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Protein

ATP-dependent RNA helicase HrpB

Gene

hrpB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 34ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12329-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase HrpB (EC:3.6.4.13)
Gene namesi
Name:hrpB
Synonyms:yadO
Ordered Locus Names:b0148, JW0144
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12329. hrpB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000551801 – 809ATP-dependent RNA helicase HrpBAdd BLAST809

Proteomic databases

PaxDbiP37024.
PRIDEiP37024.

Interactioni

Protein-protein interaction databases

BioGridi4261401. 83 interactors.
DIPiDIP-9938N.
IntActiP37024. 10 interactors.
MINTiMINT-1231977.
STRINGi511145.b0148.

Structurei

3D structure databases

ProteinModelPortaliP37024.
SMRiP37024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 177Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST164
Domaini195 – 368Helicase C-terminalPROSITE-ProRule annotationAdd BLAST174

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi123 – 126DEFH box4

Sequence similaritiesi

Belongs to the DEAD box helicase family.Curated

Phylogenomic databases

eggNOGiENOG4105CQ7. Bacteria.
COG1643. LUCA.
HOGENOMiHOG000244609.
InParanoidiP37024.
KOiK03579.
OMAiDLRILVM.
PhylomeDBiP37024.

Family and domain databases

InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR010225. RNA_helicase_ATP-dep_DEAH_HrpB.
IPR013689. RNA_helicase_ATP-dep_HrpB_C.
PANTHERiPTHR43519:SF1. PTHR43519:SF1. 1 hit.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF08482. HrpB_C. 1 hit.
PIRSFiPIRSF005496. ATP_hel_hrpB. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01970. DEAH_box_HrpB. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

P37024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLPVAAVL PELLTALDCA PQVLLSAPTG AGKSTWLPLQ LLAHPGINGK
60 70 80 90 100
IILLEPRRLA ARNVAQRLAE LLNEKPGDTV GYRMRAQNCV GPNTRLEVVT
110 120 130 140 150
EGVLTRMIQR DPELSGVGLV ILDEFHERSL QADLALALLL DVQQGLRDDL
160 170 180 190 200
KLLIMSATLD NDRLQQMLPE APVVISEGRS FPVERRYLPL PAHQRFDDAV
210 220 230 240 250
AVATAEMLRQ ESGSLLLFLP GVGEIQRVQE QLASRIGSDV LLCPLYGALS
260 270 280 290 300
LNDQRKAILP APQGMRKVVL ATNIAETSLT IEGIRLVVDC AQERVARFDP
310 320 330 340 350
RTGLTRLITQ RVSQASMTQR AGRAGRLEPG ISLHLIAKEQ AERAAAQSEP
360 370 380 390 400
EILQSDLSGL LMELLQWGCS DPAQMSWLDQ PPVVNLLAAK RLLQMLGALE
410 420 430 440 450
GERLSAQGQK MAALGNDPRL AAMLVSAKND DEAATAAKIA AILEEPPRMG
460 470 480 490 500
NSDLGVAFSR NQPAWQQRSQ QLLKRLNVRG GEADSSLIAP LLAGAFADRI
510 520 530 540 550
ARRRGQDGRY QLANGMGAML DANDALSRHE WLIAPLLLQG SASPDARILL
560 570 580 590 600
ALLVDIDELV QRCPQLVQQS DTVEWDDAQG TLKAWRRLQI GQLTVKVQPL
610 620 630 640 650
AKPSEDELHQ AMLNGIRDKG LSVLNWTAEA EQLRLRLLCA AKWLPEYDWP
660 670 680 690 700
AVDDESLLAA LETWLLPHMT GVHSLRGLKS LDIYQALRGL LDWGMQQRLD
710 720 730 740 750
SELPAHYTVP TGSRIAIRYH EDNPPALAVR MQEMFGEATN PTIAQGRVPL
760 770 780 790 800
VLELLSPAQR PLQITRDLSD FWKGAYREVQ KEMKGRYPKH VWPDDPANTA

PTRRTKKYS
Length:809
Mass (Da):89,148
Last modified:November 1, 1997 - v3
Checksum:i413605E1D2D90715
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73259.2.
AP009048 Genomic DNA. Translation: BAE76044.1.
D42122 Genomic DNA. Translation: BAA21040.1.
PIRiD64738.
RefSeqiNP_414690.4. NC_000913.3.
WP_001350480.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73259; AAC73259; b0148.
BAE76044; BAE76044; BAE76044.
GeneIDi944845.
KEGGiecj:JW0144.
eco:b0148.
PATRICi32115403. VBIEscCol129921_0153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73259.2.
AP009048 Genomic DNA. Translation: BAE76044.1.
D42122 Genomic DNA. Translation: BAA21040.1.
PIRiD64738.
RefSeqiNP_414690.4. NC_000913.3.
WP_001350480.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP37024.
SMRiP37024.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261401. 83 interactors.
DIPiDIP-9938N.
IntActiP37024. 10 interactors.
MINTiMINT-1231977.
STRINGi511145.b0148.

Proteomic databases

PaxDbiP37024.
PRIDEiP37024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73259; AAC73259; b0148.
BAE76044; BAE76044; BAE76044.
GeneIDi944845.
KEGGiecj:JW0144.
eco:b0148.
PATRICi32115403. VBIEscCol129921_0153.

Organism-specific databases

EchoBASEiEB2233.
EcoGeneiEG12329. hrpB.

Phylogenomic databases

eggNOGiENOG4105CQ7. Bacteria.
COG1643. LUCA.
HOGENOMiHOG000244609.
InParanoidiP37024.
KOiK03579.
OMAiDLRILVM.
PhylomeDBiP37024.

Enzyme and pathway databases

BioCyciEcoCyc:EG12329-MONOMER.

Miscellaneous databases

PROiPR:P37024.

Family and domain databases

InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR010225. RNA_helicase_ATP-dep_DEAH_HrpB.
IPR013689. RNA_helicase_ATP-dep_HrpB_C.
PANTHERiPTHR43519:SF1. PTHR43519:SF1. 1 hit.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF08482. HrpB_C. 1 hit.
PIRSFiPIRSF005496. ATP_hel_hrpB. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01970. DEAH_box_HrpB. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHRPB_ECOLI
AccessioniPrimary (citable) accession number: P37024
Secondary accession number(s): P75663, Q2MCG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: May 10, 2017
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.