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P36953

- AFAM_RAT

UniProt

P36953 - AFAM_RAT

Protein

Afamin

Gene

Afm

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitamin E at the blood-brain barrier By similarity.By similarity

    GO - Molecular functioni

    1. vitamin E binding Source: UniProtKB

    GO - Biological processi

    1. vitamin transport Source: UniProtKB

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Afamin
    Alternative name(s):
    Alpha-albumin
    Short name:
    Alpha-Alb
    Gene namesi
    Name:Afm
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi628614. Afm.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 608587AfaminPRO_0000001108Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
    Disulfide bondi99 ↔ 114PROSITE-ProRule annotation
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi113 ↔ 124PROSITE-ProRule annotation
    Disulfide bondi148 ↔ 193PROSITE-ProRule annotation
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi224 ↔ 270PROSITE-ProRule annotation
    Disulfide bondi269 ↔ 277PROSITE-ProRule annotation
    Disulfide bondi289 ↔ 303PROSITE-ProRule annotation
    Disulfide bondi302 ↔ 313PROSITE-ProRule annotation
    Disulfide bondi340 ↔ 385PROSITE-ProRule annotation
    Disulfide bondi384 ↔ 393PROSITE-ProRule annotation
    Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi416 ↔ 462PROSITE-ProRule annotation
    Disulfide bondi461 ↔ 470PROSITE-ProRule annotation
    Disulfide bondi483 ↔ 499PROSITE-ProRule annotation
    Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi498 ↔ 509PROSITE-ProRule annotation
    Disulfide bondi580 ↔ 589PROSITE-ProRule annotation

    Post-translational modificationi

    N-glycosylated; more than 90% of the glycans are sialylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP36953.
    PRIDEiP36953.

    PTM databases

    PhosphoSiteiP36953.

    Expressioni

    Gene expression databases

    GenevestigatoriP36953.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000057275.

    Structurei

    3D structure databases

    ProteinModelPortaliP36953.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 210189Albumin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini211 – 403193Albumin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini404 – 599196Albumin 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
    Contains 3 albumin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG47806.
    HOGENOMiHOG000293137.
    HOVERGENiHBG004207.
    InParanoidiP36953.
    PhylomeDBiP36953.

    Family and domain databases

    InterProiIPR000264. ALB/AFP/VDB.
    IPR020858. Serum_albumin-like.
    IPR021177. Serum_albumin/AFP.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    [Graphical view]
    PfamiPF00273. Serum_albumin. 3 hits.
    [Graphical view]
    PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
    PRINTSiPR00802. SERUMALBUMIN.
    SMARTiSM00103. ALBUMIN. 3 hits.
    [Graphical view]
    SUPFAMiSSF48552. SSF48552. 3 hits.
    PROSITEiPS00212. ALBUMIN_1. 1 hit.
    PS51438. ALBUMIN_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36953-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRHLKLTGFI FFLLSLTESL ALPTKPQDVD HFNATQKFIN ENVAYLTIIA    50
    SAQYVQEASF EEVEMLVKVM LDYKDRCLAD STLPECSKIA NDAIQDMLCD 100
    MKGLPQKHNF SHCCRQAGFQ RRLCFFYNKK ANVGFLPPFP TLDPEEKCQA 150
    YKNNSESFLN LYMYEVARRN PFAFAPVLLN VAARFEEAAT TCCEQQQKAT 200
    YFQDKAAPIT QYLKALSSYQ RNVCGALLKF GPKTLNSINI AVFSKKFPKI 250
    GFEDLTSLLE DVSSMYDGCC EGDVVQCIRS QSQVMHHICS KQDSISSKIK 300
    ACCEKKLPER ADCIINANKD DRPEDLSLRT PKFTDSENVC QERDSEQDKF 350
    FAEFLYDYSR RHTELSTPEL LRITKVYKDL LEDCCNRKNP LSCYRHAEDK 400
    FNETTERSLA MVQQECKQFQ ELGKDALQRH FLVKFTKAAP QLPMEELVSL 450
    SKEMVAALAT CCTLSDEFAC VDNLADLVLG ELCGMNKNRT INPTVDHCCR 500
    ADFAFRRPCF EHLKADTTYA LPSVSALVSA LRADWCQPLK EDLQNKRHRF 550
    LVNLVKWMPE ITDEERLCLF TKFTAAGEEC GNIQKPEACF SPESSKTGDV 600
    SQDAEKQR 608
    Length:608
    Mass (Da):69,335
    Last modified:June 1, 1994 - v1
    Checksum:iF33151A6E68A07F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76456 Genomic DNA. Translation: CAA53994.1.
    PIRiA53195.
    RefSeqiNP_758823.1. NM_172320.1.
    UniGeneiRn.214035.

    Genome annotation databases

    GeneIDi282708.
    KEGGirno:282708.
    UCSCiRGD:628614. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76456 Genomic DNA. Translation: CAA53994.1 .
    PIRi A53195.
    RefSeqi NP_758823.1. NM_172320.1.
    UniGenei Rn.214035.

    3D structure databases

    ProteinModelPortali P36953.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000057275.

    PTM databases

    PhosphoSitei P36953.

    Proteomic databases

    PaxDbi P36953.
    PRIDEi P36953.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 282708.
    KEGGi rno:282708.
    UCSCi RGD:628614. rat.

    Organism-specific databases

    CTDi 173.
    RGDi 628614. Afm.

    Phylogenomic databases

    eggNOGi NOG47806.
    HOGENOMi HOG000293137.
    HOVERGENi HBG004207.
    InParanoidi P36953.
    PhylomeDBi P36953.

    Miscellaneous databases

    NextBioi 624841.
    PROi P36953.

    Gene expression databases

    Genevestigatori P36953.

    Family and domain databases

    InterProi IPR000264. ALB/AFP/VDB.
    IPR020858. Serum_albumin-like.
    IPR021177. Serum_albumin/AFP.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    [Graphical view ]
    Pfami PF00273. Serum_albumin. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF002520. Serum_albumin_subgroup. 1 hit.
    PRINTSi PR00802. SERUMALBUMIN.
    SMARTi SM00103. ALBUMIN. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48552. SSF48552. 3 hits.
    PROSITEi PS00212. ALBUMIN_1. 1 hit.
    PS51438. ALBUMIN_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "New albumin gene 3' adjacent to the alpha 1-fetoprotein locus."
      Belanger L., Roy S., Allard D.
      J. Biol. Chem. 269:5481-5484(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiAFAM_RAT
    AccessioniPrimary (citable) accession number: P36953
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3