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P36982

- PP2C_LEICH

UniProt

P36982 - PP2C_LEICH

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Protein

Protein phosphatase 2C

Gene
N/A
Organism
Leishmania chagasi
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Enzyme with a broad specificity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi55 – 551Manganese 1By similarity
Metal bindingi55 – 551Manganese 2By similarity
Metal bindingi56 – 561Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi221 – 2211Manganese 2By similarity
Metal bindingi265 – 2651Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C (EC:3.1.3.16)
Short name:
PP2C
OrganismiLeishmania chagasi
Taxonomic identifieri44271 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Protein phosphatase 2CPRO_0000057764Add
BLAST

Expressioni

Developmental stagei

Found in infective promastigote and in tissue amastigote stages.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP36982.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.Curated

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36982 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGIPLPKPVM TQLQERYGNA IFRCGSNCVN GYRETMEDAH LTYLTDSWGF
60 70 80 90 100
FGVFDGHVND QCSQYLERAW RSAIEKESIP MTDERMKELA LRIDQEWMDS
110 120 130 140 150
GREGGSTGTF FVALKEGNKV HLQVGNVGDS RVVACIDGVC VPLTEDHKPN
160 170 180 190 200
NEGERQRIEN CAGRVENNRV DGSLAVSRAF GDREYKLGSG SQLEQKVIAL
210 220 230 240 250
ADVQHKDFTF DSNDFVLLCC DGVFEGNFPN EEVVAYVKQQ LETCNDLAEV
260 270 280 290 300
AGRVCEEAIE RGSRDNISCM IVQFKDGSDY AAEPHTTVVP GPFSAPRNSG
310 320 330 340 350
FRKAYESMAD KGNTTVGALL ERRYDTLKAA EALTPEETEE LSQFENGPEA
360 370 380 390 400
KLTGAERQKW FSNYFQKLCE AASNGPSDQM ERLQSLQQQA GIPLSILLSL

MGEQTQ
Length:406
Mass (Da):45,139
Last modified:June 1, 1994 - v1
Checksum:i9B2C6647FE7B93BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15559 Unassigned DNA. Translation: AAA02864.1.
PIRiA47492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15559 Unassigned DNA. Translation: AAA02864.1 .
PIRi A47492.

3D structure databases

ProteinModelPortali P36982.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of a 42-kDa protein phosphatase of Leishmania chagasi."
    Burns J.M. Jr., Parsons M., Rosman D.E., Reed S.G.
    J. Biol. Chem. 268:17155-17161(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MHOM/BR/82/BA-2.

Entry informationi

Entry nameiPP2C_LEICH
AccessioniPrimary (citable) accession number: P36982
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3