP37042. differential.

Interactioni

GO - Molecular functioni

  • gonadotropin hormone-releasing hormone activity Source: UniProtKB
  • gonadotropin-releasing hormone receptor binding Source: Roslin

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000365.

Family & Domainsi

Sequence similaritiesi

Belongs to the GnRH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18B. Eukaryota.
ENOG410ZDKS. LUCA.
GeneTreeiENSGT00390000008225.
HOGENOMiHOG000033698.
HOVERGENiHBG014746.
InParanoidiP37042.
KOiK05252.
OMAiSGQHWSY.
OrthoDBiEOG091G147V.
PhylomeDBiP37042.
TreeFamiTF330934.

Family and domain databases

InterProiIPR002012. GnRH.
IPR019792. Gonadoliberin_I.
IPR004079. Gonadoliberin_I_precursor.
[Graphical view]
PANTHERiPTHR10522. PTHR10522. 1 hit.
PRINTSiPR01541. GONADOLIBRNI.
PROSITEiPS00473. GNRH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKSRKILVG VLLFTASVAI CLAQHWSYGL QPGGKRNAEN LVESFQEIAN
60 70 80 90
EMESLGEGQK AECPGSYQHP RLSDLKETMA SLIEGEARRK EI
Length:92
Mass (Da):10,206
Last modified:June 1, 1994 - v1
Checksum:i61AEB7EBAF508B6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69491 Genomic DNA. Translation: CAA49246.1.
PIRiI50644.
RefSeqiNP_001074346.1. NM_001080877.1.
UniGeneiGga.41802.

Genome annotation databases

EnsembliENSGALT00000000366; ENSGALP00000000365; ENSGALG00000000277.
GeneIDi770134.
KEGGigga:770134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69491 Genomic DNA. Translation: CAA49246.1.
PIRiI50644.
RefSeqiNP_001074346.1. NM_001080877.1.
UniGeneiGga.41802.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000365.

Proteomic databases

PaxDbiP37042.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000000366; ENSGALP00000000365; ENSGALG00000000277.
GeneIDi770134.
KEGGigga:770134.

Organism-specific databases

CTDi2796.

Phylogenomic databases

eggNOGiENOG410J18B. Eukaryota.
ENOG410ZDKS. LUCA.
GeneTreeiENSGT00390000008225.
HOGENOMiHOG000033698.
HOVERGENiHBG014746.
InParanoidiP37042.
KOiK05252.
OMAiSGQHWSY.
OrthoDBiEOG091G147V.
PhylomeDBiP37042.
TreeFamiTF330934.

Enzyme and pathway databases

ReactomeiR-GGA-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP37042.

Gene expression databases

BgeeiENSGALG00000000277.
ExpressionAtlasiP37042. differential.

Family and domain databases

InterProiIPR002012. GnRH.
IPR019792. Gonadoliberin_I.
IPR004079. Gonadoliberin_I_precursor.
[Graphical view]
PANTHERiPTHR10522. PTHR10522. 1 hit.
PRINTSiPR01541. GONADOLIBRNI.
PROSITEiPS00473. GNRH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGON1_CHICK
AccessioniPrimary (citable) accession number: P37042
Secondary accession number(s): P20407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.