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Protein

GMP reductase 1

Gene

GMPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78NADPUniRule annotation1
Metal bindingi181Potassium; via carbonyl oxygenUniRule annotation1 Publication1
Metal bindingi183Potassium; via carbonyl oxygenUniRule annotation1 Publication1
Active sitei186Thioimidate intermediateUniRule annotation1
Metal bindingi186Potassium; via carbonyl oxygenUniRule annotation1 Publication1
Active sitei188Proton donor/acceptorUniRule annotation1
Metal bindingi189PotassiumUniRule annotation1 Publication1
Binding sitei269NADP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 27NADP; shared with neighboring subunitUniRule annotation2
Nucleotide bindingi129 – 131NADPUniRule annotation3
Nucleotide bindingi180 – 181NADPUniRule annotation2
Nucleotide bindingi285 – 286NADPUniRule annotation2
Nucleotide bindingi314 – 317NADP; shared with neighboring subunitUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, NADP, Potassium

Enzyme and pathway databases

BioCyciZFISH:HS06289-MONOMER.
ReactomeiR-HSA-74217. Purine salvage.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP reductase 1UniRule annotation (EC:1.7.1.7UniRule annotation)
Short name:
GMPR 1UniRule annotation
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase 1UniRule annotation
Short name:
Guanosine monophosphate reductase 1UniRule annotation
Gene namesi
Name:GMPR
Synonyms:GMPR1UniRule annotation
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4376. GMPR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi2766.
OpenTargetsiENSG00000137198.
PharmGKBiPA28761.

Polymorphism and mutation databases

BioMutaiGMPR.
DMDMi544455.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000937231 – 345GMP reductase 1Add BLAST345

Proteomic databases

EPDiP36959.
MaxQBiP36959.
PaxDbiP36959.
PeptideAtlasiP36959.
PRIDEiP36959.

PTM databases

iPTMnetiP36959.
PhosphoSitePlusiP36959.

Expressioni

Gene expression databases

BgeeiENSG00000137198.
CleanExiHS_GMPR.
GenevisibleiP36959. HS.

Organism-specific databases

HPAiHPA000904.
HPA021476.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi109028. 2 interactors.
STRINGi9606.ENSP00000259727.

Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi12 – 14Combined sources3
Beta strandi15 – 17Combined sources3
Helixi27 – 29Combined sources3
Beta strandi34 – 37Combined sources4
Turni39 – 41Combined sources3
Beta strandi44 – 47Combined sources4
Beta strandi50 – 52Combined sources3
Turni56 – 58Combined sources3
Helixi61 – 67Combined sources7
Helixi68 – 70Combined sources3
Beta strandi73 – 75Combined sources3
Helixi82 – 91Combined sources10
Helixi93 – 98Combined sources6
Beta strandi99 – 103Combined sources5
Helixi107 – 119Combined sources13
Beta strandi125 – 129Combined sources5
Helixi136 – 148Combined sources13
Beta strandi152 – 159Combined sources8
Helixi162 – 170Combined sources9
Beta strandi174 – 178Combined sources5
Helixi188 – 191Combined sources4
Helixi198 – 210Combined sources13
Turni211 – 213Combined sources3
Beta strandi215 – 220Combined sources6
Helixi225 – 234Combined sources10
Beta strandi237 – 242Combined sources6
Helixi243 – 245Combined sources3
Beta strandi251 – 253Combined sources3
Beta strandi263 – 267Combined sources5
Helixi272 – 277Combined sources6
Beta strandi285 – 288Combined sources4
Beta strandi292 – 296Combined sources5
Helixi301 – 319Combined sources19
Helixi324 – 326Combined sources3
Helixi327 – 330Combined sources4
Beta strandi333 – 335Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BLEX-ray1.90A1-345[»]
2BWGX-ray2.40A/B/C/D1-345[»]
ProteinModelPortaliP36959.
SMRiP36959.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36959.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 221GMP bindingUniRule annotation1 Publication3
Regioni242 – 243GMP bindingUniRule annotation1 Publication2
Regioni268 – 270GMP bindingUniRule annotation1 Publication3
Regioni286 – 290GMP bindingUniRule annotation1 Publication5

Sequence similaritiesi

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG2550. Eukaryota.
COG0516. LUCA.
GeneTreeiENSGT00530000062923.
HOGENOMiHOG000165756.
HOVERGENiHBG051744.
InParanoidiP36959.
KOiK00364.
OMAiMSQHSLF.
OrthoDBiEOG091G09KQ.
PhylomeDBiP36959.
TreeFamiTF300378.

Family and domain databases

CDDicd00381. IMPDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00596. GMP_reduct_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR005993. GMPR.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000235. GMP_reductase. 1 hit.
TIGRFAMsiTIGR01305. GMP_reduct_1. 1 hit.
PROSITEiPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRIDADLKL DFKDVLLRPK RSSLKSRAEV DLERTFTFRN SKQTYSGIPI
60 70 80 90 100
IVANMDTVGT FEMAAVMSQH SMFTAIHKHY SLDDWKLFAT NHPECLQNVA
110 120 130 140 150
VSSGSGQNDL EKMTSILEAV PQVKFICLDV ANGYSEHFVE FVKLVRAKFP
160 170 180 190 200
EHTIMAGNVV TGEMVEELIL SGADIIKVGV GPGSVCTTRT KTGVGYPQLS
210 220 230 240 250
AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM LGGMFSGHTE
260 270 280 290 300
CAGEVFERNG RKLKLFYGMS SDTAMNKHAG GVAEYRASEG KTVEVPYKGD
310 320 330 340
VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFS
Length:345
Mass (Da):37,419
Last modified:June 1, 1994 - v1
Checksum:i217E1A5A599CA510
GO

Polymorphismi

At least two different alleles are known.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_003969234A → T.1 PublicationCorresponds to variant rs760571328dbSNPEnsembl.1
Natural variantiVAR_003970256F → I.2 PublicationsCorresponds to variant rs1042391dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35304 Genomic DNA. Translation: AAA52503.1.
M27941 Genomic DNA. Translation: AAA53106.1.
M24470 mRNA. Translation: AAA52498.1.
AL009031, AL138883 Genomic DNA. Translation: CAI21422.1.
AL138883, AL009031 Genomic DNA. Translation: CAI19917.1.
BC008281 mRNA. Translation: AAH08281.1.
CCDSiCCDS4537.1.
PIRiB32902.
RefSeqiNP_006868.3. NM_006877.3.
UniGeneiHs.484741.

Genome annotation databases

EnsembliENST00000259727; ENSP00000259727; ENSG00000137198.
GeneIDi2766.
KEGGihsa:2766.
UCSCiuc003nbs.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35304 Genomic DNA. Translation: AAA52503.1.
M27941 Genomic DNA. Translation: AAA53106.1.
M24470 mRNA. Translation: AAA52498.1.
AL009031, AL138883 Genomic DNA. Translation: CAI21422.1.
AL138883, AL009031 Genomic DNA. Translation: CAI19917.1.
BC008281 mRNA. Translation: AAH08281.1.
CCDSiCCDS4537.1.
PIRiB32902.
RefSeqiNP_006868.3. NM_006877.3.
UniGeneiHs.484741.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BLEX-ray1.90A1-345[»]
2BWGX-ray2.40A/B/C/D1-345[»]
ProteinModelPortaliP36959.
SMRiP36959.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109028. 2 interactors.
STRINGi9606.ENSP00000259727.

PTM databases

iPTMnetiP36959.
PhosphoSitePlusiP36959.

Polymorphism and mutation databases

BioMutaiGMPR.
DMDMi544455.

Proteomic databases

EPDiP36959.
MaxQBiP36959.
PaxDbiP36959.
PeptideAtlasiP36959.
PRIDEiP36959.

Protocols and materials databases

DNASUi2766.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259727; ENSP00000259727; ENSG00000137198.
GeneIDi2766.
KEGGihsa:2766.
UCSCiuc003nbs.3. human.

Organism-specific databases

CTDi2766.
DisGeNETi2766.
GeneCardsiGMPR.
HGNCiHGNC:4376. GMPR.
HPAiHPA000904.
HPA021476.
MIMi139265. gene.
neXtProtiNX_P36959.
OpenTargetsiENSG00000137198.
PharmGKBiPA28761.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2550. Eukaryota.
COG0516. LUCA.
GeneTreeiENSGT00530000062923.
HOGENOMiHOG000165756.
HOVERGENiHBG051744.
InParanoidiP36959.
KOiK00364.
OMAiMSQHSLF.
OrthoDBiEOG091G09KQ.
PhylomeDBiP36959.
TreeFamiTF300378.

Enzyme and pathway databases

BioCyciZFISH:HS06289-MONOMER.
ReactomeiR-HSA-74217. Purine salvage.

Miscellaneous databases

ChiTaRSiGMPR. human.
EvolutionaryTraceiP36959.
GenomeRNAii2766.
PROiP36959.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137198.
CleanExiHS_GMPR.
GenevisibleiP36959. HS.

Family and domain databases

CDDicd00381. IMPDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00596. GMP_reduct_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR005993. GMPR.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000235. GMP_reductase. 1 hit.
TIGRFAMsiTIGR01305. GMP_reduct_1. 1 hit.
PROSITEiPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGMPR1_HUMAN
AccessioniPrimary (citable) accession number: P36959
Secondary accession number(s): Q96HQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 162 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The N-terminus was initially (PubMed:2758468) thought to be fused with glucose-6-phosphate-dehydrogenase (G6PD) protein in vivo. However, PubMed:2570640 showed that it encodes a GMP reductase, and PubMed:1694726 showed that the chimeric protein is an artifact.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.