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Protein

Complement factor H-related protein 2

Gene

CFHR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • negative regulation of protein binding Source: UniProtKB
  • positive regulation of cytolysis Source: UniProtKB
  • regulation of complement activation Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Complement factor H-related protein 2
Short name:
FHR-2
Alternative name(s):
DDESK59
H factor-like 3
H factor-like protein 2
Gene namesi
Name:CFHR2
Synonyms:CFHL2, FHR2, HFL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000080910.11
HGNCiHGNC:4890 CFHR2
MIMi600889 gene
neXtProtiNX_P36980

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3080
OpenTargetsiENSG00000080910
ENSG00000276911
PharmGKBiPA29267

Polymorphism and mutation databases

BioMutaiCFHR2
DMDMi543983

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000000589719 – 270Complement factor H-related protein 2Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 72PROSITE-ProRule annotation
Disulfide bondi55 ↔ 83PROSITE-ProRule annotation
Disulfide bondi87 ↔ 129PROSITE-ProRule annotation
Disulfide bondi114 ↔ 140PROSITE-ProRule annotation
Glycosylationi126N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi149 ↔ 192PROSITE-ProRule annotation1 Publication
Disulfide bondi178 ↔ 203PROSITE-ProRule annotation1 Publication
Disulfide bondi207 ↔ 257PROSITE-ProRule annotation1 Publication
Disulfide bondi241 ↔ 267PROSITE-ProRule annotation1 Publication

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP36980
PeptideAtlasiP36980
PRIDEiP36980

PTM databases

iPTMnetiP36980
PhosphoSitePlusiP36980

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSG00000080910
CleanExiHS_CFHR2
ExpressionAtlasiP36980 baseline and differential
GenevisibleiP36980 HS

Organism-specific databases

HPAiHPA038915
HPA040726
HPA049813

Interactioni

Subunit structurei

Head-to-tail homodimer and heterodimer with CFHR1 or CFHR5.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi109328, 2 interactors
STRINGi9606.ENSP00000356385

Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi158 – 162Combined sources5
Beta strandi173 – 178Combined sources6
Beta strandi183 – 186Combined sources4
Beta strandi188 – 193Combined sources6
Beta strandi202 – 204Combined sources3
Helixi211 – 216Combined sources6
Beta strandi219 – 222Combined sources4
Turni224 – 226Combined sources3
Beta strandi229 – 231Combined sources3
Beta strandi236 – 241Combined sources6
Beta strandi249 – 251Combined sources3
Beta strandi253 – 256Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZD1X-ray2.00A/B147-270[»]
5EA0X-ray2.00P150-162[»]
ProteinModelPortaliP36980
SMRiP36980
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 84Sushi 1PROSITE-ProRule annotationAdd BLAST63
Domaini85 – 142Sushi 2PROSITE-ProRule annotationAdd BLAST58
Domaini147 – 205Sushi 3PROSITE-ProRule annotationAdd BLAST59
Domaini206 – 268Sushi 4PROSITE-ProRule annotationAdd BLAST63

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IVIT Eukaryota
ENOG410ZN5E LUCA
GeneTreeiENSGT00910000143999
HOGENOMiHOG000049040
HOVERGENiHBG005665
InParanoidiP36980
OMAiCRSTISA
OrthoDBiEOG091G0J8N
PhylomeDBiP36980
TreeFamiTF326157

Family and domain databases

CDDicd00033 CCP, 2 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 4 hits
SMARTiView protein in SMART
SM00032 CCP, 4 hits
SUPFAMiSSF57535 SSF57535, 4 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P36980-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWLLVSVILI SRISSVGGEA MFCDFPKINH GILYDEEKYK PFSQVPTGEV
60 70 80 90 100
FYYSCEYNFV SPSKSFWTRI TCAEEGWSPT PKCLRLCFFP FVENGHSESS
110 120 130 140 150
GQTHLEGDTV QIICNTGYRL QNNENNISCV ERGWSTPPKC RSTISAEKCG
160 170 180 190 200
PPPPIDNGDI TSFLLSVYAP GSSVEYQCQN LYQLEGNNQI TCRNGQWSEP
210 220 230 240 250
PKCLDPCVIS QEIMEKYNIK LKWTNQQKLY SRTGDIVEFV CKSGYHPTKS
260 270
HSFRAMCQNG KLVYPSCEEK
Length:270
Mass (Da):30,651
Last modified:June 1, 1994 - v1
Checksum:iE1B2E9F139B217A8
GO
Isoform Short (identifier: P36980-2) [UniParc]FASTAAdd to basket
Also known as: Truncated

The sequence of this isoform differs from the canonical sequence as follows:
     144-171: ISAEKCGPPPPIDNGDITSFLLSVYAPG → S

Note: No experimental confirmation available.
Show »
Length:243
Mass (Da):27,897
Checksum:iDA366D85787A8E39
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85R → K in CAA60375 (PubMed:7672821).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001192144 – 171ISAEK…VYAPG → S in isoform Short. CuratedAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64877 mRNA Translation: CAA46096.1
X86564
, X86565, X86566, X86567 Genomic DNA Translation: CAA60375.1
AL139418 Genomic DNA Translation: CAI21979.1
BC022283 mRNA Translation: AAH22283.1
CCDSiCCDS30959.1 [P36980-1]
PIRiI37278
RefSeqiNP_001299601.1, NM_001312672.1
NP_005657.1, NM_005666.3 [P36980-1]
UniGeneiHs.632450

Genome annotation databases

EnsembliENST00000367415; ENSP00000356385; ENSG00000080910 [P36980-1]
GeneIDi3080
KEGGihsa:3080
UCSCiuc001gtq.2 human [P36980-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFHR2_HUMAN
AccessioniPrimary (citable) accession number: P36980
Secondary accession number(s): Q14310, Q5T9T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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