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Reviewed, UniProtKB/Swiss-Prot P36923 (AROD_ENTFA)

Last modified June 16, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    3-dehydroquinate dehydratase
      Short name=3-dehydroquinase
    EC=4.2.1.10
Alternative name(s):
    Type I DHQase
Gene names
Name: aroD
Synonyms: ebsD
Ordered Locus Names: EF_1731
OrganismEnterococcus faecalis (Streptococcus faecalis) [Complete proteome] [HAMAP]
Taxonomic identifier1351 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesEnterococcaceaeEnterococcus

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Molecular function3-dehydroquinate dehydratase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2532533-dehydroquinate dehydratase HAMAP MF_00214
PRO_0000138843

Sites

Active site1431Proton acceptor By similarity
Active site1701Schiff-base intermediate with substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P36923-1 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: F8F1436A80906B02

FASTA25328,085
        10         20         30         40         50         60 
MKPVIVKNVR IGEGNPKIVV PIVAPTAEDI LAEATASQTL DCDLVEWRLD YYENVADFSD 

        70         80         90        100        110        120 
VCNLSQQVME RLGQKPLLLT FRTQKEGGEM AFSEENYFAL YHELVKKGAL DLLDIELFAN 

       130        140        150        160        170        180 
PLAADTLIHE AKKAGIKIVL CNHDFQKTPS QEEIVARLRQ MQMRQADICK IAVMPQDATD 

       190        200        210        220        230        240 
VLTLLSATNE MYTHYASVPI VTMSMGQLGM ISRVTGQLFG SALTFGSAQQ ASAPGQLSVQ 

       250 
VLRNYLKTFE QNK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and molecular analysis of genes affecting expression of binding substance, the recipient-encoded receptor(s) mediating mating aggregate formation in Enterococcus faecalis."
Bensing B.A., Dunny G.M.
J. Bacteriol. 175:7421-7429(1993) [PubMed: 8226689] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: OG1SSP.
[2]"Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis."
Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin S.A. expand/collapse author list , Kolonay J.F., Madupu R., Nelson W.C., Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M., Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.
Science 299:2071-2074(2003) [PubMed: 12663927] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: V583 / ATCC 700802.

Cross-references

Sequence databases

L23802 Unassigned DNA. Translation: AAC36854.1.
AE016830 Genomic DNA. Translation: AAO81505.1.
PIRD49939.
RefSeqNP_815435.1.

3D structure databases

HSSPHSSP built from PDB template 1L9W based on UniProtKB P24670.
ModBaseSearch...

Genome annotation databases

GeneID1200622.
GenomeReviewsGene locus EF_1731 in contig AE016830_GR.
KEGGefa:EF1731.
NMPDRfig|226185.1.peg.1620.
TIGREF_1731.

Phylogenomic databases

HOGENOMP36923.
OMAP36923. MSNHDFD.

Enzyme and pathway databases

BioCycEFAE226185:EF_1731-MON.
BRENDA4.2.1.10. 704.

Family and domain databases

HAMAPMF_00214.
[Tree]
InterProIPR018508. 3-dehydroquinate_DH_AS.
IPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF01487. DHquinase_I. 1 hit.
[Graphical view]
ProDomPD005337. DHquinase_I. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01093. aroD. 1 hit.
PROSITEPS01028. DEHYDROQUINASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROD_ENTFA
AccessionPrimary (citable) accession number: P36923
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 16, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents