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P36982 (PP2C_LEICH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 2C

Short name=PP2C
EC=3.1.3.16
OrganismLeishmania chagasi
Taxonomic identifier44271 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Enzyme with a broad specificity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subunit structure

Monomer By similarity.

Developmental stage

Found in infective promastigote and in tissue amastigote stages.

Sequence similarities

Belongs to the PP2C family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 406406Protein phosphatase 2C
PRO_0000057764

Sites

Metal binding551Manganese 1 By similarity
Metal binding551Manganese 2 By similarity
Metal binding561Manganese 1; via carbonyl oxygen By similarity
Metal binding2211Manganese 2 By similarity
Metal binding2651Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P36982 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 9B2C6647FE7B93BA

FASTA40645,139
        10         20         30         40         50         60 
MGIPLPKPVM TQLQERYGNA IFRCGSNCVN GYRETMEDAH LTYLTDSWGF FGVFDGHVND 

        70         80         90        100        110        120 
QCSQYLERAW RSAIEKESIP MTDERMKELA LRIDQEWMDS GREGGSTGTF FVALKEGNKV 

       130        140        150        160        170        180 
HLQVGNVGDS RVVACIDGVC VPLTEDHKPN NEGERQRIEN CAGRVENNRV DGSLAVSRAF 

       190        200        210        220        230        240 
GDREYKLGSG SQLEQKVIAL ADVQHKDFTF DSNDFVLLCC DGVFEGNFPN EEVVAYVKQQ 

       250        260        270        280        290        300 
LETCNDLAEV AGRVCEEAIE RGSRDNISCM IVQFKDGSDY AAEPHTTVVP GPFSAPRNSG 

       310        320        330        340        350        360 
FRKAYESMAD KGNTTVGALL ERRYDTLKAA EALTPEETEE LSQFENGPEA KLTGAERQKW 

       370        380        390        400 
FSNYFQKLCE AASNGPSDQM ERLQSLQQQA GIPLSILLSL MGEQTQ 

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References

[1]"Molecular cloning and characterization of a 42-kDa protein phosphatase of Leishmania chagasi."
Burns J.M. Jr., Parsons M., Rosman D.E., Reed S.G.
J. Biol. Chem. 268:17155-17161(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MHOM/BR/82/BA-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L15559 Unassigned DNA. Translation: AAA02864.1.
PIRA47492.

3D structure databases

ProteinModelPortalP36982.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP2C_LEICH
AccessionPrimary (citable) accession number: P36982
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families