Reviewed,
UniProtKB/Swiss-Prot P36898 (BMR1B_MOUSE)
Last modified
July 22, 2008.
Version 86.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Bone morphogenetic protein receptor type-1B EC=2.7.11.30 Alternative name(s): Serine/threonine-protein kinase receptor R6 Short name=SKR6 Activin receptor-like kinase 6 Short name=ALK-6 CD_antigen=CDw293 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 502 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1. |
| Catalytic activity | ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. |
| Cofactor | Magnesium or manganese By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 13 | 13 | Potential | |||||
| Chain | 14 – 502 | 489 | Bone morphogenetic protein receptor type-1B | |||||
Regions | ||||||||
| Topological domain | 14 – 126 | 113 | Extracellular Potential | |||||
| Transmembrane | 127 – 148 | 22 | Potential | |||||
| Topological domain | 149 – 502 | 354 | Cytoplasmic Potential | |||||
| Domain | 174 – 203 | 30 | GS | |||||
| Domain | 204 – 494 | 291 | Protein kinase | |||||
| Nucleotide binding | 210 – 218 | 9 | ATP By similarity | |||||
Sites | ||||||||
| Active site | 332 | 1 | Proton acceptor By similarity | |||||
| Binding site | 231 | 1 | ATP By similarity | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of type I receptors for transforming growth factor-beta and activin." ten Dijke P., Yamashita H., Ichijo H., Franzen P., Laiho M., Miyazono K., Heldin C.-H. Science 264:101-104(1994) [PubMed: 8140412] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Head and Hypothalamus. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain and Retina. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Z23143 mRNA. Translation: CAA80674.1. AK086130 mRNA. Translation: BAC39617.1. AK162844 mRNA. Translation: BAE37078.1. BC065106 mRNA. Translation: AAH65106.1. BC065143 mRNA. Translation: AAH65143.1. | |
| PIR | A53444. |
| RefSeq | NP_031586.1. |
| UniGene | Mm.39089 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IAS based on UniProtKB P36897. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:252N. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000052430. Mus musculus. [Contig view] |
| GeneID | 12167. |
| KEGG | mmu:12167. |
Organism-specific databases | |
| MGI | MGI:107191. Bmpr1b. |
Phylogenomic databases | |
| HOGENOM | P36898. |
| HOVERGEN | P36898. |
Gene expression databases | |
| ArrayExpress | P36898. |
| CleanEx | MM_BMPR1B. |
| GermOnline | ENSMUSG00000052430. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000333. Activin_II_recpt. IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view] |
| Pfam | PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view] |
| PRINTS | PR00653. ACTIVIN2R. |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00467. GS. 1 hit. [Graphical view] |
| PROSITE | PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| BLOCKS | Search... |
Other Resources | |
| SOURCE | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | BMR1B_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P36898 Secondary accession number(s): Q3TRF2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


