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Protein

Bone morphogenetic protein receptor type-1A

Gene

Bmpr1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei261 – 2611ATPPROSITE-ProRule annotation
Active sitei362 – 3621Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi240 – 2489ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW
  3. protein homodimerization activity Source: MGI
  4. protein serine/threonine kinase activity Source: MGI
  5. receptor signaling protein serine/threonine kinase activity Source: InterPro
  6. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  7. SMAD binding Source: MGI
  8. transforming growth factor beta-activated receptor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. BMP signaling pathway Source: MGI
  3. cartilage development Source: MGI
  4. cell differentiation Source: MGI
  5. developmental growth Source: MGI
  6. dorsal/ventral axis specification Source: MGI
  7. dorsal/ventral pattern formation Source: MGI
  8. ectoderm development Source: MGI
  9. embryonic digit morphogenesis Source: MGI
  10. embryonic morphogenesis Source: MGI
  11. embryonic organ development Source: MGI
  12. endocardial cushion formation Source: MGI
  13. endoderm development Source: MGI
  14. heart development Source: MGI
  15. heart formation Source: MGI
  16. heart morphogenesis Source: MGI
  17. hindlimb morphogenesis Source: MGI
  18. immune response Source: MGI
  19. in utero embryonic development Source: MGI
  20. lateral mesoderm development Source: MGI
  21. lung development Source: MGI
  22. mesendoderm development Source: MGI
  23. mesoderm formation Source: MGI
  24. Mullerian duct regression Source: MGI
  25. negative regulation of neurogenesis Source: MGI
  26. nervous system development Source: MGI
  27. neural crest cell development Source: MGI
  28. neural plate mediolateral regionalization Source: MGI
  29. neural plate pattern specification Source: MGI
  30. odontogenesis of dentin-containing tooth Source: MGI
  31. palate development Source: MGI
  32. paraxial mesoderm development Source: MGI
  33. paraxial mesoderm structural organization Source: MGI
  34. pattern specification process Source: MGI
  35. pituitary gland development Source: MGI
  36. positive regulation of bone mineralization Source: MGI
  37. positive regulation of epithelial cell proliferation Source: MGI
  38. positive regulation of mesenchymal cell proliferation Source: MGI
  39. positive regulation of osteoblast differentiation Source: MGI
  40. positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  41. positive regulation of SMAD protein import into nucleus Source: MGI
  42. positive regulation of transcription, DNA-templated Source: MGI
  43. protein phosphorylation Source: MGI
  44. regulation of cellular senescence Source: MGI
  45. regulation of lateral mesodermal cell fate specification Source: MGI
  46. somitogenesis Source: MGI
  47. stem cell maintenance Source: MGI
  48. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_220505. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein receptor type-1A (EC:2.7.11.30)
Short name:
BMP type-1A receptor
Short name:
BMPR-1A
Alternative name(s):
Activin receptor-like kinase 3
Short name:
ALK-3
BMP-2/BMP-4 receptor
Serine/threonine-protein kinase receptor R5
Short name:
SKR5
CD_antigen: CD292
Gene namesi
Name:Bmpr1a
Synonyms:Acvrlk3, Bmpr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1338938. Bmpr1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 152129ExtracellularSequence AnalysisAdd
BLAST
Transmembranei153 – 17624HelicalSequence AnalysisAdd
BLAST
Topological domaini177 – 532356CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. caveola Source: Ensembl
  2. dendrite Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. neuronal cell body Source: Ensembl
  5. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 532509Bone morphogenetic protein receptor type-1APRO_0000024411Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi61 ↔ 82By similarity
Disulfide bondi63 ↔ 67By similarity
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi76 ↔ 100By similarity
Disulfide bondi110 ↔ 124By similarity
Disulfide bondi125 ↔ 130By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP36895.
PaxDbiP36895.
PRIDEiP36895.

PTM databases

PhosphoSiteiP36895.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiP36895.
CleanExiMM_BMPR1A.
ExpressionAtlasiP36895. baseline and differential.
GenevestigatoriP36895.

Interactioni

Protein-protein interaction databases

BioGridi198371. 4 interactions.
DIPiDIP-5796N.
IntActiP36895. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP36895.
SMRiP36895. Positions 55-143, 204-530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 23330GSPROSITE-ProRule annotationAdd
BLAST
Domaini234 – 525292Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni107 – 1093Mediates specificity for BMP ligandBy similarity

Sequence similaritiesi

Contains 1 GS domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiP36895.
KOiK04673.
OMAiCYNRDLE.
OrthoDBiEOG7Q8CN3.
PhylomeDBiP36895.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDLD QKKPENGVTL
60 70 80 90 100
APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC
110 120 130 140 150
MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS
160 170 180 190 200
IRWLVVLISM AVCIVAMIIF SSCFCYKHYC KSISSRGRYN RDLEQDEAFI
210 220 230 240 250
PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV GKGRYGEVWM
260 270 280 290 300
GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG
310 320 330 340 350
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY
360 370 380 390 400
GTQGKPAIAH RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT
410 420 430 440 450
RVGTKRYMAP EVLDESLNKN HFQPYIMADI YSFGLIIWEM ARRCITGGIV
460 470 480 490 500
EEYQLPYYNM VPSDPSYEDM REVVCVKRLR PIVSNRWNSD ECLRAVLKLM
510 520 530
SECWAHNPAS RLTALRIKKT LAKMVESQDV KI
Length:532
Mass (Da):60,063
Last modified:June 1, 1994 - v1
Checksum:i70CC83CFB07CE9D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23154 mRNA. Translation: CAA80678.1.
D16250 mRNA. Translation: BAA03769.1.
U04672 mRNA. Translation: AAA21514.1.
BC042611 mRNA. Translation: AAH42611.1.
CCDSiCCDS26938.1.
PIRiA56238.
RefSeqiNP_033888.2. NM_009758.4.
XP_006518532.1. XM_006518469.1.
XP_006518533.1. XM_006518470.1.
UniGeneiMm.237825.

Genome annotation databases

EnsembliENSMUST00000049005; ENSMUSP00000035900; ENSMUSG00000021796.
GeneIDi12166.
KEGGimmu:12166.
UCSCiuc007taw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23154 mRNA. Translation: CAA80678.1.
D16250 mRNA. Translation: BAA03769.1.
U04672 mRNA. Translation: AAA21514.1.
BC042611 mRNA. Translation: AAH42611.1.
CCDSiCCDS26938.1.
PIRiA56238.
RefSeqiNP_033888.2. NM_009758.4.
XP_006518532.1. XM_006518469.1.
XP_006518533.1. XM_006518470.1.
UniGeneiMm.237825.

3D structure databases

ProteinModelPortaliP36895.
SMRiP36895. Positions 55-143, 204-530.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198371. 4 interactions.
DIPiDIP-5796N.
IntActiP36895. 1 interaction.

Chemistry

BindingDBiP36895.
GuidetoPHARMACOLOGYi1786.

PTM databases

PhosphoSiteiP36895.

Proteomic databases

MaxQBiP36895.
PaxDbiP36895.
PRIDEiP36895.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049005; ENSMUSP00000035900; ENSMUSG00000021796.
GeneIDi12166.
KEGGimmu:12166.
UCSCiuc007taw.1. mouse.

Organism-specific databases

CTDi657.
MGIiMGI:1338938. Bmpr1a.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiP36895.
KOiK04673.
OMAiCYNRDLE.
OrthoDBiEOG7Q8CN3.
PhylomeDBiP36895.
TreeFamiTF314724.

Enzyme and pathway databases

ReactomeiREACT_220505. Signaling by BMP.

Miscellaneous databases

NextBioi280531.
PROiP36895.
SOURCEiSearch...

Gene expression databases

BgeeiP36895.
CleanExiMM_BMPR1A.
ExpressionAtlasiP36895. baseline and differential.
GenevestigatoriP36895.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis."
    Dewulf N., Verschueren K., Lonnoy O., Moren A., Grimsby S., Spiegle K., Miyazono K., Huylebroeck D., ten Dijke P.
    Endocrinology 136:2652-2663(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss.
    Tissue: Embryo.
  2. "A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo."
    Suzuki A., Thies R.S., Yamaji N., Song J.J., Wozney J., Murakami K., Kung H.
    Proc. Natl. Acad. Sci. U.S.A. 91:10255-10259(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.

Entry informationi

Entry nameiBMR1A_MOUSE
AccessioniPrimary (citable) accession number: P36895
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 4, 2015
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.