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P37039

- NCPR_CAVPO

UniProt

P37039 - NCPR_CAVPO

Protein

NADPH--cytochrome P450 reductase

Gene

POR

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

    Catalytic activityi

    NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.

    Cofactori

    FAD.
    FMN.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi170 – 20132FMNPROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi314 – 32512FADBy similarityAdd
    BLAST
    Nucleotide bindingi451 – 46111FADBy similarityAdd
    BLAST
    Nucleotide bindingi530 – 54819NADPBy similarityAdd
    BLAST
    Nucleotide bindingi625 – 64117NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. FMN binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. NADPH-hemoprotein reductase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, FMN, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADPH--cytochrome P450 reductase (EC:1.6.2.4)
    Short name:
    CPR
    Short name:
    P450R
    Gene namesi
    Name:POR
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    Endoplasmic reticulum membrane; Peripheral membrane protein
    Note: Anchored to the ER membrane by its N-terminal hydrophobic region.

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 678677NADPH--cytochrome P450 reductasePRO_0000167595Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP37039.

    Interactioni

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000005592.

    Structurei

    3D structure databases

    ProteinModelPortaliP37039.
    SMRiP37039. Positions 64-678.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini80 – 224145Flavodoxin-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini279 – 521243FAD-binding FR-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.Curated
    Contains 1 FAD-binding FR-type domain.PROSITE-ProRule annotation
    Contains 1 flavodoxin-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0369.
    HOGENOMiHOG000282027.
    HOVERGENiHBG000432.
    InParanoidiP37039.

    Family and domain databases

    Gene3Di1.20.990.10. 1 hit.
    3.40.50.360. 1 hit.
    InterProiIPR003097. FAD-binding_1.
    IPR017927. Fd_Rdtase_FAD-bd.
    IPR001094. Flavdoxin.
    IPR008254. Flavodoxin/NO_synth.
    IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
    IPR029039. Flavoprotein-like.
    IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
    IPR001433. OxRdtase_FAD/NAD-bd.
    IPR023208. P450R.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view]
    PfamiPF00667. FAD_binding_1. 1 hit.
    PF00258. Flavodoxin_1. 1 hit.
    PF00175. NAD_binding_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000208. P450R. 1 hit.
    PRINTSiPR00369. FLAVODOXIN.
    PR00371. FPNCR.
    SUPFAMiSSF52218. SSF52218. 1 hit.
    SSF63380. SSF63380. 1 hit.
    PROSITEiPS51384. FAD_FR. 1 hit.
    PS50902. FLAVODOXIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P37039-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDSHVDTGA TSTEAVAEEV SLFSMTDMIL LSVLVGFLTY FFLFRKKKEE    50
    IPEFTKISTT TSSVKESSFV EKMKKTGRNI IVFYGSQTGT AEEFANRLSK 100
    DAHRYGMRGM AADPEEYDLA DLSSLPEIDN SLAVFCMATY GEGDPTDNAQ 150
    DFYDWLQETD LDLSGVKYAV FGLGNKTYEH FNSMGKYVDQ RLEQLGAQRI 200
    FELGLGDDDG NLEEDFITWR EQFWPAVCEF FGVEATGEES SIRQYELVLH 250
    ADTDPAKVYT GEMGRLKSYE NQKPPFDAKN PFLAAVTTNR KLNQGTERHL 300
    MHLELDISDS KIRYESGDHV AVYPANDSNL VNQLGKILGA DLDVVMSLKN 350
    LDEESNKKHP FPCPTTYRTA LTYYLDITNP PRTNVLYELA QYASEPSEQE 400
    QLHKMASSSG EGKELYLTWV VEARRHILAI LQDYPSLRPP IDHLCELLPR 450
    LQARYYSIAS SSKVHPNSVH ICAVVVEYET KSGRINKGVA TSWLQAKDPA 500
    GENGRRALVP MFVRKSQFRL PFKSTTPVIM VGPGTGVAPF IGFIQERAWL 550
    QQQGKEVGET LLYYGCRRSD EDYLYREELA QFHKDGTLTQ LNVAFSREQA 600
    QKVYVQHLLK RDQEHLWKLI HEDGAHIYVC GDARNMARDV QNTFCNIAAE 650
    LGGMEHTQAV DYVKKLMTKG RYSLDVWS 678
    Length:678
    Mass (Da):76,782
    Last modified:January 23, 2007 - v2
    Checksum:i4AC01B1825F0946F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10498 mRNA. Translation: BAA01385.1.
    PIRiS27158.
    RefSeqiNP_001166473.1. NM_001173002.1.

    Genome annotation databases

    GeneIDi100135602.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10498 mRNA. Translation: BAA01385.1 .
    PIRi S27158.
    RefSeqi NP_001166473.1. NM_001173002.1.

    3D structure databases

    ProteinModelPortali P37039.
    SMRi P37039. Positions 64-678.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000005592.

    Proteomic databases

    PRIDEi P37039.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100135602.

    Organism-specific databases

    CTDi 5447.

    Phylogenomic databases

    eggNOGi COG0369.
    HOGENOMi HOG000282027.
    HOVERGENi HBG000432.
    InParanoidi P37039.

    Family and domain databases

    Gene3Di 1.20.990.10. 1 hit.
    3.40.50.360. 1 hit.
    InterProi IPR003097. FAD-binding_1.
    IPR017927. Fd_Rdtase_FAD-bd.
    IPR001094. Flavdoxin.
    IPR008254. Flavodoxin/NO_synth.
    IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
    IPR029039. Flavoprotein-like.
    IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
    IPR001433. OxRdtase_FAD/NAD-bd.
    IPR023208. P450R.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view ]
    Pfami PF00667. FAD_binding_1. 1 hit.
    PF00258. Flavodoxin_1. 1 hit.
    PF00175. NAD_binding_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000208. P450R. 1 hit.
    PRINTSi PR00369. FLAVODOXIN.
    PR00371. FPNCR.
    SUPFAMi SSF52218. SSF52218. 1 hit.
    SSF63380. SSF63380. 1 hit.
    PROSITEi PS51384. FAD_FR. 1 hit.
    PS50902. FLAVODOXIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequence analysis of guinea-pig NADPH-cytochrome P-450 oxidoreductase."
      Ohgiya S., Goda T., Ishizaki K., Kamataki T., Shinriki N.
      Biochim. Biophys. Acta 1171:103-105(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Hartley.
    2. Erratum
      Ohgiya S., Goda T., Ishizaki K., Kamataki T., Shinriki N.
      Biochim. Biophys. Acta 1174:313-313(1993) [PubMed] [Europe PMC] [Abstract]

    Entry informationi

    Entry nameiNCPR_CAVPO
    AccessioniPrimary (citable) accession number: P37039
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally thought to originate from mouse.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3