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P36956

- SRBP1_HUMAN

UniProt

P36956 - SRBP1_HUMAN

Protein

Sterol regulatory element-binding protein 1

Gene

SREBF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 160 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway By similarity. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei460 – 4612Cleavage; by caspase-3 and caspase-7By similarity
    Sitei490 – 4912Cleavage; by S2PBy similarity
    Sitei530 – 5312Cleavage; by S1PCurated

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. DNA binding Source: UniProtKB
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding Source: Ensembl
    5. sequence-specific DNA binding transcription factor activity Source: HGNC
    6. sterol response element binding Source: HGNC

    GO - Biological processi

    1. aging Source: Ensembl
    2. cellular lipid metabolic process Source: Reactome
    3. cellular response to fatty acid Source: Ensembl
    4. cellular response to starvation Source: HGNC
    5. cholesterol metabolic process Source: UniProtKB-KW
    6. insulin receptor signaling pathway Source: Ensembl
    7. lipid biosynthetic process Source: UniProtKB
    8. lipid metabolic process Source: ProtInc
    9. lung development Source: Ensembl
    10. negative regulation of insulin secretion Source: Ensembl
    11. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    12. positive regulation of cholesterol biosynthetic process Source: Ensembl
    13. positive regulation of histone deacetylation Source: Ensembl
    14. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    15. positive regulation of triglyceride biosynthetic process Source: UniProtKB
    16. regulation of fatty acid metabolic process Source: Ensembl
    17. regulation of heart rate by chemical signal Source: Ensembl
    18. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    19. response to cAMP Source: Ensembl
    20. response to drug Source: Ensembl
    21. response to food Source: Ensembl
    22. response to glucagon Source: Ensembl
    23. response to glucose Source: Ensembl
    24. response to progesterone Source: Ensembl
    25. response to retinoic acid Source: Ensembl
    26. small molecule metabolic process Source: Reactome
    27. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_116145. PPARA activates gene expression.
    REACT_118659. RORA activates circadian gene expression.
    REACT_147797. Regulation of cholesterol biosynthesis by SREBP (SREBF).
    REACT_147904. Activation of gene expression by SREBF (SREBP).
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinkiP36956.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sterol regulatory element-binding protein 1
    Short name:
    SREBP-1
    Alternative name(s):
    Class D basic helix-loop-helix protein 1
    Short name:
    bHLHd1
    Sterol regulatory element-binding transcription factor 1
    Cleaved into the following chain:
    Gene namesi
    Name:SREBF1
    Synonyms:BHLHD1, SREBP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:11289. SREBF1.

    Subcellular locationi

    Isoform SREBP-1aDelta : Nucleus 1 PublicationPROSITE-ProRule annotation
    Isoform SREBP-1cDelta : Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome
    3. endoplasmic reticulum Source: UniProtKB
    4. endoplasmic reticulum membrane Source: Reactome
    5. ER to Golgi transport vesicle membrane Source: UniProtKB-SubCell
    6. Golgi membrane Source: Reactome
    7. integral component of membrane Source: UniProtKB-KW
    8. nuclear envelope Source: ProtInc
    9. nucleoplasm Source: Reactome
    10. nucleus Source: BHF-UCL
    11. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi455 – 4551S → A: No effect on proteolytic processing. 1 Publication
    Mutagenesisi456 – 4561D → A: No effect on proteolytic processing. 1 Publication
    Mutagenesisi457 – 4571S → A: No effect on proteolytic processing. 1 Publication
    Mutagenesisi460 – 4601D → A: No effect on proteolytic processing. 1 Publication
    Mutagenesisi466 – 4661D → A: No effect on proteolytic processing. 1 Publication
    Mutagenesisi481 – 4811G → A: No effect on proteolytic processing. 1 Publication
    Mutagenesisi482 – 4821M → A: No effect on proteolytic processing. 1 Publication
    Mutagenesisi483 – 4831L → A: No effect on proteolytic processing. 1 Publication
    Mutagenesisi484 – 4874DRSR → AS: Strong reduction of proteolytic processing in response to low sterol. 1 Publication
    Mutagenesisi484 – 4841D → A: Loss of proteolytic processing in response to low sterol. 1 Publication
    Mutagenesisi485 – 4851R → A: No effect on proteolytic processing. 1 Publication
    Mutagenesisi527 – 5271R → A: Loss of proteolytic processing in response to low sterol. 1 Publication

    Organism-specific databases

    PharmGKBiPA335.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11471147Sterol regulatory element-binding protein 1PRO_0000127447Add
    BLAST
    Chaini1 – 490490Processed sterol regulatory element-binding protein 1PRO_0000314029Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei117 – 1171Phosphoserine1 Publication
    Modified residuei337 – 3371Phosphoserine; by SIK1By similarity
    Modified residuei338 – 3381Phosphoserine; by SIK1By similarity
    Modified residuei396 – 3961Phosphoserine; by AMPKBy similarity
    Modified residuei402 – 4021Phosphoserine; by SIK1By similarity

    Post-translational modificationi

    At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.
    Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression. Phosphorylation at Ser-402 by SIK1 represses activity possibly by inhibiting DNA-binding By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP36956.
    PaxDbiP36956.
    PRIDEiP36956.

    PTM databases

    PhosphoSiteiP36956.

    Miscellaneous databases

    PMAP-CutDBP36956.

    Expressioni

    Tissue specificityi

    Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.

    Gene expression databases

    ArrayExpressiP36956.
    BgeeiP36956.
    CleanExiHS_SREBF1.
    GenevestigatoriP36956.

    Organism-specific databases

    HPAiCAB005406.

    Interactioni

    Subunit structurei

    Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CrebbpP454812EBI-948328,EBI-296306From a different organism.
    MED15Q96RN56EBI-948328,EBI-394506
    SIRT1Q96EB62EBI-948338,EBI-1802965

    Protein-protein interaction databases

    BioGridi112598. 54 interactions.
    DIPiDIP-331N.
    IntActiP36956. 14 interactions.
    MINTiMINT-2803077.
    STRINGi9606.ENSP00000348069.

    Structurei

    Secondary structure

    1
    1147
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi321 – 35030
    Helixi359 – 39638

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AM9X-ray2.30A/B/C/D319-400[»]
    ProteinModelPortaliP36956.
    SMRiP36956. Positions 319-400.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP36956.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 487487CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini509 – 54739LumenalSequence AnalysisAdd
    BLAST
    Topological domaini569 – 1147579CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei488 – 50821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei548 – 56821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini323 – 37351bHLHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 6060Transcriptional activation (acidic)Add
    BLAST
    Regioni234 – 497264Interaction with LMNABy similarityAdd
    BLAST
    Regioni373 – 39422Leucine-zipperAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi61 – 178118Pro/Ser-richAdd
    BLAST
    Compositional biasi427 – 46236Gly/Pro/Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SREBP family.Curated
    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG242942.
    HOVERGENiHBG061592.
    KOiK07197.
    OMAiFDPPYAG.
    PhylomeDBiP36956.
    TreeFamiTF313894.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform SREBP-1A (identifier: P36956-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDEPPFSEAA LEQALGEPCD LDAALLTDIE DMLQLINNQD SDFPGLFDPP     50
    YAGSGAGGTD PASPDTSSPG SLSPPPATLS SSLEAFLSGP QAAPSPLSPP 100
    QPAPTPLKMY PSMPAFSPGP GIKEESVPLS ILQTPTPQPL PGALLPQSFP 150
    APAPPQFSST PVLGYPSPPG GFSTGSPPGN TQQPLPGLPL ASPPGVPPVS 200
    LHTQVQSVVP QQLLTVTAAP TAAPVTTTVT SQIQQVPVLL QPHFIKADSL 250
    LLTAMKTDGA TVKAAGLSPL VSGTTVQTGP LPTLVSGGTI LATVPLVVDA 300
    EKLPINRLAA GSKAPASAQS RGEKRTAHNA IEKRYRSSIN DKIIELKDLV 350
    VGTEAKLNKS AVLRKAIDYI RFLQHSNQKL KQENLSLRTA VHKSKSLKDL 400
    VSACGSGGNT DVLMEGVKTE VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS 450
    GGSGSDSEPD SPVFEDSKAK PEQRPSLHSR GMLDRSRLAL CTLVFLCLSC 500
    NPLASLLGAR GLPSPSDTTS VYHSPGRNVL GTESRDGPGW AQWLLPPVVW 550
    LLNGLLVLVS LVLLFVYGEP VTRPHSGPAV YFWRHRKQAD LDLARGDFAQ 600
    AAQQLWLALR ALGRPLPTSH LDLACSLLWN LIRHLLQRLW VGRWLAGRAG 650
    GLQQDCALRV DASASARDAA LVYHKLHQLH TMGKHTGGHL TATNLALSAL 700
    NLAECAGDAV SVATLAEIYV AAALRVKTSL PRALHFLTRF FLSSARQACL 750
    AQSGSVPPAM QWLCHPVGHR FFVDGDWSVL STPWESLYSL AGNPVDPLAQ 800
    VTQLFREHLL ERALNCVTQP NPSPGSADGD KEFSDALGYL QLLNSCSDAA 850
    GAPAYSFSIS SSMATTTGVD PVAKWWASLT AVVIHWLRRD EEAAERLCPL 900
    VEHLPRVLQE SERPLPRAAL HSFKAARALL GCAKAESGPA SLTICEKASG 950
    YLQDSLATTP ASSSIDKAVQ LFLCDLLLVV RTSLWRQQQP PAPAPAAQGT 1000
    SSRPQASALE LRGFQRDLSS LRRLAQSFRP AMRRVFLHEA TARLMAGASP 1050
    TRTHQLLDRS LRRRAGPGGK GGAVAELEPR PTRREHAEAL LLASCYLPPG 1100
    FLSAPGQRVG MLAEAARTLE KLGDRRLLHD CQQMLMRLGG GTTVTSS 1147
    Length:1,147
    Mass (Da):121,675
    Last modified:February 5, 2008 - v2
    Checksum:i58F28870739FF259
    GO
    Isoform SREBP-1B (identifier: P36956-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1035-1147: VFLHEATARL...LGGGTTVTSS → LMDVLTSESA...KVPGWHGRMD

    Show »
    Length:1,071
    Mass (Da):113,562
    Checksum:iB71B6010CDB8D1ED
    GO
    Isoform SREBP-1C (identifier: P36956-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-29: MDEPPFSEAALEQALGEPCDLDAALLTDI → MDCTF
         1035-1147: VFLHEATARL...LGGGTTVTSS → LMDVLTSESA...KVPGWHGRMD

    Note: Predominantly expressed in liver and adipose tissues.

    Show »
    Length:1,047
    Mass (Da):111,102
    Checksum:i05CF039C7707AFB9
    GO
    Isoform 4 (identifier: P36956-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         30-30: E → EGEVGAGRGRANGLDAPRAGADRGAMDCTFE

    Note: No experimental confirmation available.

    Show »
    Length:1,177
    Mass (Da):124,635
    Checksum:i1C9257FFC7FC7FEB
    GO
    Isoform SREBP-1aDelta (identifier: P36956-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         469-470: AK → TE
         471-1147: Missing.

    Note: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters.

    Show »
    Length:470
    Mass (Da):48,276
    Checksum:iB6BEDC238A020B8F
    GO
    Isoform SREBP-1cDelta (identifier: P36956-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-29: MDEPPFSEAALEQALGEPCDLDAALLTDI → MDCTF
         469-470: AK → TE
         471-1147: Missing.

    Note: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters.

    Show »
    Length:446
    Mass (Da):45,816
    Checksum:iB1C64DDD71DEEDEC
    GO

    Sequence cautioni

    The sequence BAD92846.1 differs from that shown. Reason: Intron retention.
    The sequence AAB28522.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti306 – 3061N → S.1 Publication
    Corresponds to variant rs17855793 [ dbSNP | Ensembl ].
    VAR_038468
    Natural varianti309 – 3091A → T.
    Corresponds to variant rs35188700 [ dbSNP | Ensembl ].
    VAR_038469
    Natural varianti417 – 4171V → M.
    Corresponds to variant rs2229590 [ dbSNP | Ensembl ].
    VAR_038470
    Natural varianti580 – 5801V → M.
    Corresponds to variant rs36215896 [ dbSNP | Ensembl ].
    VAR_038471
    Natural varianti746 – 7461R → H.
    Corresponds to variant rs2228461 [ dbSNP | Ensembl ].
    VAR_038472
    Natural varianti834 – 8341S → L.1 Publication
    Corresponds to variant rs17855792 [ dbSNP | Ensembl ].
    VAR_038473
    Natural varianti1000 – 10001T → A.2 Publications
    Corresponds to variant rs1042017 [ dbSNP | Ensembl ].
    VAR_038474
    Natural varianti1008 – 10081A → P.
    Corresponds to variant rs35014224 [ dbSNP | Ensembl ].
    VAR_038475

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2929MDEPP…LLTDI → MDCTF in isoform SREBP-1C and isoform SREBP-1cDelta. 2 PublicationsVSP_002149Add
    BLAST
    Alternative sequencei30 – 301E → EGEVGAGRGRANGLDAPRAG ADRGAMDCTFE in isoform 4. 1 PublicationVSP_030859
    Alternative sequencei469 – 4702AK → TE in isoform SREBP-1aDelta and isoform SREBP-1cDelta. 1 PublicationVSP_047598
    Alternative sequencei471 – 1147677Missing in isoform SREBP-1aDelta and isoform SREBP-1cDelta. 1 PublicationVSP_047599Add
    BLAST
    Alternative sequencei1035 – 1147113VFLHE…TVTSS → LMDVLTSESAWALPQHLGKG FPSPSGHKVPGWHGRMD in isoform SREBP-1B and isoform SREBP-1C. 1 PublicationVSP_002150Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00968 mRNA. Translation: AAC50051.2.
    S66167 mRNA. Translation: AAB28522.2. Different initiation.
    S66168 mRNA. Translation: AAB28523.1.
    AB373958 mRNA. Translation: BAG06742.1.
    AB373959 mRNA. Translation: BAG06743.1.
    AC122129 Genomic DNA. No translation available.
    CH471196 Genomic DNA. Translation: EAW55689.1.
    CH471196 Genomic DNA. Translation: EAW55690.1.
    BC023621 mRNA. Translation: AAH23621.1.
    BC026962 mRNA. Translation: AAH26962.1.
    BC057388 mRNA. Translation: AAH57388.1.
    BC063281 mRNA. Translation: AAH63281.1.
    AB209609 mRNA. Translation: BAD92846.1. Sequence problems.
    CCDSiCCDS11189.1. [P36956-1]
    CCDS32583.1. [P36956-4]
    PIRiA48845.
    RefSeqiNP_001005291.1. NM_001005291.2. [P36956-4]
    NP_004167.3. NM_004176.4. [P36956-1]
    UniGeneiHs.592123.
    Hs.733635.

    Genome annotation databases

    EnsembliENST00000261646; ENSP00000261646; ENSG00000072310. [P36956-1]
    ENST00000355815; ENSP00000348069; ENSG00000072310. [P36956-4]
    GeneIDi6720.
    KEGGihsa:6720.
    UCSCiuc002grq.2. human. [P36956-1]
    uc002grs.2. human. [P36956-4]

    Polymorphism databases

    DMDMi166897633.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Sterol regulatory element-binding protein entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00968 mRNA. Translation: AAC50051.2 .
    S66167 mRNA. Translation: AAB28522.2 . Different initiation.
    S66168 mRNA. Translation: AAB28523.1 .
    AB373958 mRNA. Translation: BAG06742.1 .
    AB373959 mRNA. Translation: BAG06743.1 .
    AC122129 Genomic DNA. No translation available.
    CH471196 Genomic DNA. Translation: EAW55689.1 .
    CH471196 Genomic DNA. Translation: EAW55690.1 .
    BC023621 mRNA. Translation: AAH23621.1 .
    BC026962 mRNA. Translation: AAH26962.1 .
    BC057388 mRNA. Translation: AAH57388.1 .
    BC063281 mRNA. Translation: AAH63281.1 .
    AB209609 mRNA. Translation: BAD92846.1 . Sequence problems.
    CCDSi CCDS11189.1. [P36956-1 ]
    CCDS32583.1. [P36956-4 ]
    PIRi A48845.
    RefSeqi NP_001005291.1. NM_001005291.2. [P36956-4 ]
    NP_004167.3. NM_004176.4. [P36956-1 ]
    UniGenei Hs.592123.
    Hs.733635.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AM9 X-ray 2.30 A/B/C/D 319-400 [» ]
    ProteinModelPortali P36956.
    SMRi P36956. Positions 319-400.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112598. 54 interactions.
    DIPi DIP-331N.
    IntActi P36956. 14 interactions.
    MINTi MINT-2803077.
    STRINGi 9606.ENSP00000348069.

    PTM databases

    PhosphoSitei P36956.

    Polymorphism databases

    DMDMi 166897633.

    Proteomic databases

    MaxQBi P36956.
    PaxDbi P36956.
    PRIDEi P36956.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261646 ; ENSP00000261646 ; ENSG00000072310 . [P36956-1 ]
    ENST00000355815 ; ENSP00000348069 ; ENSG00000072310 . [P36956-4 ]
    GeneIDi 6720.
    KEGGi hsa:6720.
    UCSCi uc002grq.2. human. [P36956-1 ]
    uc002grs.2. human. [P36956-4 ]

    Organism-specific databases

    CTDi 6720.
    GeneCardsi GC17M017714.
    HGNCi HGNC:11289. SREBF1.
    HPAi CAB005406.
    MIMi 184756. gene.
    neXtProti NX_P36956.
    PharmGKBi PA335.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG242942.
    HOVERGENi HBG061592.
    KOi K07197.
    OMAi FDPPYAG.
    PhylomeDBi P36956.
    TreeFami TF313894.

    Enzyme and pathway databases

    Reactomei REACT_116145. PPARA activates gene expression.
    REACT_118659. RORA activates circadian gene expression.
    REACT_147797. Regulation of cholesterol biosynthesis by SREBP (SREBF).
    REACT_147904. Activation of gene expression by SREBF (SREBP).
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinki P36956.

    Miscellaneous databases

    ChiTaRSi SREBF1. human.
    EvolutionaryTracei P36956.
    GeneWikii SREBF1.
    GenomeRNAii 6720.
    NextBioi 26212.
    PMAP-CutDB P36956.
    PROi P36956.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P36956.
    Bgeei P36956.
    CleanExi HS_SREBF1.
    Genevestigatori P36956.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
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    Publicationsi

    1. "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene."
      Yokoyama C., Wang X., Briggs M.R., Admon A., Wu J., Hua X., Goldstein J.L., Brown M.S.
      Cell 75:187-197(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SREBP-1A), NUCLEOTIDE SEQUENCE [MRNA] OF 1-29 (ISOFORM SREBP-1C), NUCLEOTIDE SEQUENCE [MRNA] OF 1035-1147 (ISOFORMS SREBP-1B AND SREBP-1C), PARTIAL PROTEIN SEQUENCE, VARIANT ALA-1000.
      Tissue: Cervix carcinoma.
    2. "Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13."
      Hua X., Wu J., Goldstein J.L., Brown M.S., Hobbs H.H.
      Genomics 25:667-673(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-1000.
      Tissue: Fetal brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SREBP-1ADELTA AND SREBP-1CDELTA), SUBCELLULAR LOCATION (ISOFORMS SREBP-1ADELTA AND SREBP-1CDELTA).
      Tissue: Liver.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM SREBP-1A).
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS SREBP-1A AND 4), VARIANTS SER-306 AND LEU-834.
      Tissue: Brain, Placenta and Uterus.
    7. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-1147 (ISOFORM SREBP-1A/4).
      Tissue: Spleen.
    8. "Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane."
      Hua X., Sakai J., Brown M.S., Goldstein J.L.
      J. Biol. Chem. 271:10379-10384(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, MUTAGENESIS.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Co-crystal structure of sterol regulatory element binding protein 1a at 2.3-A resolution."
      Parraga A., Bellsolell L., Ferre-D'Amare A.R., Burley S.K.
      Structure 6:661-672(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 319-394.

    Entry informationi

    Entry nameiSRBP1_HUMAN
    AccessioniPrimary (citable) accession number: P36956
    Secondary accession number(s): B0I4X3
    , B0I4X4, D3DXC4, Q16062, Q59F52, Q6P4R7, Q6PFW7, Q6PJ36, Q8TAK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 160 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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