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Protein

Galactitol utilization operon repressor

Gene

gatR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Repressor of the gat operon for galacticol transport and metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi22 – 41H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD00338.
EcoCyc:PD02366.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactitol utilization operon repressor
Gene namesi
Name:gatR
Ordered Locus Names:b4498, JW5340/JW2074
ORF Names:b2087/b2090
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12162. gatR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000502501 – 259Galactitol utilization operon repressorAdd BLAST259

Interactioni

Protein-protein interaction databases

IntActiP36930. 8 interactors.

Structurei

3D structure databases

ProteinModelPortaliP36930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 60HTH deoR-typePROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Contains 1 HTH deoR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000224684.
InParanoidiP36930.
PhylomeDBiP36930.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR014036. DeoR_C.
IPR001034. DeoR_HTH.
IPR018356. Tscrpt_reg_HTH_DeoR_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00455. DeoRC. 1 hit.
PF08220. HTH_DeoR. 1 hit.
[Graphical view]
PRINTSiPR00037. HTHLACR.
SMARTiSM00420. HTH_DEOR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00894. HTH_DEOR_1. 1 hit.
PS51000. HTH_DEOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMNSFERRN KIIQLVNEQG TVLVQDLAGV FAASEATIRA DLRFLEQKGV
60 70 80 90 100
VTRFHGGAAK IMSGNSETET QEVGFKERFQ LASAPKNRIA QAAVKMIHEG
110 120 130 140 150
MTVILDSGST TMLIAEGLMT AKNITVITNS LPAAFALSEN KDITLVVCGG
160 170 180 190 200
TVRHKTRSMH GSIAERSLQD INADLMFVGA DGIDAVNGIT TFNEGYSISG
210 220 230 240 250
AMVTAANKVI AVLDSSKFNR RGFNQVLPIE KIDIIITDDA VSEVDKLALQ

KTRVKLITV
Length:259
Mass (Da):27,959
Last modified:November 1, 1997 - v2
Checksum:iAE3403E0871F1D57
GO

Sequence cautioni

The sequence D12598 differs from that shown. Reason: Frameshift at position 117.Curated
The sequence X64217 differs from that shown. Reason: Frameshift at position 117.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23L → Q in D12598 (Ref. 5) Curated1
Sequence conflicti99E → V in X64218 (PubMed:1661252).Curated1
Sequence conflicti102T → TT in D12598 (Ref. 5) Curated1
Sequence conflicti129 – 131NSL → HLA in X64217 (PubMed:1661252).Curated3
Sequence conflicti149G → C in D12598 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. No translation available.
X79837 Genomic DNA. Translation: CAA56232.1.
D12598 Genomic DNA. No translation available.
X64217 Genomic DNA. No translation available.
X64218 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. No translation available.
X79837 Genomic DNA. Translation: CAA56232.1.
D12598 Genomic DNA. No translation available.
X64217 Genomic DNA. No translation available.
X64218 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliP36930.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP36930. 8 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

EchoBASEiEB2081.
EcoGeneiEG12162. gatR.

Phylogenomic databases

HOGENOMiHOG000224684.
InParanoidiP36930.
PhylomeDBiP36930.

Enzyme and pathway databases

BioCyciEcoCyc:PD00338.
EcoCyc:PD02366.

Miscellaneous databases

PROiP36930.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR014036. DeoR_C.
IPR001034. DeoR_HTH.
IPR018356. Tscrpt_reg_HTH_DeoR_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00455. DeoRC. 1 hit.
PF08220. HTH_DeoR. 1 hit.
[Graphical view]
PRINTSiPR00037. HTHLACR.
SMARTiSM00420. HTH_DEOR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00894. HTH_DEOR_1. 1 hit.
PS51000. HTH_DEOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGATR_ECOLI
AccessioniPrimary (citable) accession number: P36930
Secondary accession number(s): P76408, P76409
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

In E.coli K12, an insertion sequence (IS3E) is inserted in the gatR gene in position 102.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.