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Protein

Guanine nucleotide-binding protein-like 1

Gene

Gnl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Possible regulatory or functional link with the histocompatibility cluster.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi225 – 228GTPSequence analysis4
Nucleotide bindingi367 – 374GTPSequence analysis8
Nucleotide bindingi411 – 415GTPSequence analysis5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein-like 1
Alternative name(s):
GTP-binding protein MMR1
Gene namesi
Name:Gnl1
Synonyms:Gna-rs1, Mmr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95764. Gnl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224421 – 607Guanine nucleotide-binding protein-like 1Add BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineBy similarity1
Modified residuei33PhosphoserineBy similarity1
Modified residuei34PhosphoserineCombined sources1
Modified residuei48PhosphothreonineBy similarity1
Modified residuei50PhosphothreonineBy similarity1
Modified residuei51PhosphoserineBy similarity1
Modified residuei68PhosphoserineBy similarity1
Modified residuei324PhosphoserineCombined sources1
Modified residuei561PhosphoserineBy similarity1
Modified residuei562PhosphoserineBy similarity1
Modified residuei563PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP36916.
MaxQBiP36916.
PaxDbiP36916.
PeptideAtlasiP36916.
PRIDEiP36916.

PTM databases

iPTMnetiP36916.
PhosphoSitePlusiP36916.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024429.
GenevisibleiP36916. MM.

Interactioni

Protein-protein interaction databases

BioGridi199960. 1 interactor.
STRINGi10090.ENSMUSP00000084450.

Structurei

3D structure databases

ProteinModelPortaliP36916.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 418CP-type GPROSITE-ProRule annotationAdd BLAST241

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi551 – 607Asp/Glu-rich (highly acidic)Add BLAST57

Domaini

In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family.PROSITE-ProRule annotation
Contains 1 CP-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1424. Eukaryota.
COG1161. LUCA.
GeneTreeiENSGT00530000063453.
HOGENOMiHOG000007598.
HOVERGENiHBG005865.
InParanoidiP36916.
OMAiKYLRSTQ.
OrthoDBiEOG091G06S0.
TreeFamiTF324569.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR030378. G_CP_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P36916-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRKKPFSVK QKKKQLQDKR ERKRGLQDGL RSSSNSRSGS RERREEQTDT
60 70 80 90 100
SDGESVTHHI RRLNQQPSQG LGPRGYDPNR YRLHFERDSR EEVERRKRAA
110 120 130 140 150
REQVLQPVSA EVLELDIREV YQPGSVLDFP RRPPWSYEMS KEQLMSQEER
160 170 180 190 200
SFQEYLGKIH GAYTSEKLSY FEHNLETWRQ LWRVLEMSDI VLLITDIRHP
210 220 230 240 250
VVNFPPALYE YVTGELGLAL VLVLNKVDLA PPALVVAWKH YFHQCYPQLH
260 270 280 290 300
IVLFTSFPRD TRTPQEPGGV LKKNRRRGKG WTRALGPEQL LRACEAITVG
310 320 330 340 350
KVDLSSWREK IARDVAGASW GNVSGEEEEE EDGPAVLVEQ LTDSAMEPTG
360 370 380 390 400
PSRERYKDGV VTIGCIGFPN VGKSSLINGL VGRKVVSVSR TPGHTRYFQT
410 420 430 440 450
YFLTPSVKLC DCPGLIFPSL LPRQLQVLAG IYPIAQIQEP YTSVGYLASR
460 470 480 490 500
IPVQALLHLR HPEAEDPSAE HPWCAWDICE AWAEKRGYKT AKAARNDVYR
510 520 530 540 550
AANSLLRLAV DGRLSLCFYP PGYSEQRGTW ESHPETAELV LSQGRVGPAG
560 570 580 590 600
DEEEEEEEEL SSSCEEEGEE DRDADEEGEG DEDTPTSDPG SCLTARNPYA

LLGEDEC
Length:607
Mass (Da):68,771
Last modified:July 27, 2011 - v4
Checksum:i10D417265D727082
GO
Isoform 2 (identifier: P36916-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-177: Missing.
     178-183: WRQLWR → MEAAVA

Show »
Length:430
Mass (Da):47,402
Checksum:iA1E267C0C58CAF28
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti245C → R in CAA46160 (PubMed:1478666).Curated1
Sequence conflicti245C → R in AAH10298 (PubMed:15489334).Curated1
Sequence conflicti310K → Q in CAA46160 (PubMed:1478666).Curated1
Sequence conflicti491A → R in CAA46160 (PubMed:1478666).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0269941 – 177Missing in isoform 2. 1 PublicationAdd BLAST177
Alternative sequenceiVSP_026995178 – 183WRQLWR → MEAAVA in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65026 mRNA. Translation: CAA46160.1.
AC112970 Genomic DNA. No translation available.
BC010298 mRNA. Translation: AAH10298.1.
CCDSiCCDS37606.1. [P36916-1]
RefSeqiNP_032162.2. NM_008136.2. [P36916-1]
UniGeneiMm.335754.

Genome annotation databases

EnsembliENSMUST00000087200; ENSMUSP00000084450; ENSMUSG00000024429. [P36916-1]
GeneIDi14670.
KEGGimmu:14670.
UCSCiuc008cjo.1. mouse. [P36916-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65026 mRNA. Translation: CAA46160.1.
AC112970 Genomic DNA. No translation available.
BC010298 mRNA. Translation: AAH10298.1.
CCDSiCCDS37606.1. [P36916-1]
RefSeqiNP_032162.2. NM_008136.2. [P36916-1]
UniGeneiMm.335754.

3D structure databases

ProteinModelPortaliP36916.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199960. 1 interactor.
STRINGi10090.ENSMUSP00000084450.

PTM databases

iPTMnetiP36916.
PhosphoSitePlusiP36916.

Proteomic databases

EPDiP36916.
MaxQBiP36916.
PaxDbiP36916.
PeptideAtlasiP36916.
PRIDEiP36916.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087200; ENSMUSP00000084450; ENSMUSG00000024429. [P36916-1]
GeneIDi14670.
KEGGimmu:14670.
UCSCiuc008cjo.1. mouse. [P36916-1]

Organism-specific databases

CTDi2794.
MGIiMGI:95764. Gnl1.

Phylogenomic databases

eggNOGiKOG1424. Eukaryota.
COG1161. LUCA.
GeneTreeiENSGT00530000063453.
HOGENOMiHOG000007598.
HOVERGENiHBG005865.
InParanoidiP36916.
OMAiKYLRSTQ.
OrthoDBiEOG091G06S0.
TreeFamiTF324569.

Miscellaneous databases

PROiP36916.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024429.
GenevisibleiP36916. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR030378. G_CP_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGNL1_MOUSE
AccessioniPrimary (citable) accession number: P36916
Secondary accession number(s): E9QPZ9, Q91Z20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 121 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.