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P36955

- PEDF_HUMAN

UniProt

P36955 - PEDF_HUMAN

Protein

Pigment epithelium-derived factor

Gene

SERPINF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 4 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.2 Publications

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. aging Source: Ensembl
    2. cell proliferation Source: ProtInc
    3. kidney development Source: Ensembl
    4. multicellular organismal development Source: ProtInc
    5. negative regulation of angiogenesis Source: UniProtKB
    6. negative regulation of endopeptidase activity Source: RefGenome
    7. negative regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
    8. negative regulation of inflammatory response Source: Ensembl
    9. positive regulation of neurogenesis Source: UniProtKB
    10. regulation of proteolysis Source: RefGenome
    11. response to glucocorticoid Source: Ensembl
    12. response to retinoic acid Source: Ensembl
    13. short-term memory Source: Ensembl

    Protein family/group databases

    MEROPSiI04.979.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pigment epithelium-derived factor
    Short name:
    PEDF
    Alternative name(s):
    Cell proliferation-inducing gene 35 protein
    EPC-1
    Serpin F1
    Gene namesi
    Name:SERPINF1
    Synonyms:PEDF
    ORF Names:PIG35
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:8824. SERPINF1.

    Subcellular locationi

    Secreted 1 Publication. Melanosome 1 Publication
    Note: Enriched in stage I melanosomes.

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: BHF-UCL
    3. extracellular vesicular exosome Source: UniProt
    4. melanosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Osteogenesis imperfecta 6 (OI6) [MIM:613982]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI6 is a severe, autosomal recessive form compatible with OI type III in the Sillence classification.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Osteogenesis imperfecta

    Organism-specific databases

    MIMi613982. phenotype.
    Orphaneti216812. Osteogenesis imperfecta type 3.
    PharmGKBiPA35508.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 418399Pigment epithelium-derived factorPRO_0000032508Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei20 – 201Pyrrolidone carboxylic acid1 Publication
    Modified residuei24 – 241Phosphoserine; by CK21 Publication
    Modified residuei114 – 1141Phosphoserine; by CK21 Publication
    Modified residuei227 – 2271Phosphoserine; by PKA1 Publication
    Glycosylationi285 – 2851N-linked (GlcNAc...) (complex)5 Publications

    Post-translational modificationi

    The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity.1 Publication
    N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.5 Publications

    Keywords - PTMi

    Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    MaxQBiP36955.
    PaxDbiP36955.
    PeptideAtlasiP36955.
    PRIDEiP36955.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00006114.

    PTM databases

    PhosphoSiteiP36955.

    Expressioni

    Tissue specificityi

    Retinal pigment epithelial cells and blood plasma.1 Publication

    Developmental stagei

    Expressed in quiescent cells.

    Gene expression databases

    ArrayExpressiP36955.
    BgeeiP36955.
    CleanExiHS_SERPINF1.
    GenevestigatoriP36955.

    Organism-specific databases

    HPAiCAB004785.
    HPA005825.

    Interactioni

    Protein-protein interaction databases

    BioGridi111202. 5 interactions.
    IntActiP36955. 6 interactions.
    MINTiMINT-7711036.
    STRINGi9606.ENSP00000254722.

    Structurei

    Secondary structure

    1
    418
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi45 – 484
    Helixi50 – 7223
    Beta strandi78 – 803
    Helixi82 – 9211
    Helixi93 – 953
    Helixi98 – 10710
    Helixi110 – 1123
    Helixi118 – 12912
    Beta strandi136 – 1449
    Helixi152 – 16211
    Helixi173 – 18715
    Turni188 – 1903
    Beta strandi204 – 21411
    Beta strandi217 – 2193
    Helixi223 – 2253
    Beta strandi227 – 23610
    Beta strandi238 – 25619
    Turni257 – 2604
    Beta strandi261 – 2688
    Turni269 – 2713
    Beta strandi272 – 28110
    Helixi287 – 2904
    Helixi295 – 30410
    Beta strandi306 – 31510
    Beta strandi317 – 3248
    Helixi326 – 3305
    Turni331 – 3355
    Helixi336 – 3394
    Turni344 – 3463
    Beta strandi353 – 36412
    Beta strandi368 – 3703
    Beta strandi387 – 3893
    Beta strandi394 – 4007
    Turni401 – 4033
    Beta strandi406 – 4138

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1IMVX-ray2.85A21-418[»]
    ProteinModelPortaliP36955.
    SMRiP36955. Positions 36-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP36955.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni371 – 38313O-glycosylated at one siteAdd
    BLAST

    Domaini

    The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity.

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000115489.
    HOVERGENiHBG106911.
    InParanoidiP36955.
    OMAiLNCKIAQ.
    OrthoDBiEOG7K3TMD.
    PhylomeDBiP36955.
    TreeFamiTF317350.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36955-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQALVLLLCI GALLGHSSCQ NPASPPEEGS PDPDSTGALV EEEDPFFKVP    50
    VNKLAAAVSN FGYDLYRVRS STSPTTNVLL SPLSVATALS ALSLGAEQRT 100
    ESIIHRALYY DLISSPDIHG TYKELLDTVT APQKNLKSAS RIVFEKKLRI 150
    KSSFVAPLEK SYGTRPRVLT GNPRLDLQEI NNWVQAQMKG KLARSTKEIP 200
    DEISILLLGV AHFKGQWVTK FDSRKTSLED FYLDEERTVR VPMMSDPKAV 250
    LRYGLDSDLS CKIAQLPLTG SMSIIFFLPL KVTQNLTLIE ESLTSEFIHD 300
    IDRELKTVQA VLTVPKLKLS YEGEVTKSLQ EMKLQSLFDS PDFSKITGKP 350
    IKLTQVEHRA GFEWNEDGAG TTPSPGLQPA HLTFPLDYHL NQPFIFVLRD 400
    TDTGALLFIG KILDPRGP 418
    Length:418
    Mass (Da):46,312
    Last modified:November 30, 2010 - v4
    Checksum:i7630DD2B4026A0D3
    GO

    Sequence cautioni

    The sequence AAA84914.1 differs from that shown. Reason: Frameshift at position 356.
    The sequence AAA93524.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 982EQ → DE in AAA60058. (PubMed:8434014)Curated
    Sequence conflicti97 – 982EQ → DE in AAB38685. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti72 – 721T → M Polymorphism confirmed at protein level. 10 Publications
    Corresponds to variant rs1136287 [ dbSNP | Ensembl ].
    VAR_009126
    Natural varianti132 – 1321P → R.1 Publication
    Corresponds to variant rs1804145 [ dbSNP | Ensembl ].
    VAR_025500

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76979 mRNA. Translation: AAA60058.1.
    U29953 Genomic DNA. Translation: AAA84914.1. Frameshift.
    AF400442 mRNA. Translation: AAK92491.1.
    BT007222 mRNA. Translation: AAP35886.1.
    AY513280 mRNA. Translation: AAT08033.1.
    AB593011 mRNA. Translation: BAJ83966.1.
    AB593012 mRNA. Translation: BAJ83967.1.
    AB593013 mRNA. Translation: BAJ83968.1.
    AC130343 Genomic DNA. No translation available.
    AC130689 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90577.1.
    BC000522 mRNA. Translation: AAH00522.1.
    BC013984 mRNA. Translation: AAH13984.1.
    AH004879 Genomic DNA. Translation: AAB38685.1.
    M90439 mRNA. Translation: AAA93524.1. Different initiation.
    CCDSiCCDS11012.1.
    PIRiA46046.
    A47281.
    RefSeqiNP_002606.3. NM_002615.5.
    UniGeneiHs.532768.

    Genome annotation databases

    EnsembliENST00000254722; ENSP00000254722; ENSG00000132386.
    GeneIDi5176.
    KEGGihsa:5176.
    UCSCiuc002ftl.3. human.

    Polymorphism databases

    DMDMi313104314.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76979 mRNA. Translation: AAA60058.1 .
    U29953 Genomic DNA. Translation: AAA84914.1 . Frameshift.
    AF400442 mRNA. Translation: AAK92491.1 .
    BT007222 mRNA. Translation: AAP35886.1 .
    AY513280 mRNA. Translation: AAT08033.1 .
    AB593011 mRNA. Translation: BAJ83966.1 .
    AB593012 mRNA. Translation: BAJ83967.1 .
    AB593013 mRNA. Translation: BAJ83968.1 .
    AC130343 Genomic DNA. No translation available.
    AC130689 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90577.1 .
    BC000522 mRNA. Translation: AAH00522.1 .
    BC013984 mRNA. Translation: AAH13984.1 .
    AH004879 Genomic DNA. Translation: AAB38685.1 .
    M90439 mRNA. Translation: AAA93524.1 . Different initiation.
    CCDSi CCDS11012.1.
    PIRi A46046.
    A47281.
    RefSeqi NP_002606.3. NM_002615.5.
    UniGenei Hs.532768.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1IMV X-ray 2.85 A 21-418 [» ]
    ProteinModelPortali P36955.
    SMRi P36955. Positions 36-418.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111202. 5 interactions.
    IntActi P36955. 6 interactions.
    MINTi MINT-7711036.
    STRINGi 9606.ENSP00000254722.

    Protein family/group databases

    MEROPSi I04.979.

    PTM databases

    PhosphoSitei P36955.

    Polymorphism databases

    DMDMi 313104314.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00006114.

    Proteomic databases

    MaxQBi P36955.
    PaxDbi P36955.
    PeptideAtlasi P36955.
    PRIDEi P36955.

    Protocols and materials databases

    DNASUi 5176.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254722 ; ENSP00000254722 ; ENSG00000132386 .
    GeneIDi 5176.
    KEGGi hsa:5176.
    UCSCi uc002ftl.3. human.

    Organism-specific databases

    CTDi 5176.
    GeneCardsi GC17P001612.
    H-InvDB HIX0013408.
    HGNCi HGNC:8824. SERPINF1.
    HPAi CAB004785.
    HPA005825.
    MIMi 172860. gene.
    613982. phenotype.
    neXtProti NX_P36955.
    Orphaneti 216812. Osteogenesis imperfecta type 3.
    PharmGKBi PA35508.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000115489.
    HOVERGENi HBG106911.
    InParanoidi P36955.
    OMAi LNCKIAQ.
    OrthoDBi EOG7K3TMD.
    PhylomeDBi P36955.
    TreeFami TF317350.

    Miscellaneous databases

    ChiTaRSi SERPINF1. human.
    EvolutionaryTracei P36955.
    GeneWikii PEDF.
    GenomeRNAii 5176.
    NextBioi 20036.
    PROi P36955.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P36955.
    Bgeei P36955.
    CleanExi HS_SERPINF1.
    Genevestigatori P36955.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family."
      Steele F.R., Chader G.J., Johnson L.V., Tombran-Tink J.
      Proc. Natl. Acad. Sci. U.S.A. 90:1526-1530(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANT MET-72.
      Tissue: Fetal eye.
    2. "Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin."
      Tombran-Tink J., Mazuruk K., Rodriguez I.R., Chung D., Linker T., Englander E., Chader G.J.
      Mol. Vis. 2:11-11(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-72.
    3. Yin B., Peng X., Yuan J., Qiang B.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-72.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Identification of a human cell proliferation inducing gene."
      Kim J.W.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-72.
      Tissue: Liver cancer.
    6. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
      Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
      Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-72.
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-72 AND ARG-132.
      Tissue: Muscle.
    10. Coljee V.W.
      Thesis (1996), Medical College of Pennsylvania, United States
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-332, VARIANT MET-72.
      Tissue: Fetal lung fibroblast.
    11. "Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization."
      Petersen S.V., Valnickova Z., Enghild J.J.
      Biochem. J. 374:199-206(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-29; 253-262 AND 282-303, TISSUE SPECIFICITY, PYROGLUTAMATE FORMATION AT GLN-20.
      Tissue: Plasma.
    12. "Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state."
      Pignolo R.J., Cristofalo V.J., Rotenberg M.O.
      J. Biol. Chem. 268:8949-8957(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 60-418, VARIANT MET-72.
      Tissue: Fetal lung fibroblast.
    13. "Overexpression of fetal human pigment epithelium-derived factor in Escherichia coli. A functionally active neurotrophic factor."
      Becerra S.P., Palmer I., Kumar A., Steele F.R., Shiloach J., Notario V., Chader G.J.
      J. Biol. Chem. 268:23148-23156(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. "Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop."
      Becerra S.P., Sagasti A., Spinella P., Notario V.
      J. Biol. Chem. 270:25992-25999(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    15. "Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor."
      Maik-Rachline G., Shaltiel S., Seger R.
      Blood 105:670-678(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-24; SER-114 AND SER-227.
    16. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-285.
      Tissue: Plasma.
    17. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Melanoma.
    18. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-285.
      Tissue: Liver.
    19. Cited for: GLYCOSYLATION AT ASN-285.
    20. "Enrichment of glycopeptides for glycan structure and attachment site identification."
      Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E., Brinkmalm G., Larson G.
      Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS], STRUCTURE OF CARBOHYDRATES.
      Tissue: Cerebrospinal fluid.
    21. "Exome sequencing identifies truncating mutations in human SERPINF1 in autosomal-recessive osteogenesis imperfecta."
      Becker J., Semler O., Gilissen C., Li Y., Bolz H.J., Giunta C., Bergmann C., Rohrbach M., Koerber F., Zimmermann K., de Vries P., Wirth B., Schoenau E., Wollnik B., Veltman J.A., Hoischen A., Netzer C.
      Am. J. Hum. Genet. 88:362-371(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN OI6.
    22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    23. "Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor."
      Simonovic M., Gettins P.G.W., Volz K.
      Proc. Natl. Acad. Sci. U.S.A. 98:11131-11135(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 21-418, GLYCOSYLATION AT ASN-285.
    24. "Four polymorphic variations in the PEDF gene identified during the mutation screening of patients with Leber congenital amaurosis."
      Koenekoop R., Pina A.L., Loyer M., Davidson J., Robitaille J., Maumenee I., Tombran-Tink J.
      Mol. Vis. 5:10-10(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT MET-72.
    25. "Quantitative detection of single amino acid polymorphisms by targeted proteomics."
      Su Z.D., Sun L., Yu D.X., Li R.X., Li H.X., Yu Z.J., Sheng Q.H., Lin X., Zeng R., Wu J.R.
      J. Mol. Cell Biol. 3:309-315(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT MET-72, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiPEDF_HUMAN
    AccessioniPrimary (citable) accession number: P36955
    Secondary accession number(s): F1T092
    , Q13236, Q2TU83, Q96CT1, Q96R01, Q9BWA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 152 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3