Reviewed,
UniProtKB/Swiss-Prot P36941 (TNR3_HUMAN)
Last modified
June 16, 2009.
Version 92.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tumor necrosis factor receptor superfamily member 3 Alternative name(s): Lymphotoxin-beta receptor Tumor necrosis factor receptor 2-related protein Tumor necrosis factor C receptor | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 435 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. Ref.3 Ref.5 |
| Subunit structure | Self-associates. Associates with TRAF3, TRAF4 and TRAF5. Interacts with HCV core protein. Ref.6 Ref.7 Ref.8 Ref.9 |
| Subcellular location | |
| Sequence similarities | Contains 4 TNFR-Cys repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Apoptosis Host-virus interaction |
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat Signal Transmembrane |
| Molecular function | Receptor |
| PTM | Disulfide bond Glycoprotein |
| Technical term | 3D-structure |
| Gene Ontology (GO) | |
| Biological process | apoptosis Inferred from electronic annotation. Source: UniProtKB-KW interspecies interaction between organismsInferred from electronic annotation. Source: UniProtKB-KW positive regulation of I-kappaB kinase/NF-kappaB cascadeInferred from expression pattern. Source: UniProtKB signal transduction Ref.3Traceable author statement. Source: ProtInc |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | protein binding Inferred from physical interaction. Source: UniProtKB receptor activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 30 | 30 | Potential | ||||||||
| Chain | 31 – 435 | 405 | Tumor necrosis factor receptor superfamily member 3 | PRO_0000034552 | |||||||
Regions | |||||||||||
| Topological domain | 31 – 227 | 197 | Extracellular Potential | ||||||||
| Transmembrane | 228 – 248 | 21 | Potential | ||||||||
| Topological domain | 249 – 435 | 187 | Cytoplasmic Potential | ||||||||
| Repeat | 42 – 81 | 40 | TNFR-Cys 1 | ||||||||
| Repeat | 82 – 124 | 43 | TNFR-Cys 2 | ||||||||
| Repeat | 125 – 168 | 44 | TNFR-Cys 3 | ||||||||
| Repeat | 169 – 211 | 43 | TNFR-Cys 4 | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 40 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 177 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 43 ↔ 58 | By similarity | |||||||||
| Disulfide bond | 59 ↔ 72 | By similarity | |||||||||
| Disulfide bond | 62 ↔ 80 | By similarity | |||||||||
| Disulfide bond | 83 ↔ 98 | By similarity | |||||||||
| Disulfide bond | 101 ↔ 116 | By similarity | |||||||||
| Disulfide bond | 104 ↔ 124 | By similarity | |||||||||
| Disulfide bond | 126 ↔ 132 | By similarity | |||||||||
| Disulfide bond | 139 ↔ 148 | By similarity | |||||||||
| Disulfide bond | 142 ↔ 167 | By similarity | |||||||||
| Disulfide bond | 170 ↔ 185 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 274 | 1 | V → I: dbSNP rs35681405. | VAR_052346 | |||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid." Baens M., Chaffanet M., Cassiman J.-J., van den Berghe H., Marynen P. Genomics 16:214-218(1993) [PubMed: 8486360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| [3] | "A lymphotoxin-beta-specific receptor." Crowe P.D., VanArsdale T.L., Walter B.N., Ware C.F., Hession C., Ehrenfels B., Browning J.L., Din W.S., Goodwin R.G., Smith C.A. Science 264:707-710(1994) [PubMed: 8171323] [Abstract] Cited for: FUNCTION. |
| [4] | "The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells." Wu M.-Y., Wang P.-Y., Han S.-H., Hsieh S.-L. J. Biol. Chem. 274:11868-11873(1999) [PubMed: 10207006] [Abstract] Cited for: CHARACTERIZATION. |
| [5] | "The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells." Rooney I.A., Butrovich K.D., Glass A.A., Borboroglu S., Benedict C.A., Whitbeck J.C., Cohen G.H., Eisenberg R.J., Ware C.F. J. Biol. Chem. 275:14307-14315(2000) [PubMed: 10799510] [Abstract] Cited for: FUNCTION. |
| [6] | "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor." Nakano H., Oshima H., Chung W., Williams-Abbott L., Ware C.F., Yagita H., Okumura K. J. Biol. Chem. 271:14661-14664(1996) [PubMed: 8663299] [Abstract] Cited for: INTERACTION WITH TRAF3. |
| [7] | "Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor." Matsumoto M., Hsieh T.-Y., Zhu N., VanArsdale T., Hwang S.B., Jeng K.-S., Gorbalenya A.E., Lo S.-Y., Ou J.-H., Ware C.F., Lai M.M.C. J. Virol. 71:1301-1309(1997) [PubMed: 8995654] [Abstract] Cited for: INTERACTION WITH HCV CORE PROTEIN. |
| [8] | "TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues." Krajewska M., Krajewski S., Zapata J.M., VanArsdale T., Gascoyne R.D., Berern K., McFadden D., Shabaik A., Hugh J., Reynolds A., Clevenger C.V., Reed J.C. Am. J. Pathol. 152:1549-1561(1998) [PubMed: 9626059] [Abstract] Cited for: INTERACTION WITH TRAF4. |
| [9] | "Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)." Mizushima S., Fujita M., Ishida T., Azuma S., Kato K., Hirai M., Otsuka M., Yamamoto T., Inoue J. Gene 207:135-140(1998) [PubMed: 9511754] [Abstract] Cited for: INTERACTION WITH TRAF5. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| L04270 mRNA. Translation: AAA36757.1. BC026262 mRNA. Translation: AAH26262.1. | |||||||||||||
| IPI | IPI00006097. | ||||||||||||
| PIR | I54182. | ||||||||||||
| RefSeq | NP_002333.1. | ||||||||||||
| UniGene | Hs.1116 | ||||||||||||
3D structure databases | |||||||||||||
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| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| DIP | DIP:2928N. DIP:6234N. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | P36941. | ||||||||||||
Proteomic databases | |||||||||||||
| PeptideAtlas | P36941. | ||||||||||||
| PRIDE | P36941. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000111321. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 4055. | ||||||||||||
| KEGG | hsa:4055. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneCards | GC12P006363. | ||||||||||||
| H-InvDB | HIX0010362. | ||||||||||||
| HGNC | HGNC:6718. LTBR. | ||||||||||||
| MIM | 600979. gene. | ||||||||||||
| PharmGKB | PA30481. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | P36941. | ||||||||||||
| HOVERGEN | P36941. | ||||||||||||
| OMA | P36941. TNGIHVT. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P36941. | ||||||||||||
| Bgee | P36941. | ||||||||||||
| CleanEx | HS_LTBR. | ||||||||||||
| GermOnline | ENSG00000111321. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR017349. TNFR_3_LTBR. IPR001368. TNFR_Cys_rich_reg. [Graphical view] | ||||||||||||
| Pfam | PF00020. TNFR_c6. 2 hits. [Graphical view] | ||||||||||||
| PIRSF | PIRSF037999. TNFR_3_LTBR. 1 hit. | ||||||||||||
| SMART | SM00208. TNFR. 4 hits. [Graphical view] | ||||||||||||
| PROSITE | PS00652. TNFR_NGFR_1. 2 hits. PS50050. TNFR_NGFR_2. 3 hits. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 15888. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | TNR3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P36941 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


