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P36955

- PEDF_HUMAN

UniProt

P36955 - PEDF_HUMAN

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Protein

Pigment epithelium-derived factor

Gene
SERPINF1, PEDF, PIG35
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.2 Publications

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. aging Source: Ensembl
  2. cell proliferation Source: ProtInc
  3. kidney development Source: Ensembl
  4. multicellular organismal development Source: ProtInc
  5. negative regulation of angiogenesis Source: UniProtKB
  6. negative regulation of endopeptidase activity Source: RefGenome
  7. negative regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
  8. negative regulation of inflammatory response Source: Ensembl
  9. positive regulation of neurogenesis Source: UniProtKB
  10. regulation of proteolysis Source: RefGenome
  11. response to glucocorticoid Source: Ensembl
  12. response to retinoic acid Source: Ensembl
  13. short-term memory Source: Ensembl
Complete GO annotation...

Protein family/group databases

MEROPSiI04.979.

Names & Taxonomyi

Protein namesi
Recommended name:
Pigment epithelium-derived factor
Short name:
PEDF
Alternative name(s):
Cell proliferation-inducing gene 35 protein
EPC-1
Serpin F1
Gene namesi
Synonyms:PEDF
ORF Names:PIG35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:8824. SERPINF1.

Subcellular locationi

Secreted. Melanosome
Note: Enriched in stage I melanosomes.1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: BHF-UCL
  3. extracellular vesicular exosome Source: UniProt
  4. melanosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Osteogenesis imperfecta 6 (OI6) [MIM:613982]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI6 is a severe, autosomal recessive form compatible with OI type III in the Sillence classification.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Osteogenesis imperfecta

Organism-specific databases

MIMi613982. phenotype.
Orphaneti216812. Osteogenesis imperfecta type 3.
PharmGKBiPA35508.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 418399Pigment epithelium-derived factorPRO_0000032508Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Pyrrolidone carboxylic acid
Modified residuei24 – 241Phosphoserine; by CK21 Publication
Modified residuei114 – 1141Phosphoserine; by CK21 Publication
Modified residuei227 – 2271Phosphoserine; by PKA1 Publication
Glycosylationi285 – 2851N-linked (GlcNAc...) (complex)4 Publications

Post-translational modificationi

The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity.
N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP36955.
PaxDbiP36955.
PeptideAtlasiP36955.
PRIDEiP36955.

2D gel databases

REPRODUCTION-2DPAGEIPI00006114.

PTM databases

PhosphoSiteiP36955.

Expressioni

Tissue specificityi

Retinal pigment epithelial cells and blood plasma.1 Publication

Developmental stagei

Expressed in quiescent cells.

Gene expression databases

ArrayExpressiP36955.
BgeeiP36955.
CleanExiHS_SERPINF1.
GenevestigatoriP36955.

Organism-specific databases

HPAiCAB004785.
HPA005825.

Interactioni

Protein-protein interaction databases

BioGridi111202. 5 interactions.
IntActiP36955. 6 interactions.
MINTiMINT-7711036.
STRINGi9606.ENSP00000254722.

Structurei

Secondary structure

1
418
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi45 – 484
Helixi50 – 7223
Beta strandi78 – 803
Helixi82 – 9211
Helixi93 – 953
Helixi98 – 10710
Helixi110 – 1123
Helixi118 – 12912
Beta strandi136 – 1449
Helixi152 – 16211
Helixi173 – 18715
Turni188 – 1903
Beta strandi204 – 21411
Beta strandi217 – 2193
Helixi223 – 2253
Beta strandi227 – 23610
Beta strandi238 – 25619
Turni257 – 2604
Beta strandi261 – 2688
Turni269 – 2713
Beta strandi272 – 28110
Helixi287 – 2904
Helixi295 – 30410
Beta strandi306 – 31510
Beta strandi317 – 3248
Helixi326 – 3305
Turni331 – 3355
Helixi336 – 3394
Turni344 – 3463
Beta strandi353 – 36412
Beta strandi368 – 3703
Beta strandi387 – 3893
Beta strandi394 – 4007
Turni401 – 4033
Beta strandi406 – 4138

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IMVX-ray2.85A21-418[»]
ProteinModelPortaliP36955.
SMRiP36955. Positions 36-418.

Miscellaneous databases

EvolutionaryTraceiP36955.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni371 – 38313O-glycosylated at one siteAdd
BLAST

Domaini

The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity.

Sequence similaritiesi

Belongs to the serpin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000115489.
HOVERGENiHBG106911.
InParanoidiP36955.
OMAiLNCKIAQ.
OrthoDBiEOG7K3TMD.
PhylomeDBiP36955.
TreeFamiTF317350.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36955-1 [UniParc]FASTAAdd to Basket

« Hide

MQALVLLLCI GALLGHSSCQ NPASPPEEGS PDPDSTGALV EEEDPFFKVP    50
VNKLAAAVSN FGYDLYRVRS STSPTTNVLL SPLSVATALS ALSLGAEQRT 100
ESIIHRALYY DLISSPDIHG TYKELLDTVT APQKNLKSAS RIVFEKKLRI 150
KSSFVAPLEK SYGTRPRVLT GNPRLDLQEI NNWVQAQMKG KLARSTKEIP 200
DEISILLLGV AHFKGQWVTK FDSRKTSLED FYLDEERTVR VPMMSDPKAV 250
LRYGLDSDLS CKIAQLPLTG SMSIIFFLPL KVTQNLTLIE ESLTSEFIHD 300
IDRELKTVQA VLTVPKLKLS YEGEVTKSLQ EMKLQSLFDS PDFSKITGKP 350
IKLTQVEHRA GFEWNEDGAG TTPSPGLQPA HLTFPLDYHL NQPFIFVLRD 400
TDTGALLFIG KILDPRGP 418
Length:418
Mass (Da):46,312
Last modified:November 30, 2010 - v4
Checksum:i7630DD2B4026A0D3
GO

Sequence cautioni

The sequence AAA84914.1 differs from that shown. Reason: Frameshift at position 356.
The sequence AAA93524.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721T → M Polymorphism confirmed at protein level. 10 Publications
Corresponds to variant rs1136287 [ dbSNP | Ensembl ].
VAR_009126
Natural varianti132 – 1321P → R.1 Publication
Corresponds to variant rs1804145 [ dbSNP | Ensembl ].
VAR_025500

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 982EQ → DE in AAA60058. 1 Publication
Sequence conflicti97 – 982EQ → DE in AAB38685. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M76979 mRNA. Translation: AAA60058.1.
U29953 Genomic DNA. Translation: AAA84914.1. Frameshift.
AF400442 mRNA. Translation: AAK92491.1.
BT007222 mRNA. Translation: AAP35886.1.
AY513280 mRNA. Translation: AAT08033.1.
AB593011 mRNA. Translation: BAJ83966.1.
AB593012 mRNA. Translation: BAJ83967.1.
AB593013 mRNA. Translation: BAJ83968.1.
AC130343 Genomic DNA. No translation available.
AC130689 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90577.1.
BC000522 mRNA. Translation: AAH00522.1.
BC013984 mRNA. Translation: AAH13984.1.
AH004879 Genomic DNA. Translation: AAB38685.1.
M90439 mRNA. Translation: AAA93524.1. Different initiation.
CCDSiCCDS11012.1.
PIRiA46046.
A47281.
RefSeqiNP_002606.3. NM_002615.5.
UniGeneiHs.532768.

Genome annotation databases

EnsembliENST00000254722; ENSP00000254722; ENSG00000132386.
GeneIDi5176.
KEGGihsa:5176.
UCSCiuc002ftl.3. human.

Polymorphism databases

DMDMi313104314.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M76979 mRNA. Translation: AAA60058.1 .
U29953 Genomic DNA. Translation: AAA84914.1 . Frameshift.
AF400442 mRNA. Translation: AAK92491.1 .
BT007222 mRNA. Translation: AAP35886.1 .
AY513280 mRNA. Translation: AAT08033.1 .
AB593011 mRNA. Translation: BAJ83966.1 .
AB593012 mRNA. Translation: BAJ83967.1 .
AB593013 mRNA. Translation: BAJ83968.1 .
AC130343 Genomic DNA. No translation available.
AC130689 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90577.1 .
BC000522 mRNA. Translation: AAH00522.1 .
BC013984 mRNA. Translation: AAH13984.1 .
AH004879 Genomic DNA. Translation: AAB38685.1 .
M90439 mRNA. Translation: AAA93524.1 . Different initiation.
CCDSi CCDS11012.1.
PIRi A46046.
A47281.
RefSeqi NP_002606.3. NM_002615.5.
UniGenei Hs.532768.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1IMV X-ray 2.85 A 21-418 [» ]
ProteinModelPortali P36955.
SMRi P36955. Positions 36-418.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111202. 5 interactions.
IntActi P36955. 6 interactions.
MINTi MINT-7711036.
STRINGi 9606.ENSP00000254722.

Protein family/group databases

MEROPSi I04.979.

PTM databases

PhosphoSitei P36955.

Polymorphism databases

DMDMi 313104314.

2D gel databases

REPRODUCTION-2DPAGE IPI00006114.

Proteomic databases

MaxQBi P36955.
PaxDbi P36955.
PeptideAtlasi P36955.
PRIDEi P36955.

Protocols and materials databases

DNASUi 5176.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254722 ; ENSP00000254722 ; ENSG00000132386 .
GeneIDi 5176.
KEGGi hsa:5176.
UCSCi uc002ftl.3. human.

Organism-specific databases

CTDi 5176.
GeneCardsi GC17P001612.
H-InvDB HIX0013408.
HGNCi HGNC:8824. SERPINF1.
HPAi CAB004785.
HPA005825.
MIMi 172860. gene.
613982. phenotype.
neXtProti NX_P36955.
Orphaneti 216812. Osteogenesis imperfecta type 3.
PharmGKBi PA35508.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4826.
HOGENOMi HOG000115489.
HOVERGENi HBG106911.
InParanoidi P36955.
OMAi LNCKIAQ.
OrthoDBi EOG7K3TMD.
PhylomeDBi P36955.
TreeFami TF317350.

Miscellaneous databases

ChiTaRSi SERPINF1. human.
EvolutionaryTracei P36955.
GeneWikii PEDF.
GenomeRNAii 5176.
NextBioi 20036.
PROi P36955.
SOURCEi Search...

Gene expression databases

ArrayExpressi P36955.
Bgeei P36955.
CleanExi HS_SERPINF1.
Genevestigatori P36955.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family."
    Steele F.R., Chader G.J., Johnson L.V., Tombran-Tink J.
    Proc. Natl. Acad. Sci. U.S.A. 90:1526-1530(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANT MET-72.
    Tissue: Fetal eye.
  2. "Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin."
    Tombran-Tink J., Mazuruk K., Rodriguez I.R., Chung D., Linker T., Englander E., Chader G.J.
    Mol. Vis. 2:11-11(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-72.
  3. Yin B., Peng X., Yuan J., Qiang B.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-72.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Identification of a human cell proliferation inducing gene."
    Kim J.W.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-72.
    Tissue: Liver cancer.
  6. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
    Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
    Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-72.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-72 AND ARG-132.
    Tissue: Muscle.
  10. Coljee V.W.
    Thesis (1996), Medical College of Pennsylvania, United States
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-332, VARIANT MET-72.
    Tissue: Fetal lung fibroblast.
  11. "Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization."
    Petersen S.V., Valnickova Z., Enghild J.J.
    Biochem. J. 374:199-206(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-29; 253-262 AND 282-303, TISSUE SPECIFICITY, PYROGLUTAMATE FORMATION AT GLN-20.
    Tissue: Plasma.
  12. "Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state."
    Pignolo R.J., Cristofalo V.J., Rotenberg M.O.
    J. Biol. Chem. 268:8949-8957(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 60-418, VARIANT MET-72.
    Tissue: Fetal lung fibroblast.
  13. "Overexpression of fetal human pigment epithelium-derived factor in Escherichia coli. A functionally active neurotrophic factor."
    Becerra S.P., Palmer I., Kumar A., Steele F.R., Shiloach J., Notario V., Chader G.J.
    J. Biol. Chem. 268:23148-23156(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop."
    Becerra S.P., Sagasti A., Spinella P., Notario V.
    J. Biol. Chem. 270:25992-25999(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor."
    Maik-Rachline G., Shaltiel S., Seger R.
    Blood 105:670-678(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-24; SER-114 AND SER-227.
  16. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-285.
    Tissue: Plasma.
  17. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.
  18. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-285.
    Tissue: Liver.
  19. Cited for: GLYCOSYLATION AT ASN-285.
  20. "Enrichment of glycopeptides for glycan structure and attachment site identification."
    Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E., Brinkmalm G., Larson G.
    Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS], STRUCTURE OF CARBOHYDRATES.
    Tissue: Cerebrospinal fluid.
  21. "Exome sequencing identifies truncating mutations in human SERPINF1 in autosomal-recessive osteogenesis imperfecta."
    Becker J., Semler O., Gilissen C., Li Y., Bolz H.J., Giunta C., Bergmann C., Rohrbach M., Koerber F., Zimmermann K., de Vries P., Wirth B., Schoenau E., Wollnik B., Veltman J.A., Hoischen A., Netzer C.
    Am. J. Hum. Genet. 88:362-371(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN OI6.
  22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  23. "Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor."
    Simonovic M., Gettins P.G.W., Volz K.
    Proc. Natl. Acad. Sci. U.S.A. 98:11131-11135(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 21-418, GLYCOSYLATION AT ASN-285.
  24. "Four polymorphic variations in the PEDF gene identified during the mutation screening of patients with Leber congenital amaurosis."
    Koenekoop R., Pina A.L., Loyer M., Davidson J., Robitaille J., Maumenee I., Tombran-Tink J.
    Mol. Vis. 5:10-10(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT MET-72.
  25. "Quantitative detection of single amino acid polymorphisms by targeted proteomics."
    Su Z.D., Sun L., Yu D.X., Li R.X., Li H.X., Yu Z.J., Sheng Q.H., Lin X., Zeng R., Wu J.R.
    J. Mol. Cell Biol. 3:309-315(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT MET-72, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPEDF_HUMAN
AccessioniPrimary (citable) accession number: P36955
Secondary accession number(s): F1T092
, Q13236, Q2TU83, Q96CT1, Q96R01, Q9BWA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 151 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi