P36941 (TNR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor necrosis factor receptor superfamily member 3

Alternative name(s):
Lymphotoxin-beta receptor
Tumor necrosis factor C receptor
Tumor necrosis factor receptor 2-related protein
Tumor necrosis factor receptor type III
Short name=TNF-RIII
Short name=TNFR-III

Gene names

Name:	LTBR
Synonyms:	D12S370, TNFCR, TNFR3, TNFRSF3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. Ref.4 Ref.6
Subunit structure	Self-associates. Associates with TRAF3, TRAF4 and TRAF5. Interacts with HCV core protein. Ref.7 Ref.8 Ref.9 Ref.10
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 4 TNFR-Cys repeats.

Ontologies

Keywords
Biological process	Apoptosis Host-virus interaction
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW cellular response to mechanical stimulus Inferred from expression pattern. Source: UniProtKB interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from expression pattern. Source: UniProtKB positive regulation of JNK cascade Inferred from mutant phenotype. Source: UniProtKB positive regulation of apoptotic process Inferred from mutant phenotype. Source: UniProtKB signal transduction Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	identical protein binding Inferred from physical interaction. Source: IntAct receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-3509981,EBI-3509981
ZMYND11	Q15326	5	EBI-3509981,EBI-2799565

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 435	405	Tumor necrosis factor receptor superfamily member 3		PRO_0000034552
Regions
	Topological domain	31 – 227	197	Extracellular Potential
	Transmembrane	228 – 248	21	Helical; Potential
	Topological domain	249 – 435	187	Cytoplasmic Potential
	Repeat	42 – 81	40	TNFR-Cys 1
	Repeat	82 – 124	43	TNFR-Cys 2
	Repeat	125 – 168	44	TNFR-Cys 3
	Repeat	169 – 211	43	TNFR-Cys 4
Amino acid modifications
	Glycosylation	40	1	N-linked (GlcNAc...) Potential
	Glycosylation	177	1	N-linked (GlcNAc...) Potential
	Disulfide bond	43 ↔ 58		By similarity
	Disulfide bond	59 ↔ 72		By similarity
	Disulfide bond	62 ↔ 80		By similarity
	Disulfide bond	83 ↔ 98		By similarity
	Disulfide bond	101 ↔ 116		By similarity
	Disulfide bond	104 ↔ 124		By similarity
	Disulfide bond	126 ↔ 132		By similarity
	Disulfide bond	139 ↔ 148		By similarity
	Disulfide bond	142 ↔ 167		By similarity
	Disulfide bond	170 ↔ 185		By similarity
Natural variations
	Natural variant	274	1	V → I. Corresponds to variant rs35681405 [ dbSNP | Ensembl ].		VAR_052346

Sequences

	Sequence		Length	Mass (Da)
	P36941 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 624626E6022F656F	FASTA	435	46,709
	10 20 30 40 50 60 MLLPWATSAP GLAWGPLVLG LFGLLAASQP QAVPPYASEN QTCRDQEKEY YEPQHRICCS 70 80 90 100 110 120 RCPPGTYVSA KCSRIRDTVC ATCAENSYNE HWNYLTICQL CRPCDPVMGL EEIAPCTSKR 130 140 150 160 170 180 KTQCRCQPGM FCAAWALECT HCELLSDCPP GTEAELKDEV GKGNNHCVPC KAGHFQNTSS 190 200 210 220 230 240 PSARCQPHTR CENQGLVEAA PGTAQSDTTC KNPLEPLPPE MSGTMLMLAV LLPLAFFLLL 250 260 270 280 290 300 ATVFSCIWKS HPSLCRKLGS LLKRRPQGEG PNPVAGSWEP PKAHPYFPDL VQPLLPISGD 310 320 330 340 350 360 VSPVSTGLPA APVLEAGVPQ QQSPLDLTRE PQLEPGEQSQ VAHGTNGIHV TGGSMTITGN 370 380 390 400 410 420 IYIYNGPVLG GPPGPGDLPA TPEPPYPIPE EGDPGPPGLS TPHQEDGKAW HLAETEHCGA 430 TPSNRGPRNQ FITHD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid." Baens M., Chaffanet M., Cassiman J.-J., van den Berghe H., Marynen P. Genomics 16:214-218(1993) [PubMed: 8486360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"A lymphotoxin-beta-specific receptor." Crowe P.D., VanArsdale T.L., Walter B.N., Ware C.F., Hession C., Ehrenfels B., Browning J.L., Din W.S., Goodwin R.G., Smith C.A. Science 264:707-710(1994) [PubMed: 8171323] [Abstract] Cited for: FUNCTION.
[5]	"The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells." Wu M.-Y., Wang P.-Y., Han S.-H., Hsieh S.-L. J. Biol. Chem. 274:11868-11873(1999) [PubMed: 10207006] [Abstract] Cited for: CHARACTERIZATION.
[6]	"The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells." Rooney I.A., Butrovich K.D., Glass A.A., Borboroglu S., Benedict C.A., Whitbeck J.C., Cohen G.H., Eisenberg R.J., Ware C.F. J. Biol. Chem. 275:14307-14315(2000) [PubMed: 10799510] [Abstract] Cited for: FUNCTION.
[7]	"TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor." Nakano H., Oshima H., Chung W., Williams-Abbott L., Ware C.F., Yagita H., Okumura K. J. Biol. Chem. 271:14661-14664(1996) [PubMed: 8663299] [Abstract] Cited for: INTERACTION WITH TRAF3.
[8]	"Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor." Matsumoto M., Hsieh T.-Y., Zhu N., VanArsdale T., Hwang S.B., Jeng K.-S., Gorbalenya A.E., Lo S.-Y., Ou J.-H., Ware C.F., Lai M.M.C. J. Virol. 71:1301-1309(1997) [PubMed: 8995654] [Abstract] Cited for: INTERACTION WITH HCV CORE PROTEIN.
[9]	"TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues." Krajewska M., Krajewski S., Zapata J.M., VanArsdale T., Gascoyne R.D., Berern K., McFadden D., Shabaik A., Hugh J., Reynolds A., Clevenger C.V., Reed J.C. Am. J. Pathol. 152:1549-1561(1998) [PubMed: 9626059] [Abstract] Cited for: INTERACTION WITH TRAF4.
[10]	"Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)." Mizushima S., Fujita M., Ishida T., Azuma S., Kato K., Hirai M., Otsuka M., Yamamoto T., Inoue J. Gene 207:135-140(1998) [PubMed: 9511754] [Abstract] Cited for: INTERACTION WITH TRAF5.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L04270 mRNA. Translation: AAA36757.1.
CH471116 Genomic DNA. Translation: EAW88801.1.
CH471116 Genomic DNA. Translation: EAW88802.1.
BC026262 mRNA. Translation: AAH26262.1.

IPI

IPI00006097.

PIR

I54182.

RefSeq

NP_002333.1. NM_002342.1.

UniGene

Hs.1116.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1RF3	X-ray	3.50	B	385-408	[»]

ProteinModelPortal

P36941.

SMR

P36941. Positions 46-211.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-2928N.

IntAct

P36941. 8 interactions.

STRING

P36941.

PTM databases

PhosphoSite

P36941.

Polymorphism databases

DMDM

549090.

Proteomic databases

PeptideAtlas

P36941.

PRIDE

P36941.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000228918; ENSP00000228918; ENSG00000111321.

GeneID

4055.

KEGG

hsa:4055.

UCSC

uc001qny.1. human.

Organism-specific databases

CTD

4055.

GeneCards

GC12P006467.

H-InvDB

HIX0010362.

HGNC

HGNC:6718. LTBR.

HPA

CAB026202.

MIM

600979. gene.

neXtProt

NX_P36941.

PharmGKB

PA30481.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG16605.

HOGENOM

HBG126624.

HOVERGEN

HBG023187.

InParanoid

P36941.

OMA

TNGIHVT.

OrthoDB

EOG41ZFC0.

PhylomeDB

P36941.

Gene expression databases

ArrayExpress

P36941.

Bgee

P36941.

CleanEx

HS_LTBR.

Genevestigator

P36941.

GermOnline

ENSG00000111321. Homo sapiens.

Family and domain databases

InterPro

IPR017349. TNFR_3_LTBR.
IPR001368. TNFR_Cys_rich_reg.
[Graphical view]

KO

K03159.

Pfam

PF00020. TNFR_c6. 2 hits.
[Graphical view]

PIRSF

PIRSF037999. TNFR_3_LTBR. 1 hit.

PRINTS

PR01920. TNFACTORR3.

SMART

SM00208. TNFR. 4 hits.
[Graphical view]

PROSITE

PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

15888.

SOURCE

Search...

Entry information

Entry name

TNR3_HUMAN

Accession

Primary (citable) accession number: P36941
Secondary accession number(s): D3DUR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	January 25, 2012
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.