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P37012

- PGM2_YEAST

UniProt

P37012 - PGM2_YEAST

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Protein

Phosphoglucomutase-2

Gene

PGM2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This enzyme participates in both the breakdown and synthesis of glucose. Can also act on mannose.

Catalytic activityi

Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.

Cofactori

Binds 1 magnesium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei119 – 1191Phosphoserine intermediateBy similarity
Metal bindingi119 – 1191Magnesium; via phosphate groupBy similarity
Metal bindingi290 – 2901MagnesiumBy similarity
Metal bindingi292 – 2921MagnesiumBy similarity
Metal bindingi294 – 2941MagnesiumBy similarity

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. phosphoglucomutase activity Source: SGD

GO - Biological processi

  1. cellular calcium ion homeostasis Source: SGD
  2. cellular cation homeostasis Source: SGD
  3. galactose catabolic process Source: SGD
  4. glucose 1-phosphate metabolic process Source: SGD
  5. glucose 6-phosphate metabolic process Source: SGD
  6. glucose metabolic process Source: UniProtKB-KW
  7. glycogen biosynthetic process Source: SGD
  8. trehalose biosynthetic process Source: SGD
  9. UDP-glucose metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17136.
YEAST:YMR105C-MONOMER.
SABIO-RKP37012.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglucomutase-2 (EC:5.4.2.2)
Short name:
PGM 2
Alternative name(s):
Glucose phosphomutase 2
Gene namesi
Name:PGM2
Synonyms:GAL5
Ordered Locus Names:YMR105C
ORF Names:YM9718.04C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR105c.
SGDiS000004711. PGM2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 569568Phosphoglucomutase-2PRO_0000147797Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei111 – 1111Phosphothreonine1 Publication
Modified residuei117 – 1171Phosphothreonine1 Publication
Modified residuei119 – 1191Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP37012.
PaxDbiP37012.
PeptideAtlasiP37012.
PRIDEiP37012.

Expressioni

Gene expression databases

GenevestigatoriP37012.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi35280. 85 interactions.
DIPiDIP-6499N.
IntActiP37012. 13 interactions.
MINTiMINT-705119.
STRINGi4932.YMR105C.

Structurei

3D structure databases

ProteinModelPortaliP37012.
SMRiP37012. Positions 4-569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiCOG0033.
GeneTreeiENSGT00390000011831.
HOGENOMiHOG000009550.
InParanoidiP37012.
KOiK01835.
OMAiRYYCKEA.
OrthoDBiEOG70S7FF.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37012 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFQIETVPT KPYEDQKPGT SGLRKKTKVF KDEPNYTENF IQSIMEAIPE
60 70 80 90 100
GSKGATLVVG GDGRYYNDVI LHKIAAIGAA NGIKKLVIGQ HGLLSTPAAS
110 120 130 140 150
HIMRTYEEKC TGGIILTASH NPGGPENDMG IKYNLSNGGP APESVTNAIW
160 170 180 190 200
EISKKLTSYK IIKDFPELDL GTIGKNKKYG PLLVDIIDIT KDYVNFLKEI
210 220 230 240 250
FDFDLIKKFI DNQRSTKNWK LLFDSMNGVT GPYGKAIFVD EFGLPADEVL
260 270 280 290 300
QNWHPSPDFG GMHPDPNLTY ASSLVKRVDR EKIEFGAASD GDGDRNMIYG
310 320 330 340 350
YGPSFVSPGD SVAIIAEYAA EIPYFAKQGI YGLARSFPTS GAIDRVAKAH
360 370 380 390 400
GLNCYEVPTG WKFFCALFDA KKLSICGEES FGTGSNHVRE KDGVWAIMAW
410 420 430 440 450
LNILAIYNKH HPENEASIKT IQNEFWAKYG RTFFTRYDFE KVETEKANKI
460 470 480 490 500
VDQLRAYVTK SGVVNSAFPA DESLKVTDCG DFSYTDLDGS VSDHQGLYVK
510 520 530 540 550
LSNGARFVLR LSGTGSSGAT IRLYIEKYCD DKSQYQKTAE EYLKPIINSV
560
IKFLNFKQVL GTEEPTVRT
Length:569
Mass (Da):63,089
Last modified:June 1, 1994 - v1
Checksum:i45B78AFF8197645E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74823 Genomic DNA. Translation: CAA52820.1.
U09499 Genomic DNA. Translation: AAA91282.1.
Z49702 Genomic DNA. Translation: CAA89741.1.
AY723853 Genomic DNA. Translation: AAU09770.1.
BK006946 Genomic DNA. Translation: DAA10001.1.
PIRiS41200.
RefSeqiNP_013823.1. NM_001182605.1.

Genome annotation databases

EnsemblFungiiYMR105C; YMR105C; YMR105C.
GeneIDi855131.
KEGGisce:YMR105C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74823 Genomic DNA. Translation: CAA52820.1 .
U09499 Genomic DNA. Translation: AAA91282.1 .
Z49702 Genomic DNA. Translation: CAA89741.1 .
AY723853 Genomic DNA. Translation: AAU09770.1 .
BK006946 Genomic DNA. Translation: DAA10001.1 .
PIRi S41200.
RefSeqi NP_013823.1. NM_001182605.1.

3D structure databases

ProteinModelPortali P37012.
SMRi P37012. Positions 4-569.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35280. 85 interactions.
DIPi DIP-6499N.
IntActi P37012. 13 interactions.
MINTi MINT-705119.
STRINGi 4932.YMR105C.

Proteomic databases

MaxQBi P37012.
PaxDbi P37012.
PeptideAtlasi P37012.
PRIDEi P37012.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR105C ; YMR105C ; YMR105C .
GeneIDi 855131.
KEGGi sce:YMR105C.

Organism-specific databases

CYGDi YMR105c.
SGDi S000004711. PGM2.

Phylogenomic databases

eggNOGi COG0033.
GeneTreei ENSGT00390000011831.
HOGENOMi HOG000009550.
InParanoidi P37012.
KOi K01835.
OMAi RYYCKEA.
OrthoDBi EOG70S7FF.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-17136.
YEAST:YMR105C-MONOMER.
SABIO-RK P37012.

Miscellaneous databases

NextBioi 978502.

Gene expression databases

Genevestigatori P37012.

Family and domain databases

Gene3Di 3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view ]
Pfami PF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view ]
PRINTSi PR00509. PGMPMM.
SUPFAMi SSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEi PS00710. PGM_PMM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A family of hexosephosphate mutases in Saccharomyces cerevisiae."
    Boles E., Liebetrau W., Hofmann M., Zimmermann F.K.
    Eur. J. Biochem. 220:83-96(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Fu L., Bounelis P., Dey N., Browne B.L., Marchase R.B., Bedwell D.M.
    Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-111; THR-117 AND SER-119, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPGM2_YEAST
AccessioniPrimary (citable) accession number: P37012
Secondary accession number(s): D6VZS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3790 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3