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Protein

Serpin B5

Gene

SERPINB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei340 – 341Reactive bond homologBy similarity2

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SIGNORiP36952

Protein family/group databases

MEROPSiI04.980

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B5
Alternative name(s):
Maspin
Peptidase inhibitor 5
Short name:
PI-5
Gene namesi
Name:SERPINB5
Synonyms:PI5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000206075.13
HGNCiHGNC:8949 SERPINB5
MIMi154790 gene
neXtProtiNX_P36952

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5268
OpenTargetsiENSG00000206075
PharmGKBiPA35515

Polymorphism and mutation databases

BioMutaiSERPINB5
DMDMi229462757

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000324861 – 375Serpin B5Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP36952
MaxQBiP36952
PaxDbiP36952
PeptideAtlasiP36952
PRIDEiP36952
ProteomicsDBi55240
55241 [P36952-2]
TopDownProteomicsiP36952-1 [P36952-1]

PTM databases

iPTMnetiP36952
PhosphoSitePlusiP36952

Expressioni

Tissue specificityi

Normal mammary epithelial cells.

Gene expression databases

BgeeiENSG00000206075
CleanExiHS_SERPINB5
ExpressionAtlasiP36952 baseline and differential
GenevisibleiP36952 HS

Organism-specific databases

HPAiCAB009570
HPA019025
HPA019132
HPA020136

Interactioni

Subunit structurei

Interacts with IRF6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PRSS21Q9Y6M07EBI-2371394,EBI-7054564

Protein-protein interaction databases

BioGridi111286, 104 interactors
IntActiP36952, 13 interactors
MINTiP36952
STRINGi9606.ENSP00000372221

Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 22Combined sources21
Beta strandi28 – 30Combined sources3
Helixi32 – 45Combined sources14
Helixi48 – 57Combined sources10
Helixi60 – 62Combined sources3
Helixi66 – 80Combined sources15
Turni81 – 83Combined sources3
Beta strandi84 – 95Combined sources12
Helixi96 – 98Combined sources3
Helixi102 – 108Combined sources7
Turni109 – 115Combined sources7
Beta strandi116 – 119Combined sources4
Turni121 – 123Combined sources3
Helixi125 – 139Combined sources15
Turni140 – 142Combined sources3
Turni147 – 150Combined sources4
Beta strandi159 – 168Combined sources10
Beta strandi171 – 173Combined sources3
Helixi177 – 179Combined sources3
Beta strandi181 – 190Combined sources10
Beta strandi192 – 209Combined sources18
Turni210 – 213Combined sources4
Beta strandi214 – 221Combined sources8
Helixi222 – 224Combined sources3
Beta strandi225 – 235Combined sources11
Helixi239 – 249Combined sources11
Helixi252 – 258Combined sources7
Helixi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Beta strandi276 – 282Combined sources7
Helixi284 – 291Combined sources8
Turni295 – 297Combined sources3
Turni299 – 301Combined sources3
Turni305 – 307Combined sources3
Beta strandi315 – 326Combined sources12
Turni337 – 341Combined sources5
Beta strandi344 – 349Combined sources6
Beta strandi354 – 360Combined sources7
Turni361 – 364Combined sources4
Beta strandi365 – 372Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WZ9X-ray2.10A/B1-375[»]
1XQGX-ray3.10A/B1-375[»]
1XQJX-ray3.10A1-375[»]
1XU8X-ray2.80A/B1-375[»]
ProteinModelPortaliP36952
SMRiP36952
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36952

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiP36952
KOiK10139
OMAiIHRVCLE
OrthoDBiEOG091G0ION
PhylomeDBiP36952
TreeFamiTF352619

Family and domain databases

CDDicd02057 maspin_like, 1 hit
InterProiView protein in InterPro
IPR000240 Serpin_B9/Maspin
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
IPR033836 SERPINB5
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
PRINTSiPR00676 MASPIN
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P36952-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT
60 70 80 90 100
ANEIGQVLHF ENVKDVPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL
110 120 130 140 150
STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIKDLT DGHFENILAD
160 170 180 190 200
NSVNDQTKIL VVNAAYFVGK WMKKFSESET KECPFRVNKT DTKPVQMMNM
210 220 230 240 250
EATFCMGNID SINCKIIELP FQNKHLSMFI LLPKDVEDES TGLEKIEKQL
260 270 280 290 300
NSESLSQWTN PSTMANAKVK LSIPKFKVEK MIDPKACLEN LGLKHIFSED
310 320 330 340 350
TSDFSGMSET KGVALSNVIH KVCLEITEDG GDSIEVPGAR ILQHKDELNA
360 370
DHPFIYIIRH NKTRNIIFFG KFCSP
Length:375
Mass (Da):42,100
Last modified:May 5, 2009 - v2
Checksum:i9F24E18505912804
GO
Isoform 2 (identifier: P36952-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-231: TDTKPVQMMN...QNKHLSMFIL → VCGAACSSKR...LRARPAKCLS
     232-375: Missing.

Show »
Length:231
Mass (Da):25,763
Checksum:i62DF767BBA9B5471
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66V → I in AAA18957 (PubMed:8290962).Curated1
Sequence conflicti245K → Q in CAE45703 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055223176S → PCombined sources3 PublicationsCorresponds to variant dbSNP:rs2289519Ensembl.1
Natural variantiVAR_055224187V → L1 PublicationCorresponds to variant dbSNP:rs2289520Ensembl.1
Natural variantiVAR_022115319I → V1 PublicationCorresponds to variant dbSNP:rs1455555Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037145190 – 231TDTKP…SMFIL → VCGAACSSKRSPIIDVKNDR DRVGHKSIPMRNLRARPAKC LS in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_037146232 – 375Missing in isoform 2. 1 PublicationAdd BLAST144

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04313 mRNA Translation: AAA18957.1
AK312765 mRNA Translation: BAG35631.1
AC036176 Genomic DNA No translation available.
BC020713 mRNA Translation: AAH20713.1
BX640597 mRNA Translation: CAE45703.1
CCDSiCCDS32839.1 [P36952-1]
PIRiA36898
RefSeqiNP_002630.2, NM_002639.4 [P36952-1]
UniGeneiHs.55279

Genome annotation databases

EnsembliENST00000382771; ENSP00000372221; ENSG00000206075 [P36952-1]
ENST00000489441; ENSP00000467158; ENSG00000206075 [P36952-2]
GeneIDi5268
KEGGihsa:5268
UCSCiuc002liy.3 human [P36952-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPB5_HUMAN
AccessioniPrimary (citable) accession number: P36952
Secondary accession number(s): B2R6Y4, Q6N0B4, Q8WW89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 5, 2009
Last modified: June 20, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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