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P36982

- PP2C_LEICH

UniProt

P36982 - PP2C_LEICH

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Protein
Protein phosphatase 2C
Gene
N/A
Organism
Leishmania chagasi
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Enzyme with a broad specificity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi55 – 551Manganese 1 By similarity
Metal bindingi55 – 551Manganese 2 By similarity
Metal bindingi56 – 561Manganese 1; via carbonyl oxygen By similarity
Metal bindingi221 – 2211Manganese 2 By similarity
Metal bindingi265 – 2651Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C (EC:3.1.3.16)
Short name:
PP2C
OrganismiLeishmania chagasi
Taxonomic identifieri44271 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Protein phosphatase 2C
PRO_0000057764Add
BLAST

Expressioni

Developmental stagei

Found in infective promastigote and in tissue amastigote stages.

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP36982.

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36982-1 [UniParc]FASTAAdd to Basket

« Hide

MGIPLPKPVM TQLQERYGNA IFRCGSNCVN GYRETMEDAH LTYLTDSWGF    50
FGVFDGHVND QCSQYLERAW RSAIEKESIP MTDERMKELA LRIDQEWMDS 100
GREGGSTGTF FVALKEGNKV HLQVGNVGDS RVVACIDGVC VPLTEDHKPN 150
NEGERQRIEN CAGRVENNRV DGSLAVSRAF GDREYKLGSG SQLEQKVIAL 200
ADVQHKDFTF DSNDFVLLCC DGVFEGNFPN EEVVAYVKQQ LETCNDLAEV 250
AGRVCEEAIE RGSRDNISCM IVQFKDGSDY AAEPHTTVVP GPFSAPRNSG 300
FRKAYESMAD KGNTTVGALL ERRYDTLKAA EALTPEETEE LSQFENGPEA 350
KLTGAERQKW FSNYFQKLCE AASNGPSDQM ERLQSLQQQA GIPLSILLSL 400
MGEQTQ 406
Length:406
Mass (Da):45,139
Last modified:June 1, 1994 - v1
Checksum:i9B2C6647FE7B93BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15559 Unassigned DNA. Translation: AAA02864.1.
PIRiA47492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15559 Unassigned DNA. Translation: AAA02864.1 .
PIRi A47492.

3D structure databases

ProteinModelPortali P36982.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of a 42-kDa protein phosphatase of Leishmania chagasi."
    Burns J.M. Jr., Parsons M., Rosman D.E., Reed S.G.
    J. Biol. Chem. 268:17155-17161(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MHOM/BR/82/BA-2.

Entry informationi

Entry nameiPP2C_LEICH
AccessioniPrimary (citable) accession number: P36982
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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