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P36898

- BMR1B_MOUSE

UniProt

P36898 - BMR1B_MOUSE

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Protein

Bone morphogenetic protein receptor type-1B

Gene

Bmpr1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Magnesium or manganese.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei231 – 2311ATPPROSITE-ProRule annotation
Active sitei332 – 3321Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi210 – 2189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. receptor signaling protein serine/threonine kinase activity Source: InterPro
  4. transforming growth factor beta-activated receptor activity Source: MGI
  5. transforming growth factor beta receptor activity, type I Source: MGI

GO - Biological processi

  1. BMP signaling pathway Source: MGI
  2. camera-type eye development Source: MGI
  3. cartilage condensation Source: MGI
  4. cell differentiation Source: MGI
  5. chondrocyte differentiation Source: MGI
  6. dorsal/ventral pattern formation Source: MGI
  7. estrogen biosynthetic process Source: UniProtKB
  8. eye development Source: MGI
  9. inflammatory response Source: UniProtKB
  10. limb morphogenesis Source: Ensembl
  11. ovarian cumulus expansion Source: UniProtKB
  12. ovulation cycle Source: UniProtKB
  13. positive regulation of bone mineralization Source: Ensembl
  14. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  15. positive regulation of osteoblast differentiation Source: Ensembl
  16. retina development in camera-type eye Source: MGI
  17. retinal ganglion cell axon guidance Source: MGI
  18. transforming growth factor beta receptor signaling pathway Source: MGI
  19. transmembrane receptor protein serine/threonine kinase signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Chondrogenesis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.
ReactomeiREACT_220505. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein receptor type-1B (EC:2.7.11.30)
Short name:
BMP type-1B receptor
Short name:
BMPR-1B
Alternative name(s):
Activin receptor-like kinase 6
Short name:
ALK-6
Serine/threonine-protein kinase receptor R6
Short name:
SKR6
CD_antigen: CDw293
Gene namesi
Name:Bmpr1b
Synonyms:Acvrlk6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:107191. Bmpr1b.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1313Sequence AnalysisAdd
BLAST
Chaini14 – 502489Bone morphogenetic protein receptor type-1BPRO_0000024413Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 531 Publication
Disulfide bondi34 ↔ 381 Publication
Disulfide bondi47 ↔ 711 Publication
Disulfide bondi81 ↔ 951 Publication
Disulfide bondi96 ↔ 1021 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP36898.
PRIDEiP36898.

PTM databases

PhosphoSiteiP36898.

Expressioni

Gene expression databases

BgeeiP36898.
CleanExiMM_BMPR1B.
ExpressionAtlasiP36898. baseline and differential.
GenevestigatoriP36898.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Smad6O351822EBI-7107883,EBI-4321242

Protein-protein interaction databases

DIPiDIP-252N.
IntActiP36898. 1 interaction.
MINTiMINT-124245.

Structurei

Secondary structure

1
502
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 334
Beta strandi35 – 373
Beta strandi46 – 5914
Beta strandi64 – 729
Helixi77 – 804
Beta strandi91 – 966
Helixi102 – 1054

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EVSX-ray2.10C14-126[»]
ProteinModelPortaliP36898.
SMRiP36898. Positions 29-113, 174-500.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36898.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini14 – 126113ExtracellularSequence AnalysisAdd
BLAST
Topological domaini149 – 502354CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei127 – 14822HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 20330GSPROSITE-ProRule annotationAdd
BLAST
Domaini204 – 494291Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GS domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiP36898.
KOiK13578.
OMAiLRCKCHH.
OrthoDBiEOG7Q8CN3.
PhylomeDBiP36898.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36898-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLRSSGKLN VGTKKEDGES TAPTPRPKIL RCKCHHHCPE DSVNNICSTD
60 70 80 90 100
GYCFTMIEED DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN
110 120 130 140 150
ECNKDLHPTL PPLKDRDFVD GPIHHKALLI SVTVCSLLLV LIILFCYFRY
160 170 180 190 200
KRQEARPRYS IGLEQDETYI PPGESLRDLI EQSQSSGSGS GLPLLVQRTI
210 220 230 240 250
AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT
260 270 280 290 300
VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDAKS
310 320 330 340 350
MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD
360 370 380 390 400
LGLAVKFISD TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM
410 420 430 440 450
YSFGLILWEI ARRCVSGGIV EEYQLPYHDL VPSDPSYEDM REIVCMKKLR
460 470 480 490 500
PSFPNRWSSD ECLRQMGKLM TECWAQNPAS RLTALRVKKT LAKMSESQDI

KL
Length:502
Mass (Da):56,944
Last modified:June 1, 1994 - v1
Checksum:iAB29681F3FF5A361
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z23143 mRNA. Translation: CAA80674.1.
AK086130 mRNA. Translation: BAC39617.1.
AK162844 mRNA. Translation: BAE37078.1.
BC065106 mRNA. Translation: AAH65106.1.
BC065143 mRNA. Translation: AAH65143.1.
CCDSiCCDS17874.1.
PIRiA53444.
RefSeqiNP_001264145.1. NM_001277216.1.
NP_001264146.1. NM_001277217.1.
NP_001264147.1. NM_001277218.1.
NP_001264149.1. NM_001277220.1.
NP_031586.1. NM_007560.4.
XP_006501002.1. XM_006500939.1.
XP_006501003.1. XM_006500940.1.
XP_006501004.1. XM_006500941.1.
XP_006501005.1. XM_006500942.1.
XP_006501006.1. XM_006500943.1.
XP_006501007.1. XM_006500944.1.
XP_006501008.1. XM_006500945.1.
UniGeneiMm.39089.

Genome annotation databases

EnsembliENSMUST00000029948; ENSMUSP00000029948; ENSMUSG00000052430.
ENSMUST00000098568; ENSMUSP00000096167; ENSMUSG00000052430.
ENSMUST00000106230; ENSMUSP00000101837; ENSMUSG00000052430.
ENSMUST00000106232; ENSMUSP00000101839; ENSMUSG00000052430.
GeneIDi12167.
KEGGimmu:12167.
UCSCiuc008rog.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z23143 mRNA. Translation: CAA80674.1 .
AK086130 mRNA. Translation: BAC39617.1 .
AK162844 mRNA. Translation: BAE37078.1 .
BC065106 mRNA. Translation: AAH65106.1 .
BC065143 mRNA. Translation: AAH65143.1 .
CCDSi CCDS17874.1.
PIRi A53444.
RefSeqi NP_001264145.1. NM_001277216.1.
NP_001264146.1. NM_001277217.1.
NP_001264147.1. NM_001277218.1.
NP_001264149.1. NM_001277220.1.
NP_031586.1. NM_007560.4.
XP_006501002.1. XM_006500939.1.
XP_006501003.1. XM_006500940.1.
XP_006501004.1. XM_006500941.1.
XP_006501005.1. XM_006500942.1.
XP_006501006.1. XM_006500943.1.
XP_006501007.1. XM_006500944.1.
XP_006501008.1. XM_006500945.1.
UniGenei Mm.39089.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3EVS X-ray 2.10 C 14-126 [» ]
ProteinModelPortali P36898.
SMRi P36898. Positions 29-113, 174-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-252N.
IntActi P36898. 1 interaction.
MINTi MINT-124245.

PTM databases

PhosphoSitei P36898.

Proteomic databases

PaxDbi P36898.
PRIDEi P36898.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029948 ; ENSMUSP00000029948 ; ENSMUSG00000052430 .
ENSMUST00000098568 ; ENSMUSP00000096167 ; ENSMUSG00000052430 .
ENSMUST00000106230 ; ENSMUSP00000101837 ; ENSMUSG00000052430 .
ENSMUST00000106232 ; ENSMUSP00000101839 ; ENSMUSG00000052430 .
GeneIDi 12167.
KEGGi mmu:12167.
UCSCi uc008rog.1. mouse.

Organism-specific databases

CTDi 658.
MGIi MGI:107191. Bmpr1b.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118876.
HOGENOMi HOG000230587.
HOVERGENi HBG054502.
InParanoidi P36898.
KOi K13578.
OMAi LRCKCHH.
OrthoDBi EOG7Q8CN3.
PhylomeDBi P36898.
TreeFami TF314724.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 3474.
Reactomei REACT_220505. Signaling by BMP.

Miscellaneous databases

ChiTaRSi BMPR1B. mouse.
EvolutionaryTracei P36898.
NextBioi 280535.
PROi P36898.
SOURCEi Search...

Gene expression databases

Bgeei P36898.
CleanExi MM_BMPR1B.
ExpressionAtlasi P36898. baseline and differential.
Genevestigatori P36898.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of type I receptors for transforming growth factor-beta and activin."
    ten Dijke P., Yamashita H., Ichijo H., Franzen P., Laiho M., Miyazono K., Heldin C.-H.
    Science 264:101-104(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Hypothalamus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Retina.
  4. "Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity."
    Kotzsch A., Nickel J., Seher A., Sebald W., Muller T.D.
    EMBO J. 28:937-947(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 14-126 IN COMPLEX WITH HUMAN GDF5, DISULFIDE BONDS.

Entry informationi

Entry nameiBMR1B_MOUSE
AccessioniPrimary (citable) accession number: P36898
Secondary accession number(s): Q3TRF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3