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Protein

Adenine phosphoribosyltransferase

Gene

Aprt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.

Catalytic activityi

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenine phosphoribosyltransferase (Aprt)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

  • adenine binding Source: Ensembl
  • adenine phosphoribosyltransferase activity Source: UniProtKB-EC
  • AMP binding Source: RGD

GO - Biological processi

  • adenine salvage Source: Ensembl
  • AMP salvage Source: UniProtKB-UniPathway
  • cellular response to insulin stimulus Source: RGD
  • grooming behavior Source: Ensembl
  • lactation Source: RGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.
R-RNO-74217. Purine salvage.
SABIO-RKP36972.
UniPathwayiUPA00588; UER00646.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine phosphoribosyltransferase (EC:2.4.2.7)
Short name:
APRT
Gene namesi
Name:Aprt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1307758. Aprt.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001495092 – 180Adenine phosphoribosyltransferaseAdd BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei4PhosphoserineBy similarity1
Modified residuei15PhosphoserineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei60PhosphotyrosineBy similarity1
Modified residuei66PhosphoserineCombined sources1
Modified residuei114N6-acetyllysineBy similarity1
Modified residuei135PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP36972.
PRIDEiP36972.

PTM databases

iPTMnetiP36972.
PhosphoSitePlusiP36972.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014405.
GenevisibleiP36972. RN.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiP36972. 2 interactors.
MINTiMINT-4578157.
STRINGi10116.ENSRNOP00000061449.

Structurei

3D structure databases

ProteinModelPortaliP36972.
SMRiP36972.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1712. Eukaryota.
COG0503. LUCA.
GeneTreeiENSGT00390000017259.
HOGENOMiHOG000036776.
HOVERGENiHBG003144.
InParanoidiP36972.
KOiK00759.
OMAiATVEIHA.
OrthoDBiEOG09040KG2.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_00004. Aden_phosphoribosyltr. 1 hit.
InterProiView protein in InterPro
IPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
PfamiView protein in Pfam
PF00156. Pribosyltran. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01090. apt. 1 hit.
PROSITEiView protein in PROSITE
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESELQLVA RRIRSFPDFP IPGVLFRDIS PLLKDPDSFR ASIRLLAGHL
60 70 80 90 100
KSTHGGKIDY IAGLDSRGFL FGPSLAQELG VGCVLIRKRG KLPGPTVSAS
110 120 130 140 150
YSLEYGKAEL EIQKDALEPG QKVVIVDDLL ATGGTMCAAC ELLSQLRAEV
160 170 180
VECVSLVELT SLKGREKLGP VPFFSLLQYE
Length:180
Mass (Da):19,546
Last modified:June 1, 1994 - v1
Checksum:iD5563374DDEBB3EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04970 Genomic DNA. Translation: AAA40757.1.
RefSeqiNP_001013079.1. NM_001013061.1.
UniGeneiRn.2498.

Genome annotation databases

EnsembliENSRNOT00000064180; ENSRNOP00000061449; ENSRNOG00000014405.
GeneIDi292072.
KEGGirno:292072.
UCSCiRGD:1307758. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04970 Genomic DNA. Translation: AAA40757.1.
RefSeqiNP_001013079.1. NM_001013061.1.
UniGeneiRn.2498.

3D structure databases

ProteinModelPortaliP36972.
SMRiP36972.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP36972. 2 interactors.
MINTiMINT-4578157.
STRINGi10116.ENSRNOP00000061449.

PTM databases

iPTMnetiP36972.
PhosphoSitePlusiP36972.

Proteomic databases

PaxDbiP36972.
PRIDEiP36972.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000064180; ENSRNOP00000061449; ENSRNOG00000014405.
GeneIDi292072.
KEGGirno:292072.
UCSCiRGD:1307758. rat.

Organism-specific databases

CTDi353.
RGDi1307758. Aprt.

Phylogenomic databases

eggNOGiKOG1712. Eukaryota.
COG0503. LUCA.
GeneTreeiENSGT00390000017259.
HOGENOMiHOG000036776.
HOVERGENiHBG003144.
InParanoidiP36972.
KOiK00759.
OMAiATVEIHA.
OrthoDBiEOG09040KG2.

Enzyme and pathway databases

UniPathwayiUPA00588; UER00646.
ReactomeiR-RNO-6798695. Neutrophil degranulation.
R-RNO-74217. Purine salvage.
SABIO-RKP36972.

Miscellaneous databases

PROiP36972.

Gene expression databases

BgeeiENSRNOG00000014405.
GenevisibleiP36972. RN.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_00004. Aden_phosphoribosyltr. 1 hit.
InterProiView protein in InterPro
IPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
PfamiView protein in Pfam
PF00156. Pribosyltran. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01090. apt. 1 hit.
PROSITEiView protein in PROSITE
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAPT_RAT
AccessioniPrimary (citable) accession number: P36972
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 15, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.