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Protein

Fe(3+) ions import ATP-binding protein FbpC

Gene

fbpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the ABC transporter complex FbpABC involved in Fe3+ ions import. Responsible for energy coupling to the transport system.UniRule annotation

Miscellaneous

In E.coli, the afu system seems to have been deleted by an insertion sequence. AfuA is totally lost, afuB is partially present and afuC is totally conserved.

Catalytic activityi

ATP + H2O + Fe3+(Out) = ADP + phosphate + Fe3+(In).UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 46ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processIon transport, Iron transport, Transport
LigandATP-binding, Iron, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:YAGC-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Fe(3+) ions import ATP-binding protein FbpCUniRule annotation (EC:3.6.3.30UniRule annotation)
Gene namesi
Name:fbpCUniRule annotation
Synonyms:afuC, yagC
Ordered Locus Names:b0262, JW0254
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12340 fbpC

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000923471 – 348Fe(3+) ions import ATP-binding protein FbpCAdd BLAST348

Proteomic databases

PaxDbiP37009
PRIDEiP37009

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (FbpC), two transmembrane proteins (FbpB) and a solute-binding protein (FbpA).UniRule annotation

Protein-protein interaction databases

BioGridi4262792, 86 interactors
DIPiDIP-9064N
IntActiP37009, 7 interactors
STRINGi316385.ECDH10B_0248

Structurei

3D structure databases

ProteinModelPortaliP37009
SMRiP37009
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 237ABC transporterUniRule annotationAdd BLAST231

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Fe(3+) ion importer (TC 3.A.1.10) family. [View classification]UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C53 Bacteria
COG3842 LUCA
InParanoidiP37009
KOiK02010
OMAiMGKTNVI
PhylomeDBiP37009

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR015853 ABC_transpr_FbpC
IPR008995 Mo/tungstate-bd_C_term_dom
IPR027417 P-loop_NTPase
IPR013611 Transp-assoc_OB_typ2
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
PF08402 TOBE_2, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF50331 SSF50331, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51242 FBPC, 1 hit

Sequencei

Sequence statusi: Complete.

P37009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQKNFVELR NVTKRFGSNT VIDNINLTIP QGQMVTLLGP SGCGKTTILR
60 70 80 90 100
LVAGLEKPSE GQIFIDGEDV THRSIQQRDI CMVFQSYALF PHMSLGENVG
110 120 130 140 150
YGLKMLGVPR AELKARVKEA LAMVDLEGFE DRFVDQISGG QQQRVALARA
160 170 180 190 200
LILKPKVLLF DEPLSNLDAN LRRSMRDKIR ELQKQFDITS LYVTHDQSEA
210 220 230 240 250
FAVSDTVLVM NKGHIMQIGS PQDLYRQPAS RFMASFMGDA NLFPATFSDG
260 270 280 290 300
YVDIYGYHLP RPLHFGTQGE GMVGVRPEAI TLSDRGEESQ RCVIRHVAYM
310 320 330 340
GPQYEVTVEW HGQEILLQVN ATRLQPDVGE QYYLEIHPYG MFVLADAA
Length:348
Mass (Da):39,059
Last modified:November 1, 1997 - v3
Checksum:iD4AD33754217DA1A
GO

Sequence cautioni

The sequence AAB08683 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence L20943 differs from that shown. Reason: Frameshift at positions 147 and 220.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA Translation: AAB08683.1 Different initiation.
U00096 Genomic DNA Translation: AAC73365.2
AP009048 Genomic DNA Translation: BAA77930.2
L20943 Unassigned DNA No translation available.
RefSeqiNP_414796.2, NC_000913.3
WP_000192349.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73365; AAC73365; b0262
BAA77930; BAA77930; BAA77930
GeneIDi947676
KEGGiecj:JW0254
eco:b0262
PATRICifig|1411691.4.peg.2019

Similar proteinsi

Entry informationi

Entry nameiFBPC_ECOLI
AccessioniPrimary (citable) accession number: P37009
Secondary accession number(s): P77157
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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