Reviewed, UniProtKB/Swiss-Prot P37009 (FBPC_ECOLI)

Names and origin

Protein names

Recommended name:
    Fe(3+) ions import ATP-binding protein fbpC
    EC=3.6.3.30

Gene names

Name:	fbpC
Synonyms:	afuC, yagC
Ordered Locus Names:	b0262, JW0254

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of the ABC transporter complex fbpABC involved in Fe3+ ions import. Responsible for energy coupling to the transport system By similarity.
Catalytic activity	ATP + H2O + Fe3+(Out) = ADP + phosphate + Fe3+(In). HAMAP MF_01706
Subunit structure	The complex is composed of two ATP-binding proteins (fbpC), two transmembrane proteins (fbpB) and a solute-binding protein (fbpA) Probable.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Miscellaneous	In E.coli, the afu system seems to have been deleted by an insertion sequence. AfuA is totally lost, afuB is partially present and afuC is totally conserved. HAMAP MF_01706
Sequence similarities	Belongs to the ABC transporter family. Fe(3+) ion importer (TC 3.A.1.10) subfamily. [View classification] Contains 1 ABC transporter domain.
Sequence caution	The sequence L20943 differs from that shown. Reason: Frameshift at positions 147 and 220.

Ontologies

Keywords
Biological process	Ion transport Iron transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Iron Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ferric iron transport Inferred from electronic annotation. Source: HAMAP
Cellular component	ATP-binding cassette (ABC) transporter complex Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ferric-transporting ATPase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Fe(3+) ions import ATP-binding protein fbpC HAMAP MF_01706		PRO_0000092347
Regions
	Domain	7 – 237	231	ABC transporter
	Nucleotide binding	39 – 46	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P37009-1 [UniParc]. Last modified November 1, 1997. Version 3. Checksum: D4AD33754217DA1A	FASTA	348	39,059
	10 20 30 40 50 60 MTQKNFVELR NVTKRFGSNT VIDNINLTIP QGQMVTLLGP SGCGKTTILR LVAGLEKPSE 70 80 90 100 110 120 GQIFIDGEDV THRSIQQRDI CMVFQSYALF PHMSLGENVG YGLKMLGVPR AELKARVKEA 130 140 150 160 170 180 LAMVDLEGFE DRFVDQISGG QQQRVALARA LILKPKVLLF DEPLSNLDAN LRRSMRDKIR 190 200 210 220 230 240 ELQKQFDITS LYVTHDQSEA FAVSDTVLVM NKGHIMQIGS PQDLYRQPAS RFMASFMGDA 250 260 270 280 290 300 NLFPATFSDG YVDIYGYHLP RPLHFGTQGE GMVGVRPEAI TLSDRGEESQ RCVIRHVAYM 310 320 330 340 GPQYEVTVEW HGQEILLQVN ATRLQPDVGE QYYLEIHPYG MFVLADAA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"Systematic sequencing of the Escherichia coli genome: analysis of the 4.0 - 6.0 min (189,987 - 281,416bp) region." Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T., Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S., Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO 147-148. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"The delta (argF-lacZ)205(U169) deletion greatly enhances resistance to hydrogen peroxide in stationary-phase Escherichia coli." Volkert M.R., Loewen P.C., Switala J., Crowley D., Conley M. J. Bacteriol. 176:1297-1302(1994) [PubMed: 8113168] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-220.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U70214 Genomic DNA. Translation: AAB08683.1. Different initiation. U00096 Genomic DNA. Translation: AAC73365.1. Different initiation. AP009048 Genomic DNA. Translation: BAA77930.2. L20943 Unassigned DNA. No translation available.
RefSeq	AP_000915.1. NP_414796.2.
3D structure databases
HSSP	HSSP built from PDB template 1G29 based on UniProtKB Q9YGA6.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:9064N.
Genome annotation databases
GeneID	947676.
GenomeReviews	Gene locus JW0254 in contig AP009048_GR. Gene locus b0262 in contig U00096_GR.
KEGG	ecj:JW0254. eco:b0262.
Organism-specific databases
EchoBASE	EB2244.
EcoGene	EG12340. fbpC.
CMR	Search...
Phylogenomic databases
HOGENOM	P37009.
OMA	P37009. LVIKRGT.
Enzyme and pathway databases
BioCyc	EcoCyc:YAGC-MON.
Family and domain databases
HAMAP	MF_01706. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR015853. ABC_transpr_FbpC. IPR003593. ATPase_AAA+_core. IPR013611. Transp-assoc_OB_typ2. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. PF08402. TOBE_2. 1 hit. [Graphical view]
ProDom	PD000006. ABC_transporter. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51242. FBPC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FBPC_ECOLI

Accession

Primary (citable) accession number: P37009
Secondary accession number(s): P77157

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)