Tumor necrosis factor receptor superfamily member 3 precursor

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Reviewed, UniProtKB/Swiss-Prot P36941 (TNR3_HUMAN)

Last modified June 16, 2009. Version 92. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Tumor necrosis factor receptor superfamily member 3
Alternative name(s):
    Lymphotoxin-beta receptor
    Tumor necrosis factor receptor 2-related protein
    Tumor necrosis factor C receptor

Gene names

Name:	LTBR
Synonyms:	D12S370, TNFCR, TNFRSF3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. Ref.3 Ref.5
Subunit structure	Self-associates. Associates with TRAF3, TRAF4 and TRAF5. Interacts with HCV core protein. Ref.6 Ref.7 Ref.8 Ref.9
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 4 TNFR-Cys repeats.

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Ontologies

Keywords
Biological process	Apoptosis Host-virus interaction
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from expression pattern. Source: UniProtKB signal transduction Ref.3 Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 30

Potential

Chain

31 – 435

405

Tumor necrosis factor receptor superfamily member 3

PRO_0000034552

Regions

Topological domain

31 – 227

197

Extracellular Potential

Transmembrane

228 – 248

Potential

Topological domain

249 – 435

187

Cytoplasmic Potential

Repeat

42 – 81

TNFR-Cys 1

Repeat

82 – 124

TNFR-Cys 2

Repeat

125 – 168

TNFR-Cys 3

Repeat

169 – 211

TNFR-Cys 4

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

177

N-linked (GlcNAc...) Potential

Disulfide bond

43 ↔ 58

By similarity

Disulfide bond

59 ↔ 72

By similarity

Disulfide bond

62 ↔ 80

By similarity

Disulfide bond

83 ↔ 98

By similarity

Disulfide bond

101 ↔ 116

By similarity

Disulfide bond

104 ↔ 124

By similarity

Disulfide bond

126 ↔ 132

By similarity

Disulfide bond

139 ↔ 148

By similarity

Disulfide bond

142 ↔ 167

By similarity

Disulfide bond

170 ↔ 185

By similarity

Natural variations

Natural variant

274

V → I: dbSNP rs35681405.

VAR_052346

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Sequences

Sequence

Length

Mass (Da)

Tools

P36941-1 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 624626E6022F656F
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FASTA

435

46,709

        10         20         30         40         50         60 
MLLPWATSAP GLAWGPLVLG LFGLLAASQP QAVPPYASEN QTCRDQEKEY YEPQHRICCS 

        70         80         90        100        110        120 
RCPPGTYVSA KCSRIRDTVC ATCAENSYNE HWNYLTICQL CRPCDPVMGL EEIAPCTSKR 

       130        140        150        160        170        180 
KTQCRCQPGM FCAAWALECT HCELLSDCPP GTEAELKDEV GKGNNHCVPC KAGHFQNTSS 

       190        200        210        220        230        240 
PSARCQPHTR CENQGLVEAA PGTAQSDTTC KNPLEPLPPE MSGTMLMLAV LLPLAFFLLL 

       250        260        270        280        290        300 
ATVFSCIWKS HPSLCRKLGS LLKRRPQGEG PNPVAGSWEP PKAHPYFPDL VQPLLPISGD 

       310        320        330        340        350        360 
VSPVSTGLPA APVLEAGVPQ QQSPLDLTRE PQLEPGEQSQ VAHGTNGIHV TGGSMTITGN 

       370        380        390        400        410        420 
IYIYNGPVLG GPPGPGDLPA TPEPPYPIPE EGDPGPPGLS TPHQEDGKAW HLAETEHCGA 

       430 
TPSNRGPRNQ FITHD

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid." Baens M., Chaffanet M., Cassiman J.-J., van den Berghe H., Marynen P. Genomics 16:214-218(1993) [PubMed: 8486360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"A lymphotoxin-beta-specific receptor." Crowe P.D., VanArsdale T.L., Walter B.N., Ware C.F., Hession C., Ehrenfels B., Browning J.L., Din W.S., Goodwin R.G., Smith C.A. Science 264:707-710(1994) [PubMed: 8171323] [Abstract] Cited for: FUNCTION.
[4]	"The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells." Wu M.-Y., Wang P.-Y., Han S.-H., Hsieh S.-L. J. Biol. Chem. 274:11868-11873(1999) [PubMed: 10207006] [Abstract] Cited for: CHARACTERIZATION.
[5]	"The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells." Rooney I.A., Butrovich K.D., Glass A.A., Borboroglu S., Benedict C.A., Whitbeck J.C., Cohen G.H., Eisenberg R.J., Ware C.F. J. Biol. Chem. 275:14307-14315(2000) [PubMed: 10799510] [Abstract] Cited for: FUNCTION.
[6]	"TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor." Nakano H., Oshima H., Chung W., Williams-Abbott L., Ware C.F., Yagita H., Okumura K. J. Biol. Chem. 271:14661-14664(1996) [PubMed: 8663299] [Abstract] Cited for: INTERACTION WITH TRAF3.
[7]	"Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor." Matsumoto M., Hsieh T.-Y., Zhu N., VanArsdale T., Hwang S.B., Jeng K.-S., Gorbalenya A.E., Lo S.-Y., Ou J.-H., Ware C.F., Lai M.M.C. J. Virol. 71:1301-1309(1997) [PubMed: 8995654] [Abstract] Cited for: INTERACTION WITH HCV CORE PROTEIN.
[8]	"TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues." Krajewska M., Krajewski S., Zapata J.M., VanArsdale T., Gascoyne R.D., Berern K., McFadden D., Shabaik A., Hugh J., Reynolds A., Clevenger C.V., Reed J.C. Am. J. Pathol. 152:1549-1561(1998) [PubMed: 9626059] [Abstract] Cited for: INTERACTION WITH TRAF4.
[9]	"Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)." Mizushima S., Fujita M., Ishida T., Azuma S., Kato K., Hirai M., Otsuka M., Yamamoto T., Inoue J. Gene 207:135-140(1998) [PubMed: 9511754] [Abstract] Cited for: INTERACTION WITH TRAF5.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

L04270 mRNA. Translation: AAA36757.1.
BC026262 mRNA. Translation: AAH26262.1.

IPI

IPI00006097.

PIR

I54182.

RefSeq

NP_002333.1.

UniGene

Hs.1116

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1RF3	X-ray	3.50	B	385-408	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:2928N.
DIP:6234N.

PTM databases

PhosphoSite

P36941.

Proteomic databases

PeptideAtlas

P36941.

PRIDE

P36941.

Genome annotation databases

Ensembl

ENSG00000111321. Homo sapiens. [Contig view]

GeneID

4055.

KEGG

hsa:4055.

Organism-specific databases

GeneCards

GC12P006363.

H-InvDB

HIX0010362.

HGNC

HGNC:6718. LTBR.

MIM

600979. gene.

PharmGKB

PA30481.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P36941.

HOVERGEN

P36941.

OMA

P36941. TNGIHVT.

Gene expression databases

ArrayExpress

P36941.

Bgee

P36941.

CleanEx

HS_LTBR.

GermOnline

ENSG00000111321. Homo sapiens.

Family and domain databases

InterPro

IPR017349. TNFR_3_LTBR.
IPR001368. TNFR_Cys_rich_reg.
[Graphical view]

Pfam

PF00020. TNFR_c6. 2 hits.
[Graphical view]

PIRSF

PIRSF037999. TNFR_3_LTBR. 1 hit.

SMART

SM00208. TNFR. 4 hits.
[Graphical view]

PROSITE

PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

15888.

SOURCE

Search...

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Entry information

Entry name

TNR3_HUMAN

Accession

Primary (citable) accession number: P36941

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	June 16, 2009
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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