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Protein

Progonadoliberin-1

Gene

GNRH1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates the secretion of gonadotropins.

GO - Molecular functioni

  • gonadotropin hormone-releasing hormone activity Source: UniProtKB
  • gonadotropin-releasing hormone receptor binding Source: Roslin

GO - Biological processi

  • luteinizing hormone secretion Source: AgBase
  • multicellular organism development Source: UniProtKB
  • negative regulation of neuron migration Source: Ensembl
  • positive regulation of luteinizing hormone secretion Source: AgBase
  • regulation of gene expression Source: Ensembl
  • regulation of hormone biosynthetic process Source: AgBase
  • regulation of ovarian follicle development Source: Ensembl
  • regulation of testosterone secretion Source: AgBase
  • reproduction Source: Roslin
  • response to alkaloid Source: AgBase
  • response to ethanol Source: Ensembl
  • response to serotonin Source: AgBase
  • response to steroid hormone Source: Ensembl

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-GGA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Progonadoliberin-1
Alternative name(s):
Progonadoliberin I
Cleaved into the following 2 chains:
Alternative name(s):
Gonadoliberin I
Gonadotropin-releasing hormone I
Short name:
GnRH-I
Luliberin I
Luteinizing hormone-releasing hormone I
Short name:
LH-RH I
Alternative name(s):
GnRH-associated peptide I
Gene namesi
Name:GNRH1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 22

Subcellular locationi

GO - Cellular componenti

  • axon Source: AgBase
  • extracellular region Source: UniProtKB
  • perikaryon Source: AgBase

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 232 PublicationsAdd BLAST23
ChainiPRO_000001241924 – 92Progonadoliberin-1Add BLAST69
PeptideiPRO_000001242024 – 33Gonadoliberin-110
PeptideiPRO_000001242137 – 92GnRH-associated peptide 1Add BLAST56

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acid1 Publication1
Modified residuei33Glycine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP37042.

Expressioni

Gene expression databases

BgeeiENSGALG00000000277.
ExpressionAtlasiP37042. baseline.

Interactioni

GO - Molecular functioni

  • gonadotropin hormone-releasing hormone activity Source: UniProtKB
  • gonadotropin-releasing hormone receptor binding Source: Roslin

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000365.

Structurei

3D structure databases

SMRiP37042.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GnRH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18B. Eukaryota.
ENOG410ZDKS. LUCA.
GeneTreeiENSGT00390000008225.
HOGENOMiHOG000033698.
HOVERGENiHBG014746.
InParanoidiP37042.
KOiK05252.
OMAiEPQRFEC.
OrthoDBiEOG091G147V.
PhylomeDBiP37042.
TreeFamiTF330934.

Family and domain databases

InterProiView protein in InterPro
IPR002012. GnRH.
IPR019792. Gonadoliberin_I.
IPR004079. Gonadoliberin_I_precursor.
PANTHERiPTHR10522. PTHR10522. 1 hit.
PTHR10522:SF10. PTHR10522:SF10. 1 hit.
PRINTSiPR01541. GONADOLIBRNI.
PROSITEiView protein in PROSITE
PS00473. GNRH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKSRKILVG VLLFTASVAI CLAQHWSYGL QPGGKRNAEN LVESFQEIAN
60 70 80 90
EMESLGEGQK AECPGSYQHP RLSDLKETMA SLIEGEARRK EI
Length:92
Mass (Da):10,206
Last modified:June 1, 1994 - v1
Checksum:i61AEB7EBAF508B6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69491 Genomic DNA. Translation: CAA49246.1.
PIRiI50644.
RefSeqiNP_001074346.1. NM_001080877.1.
UniGeneiGga.41802.

Genome annotation databases

EnsembliENSGALT00000000366; ENSGALP00000000365; ENSGALG00000000277.
GeneIDi770134.
KEGGigga:770134.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGON1_CHICK
AccessioniPrimary (citable) accession number: P37042
Secondary accession number(s): P20407
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 7, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families