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P36956

- SRBP1_HUMAN

UniProt

P36956 - SRBP1_HUMAN

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Protein

Sterol regulatory element-binding protein 1

Gene

SREBF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei460 – 4612Cleavage; by caspase-3 and caspase-7By similarity
Sitei490 – 4912Cleavage; by S2PBy similarity
Sitei530 – 5312Cleavage; by S1PCurated

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. DNA binding Source: UniProtKB
  3. sequence-specific DNA binding Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: HGNC
  5. sterol response element binding Source: HGNC

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular lipid metabolic process Source: Reactome
  3. cellular response to fatty acid Source: Ensembl
  4. cellular response to starvation Source: HGNC
  5. cholesterol metabolic process Source: UniProtKB-KW
  6. circadian rhythm Source: Ensembl
  7. insulin receptor signaling pathway Source: Ensembl
  8. lipid biosynthetic process Source: UniProtKB
  9. lipid metabolic process Source: ProtInc
  10. lung development Source: Ensembl
  11. negative regulation of insulin secretion Source: Ensembl
  12. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  13. positive regulation of cholesterol biosynthetic process Source: Ensembl
  14. positive regulation of histone deacetylation Source: Ensembl
  15. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  16. positive regulation of triglyceride biosynthetic process Source: UniProtKB
  17. regulation of fatty acid metabolic process Source: Ensembl
  18. regulation of heart rate by chemical signal Source: Ensembl
  19. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  20. response to cAMP Source: Ensembl
  21. response to drug Source: Ensembl
  22. response to food Source: Ensembl
  23. response to glucagon Source: Ensembl
  24. response to glucose Source: Ensembl
  25. response to progesterone Source: Ensembl
  26. response to retinoic acid Source: Ensembl
  27. small molecule metabolic process Source: Reactome
  28. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.
REACT_118659. RORA activates circadian gene expression.
REACT_147797. Regulation of cholesterol biosynthesis by SREBP (SREBF).
REACT_147904. Activation of gene expression by SREBF (SREBP).
REACT_27161. Transcriptional regulation of white adipocyte differentiation.
SignaLinkiP36956.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol regulatory element-binding protein 1
Short name:
SREBP-1
Alternative name(s):
Class D basic helix-loop-helix protein 1
Short name:
bHLHd1
Sterol regulatory element-binding transcription factor 1
Cleaved into the following chain:
Gene namesi
Name:SREBF1
Synonyms:BHLHD1, SREBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:11289. SREBF1.

Subcellular locationi

Isoform SREBP-1aDelta : Nucleus 1 PublicationPROSITE-ProRule annotation
Isoform SREBP-1cDelta : Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. cytosol Source: Reactome
  4. endoplasmic reticulum Source: UniProtKB
  5. endoplasmic reticulum membrane Source: Reactome
  6. Golgi membrane Source: Reactome
  7. integral component of membrane Source: UniProtKB-KW
  8. nuclear envelope Source: ProtInc
  9. nucleoplasm Source: Reactome
  10. nucleus Source: BHF-UCL
  11. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi455 – 4551S → A: No effect on proteolytic processing. 1 Publication
Mutagenesisi456 – 4561D → A: No effect on proteolytic processing. 1 Publication
Mutagenesisi457 – 4571S → A: No effect on proteolytic processing. 1 Publication
Mutagenesisi460 – 4601D → A: No effect on proteolytic processing. 1 Publication
Mutagenesisi466 – 4661D → A: No effect on proteolytic processing. 1 Publication
Mutagenesisi481 – 4811G → A: No effect on proteolytic processing. 1 Publication
Mutagenesisi482 – 4821M → A: No effect on proteolytic processing. 1 Publication
Mutagenesisi483 – 4831L → A: No effect on proteolytic processing. 1 Publication
Mutagenesisi484 – 4874DRSR → AS: Strong reduction of proteolytic processing in response to low sterol. 1 Publication
Mutagenesisi484 – 4841D → A: Loss of proteolytic processing in response to low sterol. 1 Publication
Mutagenesisi485 – 4851R → A: No effect on proteolytic processing. 1 Publication
Mutagenesisi527 – 5271R → A: Loss of proteolytic processing in response to low sterol. 1 Publication

Organism-specific databases

PharmGKBiPA335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11471147Sterol regulatory element-binding protein 1PRO_0000127447Add
BLAST
Chaini1 – 490490Processed sterol regulatory element-binding protein 1PRO_0000314029Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 1171Phosphoserine1 Publication
Modified residuei337 – 3371Phosphoserine; by SIK1By similarity
Modified residuei338 – 3381Phosphoserine; by SIK1By similarity
Modified residuei396 – 3961Phosphoserine; by AMPKBy similarity
Modified residuei402 – 4021Phosphoserine; by SIK1By similarity

Post-translational modificationi

At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.
Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression. Phosphorylation at Ser-402 by SIK1 represses activity possibly by inhibiting DNA-binding (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36956.
PaxDbiP36956.
PRIDEiP36956.

PTM databases

PhosphoSiteiP36956.

Miscellaneous databases

PMAP-CutDBP36956.

Expressioni

Tissue specificityi

Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.

Gene expression databases

BgeeiP36956.
CleanExiHS_SREBF1.
ExpressionAtlasiP36956. baseline and differential.
GenevestigatoriP36956.

Organism-specific databases

HPAiCAB005406.

Interactioni

Subunit structurei

Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA.

Binary interactionsi

WithEntry#Exp.IntActNotes
CrebbpP454812EBI-948328,EBI-296306From a different organism.
MED15Q96RN56EBI-948328,EBI-394506
SIRT1Q96EB62EBI-948338,EBI-1802965

Protein-protein interaction databases

BioGridi112598. 55 interactions.
DIPiDIP-331N.
IntActiP36956. 14 interactions.
MINTiMINT-2803077.
STRINGi9606.ENSP00000348069.

Structurei

Secondary structure

1
1147
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi321 – 35030
Helixi359 – 39638

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AM9X-ray2.30A/B/C/D319-400[»]
ProteinModelPortaliP36956.
SMRiP36956. Positions 319-400.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36956.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 487487CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini509 – 54739LumenalSequence AnalysisAdd
BLAST
Topological domaini569 – 1147579CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei488 – 50821HelicalSequence AnalysisAdd
BLAST
Transmembranei548 – 56821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini323 – 37351bHLHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 6060Transcriptional activation (acidic)Add
BLAST
Regioni234 – 497264Interaction with LMNABy similarityAdd
BLAST
Regioni373 – 39422Leucine-zipperAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi61 – 178118Pro/Ser-richAdd
BLAST
Compositional biasi427 – 46236Gly/Pro/Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the SREBP family.Curated
Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG242942.
GeneTreeiENSGT00390000017651.
HOVERGENiHBG061592.
InParanoidiP36956.
KOiK07197.
OMAiFDPPYAG.
PhylomeDBiP36956.
TreeFamiTF313894.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform SREBP-1A (identifier: P36956-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEPPFSEAA LEQALGEPCD LDAALLTDIE DMLQLINNQD SDFPGLFDPP
60 70 80 90 100
YAGSGAGGTD PASPDTSSPG SLSPPPATLS SSLEAFLSGP QAAPSPLSPP
110 120 130 140 150
QPAPTPLKMY PSMPAFSPGP GIKEESVPLS ILQTPTPQPL PGALLPQSFP
160 170 180 190 200
APAPPQFSST PVLGYPSPPG GFSTGSPPGN TQQPLPGLPL ASPPGVPPVS
210 220 230 240 250
LHTQVQSVVP QQLLTVTAAP TAAPVTTTVT SQIQQVPVLL QPHFIKADSL
260 270 280 290 300
LLTAMKTDGA TVKAAGLSPL VSGTTVQTGP LPTLVSGGTI LATVPLVVDA
310 320 330 340 350
EKLPINRLAA GSKAPASAQS RGEKRTAHNA IEKRYRSSIN DKIIELKDLV
360 370 380 390 400
VGTEAKLNKS AVLRKAIDYI RFLQHSNQKL KQENLSLRTA VHKSKSLKDL
410 420 430 440 450
VSACGSGGNT DVLMEGVKTE VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS
460 470 480 490 500
GGSGSDSEPD SPVFEDSKAK PEQRPSLHSR GMLDRSRLAL CTLVFLCLSC
510 520 530 540 550
NPLASLLGAR GLPSPSDTTS VYHSPGRNVL GTESRDGPGW AQWLLPPVVW
560 570 580 590 600
LLNGLLVLVS LVLLFVYGEP VTRPHSGPAV YFWRHRKQAD LDLARGDFAQ
610 620 630 640 650
AAQQLWLALR ALGRPLPTSH LDLACSLLWN LIRHLLQRLW VGRWLAGRAG
660 670 680 690 700
GLQQDCALRV DASASARDAA LVYHKLHQLH TMGKHTGGHL TATNLALSAL
710 720 730 740 750
NLAECAGDAV SVATLAEIYV AAALRVKTSL PRALHFLTRF FLSSARQACL
760 770 780 790 800
AQSGSVPPAM QWLCHPVGHR FFVDGDWSVL STPWESLYSL AGNPVDPLAQ
810 820 830 840 850
VTQLFREHLL ERALNCVTQP NPSPGSADGD KEFSDALGYL QLLNSCSDAA
860 870 880 890 900
GAPAYSFSIS SSMATTTGVD PVAKWWASLT AVVIHWLRRD EEAAERLCPL
910 920 930 940 950
VEHLPRVLQE SERPLPRAAL HSFKAARALL GCAKAESGPA SLTICEKASG
960 970 980 990 1000
YLQDSLATTP ASSSIDKAVQ LFLCDLLLVV RTSLWRQQQP PAPAPAAQGT
1010 1020 1030 1040 1050
SSRPQASALE LRGFQRDLSS LRRLAQSFRP AMRRVFLHEA TARLMAGASP
1060 1070 1080 1090 1100
TRTHQLLDRS LRRRAGPGGK GGAVAELEPR PTRREHAEAL LLASCYLPPG
1110 1120 1130 1140
FLSAPGQRVG MLAEAARTLE KLGDRRLLHD CQQMLMRLGG GTTVTSS
Length:1,147
Mass (Da):121,675
Last modified:February 5, 2008 - v2
Checksum:i58F28870739FF259
GO
Isoform SREBP-1B (identifier: P36956-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1035-1147: VFLHEATARL...LGGGTTVTSS → LMDVLTSESA...KVPGWHGRMD

Show »
Length:1,071
Mass (Da):113,562
Checksum:iB71B6010CDB8D1ED
GO
Isoform SREBP-1C (identifier: P36956-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MDEPPFSEAALEQALGEPCDLDAALLTDI → MDCTF
     1035-1147: VFLHEATARL...LGGGTTVTSS → LMDVLTSESA...KVPGWHGRMD

Note: Predominantly expressed in liver and adipose tissues.

Show »
Length:1,047
Mass (Da):111,102
Checksum:i05CF039C7707AFB9
GO
Isoform 4 (identifier: P36956-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-30: E → EGEVGAGRGRANGLDAPRAGADRGAMDCTFE

Note: No experimental confirmation available.

Show »
Length:1,177
Mass (Da):124,635
Checksum:i1C9257FFC7FC7FEB
GO
Isoform SREBP-1aDelta (identifier: P36956-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     469-470: AK → TE
     471-1147: Missing.

Note: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters.

Show »
Length:470
Mass (Da):48,276
Checksum:iB6BEDC238A020B8F
GO
Isoform SREBP-1cDelta (identifier: P36956-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MDEPPFSEAALEQALGEPCDLDAALLTDI → MDCTF
     469-470: AK → TE
     471-1147: Missing.

Note: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters.

Show »
Length:446
Mass (Da):45,816
Checksum:iB1C64DDD71DEEDEC
GO

Sequence cautioni

The sequence BAD92846.1 differs from that shown. Reason: Intron retention.
The sequence AAB28522.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti306 – 3061N → S.1 Publication
Corresponds to variant rs17855793 [ dbSNP | Ensembl ].
VAR_038468
Natural varianti309 – 3091A → T.
Corresponds to variant rs35188700 [ dbSNP | Ensembl ].
VAR_038469
Natural varianti417 – 4171V → M.
Corresponds to variant rs2229590 [ dbSNP | Ensembl ].
VAR_038470
Natural varianti580 – 5801V → M.
Corresponds to variant rs36215896 [ dbSNP | Ensembl ].
VAR_038471
Natural varianti746 – 7461R → H.
Corresponds to variant rs2228461 [ dbSNP | Ensembl ].
VAR_038472
Natural varianti834 – 8341S → L.1 Publication
Corresponds to variant rs17855792 [ dbSNP | Ensembl ].
VAR_038473
Natural varianti1000 – 10001T → A.2 Publications
Corresponds to variant rs1042017 [ dbSNP | Ensembl ].
VAR_038474
Natural varianti1008 – 10081A → P.
Corresponds to variant rs35014224 [ dbSNP | Ensembl ].
VAR_038475

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2929MDEPP…LLTDI → MDCTF in isoform SREBP-1C and isoform SREBP-1cDelta. 2 PublicationsVSP_002149Add
BLAST
Alternative sequencei30 – 301E → EGEVGAGRGRANGLDAPRAG ADRGAMDCTFE in isoform 4. 1 PublicationVSP_030859
Alternative sequencei469 – 4702AK → TE in isoform SREBP-1aDelta and isoform SREBP-1cDelta. 1 PublicationVSP_047598
Alternative sequencei471 – 1147677Missing in isoform SREBP-1aDelta and isoform SREBP-1cDelta. 1 PublicationVSP_047599Add
BLAST
Alternative sequencei1035 – 1147113VFLHE…TVTSS → LMDVLTSESAWALPQHLGKG FPSPSGHKVPGWHGRMD in isoform SREBP-1B and isoform SREBP-1C. 1 PublicationVSP_002150Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00968 mRNA. Translation: AAC50051.2.
S66167 mRNA. Translation: AAB28522.2. Different initiation.
S66168 mRNA. Translation: AAB28523.1.
AB373958 mRNA. Translation: BAG06742.1.
AB373959 mRNA. Translation: BAG06743.1.
AC122129 Genomic DNA. No translation available.
CH471196 Genomic DNA. Translation: EAW55689.1.
CH471196 Genomic DNA. Translation: EAW55690.1.
BC023621 mRNA. Translation: AAH23621.1.
BC026962 mRNA. Translation: AAH26962.1.
BC057388 mRNA. Translation: AAH57388.1.
BC063281 mRNA. Translation: AAH63281.1.
AB209609 mRNA. Translation: BAD92846.1. Sequence problems.
CCDSiCCDS11189.1. [P36956-1]
CCDS32583.1. [P36956-4]
PIRiA48845.
RefSeqiNP_001005291.1. NM_001005291.2. [P36956-4]
NP_004167.3. NM_004176.4. [P36956-1]
UniGeneiHs.592123.
Hs.733635.

Genome annotation databases

EnsembliENST00000261646; ENSP00000261646; ENSG00000072310. [P36956-1]
ENST00000355815; ENSP00000348069; ENSG00000072310. [P36956-4]
GeneIDi6720.
KEGGihsa:6720.
UCSCiuc002grq.2. human. [P36956-1]
uc002grs.2. human. [P36956-4]
uc010cpq.1. human.

Polymorphism databases

DMDMi166897633.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Sterol regulatory element-binding protein entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00968 mRNA. Translation: AAC50051.2 .
S66167 mRNA. Translation: AAB28522.2 . Different initiation.
S66168 mRNA. Translation: AAB28523.1 .
AB373958 mRNA. Translation: BAG06742.1 .
AB373959 mRNA. Translation: BAG06743.1 .
AC122129 Genomic DNA. No translation available.
CH471196 Genomic DNA. Translation: EAW55689.1 .
CH471196 Genomic DNA. Translation: EAW55690.1 .
BC023621 mRNA. Translation: AAH23621.1 .
BC026962 mRNA. Translation: AAH26962.1 .
BC057388 mRNA. Translation: AAH57388.1 .
BC063281 mRNA. Translation: AAH63281.1 .
AB209609 mRNA. Translation: BAD92846.1 . Sequence problems.
CCDSi CCDS11189.1. [P36956-1 ]
CCDS32583.1. [P36956-4 ]
PIRi A48845.
RefSeqi NP_001005291.1. NM_001005291.2. [P36956-4 ]
NP_004167.3. NM_004176.4. [P36956-1 ]
UniGenei Hs.592123.
Hs.733635.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AM9 X-ray 2.30 A/B/C/D 319-400 [» ]
ProteinModelPortali P36956.
SMRi P36956. Positions 319-400.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112598. 55 interactions.
DIPi DIP-331N.
IntActi P36956. 14 interactions.
MINTi MINT-2803077.
STRINGi 9606.ENSP00000348069.

PTM databases

PhosphoSitei P36956.

Polymorphism databases

DMDMi 166897633.

Proteomic databases

MaxQBi P36956.
PaxDbi P36956.
PRIDEi P36956.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261646 ; ENSP00000261646 ; ENSG00000072310 . [P36956-1 ]
ENST00000355815 ; ENSP00000348069 ; ENSG00000072310 . [P36956-4 ]
GeneIDi 6720.
KEGGi hsa:6720.
UCSCi uc002grq.2. human. [P36956-1 ]
uc002grs.2. human. [P36956-4 ]
uc010cpq.1. human.

Organism-specific databases

CTDi 6720.
GeneCardsi GC17M017714.
HGNCi HGNC:11289. SREBF1.
HPAi CAB005406.
MIMi 184756. gene.
neXtProti NX_P36956.
PharmGKBi PA335.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG242942.
GeneTreei ENSGT00390000017651.
HOVERGENi HBG061592.
InParanoidi P36956.
KOi K07197.
OMAi FDPPYAG.
PhylomeDBi P36956.
TreeFami TF313894.

Enzyme and pathway databases

Reactomei REACT_116145. PPARA activates gene expression.
REACT_118659. RORA activates circadian gene expression.
REACT_147797. Regulation of cholesterol biosynthesis by SREBP (SREBF).
REACT_147904. Activation of gene expression by SREBF (SREBP).
REACT_27161. Transcriptional regulation of white adipocyte differentiation.
SignaLinki P36956.

Miscellaneous databases

ChiTaRSi SREBF1. human.
EvolutionaryTracei P36956.
GeneWikii SREBF1.
GenomeRNAii 6720.
NextBioi 26212.
PMAP-CutDB P36956.
PROi P36956.
SOURCEi Search...

Gene expression databases

Bgeei P36956.
CleanExi HS_SREBF1.
ExpressionAtlasi P36956. baseline and differential.
Genevestigatori P36956.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene."
    Yokoyama C., Wang X., Briggs M.R., Admon A., Wu J., Hua X., Goldstein J.L., Brown M.S.
    Cell 75:187-197(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SREBP-1A), NUCLEOTIDE SEQUENCE [MRNA] OF 1-29 (ISOFORM SREBP-1C), NUCLEOTIDE SEQUENCE [MRNA] OF 1035-1147 (ISOFORMS SREBP-1B AND SREBP-1C), PARTIAL PROTEIN SEQUENCE, VARIANT ALA-1000.
    Tissue: Cervix carcinoma.
  2. "Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13."
    Hua X., Wu J., Goldstein J.L., Brown M.S., Hobbs H.H.
    Genomics 25:667-673(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-1000.
    Tissue: Fetal brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SREBP-1ADELTA AND SREBP-1CDELTA), SUBCELLULAR LOCATION (ISOFORMS SREBP-1ADELTA AND SREBP-1CDELTA).
    Tissue: Liver.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM SREBP-1A).
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS SREBP-1A AND 4), VARIANTS SER-306 AND LEU-834.
    Tissue: Brain, Placenta and Uterus.
  7. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-1147 (ISOFORM SREBP-1A/4).
    Tissue: Spleen.
  8. "Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane."
    Hua X., Sakai J., Brown M.S., Goldstein J.L.
    J. Biol. Chem. 271:10379-10384(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, MUTAGENESIS.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Co-crystal structure of sterol regulatory element binding protein 1a at 2.3-A resolution."
    Parraga A., Bellsolell L., Ferre-D'Amare A.R., Burley S.K.
    Structure 6:661-672(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 319-394.

Entry informationi

Entry nameiSRBP1_HUMAN
AccessioniPrimary (citable) accession number: P36956
Secondary accession number(s): B0I4X3
, B0I4X4, D3DXC4, Q16062, Q59F52, Q6P4R7, Q6PFW7, Q6PJ36, Q8TAK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3