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Protein

D-ribose pyranase

Gene

rbsD

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.By similarity

Catalytic activityi

Beta-D-ribopyranose = beta-D-ribofuranose.

Pathwayi: D-ribose degradation

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from beta-D-ribopyranose.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. D-ribose pyranase (rbsD)
  2. Ribokinase (rbsK)
This subpathway is part of the pathway D-ribose degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from beta-D-ribopyranose, the pathway D-ribose degradation and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei20 – 201Proton donorCurated
Binding sitei28 – 281Substrate
Binding sitei98 – 981Substrate

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BioCyciBSUB:BSU35930-MONOMER.
UniPathwayiUPA00916; UER00888.

Names & Taxonomyi

Protein namesi
Recommended name:
D-ribose pyranase (EC:5.4.99.62)
Gene namesi
Name:rbsD
Ordered Locus Names:BSU35930
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi98 – 981H → A: Reduced sugar-binding affinity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131D-ribose pyranasePRO_0000097190Add
BLAST

Proteomic databases

PaxDbiP36946.

Interactioni

Subunit structurei

Homodecamer; dimer of pentamers.1 Publication

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100019436.

Structurei

Secondary structure

1
131
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 179Combined sources
Beta strandi23 – 275Combined sources
Beta strandi37 – 415Combined sources
Helixi51 – 6111Combined sources
Beta strandi64 – 707Combined sources
Helixi72 – 765Combined sources
Helixi78 – 8710Combined sources
Beta strandi89 – 968Combined sources
Helixi98 – 1047Combined sources
Helixi105 – 1073Combined sources
Beta strandi109 – 1135Combined sources
Beta strandi123 – 1275Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OGCX-ray2.00A/B/C/D/E1-131[»]
1OGDX-ray1.95A/B/C/D/E1-131[»]
1OGEX-ray2.05A/B/C/D/E1-131[»]
1OGFX-ray2.30A/B/C/D/E1-131[»]
ProteinModelPortaliP36946.
SMRiP36946. Positions 1-131.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36946.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni120 – 1223Substrate binding

Sequence similaritiesi

Belongs to the RbsD / FucU family. RbsD subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105MRB. Bacteria.
COG1869. LUCA.
HOGENOMiHOG000219040.
InParanoidiP36946.
KOiK06726.
OMAiIIRTGEC.
PhylomeDBiP36946.

Family and domain databases

Gene3Di3.40.1650.10. 1 hit.
HAMAPiMF_01661. D_rib_pyranase. 1 hit.
InterProiIPR023064. D-ribose_pyranase.
IPR023750. RbsD-like.
IPR007721. RbsD_FucU.
[Graphical view]
PfamiPF05025. RbsD_FucU. 1 hit.
[Graphical view]
SUPFAMiSSF102546. SSF102546. 1 hit.

Sequencei

Sequence statusi: Complete.

P36946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKHGILNSH LAKILADLGH TDKIVIADAG LPVPDGVLKI DLSLKPGLPA
60 70 80 90 100
FQDTAAVLAE EMAVEKVIAA AEIKASNQEN AKFLENLFSE QEIEYLSHEE
110 120 130
FKLLTKDAKA VIRTGEFTPY ANCILQAGVL F
Length:131
Mass (Da):14,227
Last modified:June 1, 1994 - v1
Checksum:i053F1AC529CC98D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25798 Genomic DNA. Translation: CAA81050.1.
Z92953 Genomic DNA. Translation: CAB07464.1.
AL009126 Genomic DNA. Translation: CAB15610.1.
PIRiI40464.
RefSeqiNP_391474.1. NC_000964.3.
WP_003244175.1. NZ_JNCM01000034.1.

Genome annotation databases

EnsemblBacteriaiCAB15610; CAB15610; BSU35930.
GeneIDi936846.
KEGGibsu:BSU35930.
PATRICi18979206. VBIBacSub10457_3765.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25798 Genomic DNA. Translation: CAA81050.1.
Z92953 Genomic DNA. Translation: CAB07464.1.
AL009126 Genomic DNA. Translation: CAB15610.1.
PIRiI40464.
RefSeqiNP_391474.1. NC_000964.3.
WP_003244175.1. NZ_JNCM01000034.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OGCX-ray2.00A/B/C/D/E1-131[»]
1OGDX-ray1.95A/B/C/D/E1-131[»]
1OGEX-ray2.05A/B/C/D/E1-131[»]
1OGFX-ray2.30A/B/C/D/E1-131[»]
ProteinModelPortaliP36946.
SMRiP36946. Positions 1-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100019436.

Proteomic databases

PaxDbiP36946.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15610; CAB15610; BSU35930.
GeneIDi936846.
KEGGibsu:BSU35930.
PATRICi18979206. VBIBacSub10457_3765.

Phylogenomic databases

eggNOGiENOG4105MRB. Bacteria.
COG1869. LUCA.
HOGENOMiHOG000219040.
InParanoidiP36946.
KOiK06726.
OMAiIIRTGEC.
PhylomeDBiP36946.

Enzyme and pathway databases

UniPathwayiUPA00916; UER00888.
BioCyciBSUB:BSU35930-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP36946.

Family and domain databases

Gene3Di3.40.1650.10. 1 hit.
HAMAPiMF_01661. D_rib_pyranase. 1 hit.
InterProiIPR023064. D-ribose_pyranase.
IPR023750. RbsD-like.
IPR007721. RbsD_FucU.
[Graphical view]
PfamiPF05025. RbsD_FucU. 1 hit.
[Graphical view]
SUPFAMiSSF102546. SSF102546. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRBSD_BACSU
AccessioniPrimary (citable) accession number: P36946
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally thought (PubMed:7921236 and PubMed:9353933) to be a high affinity ribose transport protein.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.