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Protein

Chitinase C

Gene

chiC

Organism
Streptomyces lividans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei382 – 3821Proton donorPROSITE-ProRule annotation

GO - Molecular functioni

  1. chitinase activity Source: UniProtKB-EC
  2. chitin binding Source: UniProtKB-KW
  3. polysaccharide binding Source: InterPro

GO - Biological processi

  1. chitin catabolic process Source: UniProtKB-KW
  2. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Chitin degradation, Polysaccharide degradation

Keywords - Ligandi

Chitin-binding

Protein family/group databases

CAZyiCBM2. Carbohydrate-Binding Module Family 2.
GH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Chitinase C (EC:3.2.1.14)
Gene namesi
Name:chiC
OrganismiStreptomyces lividans
Taxonomic identifieri1916 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 619589Chitinase CPRO_0000011911Add
BLAST

Expressioni

Inductioni

By chitin.

Structurei

3D structure databases

ProteinModelPortaliP36909.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 134104CBM2Add
BLAST
Domaini144 – 22986Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni240 – 619380CatalyticAdd
BLAST

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.290. 1 hit.
3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR018366. CBM2_CS.
IPR001919. Cellulose-bd_dom_fam2_bac.
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR003961. FN3_dom.
IPR001223. Glyco_hydro18cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00553. CBM_2. 1 hit.
PF00041. fn3. 1 hit.
PF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00637. CBD_II. 1 hit.
SM00060. FN3. 1 hit.
SM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
PROSITEiPS51173. CBM2. 1 hit.
PS00561. CBM2_A. 1 hit.
PS01095. CHITINASE_18. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36909-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRFRHKAAAL AATLALPLAG LVGLASPAQA ATSATATFAK TSDWGTGFGG
60 70 80 90 100
SWTVKNTGTT SLSSWTVEWD FPTGTKVTSA WDATVTNSGD HWTAKNVGWN
110 120 130 140 150
GTLAPGASVS FGFNGSGPGS PSNCKLNGGS CDGTSVPGDA APSAPGTPTA
160 170 180 190 200
SNITDTSVKL SWSAATDDKG VKNYDVLRDG AKVATVTGTT YTDNGLTKGT
210 220 230 240 250
AYSYSVKARD TADQTGPASG AVKVTTTGGG DGGNPGTGAE VKMGYFTNWG
260 270 280 290 300
VYGRNYHVKN LVTSGSADKI THINYAFGNV QGGKCTIGDS YADYDKAYTA
310 320 330 340 350
DQSVDGVADT WDQPLRGNFN QLRKLKAKYP NIKILYSFGG WTWSGGFPDA
360 370 380 390 400
VKNPAAFAKS CHDLVEDPRW ADVFDGIDLD WEYPNACGLS CDETSAPNAF
410 420 430 440 450
SSMMKAMRAE FGQDYLITAA VTADGSDGGK IDAADYGEAS KYIDWYNVMT
460 470 480 490 500
YDFFGAWAKN GPTAPHSPLT AYDGIPQQGF NTADAMAKFK SKGVPADKLL
510 520 530 540 550
IGIGFYGRGW TGVTQSAPGG TATGPATGTY EAGIEDYKVL KNSCPATGTI
560 570 580 590 600
AGTAYAHCGS NWWSYDTPAT IKSKMDWAEQ QGLGGAFFWE FSGDTANGDW
610
WRHRQRPQVT PAVRTTRRH
Length:619
Mass (Da):65,200
Last modified:June 1, 1994 - v1
Checksum:iA23CEE5B3C5D6F21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12647 Genomic DNA. Translation: BAA02168.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12647 Genomic DNA. Translation: BAA02168.1.

3D structure databases

ProteinModelPortaliP36909.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM2. Carbohydrate-Binding Module Family 2.
GH18. Glycoside Hydrolase Family 18.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.290. 1 hit.
3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR018366. CBM2_CS.
IPR001919. Cellulose-bd_dom_fam2_bac.
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR003961. FN3_dom.
IPR001223. Glyco_hydro18cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00553. CBM_2. 1 hit.
PF00041. fn3. 1 hit.
PF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00637. CBD_II. 1 hit.
SM00060. FN3. 1 hit.
SM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
PROSITEiPS51173. CBM2. 1 hit.
PS00561. CBM2_A. 1 hit.
PS01095. CHITINASE_18. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Multiple domain structure in a chitinase gene (chiC) of Streptomyces lividans."
    Fujii T., Miyashita K.
    J. Gen. Microbiol. 139:677-686(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCHIT_STRLI
AccessioniPrimary (citable) accession number: P36909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.