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P36982

- PP2C_LEICH

UniProt

P36982 - PP2C_LEICH

Protein

Protein phosphatase 2C

Gene
N/A
Organism
Leishmania chagasi
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Enzyme with a broad specificity.

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi55 – 551Manganese 1By similarity
    Metal bindingi55 – 551Manganese 2By similarity
    Metal bindingi56 – 561Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi221 – 2211Manganese 2By similarity
    Metal bindingi265 – 2651Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 2C (EC:3.1.3.16)
    Short name:
    PP2C
    OrganismiLeishmania chagasi
    Taxonomic identifieri44271 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406Protein phosphatase 2CPRO_0000057764Add
    BLAST

    Expressioni

    Developmental stagei

    Found in infective promastigote and in tissue amastigote stages.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP36982.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36982-1 [UniParc]FASTAAdd to Basket

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    MGIPLPKPVM TQLQERYGNA IFRCGSNCVN GYRETMEDAH LTYLTDSWGF    50
    FGVFDGHVND QCSQYLERAW RSAIEKESIP MTDERMKELA LRIDQEWMDS 100
    GREGGSTGTF FVALKEGNKV HLQVGNVGDS RVVACIDGVC VPLTEDHKPN 150
    NEGERQRIEN CAGRVENNRV DGSLAVSRAF GDREYKLGSG SQLEQKVIAL 200
    ADVQHKDFTF DSNDFVLLCC DGVFEGNFPN EEVVAYVKQQ LETCNDLAEV 250
    AGRVCEEAIE RGSRDNISCM IVQFKDGSDY AAEPHTTVVP GPFSAPRNSG 300
    FRKAYESMAD KGNTTVGALL ERRYDTLKAA EALTPEETEE LSQFENGPEA 350
    KLTGAERQKW FSNYFQKLCE AASNGPSDQM ERLQSLQQQA GIPLSILLSL 400
    MGEQTQ 406
    Length:406
    Mass (Da):45,139
    Last modified:June 1, 1994 - v1
    Checksum:i9B2C6647FE7B93BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L15559 Unassigned DNA. Translation: AAA02864.1.
    PIRiA47492.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L15559 Unassigned DNA. Translation: AAA02864.1 .
    PIRi A47492.

    3D structure databases

    ProteinModelPortali P36982.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a 42-kDa protein phosphatase of Leishmania chagasi."
      Burns J.M. Jr., Parsons M., Rosman D.E., Reed S.G.
      J. Biol. Chem. 268:17155-17161(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MHOM/BR/82/BA-2.

    Entry informationi

    Entry nameiPP2C_LEICH
    AccessioniPrimary (citable) accession number: P36982
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3