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Protein

Fe(3+) ions import ATP-binding protein FbpC

Gene

fbpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex FbpABC involved in Fe3+ ions import. Responsible for energy coupling to the transport system.UniRule annotation

Catalytic activityi

ATP + H2O + Fe3+(Out) = ADP + phosphate + Fe3+(In).UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi39 – 468ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

ATP-binding, Iron, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:YAGC-MONOMER.
ECOL316407:JW0254-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fe(3+) ions import ATP-binding protein FbpCUniRule annotation (EC:3.6.3.30UniRule annotation)
Gene namesi
Name:fbpCUniRule annotation
Synonyms:afuC, yagC
Ordered Locus Names:b0262, JW0254
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12340. fbpC.

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Fe(3+) ions import ATP-binding protein FbpCPRO_0000092347Add
BLAST

Proteomic databases

PaxDbiP37009.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (FbpC), two transmembrane proteins (FbpB) and a solute-binding protein (FbpA).UniRule annotation

Protein-protein interaction databases

BioGridi4262792. 86 interactions.
DIPiDIP-9064N.
IntActiP37009. 6 interactions.
MINTiMINT-1316081.
STRINGi511145.b0262.

Structurei

3D structure databases

ProteinModelPortaliP37009.
SMRiP37009. Positions 7-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 237231ABC transporterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Fe(3+) ion importer (TC 3.A.1.10) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C53. Bacteria.
COG3842. LUCA.
InParanoidiP37009.
KOiK02010.
OMAiDAQRCEI.
OrthoDBiEOG6T7N3V.
PhylomeDBiP37009.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015853. ABC_transpr_FbpC.
IPR008995. Mo/tungstate-bd_C_term_dom.
IPR027417. P-loop_NTPase.
IPR013611. Transp-assoc_OB_typ2.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
PF08402. TOBE_2. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF50331. SSF50331. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51242. FBPC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQKNFVELR NVTKRFGSNT VIDNINLTIP QGQMVTLLGP SGCGKTTILR
60 70 80 90 100
LVAGLEKPSE GQIFIDGEDV THRSIQQRDI CMVFQSYALF PHMSLGENVG
110 120 130 140 150
YGLKMLGVPR AELKARVKEA LAMVDLEGFE DRFVDQISGG QQQRVALARA
160 170 180 190 200
LILKPKVLLF DEPLSNLDAN LRRSMRDKIR ELQKQFDITS LYVTHDQSEA
210 220 230 240 250
FAVSDTVLVM NKGHIMQIGS PQDLYRQPAS RFMASFMGDA NLFPATFSDG
260 270 280 290 300
YVDIYGYHLP RPLHFGTQGE GMVGVRPEAI TLSDRGEESQ RCVIRHVAYM
310 320 330 340
GPQYEVTVEW HGQEILLQVN ATRLQPDVGE QYYLEIHPYG MFVLADAA
Length:348
Mass (Da):39,059
Last modified:November 1, 1997 - v3
Checksum:iD4AD33754217DA1A
GO

Sequence cautioni

The sequence AAB08683.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence L20943 differs from that shown. Reason: Frameshift at positions 147 and 220. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA. Translation: AAB08683.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73365.2.
AP009048 Genomic DNA. Translation: BAA77930.2.
L20943 Unassigned DNA. No translation available.
RefSeqiNP_414796.2. NC_000913.3.
WP_000192349.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73365; AAC73365; b0262.
BAA77930; BAA77930; BAA77930.
GeneIDi947676.
KEGGiecj:JW0254.
eco:b0262.
PATRICi32115643. VBIEscCol129921_0265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA. Translation: AAB08683.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73365.2.
AP009048 Genomic DNA. Translation: BAA77930.2.
L20943 Unassigned DNA. No translation available.
RefSeqiNP_414796.2. NC_000913.3.
WP_000192349.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP37009.
SMRiP37009. Positions 7-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262792. 86 interactions.
DIPiDIP-9064N.
IntActiP37009. 6 interactions.
MINTiMINT-1316081.
STRINGi511145.b0262.

Proteomic databases

PaxDbiP37009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73365; AAC73365; b0262.
BAA77930; BAA77930; BAA77930.
GeneIDi947676.
KEGGiecj:JW0254.
eco:b0262.
PATRICi32115643. VBIEscCol129921_0265.

Organism-specific databases

EchoBASEiEB2244.
EcoGeneiEG12340. fbpC.

Phylogenomic databases

eggNOGiENOG4105C53. Bacteria.
COG3842. LUCA.
InParanoidiP37009.
KOiK02010.
OMAiDAQRCEI.
OrthoDBiEOG6T7N3V.
PhylomeDBiP37009.

Enzyme and pathway databases

BioCyciEcoCyc:YAGC-MONOMER.
ECOL316407:JW0254-MONOMER.

Miscellaneous databases

PROiP37009.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015853. ABC_transpr_FbpC.
IPR008995. Mo/tungstate-bd_C_term_dom.
IPR027417. P-loop_NTPase.
IPR013611. Transp-assoc_OB_typ2.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
PF08402. TOBE_2. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF50331. SSF50331. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51242. FBPC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Systematic sequencing of the Escherichia coli genome: analysis of the 4.0 - 6.0 min (189,987 - 281,416bp) region."
    Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T., Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S., Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO 147-148.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "The delta (argF-lacZ)205(U169) deletion greatly enhances resistance to hydrogen peroxide in stationary-phase Escherichia coli."
    Volkert M.R., Loewen P.C., Switala J., Crowley D., Conley M.
    J. Bacteriol. 176:1297-1302(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-220.

Entry informationi

Entry nameiFBPC_ECOLI
AccessioniPrimary (citable) accession number: P37009
Secondary accession number(s): P77157
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: April 13, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

In E.coli, the afu system seems to have been deleted by an insertion sequence. AfuA is totally lost, afuB is partially present and afuC is totally conserved.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.