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P37032 (ACON_LEGPH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aconitate hydratase
Short name=Aconitase
EC=4.2.1.3
Alternative name(s):
Citrate hydro-lyase
IP210
Major iron-containing protein
Short name=MICP
Gene names
Name:acn
Ordered Locus Names:lpg1690
OrganismLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]
Taxonomic identifier272624 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length891 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate By similarity.

Catalytic activity

Citrate = isocitrate.

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the aconitase/IPM isomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 891891Aconitate hydratase
PRO_0000076662

Sites

Metal binding4351Iron-sulfur (4Fe-4S) By similarity
Metal binding5011Iron-sulfur (4Fe-4S) By similarity
Metal binding5041Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
P37032 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: F81FC99520859B48

FASTA89198,209
        10         20         30         40         50         60 
MKVGQDSLST KSQLTVDGKT YNYYSLKEAE NKHFKGINRL PYSLKVLLEN LLRFEDGNTV 

        70         80         90        100        110        120 
TTKDIKAIAD WLHNKTSQHE IAFRPTRVLM QDFTGVPAVV DLAAMRTAIV KMGGNADKIS 

       130        140        150        160        170        180 
PLSPVDLVID HSVMVDKFAS ADALEVNTKI EIERNKERYE FLRWGQKAFS NFQVVPPGTG 

       190        200        210        220        230        240 
ICHQVNLEYL GKTVWNSEND GQLYAYPDTL VGTDSHTTMI NGLGVLGWGV GGIEAEAAML 

       250        260        270        280        290        300 
GQPVSMLIPE VIGFKLSGKL KEGITATDLV LTVTQMLRKK GVVGKFVEFY GPGLNDLPLA 

       310        320        330        340        350        360 
DRATISNMAP EYGATCGFFP VDKETIKYLE LTGRDKHTIA LVEAYAKAQG MWYDKDNEEP 

       370        380        390        400        410        420 
VFTDSLHLDL GSVEPSLAGP KRPQDKVNLS SLPVEFNNFL IEVGKEKEKE KTFAVKNKDF 

       430        440        450        460        470        480 
QMKHGHVVIA AITSCTNTSN PSVLMAAGLV AKKAIEKGLQ RKPWVKSSLA PGSKVVTDYL 

       490        500        510        520        530        540 
RHAGLQTYLD QLGFNLVGYG CTTCIGNSGP LPDDISHCVA EHDLVVSSVL SGNRNFEGRV 

       550        560        570        580        590        600 
HPQVRANWLA SPPLVVAYAL CGTTCSDLSR EPIGQDKEGN DVYLKDIWPS NEEIAAEVAK 

       610        620        630        640        650        660 
VSGTMFRKEY AEVFKGDAHW QAIQTSSGQT YEWNPDSTYI QHPPFFENLS LKPEPLKPIK 

       670        680        690        700        710        720 
QAYVLALFGD SITTDHISPA GSIKASSPAG LYLKSKGVDE KDFNSYGSRR GNHEVMMRGT 

       730        740        750        760        770        780 
FANIRIRNEM TPGQEGGVTR YVPTGETMSI YDAAMRYQEN QQDLVIIAGK EYGTGSSRDW 

       790        800        810        820        830        840 
AAKGTNLLGV KAVITESFER IHRSNLIGMG ILPLQFKEGT TRKTLKLDGS ERISIEISDK 

       850        860        870        880        890 
LTPGAMVPVT IERQDGDIEK IETLCRIDTA DELEYYKNGG ILQYVLRKIS S

« Hide

References

« Hide 'large scale' references
[1]"The major iron-containing protein of Legionella pneumophila is an aconitase homologous with the human iron-responsive element-binding protein."
Mengaud J.M., Horwitz M.A.
J. Bacteriol. 175:5666-5676(1993) [PubMed: 8366052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genomic sequence of the accidental pathogen Legionella pneumophila."
Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S. expand/collapse author list , Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., Russo J.J.
Science 305:1966-1968(2004) [PubMed: 15448271] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L22081 Genomic DNA. Translation: AAA25295.1.
AE017354 Genomic DNA. Translation: AAU27770.1.
PIRB48642.
RefSeqYP_095717.1. NC_002942.5.

3D structure databases

ProteinModelPortalP37032.
SMRP37032. Positions 9-890.
ModBaseSearch...

Protein-protein interaction databases

STRINGP37032.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3078080.
GenomeReviewsGene locus lpg1690 in contig AE017354_GR.
KEGGlpn:lpg1690.
NMPDRfig|272624.3.peg.514.
PATRIC22330500. VBILegPne29832_1771.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1048.
HOGENOMHBG289738.
OMAYSKAQGM.
PhylomeDBP37032.
ProtClustDBPRK09277.

Enzyme and pathway databases

BioCycLPNE272624:LPG1690-MONOMER.

Family and domain databases

InterProIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR006249. Aconitase/Fe_reg_prot_2.
IPR015934. Aconitase/Fe_reg_prot_2/AcnD.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
Gene3DG3DSA:3.30.499.10. Acnase/IPM_dHydase_lsu_aba_1/3. 2 hits.
G3DSA:3.20.19.10. Aconitase/3IPM_dehydase_swvl. 1 hit.
G3DSA:3.40.1060.10. Aconitase/IPMdHydase_lsu_aba_2. 1 hit.
KOK01681.
PANTHERPTHR11670. Aconitase-like_core. 1 hit.
PTHR11670:SF1. Aconitase/Fe_reg_prot_2/AcnD. 1 hit.
PfamPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSPR00415. ACONITASE.
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
SSF53732. Aconitase_N. 1 hit.
TIGRFAMsTIGR01341. Aconitase_1. 1 hit.
PROSITEPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACON_LEGPH
AccessionPrimary (citable) accession number: P37032
Secondary accession number(s): Q5ZUV2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents