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P37039

- NCPR_CAVPO

UniProt

P37039 - NCPR_CAVPO

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Protein
NADPH--cytochrome P450 reductase
Gene
POR
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

Catalytic activityi

NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.

Cofactori

FAD.
FMN.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi170 – 20132FMN By similarity
Add
BLAST
Nucleotide bindingi314 – 32512FAD By similarity
Add
BLAST
Nucleotide bindingi451 – 46111FAD By similarity
Add
BLAST
Nucleotide bindingi530 – 54819NADP By similarity
Add
BLAST
Nucleotide bindingi625 – 64117NADP By similarity
Add
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. NADPH-hemoprotein reductase activity Source: UniProtKB-EC
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, FMN, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH--cytochrome P450 reductase (EC:1.6.2.4)
Short name:
CPR
Short name:
P450R
Gene namesi
Name:POR
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

Endoplasmic reticulum membrane; Peripheral membrane protein
Note: Anchored to the ER membrane by its N-terminal hydrophobic region.

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 678677NADPH--cytochrome P450 reductase
PRO_0000167595Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP37039.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000005592.

Structurei

3D structure databases

ProteinModelPortaliP37039.
SMRiP37039. Positions 64-678.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 224145Flavodoxin-like
Add
BLAST
Domaini279 – 521243FAD-binding FR-type
Add
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

Phylogenomic databases

eggNOGiCOG0369.
HOGENOMiHOG000282027.
HOVERGENiHBG000432.
InParanoidiP37039.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000208. P450R. 1 hit.
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37039-1 [UniParc]FASTAAdd to Basket

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MGDSHVDTGA TSTEAVAEEV SLFSMTDMIL LSVLVGFLTY FFLFRKKKEE    50
IPEFTKISTT TSSVKESSFV EKMKKTGRNI IVFYGSQTGT AEEFANRLSK 100
DAHRYGMRGM AADPEEYDLA DLSSLPEIDN SLAVFCMATY GEGDPTDNAQ 150
DFYDWLQETD LDLSGVKYAV FGLGNKTYEH FNSMGKYVDQ RLEQLGAQRI 200
FELGLGDDDG NLEEDFITWR EQFWPAVCEF FGVEATGEES SIRQYELVLH 250
ADTDPAKVYT GEMGRLKSYE NQKPPFDAKN PFLAAVTTNR KLNQGTERHL 300
MHLELDISDS KIRYESGDHV AVYPANDSNL VNQLGKILGA DLDVVMSLKN 350
LDEESNKKHP FPCPTTYRTA LTYYLDITNP PRTNVLYELA QYASEPSEQE 400
QLHKMASSSG EGKELYLTWV VEARRHILAI LQDYPSLRPP IDHLCELLPR 450
LQARYYSIAS SSKVHPNSVH ICAVVVEYET KSGRINKGVA TSWLQAKDPA 500
GENGRRALVP MFVRKSQFRL PFKSTTPVIM VGPGTGVAPF IGFIQERAWL 550
QQQGKEVGET LLYYGCRRSD EDYLYREELA QFHKDGTLTQ LNVAFSREQA 600
QKVYVQHLLK RDQEHLWKLI HEDGAHIYVC GDARNMARDV QNTFCNIAAE 650
LGGMEHTQAV DYVKKLMTKG RYSLDVWS 678
Length:678
Mass (Da):76,782
Last modified:January 23, 2007 - v2
Checksum:i4AC01B1825F0946F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10498 mRNA. Translation: BAA01385.1.
PIRiS27158.
RefSeqiNP_001166473.1. NM_001173002.1.

Genome annotation databases

GeneIDi100135602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10498 mRNA. Translation: BAA01385.1 .
PIRi S27158.
RefSeqi NP_001166473.1. NM_001173002.1.

3D structure databases

ProteinModelPortali P37039.
SMRi P37039. Positions 64-678.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000005592.

Proteomic databases

PRIDEi P37039.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100135602.

Organism-specific databases

CTDi 5447.

Phylogenomic databases

eggNOGi COG0369.
HOGENOMi HOG000282027.
HOVERGENi HBG000432.
InParanoidi P37039.

Family and domain databases

Gene3Di 1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
InterProi IPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view ]
Pfami PF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF000208. P450R. 1 hit.
PRINTSi PR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMi SSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEi PS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and sequence analysis of guinea-pig NADPH-cytochrome P-450 oxidoreductase."
    Ohgiya S., Goda T., Ishizaki K., Kamataki T., Shinriki N.
    Biochim. Biophys. Acta 1171:103-105(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Hartley.
  2. Erratum
    Ohgiya S., Goda T., Ishizaki K., Kamataki T., Shinriki N.
    Biochim. Biophys. Acta 1174:313-313(1993) [PubMed] [Europe PMC] [Abstract]

Entry informationi

Entry nameiNCPR_CAVPO
AccessioniPrimary (citable) accession number: P37039
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally (1 Publication) thought to originate from mouse.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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