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P36953

- AFAM_RAT

UniProt

P36953 - AFAM_RAT

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Protein
Afamin
Gene
Afm
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitamin E at the blood-brain barrier By similarity.

GO - Molecular functioni

  1. vitamin E binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. vitamin transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Afamin
Alternative name(s):
Alpha-albumin
Short name:
Alpha-Alb
Gene namesi
Name:Afm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi628614. Afm.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 By similarity
Add
BLAST
Chaini22 – 608587Afamin
PRO_0000001108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi77 ↔ 86 By similarity
Disulfide bondi99 ↔ 114 By similarity
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi113 ↔ 124 By similarity
Disulfide bondi148 ↔ 193 By similarity
Glycosylationi153 – 1531N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi224 ↔ 270 By similarity
Disulfide bondi269 ↔ 277 By similarity
Disulfide bondi289 ↔ 303 By similarity
Disulfide bondi302 ↔ 313 By similarity
Disulfide bondi340 ↔ 385 By similarity
Disulfide bondi384 ↔ 393 By similarity
Glycosylationi402 – 4021N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi416 ↔ 462 By similarity
Disulfide bondi461 ↔ 470 By similarity
Disulfide bondi483 ↔ 499 By similarity
Glycosylationi488 – 4881N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi498 ↔ 509 By similarity
Disulfide bondi580 ↔ 589 By similarity

Post-translational modificationi

N-glycosylated; more than 90% of the glycans are sialylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP36953.
PRIDEiP36953.

PTM databases

PhosphoSiteiP36953.

Expressioni

Gene expression databases

GenevestigatoriP36953.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057275.

Structurei

3D structure databases

ProteinModelPortaliP36953.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 210189Albumin 1
Add
BLAST
Domaini211 – 403193Albumin 2
Add
BLAST
Domaini404 – 599196Albumin 3
Add
BLAST

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.
Contains 3 albumin domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG47806.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP36953.
PhylomeDBiP36953.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 1 hit.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36953-1 [UniParc]FASTAAdd to Basket

« Hide

MRHLKLTGFI FFLLSLTESL ALPTKPQDVD HFNATQKFIN ENVAYLTIIA    50
SAQYVQEASF EEVEMLVKVM LDYKDRCLAD STLPECSKIA NDAIQDMLCD 100
MKGLPQKHNF SHCCRQAGFQ RRLCFFYNKK ANVGFLPPFP TLDPEEKCQA 150
YKNNSESFLN LYMYEVARRN PFAFAPVLLN VAARFEEAAT TCCEQQQKAT 200
YFQDKAAPIT QYLKALSSYQ RNVCGALLKF GPKTLNSINI AVFSKKFPKI 250
GFEDLTSLLE DVSSMYDGCC EGDVVQCIRS QSQVMHHICS KQDSISSKIK 300
ACCEKKLPER ADCIINANKD DRPEDLSLRT PKFTDSENVC QERDSEQDKF 350
FAEFLYDYSR RHTELSTPEL LRITKVYKDL LEDCCNRKNP LSCYRHAEDK 400
FNETTERSLA MVQQECKQFQ ELGKDALQRH FLVKFTKAAP QLPMEELVSL 450
SKEMVAALAT CCTLSDEFAC VDNLADLVLG ELCGMNKNRT INPTVDHCCR 500
ADFAFRRPCF EHLKADTTYA LPSVSALVSA LRADWCQPLK EDLQNKRHRF 550
LVNLVKWMPE ITDEERLCLF TKFTAAGEEC GNIQKPEACF SPESSKTGDV 600
SQDAEKQR 608
Length:608
Mass (Da):69,335
Last modified:June 1, 1994 - v1
Checksum:iF33151A6E68A07F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76456 Genomic DNA. Translation: CAA53994.1.
PIRiA53195.
RefSeqiNP_758823.1. NM_172320.1.
UniGeneiRn.214035.

Genome annotation databases

GeneIDi282708.
KEGGirno:282708.
UCSCiRGD:628614. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76456 Genomic DNA. Translation: CAA53994.1 .
PIRi A53195.
RefSeqi NP_758823.1. NM_172320.1.
UniGenei Rn.214035.

3D structure databases

ProteinModelPortali P36953.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000057275.

PTM databases

PhosphoSitei P36953.

Proteomic databases

PaxDbi P36953.
PRIDEi P36953.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 282708.
KEGGi rno:282708.
UCSCi RGD:628614. rat.

Organism-specific databases

CTDi 173.
RGDi 628614. Afm.

Phylogenomic databases

eggNOGi NOG47806.
HOGENOMi HOG000293137.
HOVERGENi HBG004207.
InParanoidi P36953.
PhylomeDBi P36953.

Miscellaneous databases

NextBioi 624841.
PROi P36953.

Gene expression databases

Genevestigatori P36953.

Family and domain databases

InterProi IPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view ]
Pfami PF00273. Serum_albumin. 3 hits.
[Graphical view ]
PIRSFi PIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSi PR00802. SERUMALBUMIN.
SMARTi SM00103. ALBUMIN. 3 hits.
[Graphical view ]
SUPFAMi SSF48552. SSF48552. 3 hits.
PROSITEi PS00212. ALBUMIN_1. 1 hit.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "New albumin gene 3' adjacent to the alpha 1-fetoprotein locus."
    Belanger L., Roy S., Allard D.
    J. Biol. Chem. 269:5481-5484(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiAFAM_RAT
AccessioniPrimary (citable) accession number: P36953
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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