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Protein

Bone morphogenetic protein receptor type-1B

Gene

Bmpr1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1. Receptor for GDF5 (PubMed:26105076, PubMed:19229295). Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149).3 Publications

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei231ATPPROSITE-ProRule annotation1
Active sitei332Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi210 – 218ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • BMP signaling pathway Source: UniProtKB
  • camera-type eye development Source: MGI
  • cartilage condensation Source: MGI
  • cell differentiation Source: MGI
  • cellular response to BMP stimulus Source: MGI
  • cellular response to growth factor stimulus Source: UniProtKB
  • chondrocyte development Source: AgBase
  • chondrocyte differentiation Source: UniProtKB
  • dorsal/ventral pattern formation Source: MGI
  • endochondral bone morphogenesis Source: AgBase
  • estrogen biosynthetic process Source: UniProtKB
  • eye development Source: MGI
  • inflammatory response Source: UniProtKB
  • limb morphogenesis Source: MGI
  • negative regulation of chondrocyte proliferation Source: AgBase
  • ovarian cumulus expansion Source: UniProtKB
  • ovulation cycle Source: UniProtKB
  • positive regulation of bone mineralization Source: MGI
  • positive regulation of cartilage development Source: AgBase
  • positive regulation of cell differentiation Source: MGI
  • positive regulation of chondrocyte differentiation Source: UniProtKB
  • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • protein phosphorylation Source: MGI
  • proteoglycan biosynthetic process Source: AgBase
  • retina development in camera-type eye Source: MGI
  • retinal ganglion cell axon guidance Source: MGI
  • skeletal system development Source: MGI
  • transforming growth factor beta receptor signaling pathway Source: MGI
  • transmembrane receptor protein serine/threonine kinase signaling pathway Source: MGI

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
Biological processChondrogenesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 3474
ReactomeiR-MMU-201451 Signaling by BMP

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein receptor type-1B (EC:2.7.11.30)
Short name:
BMP type-1B receptor
Short name:
BMPR-1B
Alternative name(s):
Activin receptor-like kinase 6
Short name:
ALK-6
Serine/threonine-protein kinase receptor R6
Short name:
SKR6
CD_antigen: CDw293
Gene namesi
Name:Bmpr1b
Synonyms:Acvrlk6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:107191 Bmpr1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini14 – 126ExtracellularSequence analysisAdd BLAST113
Transmembranei127 – 148HelicalSequence analysisAdd BLAST22
Topological domaini149 – 502CytoplasmicSequence analysisAdd BLAST354

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 13Sequence analysisAdd BLAST13
ChainiPRO_000002441314 – 502Bone morphogenetic protein receptor type-1BAdd BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 531 Publication
Disulfide bondi34 ↔ 381 Publication
Disulfide bondi47 ↔ 711 Publication
Disulfide bondi81 ↔ 951 Publication
Disulfide bondi96 ↔ 1021 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP36898
PRIDEiP36898

PTM databases

PhosphoSitePlusiP36898

Expressioni

Gene expression databases

BgeeiENSMUSG00000052430
CleanExiMM_BMPR1B
ExpressionAtlasiP36898 baseline and differential
GenevisibleiP36898 MM

Interactioni

Subunit structurei

Interacts with high affinity with GDF5; positively regulates chondrocyte differentiation.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Smad6O351822EBI-7107883,EBI-4321242

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-252N
IntActiP36898, 1 interactor
MINTiP36898
STRINGi10090.ENSMUSP00000029948

Structurei

Secondary structure

1502
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 33Combined sources4
Beta strandi35 – 37Combined sources3
Beta strandi46 – 59Combined sources14
Beta strandi64 – 72Combined sources9
Helixi77 – 80Combined sources4
Beta strandi91 – 96Combined sources6
Helixi102 – 105Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EVSX-ray2.10C14-126[»]
ProteinModelPortaliP36898
SMRiP36898
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36898

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 203GSPROSITE-ProRule annotationAdd BLAST30
Domaini204 – 494Protein kinasePROSITE-ProRule annotationAdd BLAST291

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2052 Eukaryota
ENOG410XQT0 LUCA
GeneTreeiENSGT00760000118876
HOGENOMiHOG000230587
HOVERGENiHBG054502
InParanoidiP36898
KOiK13578
OMAiDGPIHHK
OrthoDBiEOG091G0BIU
PhylomeDBiP36898
TreeFamiTF314724

Family and domain databases

InterProiView protein in InterPro
IPR000472 Activin_recp
IPR003605 GS_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF01064 Activin_recp, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF08515 TGF_beta_GS, 1 hit
SMARTiView protein in SMART
SM00467 GS, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51256 GS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLRSSGKLN VGTKKEDGES TAPTPRPKIL RCKCHHHCPE DSVNNICSTD
60 70 80 90 100
GYCFTMIEED DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN
110 120 130 140 150
ECNKDLHPTL PPLKDRDFVD GPIHHKALLI SVTVCSLLLV LIILFCYFRY
160 170 180 190 200
KRQEARPRYS IGLEQDETYI PPGESLRDLI EQSQSSGSGS GLPLLVQRTI
210 220 230 240 250
AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT
260 270 280 290 300
VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDAKS
310 320 330 340 350
MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD
360 370 380 390 400
LGLAVKFISD TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM
410 420 430 440 450
YSFGLILWEI ARRCVSGGIV EEYQLPYHDL VPSDPSYEDM REIVCMKKLR
460 470 480 490 500
PSFPNRWSSD ECLRQMGKLM TECWAQNPAS RLTALRVKKT LAKMSESQDI

KL
Length:502
Mass (Da):56,944
Last modified:June 1, 1994 - v1
Checksum:iAB29681F3FF5A361
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23143 mRNA Translation: CAA80674.1
AK086130 mRNA Translation: BAC39617.1
AK162844 mRNA Translation: BAE37078.1
BC065106 mRNA Translation: AAH65106.1
BC065143 mRNA Translation: AAH65143.1
CCDSiCCDS17874.1
PIRiA53444
RefSeqiNP_001264145.1, NM_001277216.1
NP_001264146.1, NM_001277217.1
NP_001264147.1, NM_001277218.1
NP_001264149.1, NM_001277220.1
NP_031586.1, NM_007560.4
XP_006501002.1, XM_006500939.3
XP_006501003.1, XM_006500940.3
XP_006501005.1, XM_006500942.1
XP_006501006.1, XM_006500943.3
XP_006501007.1, XM_006500944.2
XP_011238303.1, XM_011240001.1
XP_011238304.1, XM_011240002.2
UniGeneiMm.39089

Genome annotation databases

EnsembliENSMUST00000029948; ENSMUSP00000029948; ENSMUSG00000052430
ENSMUST00000098568; ENSMUSP00000096167; ENSMUSG00000052430
ENSMUST00000106230; ENSMUSP00000101837; ENSMUSG00000052430
ENSMUST00000106232; ENSMUSP00000101839; ENSMUSG00000052430
GeneIDi12167
KEGGimmu:12167
UCSCiuc008rog.2 mouse

Similar proteinsi

Entry informationi

Entry nameiBMR1B_MOUSE
AccessioniPrimary (citable) accession number: P36898
Secondary accession number(s): Q3TRF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

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