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Protein

Adenine phosphoribosyltransferase 2

Gene

APT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. May lack catalytic activity.

Catalytic activityi

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenine phosphoribosyltransferase 2 (APT2), Adenine phosphoribosyltransferase 1 (APT1)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciYEAST:YDR441C-MONOMER.
ReactomeiR-SCE-74217. Purine salvage.
UniPathwayiUPA00588; UER00646.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine phosphoribosyltransferase 2 (EC:2.4.2.7)
Short name:
APRT 2
Gene namesi
Name:APT2
Ordered Locus Names:YDR441C
ORF Names:D9461.27
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR441C.
SGDiS000002849. APT2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 181180Adenine phosphoribosyltransferase 2PRO_0000149518Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP36973.

Interactioni

Protein-protein interaction databases

BioGridi32497. 26 interactions.
DIPiDIP-2056N.
IntActiP36973. 3 interactions.
MINTiMINT-494912.

Structurei

3D structure databases

ProteinModelPortaliP36973.
SMRiP36973. Positions 6-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000017259.
HOGENOMiHOG000036776.
InParanoidiP36973.
KOiK00759.
OMAiECASITF.
OrthoDBiEOG092C4X82.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISESYAKE IKTAFRQFTD FPIEGEQFED FLPIIGNPTL FQKLVHTFKT
60 70 80 90 100
HLEEKFGKEK IDFIAGIEAR GLLFGPSLAL ALGVGFVPIR RVGKLPGECA
110 120 130 140 150
SITFTKLDHE EIFEMQVEAI PFDSNVVVVD DVLATGGTAY AAGDLIRQVG
160 170 180
AHILEYDFVL VLDSLHGEEK LSAPIFSILH S
Length:181
Mass (Da):19,986
Last modified:November 30, 2010 - v2
Checksum:i58AB48E13BADF8B3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571G → A in AAA62848 (PubMed:7941749).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14434 Genomic DNA. Translation: AAA62848.1.
U33007 Genomic DNA. Translation: AAB64883.1.
BK006938 Genomic DNA. Translation: DAA12278.1.
PIRiS69721.
RefSeqiNP_010729.3. NM_001180749.3.

Genome annotation databases

EnsemblFungiiYDR441C; YDR441C; YDR441C.
GeneIDi852051.
KEGGisce:YDR441C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14434 Genomic DNA. Translation: AAA62848.1.
U33007 Genomic DNA. Translation: AAB64883.1.
BK006938 Genomic DNA. Translation: DAA12278.1.
PIRiS69721.
RefSeqiNP_010729.3. NM_001180749.3.

3D structure databases

ProteinModelPortaliP36973.
SMRiP36973. Positions 6-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32497. 26 interactions.
DIPiDIP-2056N.
IntActiP36973. 3 interactions.
MINTiMINT-494912.

Proteomic databases

MaxQBiP36973.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR441C; YDR441C; YDR441C.
GeneIDi852051.
KEGGisce:YDR441C.

Organism-specific databases

EuPathDBiFungiDB:YDR441C.
SGDiS000002849. APT2.

Phylogenomic databases

GeneTreeiENSGT00390000017259.
HOGENOMiHOG000036776.
InParanoidiP36973.
KOiK00759.
OMAiECASITF.
OrthoDBiEOG092C4X82.

Enzyme and pathway databases

UniPathwayiUPA00588; UER00646.
BioCyciYEAST:YDR441C-MONOMER.
ReactomeiR-SCE-74217. Purine salvage.

Miscellaneous databases

PROiP36973.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPT2_YEAST
AccessioniPrimary (citable) accession number: P36973
Secondary accession number(s): Q04090
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 30, 2010
Last modified: September 7, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 937 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.