Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bone morphogenetic protein receptor type-1A

Gene

Bmpr1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149). Mediates induction of adipogenesis by GDF6 (PubMed:23527555).2 Publications

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei261ATPPROSITE-ProRule annotation1
Active sitei362Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi240 – 248ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • BMP signaling pathway Source: UniProtKB
  • BMP signaling pathway involved in heart development Source: BHF-UCL
  • cardiac conduction system development Source: BHF-UCL
  • cardiac right ventricle morphogenesis Source: BHF-UCL
  • cartilage development Source: MGI
  • cell differentiation Source: MGI
  • cellular response to BMP stimulus Source: MGI
  • chondrocyte differentiation Source: UniProtKB
  • developmental growth Source: MGI
  • dorsal/ventral axis specification Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • dorsal aorta morphogenesis Source: BHF-UCL
  • ectoderm development Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic morphogenesis Source: MGI
  • embryonic organ development Source: MGI
  • endocardial cushion formation Source: MGI
  • endocardial cushion morphogenesis Source: BHF-UCL
  • endoderm development Source: MGI
  • fibrous ring of heart morphogenesis Source: BHF-UCL
  • heart development Source: MGI
  • heart formation Source: MGI
  • heart morphogenesis Source: MGI
  • hindlimb morphogenesis Source: MGI
  • immune response Source: MGI
  • in utero embryonic development Source: MGI
  • lateral mesoderm development Source: MGI
  • lung development Source: MGI
  • mesendoderm development Source: MGI
  • mesoderm formation Source: MGI
  • mitral valve morphogenesis Source: BHF-UCL
  • Mullerian duct regression Source: MGI
  • negative regulation of neurogenesis Source: MGI
  • negative regulation of smooth muscle cell migration Source: MGI
  • nervous system development Source: MGI
  • neural crest cell development Source: MGI
  • neural plate mediolateral regionalization Source: MGI
  • neural plate pattern specification Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • outflow tract morphogenesis Source: BHF-UCL
  • outflow tract septum morphogenesis Source: BHF-UCL
  • palate development Source: MGI
  • paraxial mesoderm development Source: MGI
  • paraxial mesoderm structural organization Source: MGI
  • pattern specification process Source: MGI
  • pharyngeal arch artery morphogenesis Source: BHF-UCL
  • pituitary gland development Source: MGI
  • positive regulation of bone mineralization Source: MGI
  • positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
  • positive regulation of cardiac ventricle development Source: BHF-UCL
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  • positive regulation of pri-miRNA transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of SMAD protein import into nucleus Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of vascular smooth muscle cell proliferation Source: BHF-UCL
  • protein phosphorylation Source: MGI
  • regulation of cardiac muscle cell proliferation Source: BHF-UCL
  • regulation of cellular senescence Source: MGI
  • regulation of lateral mesodermal cell fate specification Source: MGI
  • somitogenesis Source: MGI
  • stem cell population maintenance Source: MGI
  • tricuspid valve morphogenesis Source: BHF-UCL
  • ventricular compact myocardium morphogenesis Source: BHF-UCL
  • ventricular trabecula myocardium morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.
ReactomeiR-MMU-201451. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein receptor type-1A (EC:2.7.11.30)
Short name:
BMP type-1A receptor
Short name:
BMPR-1A
Alternative name(s):
Activin receptor-like kinase 3
Short name:
ALK-3
BMP-2/BMP-4 receptor
Serine/threonine-protein kinase receptor R5
Short name:
SKR5
CD_antigen: CD292
Gene namesi
Name:Bmpr1a
Synonyms:Acvrlk3, Bmpr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1338938. Bmpr1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 152ExtracellularSequence analysisAdd BLAST129
Transmembranei153 – 176HelicalSequence analysisAdd BLAST24
Topological domaini177 – 532CytoplasmicSequence analysisAdd BLAST356

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002441124 – 532Bone morphogenetic protein receptor type-1AAdd BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi61 ↔ 82By similarity
Disulfide bondi63 ↔ 67By similarity
Glycosylationi73N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi76 ↔ 100By similarity
Disulfide bondi110 ↔ 124By similarity
Disulfide bondi125 ↔ 130By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP36895.
PeptideAtlasiP36895.
PRIDEiP36895.

PTM databases

iPTMnetiP36895.
PhosphoSitePlusiP36895.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000021796.
CleanExiMM_BMPR1A.
ExpressionAtlasiP36895. baseline and differential.
GenevisibleiP36895. MM.

Interactioni

Subunit structurei

Interacts with low affinity with GDF5; positively regulates chondrocyte differentiation.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198371. 140 interactors.
DIPiDIP-5796N.
IntActiP36895. 137 interactors.
STRINGi10090.ENSMUSP00000035900.

Chemistry databases

BindingDBiP36895.

Structurei

3D structure databases

ProteinModelPortaliP36895.
SMRiP36895.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini204 – 233GSPROSITE-ProRule annotationAdd BLAST30
Domaini234 – 525Protein kinasePROSITE-ProRule annotationAdd BLAST292

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 109Mediates specificity for BMP ligandBy similarity3

Sequence similaritiesi

Contains 1 GS domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2052. Eukaryota.
ENOG410XQT0. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiP36895.
KOiK04673.
OMAiKHYCKSM.
OrthoDBiEOG091G0BIU.
PhylomeDBiP36895.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR003605. GS_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDLD QKKPENGVTL
60 70 80 90 100
APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC
110 120 130 140 150
MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS
160 170 180 190 200
IRWLVVLISM AVCIVAMIIF SSCFCYKHYC KSISSRGRYN RDLEQDEAFI
210 220 230 240 250
PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV GKGRYGEVWM
260 270 280 290 300
GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG
310 320 330 340 350
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY
360 370 380 390 400
GTQGKPAIAH RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT
410 420 430 440 450
RVGTKRYMAP EVLDESLNKN HFQPYIMADI YSFGLIIWEM ARRCITGGIV
460 470 480 490 500
EEYQLPYYNM VPSDPSYEDM REVVCVKRLR PIVSNRWNSD ECLRAVLKLM
510 520 530
SECWAHNPAS RLTALRIKKT LAKMVESQDV KI
Length:532
Mass (Da):60,063
Last modified:June 1, 1994 - v1
Checksum:i70CC83CFB07CE9D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23154 mRNA. Translation: CAA80678.1.
D16250 mRNA. Translation: BAA03769.1.
U04672 mRNA. Translation: AAA21514.1.
BC042611 mRNA. Translation: AAH42611.1.
CCDSiCCDS26938.1.
PIRiA56238.
RefSeqiNP_033888.2. NM_009758.4.
XP_006518532.1. XM_006518469.3.
XP_006518533.1. XM_006518470.3.
XP_017171295.1. XM_017315806.1.
UniGeneiMm.237825.

Genome annotation databases

EnsembliENSMUST00000049005; ENSMUSP00000035900; ENSMUSG00000021796.
GeneIDi12166.
KEGGimmu:12166.
UCSCiuc007taw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23154 mRNA. Translation: CAA80678.1.
D16250 mRNA. Translation: BAA03769.1.
U04672 mRNA. Translation: AAA21514.1.
BC042611 mRNA. Translation: AAH42611.1.
CCDSiCCDS26938.1.
PIRiA56238.
RefSeqiNP_033888.2. NM_009758.4.
XP_006518532.1. XM_006518469.3.
XP_006518533.1. XM_006518470.3.
XP_017171295.1. XM_017315806.1.
UniGeneiMm.237825.

3D structure databases

ProteinModelPortaliP36895.
SMRiP36895.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198371. 140 interactors.
DIPiDIP-5796N.
IntActiP36895. 137 interactors.
STRINGi10090.ENSMUSP00000035900.

Chemistry databases

BindingDBiP36895.

PTM databases

iPTMnetiP36895.
PhosphoSitePlusiP36895.

Proteomic databases

PaxDbiP36895.
PeptideAtlasiP36895.
PRIDEiP36895.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049005; ENSMUSP00000035900; ENSMUSG00000021796.
GeneIDi12166.
KEGGimmu:12166.
UCSCiuc007taw.1. mouse.

Organism-specific databases

CTDi657.
MGIiMGI:1338938. Bmpr1a.

Phylogenomic databases

eggNOGiKOG2052. Eukaryota.
ENOG410XQT0. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiP36895.
KOiK04673.
OMAiKHYCKSM.
OrthoDBiEOG091G0BIU.
PhylomeDBiP36895.
TreeFamiTF314724.

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.
ReactomeiR-MMU-201451. Signaling by BMP.

Miscellaneous databases

PROiP36895.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021796.
CleanExiMM_BMPR1A.
ExpressionAtlasiP36895. baseline and differential.
GenevisibleiP36895. MM.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR003605. GS_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBMR1A_MOUSE
AccessioniPrimary (citable) accession number: P36895
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 170 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.