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Protein

Potassium-transporting ATPase KdpF subunit

Gene

kdpF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm (PubMed:23930894). This subunit may be involved in stabilization of the complex (PubMed:10608856).2 Publications

GO - Molecular functioni

  • potassium-transporting ATPase activity Source: EcoCyc

GO - Biological processi

  • regulation of ATPase activity Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-12.
ECOL316407:JW0687-MONOMER.
MetaCyc:MONOMER0-12.

Protein family/group databases

TCDBi3.A.3.7.1. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase KdpF subunitCurated
Alternative name(s):
ATP phosphohydrolase [potassium-transporting] F chainCurated
Potassium-binding and translocating subunit FCurated
Potassium-translocating ATPase F chainCurated
Gene namesi
Name:kdpF
Ordered Locus Names:b4513, JW0687
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12126. kdpF.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Inactivation of kdpF still leads to a functional KdpABC complex in vivo. Deletion impairs ATPase activity of the complex in vitro.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000842991 – 29Potassium-transporting ATPase KdpF subunitAdd BLAST29

Proteomic databases

PaxDbiP36937.

Expressioni

Inductioni

Transcriptionally regulated by the KdpD/KdpE two-component regulatory system.1 Publication

Interactioni

Subunit structurei

The system is composed of three essential subunits: KdpA, KdpB and KdpC (PubMed:10608856). The complex also contains KdpF, a small non-essential subunit (PubMed:10608856). The KdpFABC complex exists as a dimer above concentrations of 30-50 nM, whereas the complex exists as a functional monomer at lower concentrations (PubMed:18298081).2 Publications

Protein-protein interaction databases

BioGridi4259926. 3 interactors.
STRINGi511145.b4513.

Family & Domainsi

Sequence similaritiesi

Belongs to the KdpF family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01545.

Family and domain databases

InterProiIPR011726. KdpF.
[Graphical view]
PfamiPF09604. Potass_KdpF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02115. potass_kdpF. 1 hit.

Sequencei

Sequence statusi: Complete.

P36937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
MSAGVITGVL LVFLLLGYLV YALINAEAF
Length:29
Mass (Da):3,072
Last modified:June 1, 1994 - v1
Checksum:iA925E36F96B17820
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02670 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: ABD18643.1.
AP009048 Genomic DNA. Translation: BAA35357.1.
PIRiT48910.
RefSeqiWP_001272653.1. NZ_LN832404.1.
YP_588443.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiABD18643; ABD18643; b4513.
BAA35357; BAA35357; BAA35357.
GeneIDi948946.
KEGGiecj:JW0687.
eco:b4513.
PATRICi32116593. VBIEscCol129921_0729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02670 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: ABD18643.1.
AP009048 Genomic DNA. Translation: BAA35357.1.
PIRiT48910.
RefSeqiWP_001272653.1. NZ_LN832404.1.
YP_588443.1. NC_000913.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259926. 3 interactors.
STRINGi511145.b4513.

Protein family/group databases

TCDBi3.A.3.7.1. the p-type atpase (p-atpase) superfamily.

Proteomic databases

PaxDbiP36937.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD18643; ABD18643; b4513.
BAA35357; BAA35357; BAA35357.
GeneIDi948946.
KEGGiecj:JW0687.
eco:b4513.
PATRICi32116593. VBIEscCol129921_0729.

Organism-specific databases

EchoBASEiEB2047.
EcoGeneiEG12126. kdpF.

Phylogenomic databases

KOiK01545.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-12.
ECOL316407:JW0687-MONOMER.
MetaCyc:MONOMER0-12.

Miscellaneous databases

PROiP36937.

Family and domain databases

InterProiIPR011726. KdpF.
[Graphical view]
PfamiPF09604. Potass_KdpF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02115. potass_kdpF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKDPF_ECOLI
AccessioniPrimary (citable) accession number: P36937
Secondary accession number(s): Q2EEQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.