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P36895

- BMR1A_MOUSE

UniProt

P36895 - BMR1A_MOUSE

Protein

Bone morphogenetic protein receptor type-1A

Gene

Bmpr1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei261 – 2611ATPPROSITE-ProRule annotation
    Active sitei362 – 3621Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi240 – 2489ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. receptor signaling protein serine/threonine kinase activity Source: InterPro
    4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    5. transforming growth factor beta-activated receptor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. BMP signaling pathway Source: MGI
    3. cartilage development Source: MGI
    4. cell differentiation Source: MGI
    5. developmental growth Source: MGI
    6. dorsal/ventral axis specification Source: MGI
    7. dorsal/ventral pattern formation Source: MGI
    8. ectoderm development Source: MGI
    9. embryonic digit morphogenesis Source: MGI
    10. embryonic morphogenesis Source: MGI
    11. embryonic organ development Source: MGI
    12. endocardial cushion formation Source: MGI
    13. endoderm development Source: MGI
    14. heart development Source: MGI
    15. heart formation Source: MGI
    16. heart morphogenesis Source: MGI
    17. hindlimb morphogenesis Source: MGI
    18. immune response Source: Ensembl
    19. in utero embryonic development Source: MGI
    20. lateral mesoderm development Source: MGI
    21. lung development Source: MGI
    22. mesendoderm development Source: MGI
    23. mesoderm formation Source: MGI
    24. Mullerian duct regression Source: MGI
    25. negative regulation of neurogenesis Source: MGI
    26. nervous system development Source: MGI
    27. neural crest cell development Source: MGI
    28. neural plate mediolateral regionalization Source: MGI
    29. neural plate pattern specification Source: MGI
    30. odontogenesis of dentin-containing tooth Source: MGI
    31. palate development Source: MGI
    32. paraxial mesoderm development Source: MGI
    33. paraxial mesoderm structural organization Source: MGI
    34. pattern specification process Source: MGI
    35. pituitary gland development Source: MGI
    36. positive regulation of bone mineralization Source: Ensembl
    37. positive regulation of epithelial cell proliferation Source: MGI
    38. positive regulation of mesenchymal cell proliferation Source: MGI
    39. positive regulation of osteoblast differentiation Source: Ensembl
    40. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    41. positive regulation of SMAD protein import into nucleus Source: Ensembl
    42. positive regulation of transcription, DNA-templated Source: MGI
    43. regulation of lateral mesodermal cell fate specification Source: MGI
    44. somitogenesis Source: MGI
    45. stem cell maintenance Source: MGI
    46. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_220505. Signaling by BMP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein receptor type-1A (EC:2.7.11.30)
    Short name:
    BMP type-1A receptor
    Short name:
    BMPR-1A
    Alternative name(s):
    Activin receptor-like kinase 3
    Short name:
    ALK-3
    BMP-2/BMP-4 receptor
    Serine/threonine-protein kinase receptor R5
    Short name:
    SKR5
    CD_antigen: CD292
    Gene namesi
    Name:Bmpr1a
    Synonyms:Acvrlk3, Bmpr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1338938. Bmpr1a.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: Ensembl
    2. dendrite Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 532509Bone morphogenetic protein receptor type-1APRO_0000024411Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi61 ↔ 82By similarity
    Disulfide bondi63 ↔ 67By similarity
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi76 ↔ 100By similarity
    Disulfide bondi110 ↔ 124By similarity
    Disulfide bondi125 ↔ 130By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP36895.
    PRIDEiP36895.

    PTM databases

    PhosphoSiteiP36895.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    ArrayExpressiP36895.
    BgeeiP36895.
    CleanExiMM_BMPR1A.
    GenevestigatoriP36895.

    Interactioni

    Protein-protein interaction databases

    BioGridi198371. 4 interactions.
    DIPiDIP-5796N.
    IntActiP36895. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP36895.
    SMRiP36895. Positions 55-143, 204-530.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 152129ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini177 – 532356CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei153 – 17624HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini204 – 23330GSPROSITE-ProRule annotationAdd
    BLAST
    Domaini234 – 525292Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni107 – 1093Mediates specificity for BMP ligandBy similarity

    Sequence similaritiesi

    Contains 1 GS domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000230587.
    HOVERGENiHBG054502.
    InParanoidiP36895.
    KOiK04673.
    OMAiCYNRDLE.
    OrthoDBiEOG7Q8CN3.
    PhylomeDBiP36895.
    TreeFamiTF314724.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36895-1 [UniParc]FASTAAdd to Basket

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    MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDLD QKKPENGVTL    50
    APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC 100
    MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS 150
    IRWLVVLISM AVCIVAMIIF SSCFCYKHYC KSISSRGRYN RDLEQDEAFI 200
    PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV GKGRYGEVWM 250
    GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300
    SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY 350
    GTQGKPAIAH RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT 400
    RVGTKRYMAP EVLDESLNKN HFQPYIMADI YSFGLIIWEM ARRCITGGIV 450
    EEYQLPYYNM VPSDPSYEDM REVVCVKRLR PIVSNRWNSD ECLRAVLKLM 500
    SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532
    Length:532
    Mass (Da):60,063
    Last modified:June 1, 1994 - v1
    Checksum:i70CC83CFB07CE9D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z23154 mRNA. Translation: CAA80678.1.
    D16250 mRNA. Translation: BAA03769.1.
    U04672 mRNA. Translation: AAA21514.1.
    BC042611 mRNA. Translation: AAH42611.1.
    CCDSiCCDS26938.1.
    PIRiA56238.
    RefSeqiNP_033888.2. NM_009758.4.
    XP_006518532.1. XM_006518469.1.
    XP_006518533.1. XM_006518470.1.
    UniGeneiMm.237825.

    Genome annotation databases

    EnsembliENSMUST00000049005; ENSMUSP00000035900; ENSMUSG00000021796.
    GeneIDi12166.
    KEGGimmu:12166.
    UCSCiuc007taw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z23154 mRNA. Translation: CAA80678.1 .
    D16250 mRNA. Translation: BAA03769.1 .
    U04672 mRNA. Translation: AAA21514.1 .
    BC042611 mRNA. Translation: AAH42611.1 .
    CCDSi CCDS26938.1.
    PIRi A56238.
    RefSeqi NP_033888.2. NM_009758.4.
    XP_006518532.1. XM_006518469.1.
    XP_006518533.1. XM_006518470.1.
    UniGenei Mm.237825.

    3D structure databases

    ProteinModelPortali P36895.
    SMRi P36895. Positions 55-143, 204-530.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198371. 4 interactions.
    DIPi DIP-5796N.
    IntActi P36895. 1 interaction.

    Chemistry

    GuidetoPHARMACOLOGYi 1786.

    PTM databases

    PhosphoSitei P36895.

    Proteomic databases

    PaxDbi P36895.
    PRIDEi P36895.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049005 ; ENSMUSP00000035900 ; ENSMUSG00000021796 .
    GeneIDi 12166.
    KEGGi mmu:12166.
    UCSCi uc007taw.1. mouse.

    Organism-specific databases

    CTDi 657.
    MGIi MGI:1338938. Bmpr1a.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000230587.
    HOVERGENi HBG054502.
    InParanoidi P36895.
    KOi K04673.
    OMAi CYNRDLE.
    OrthoDBi EOG7Q8CN3.
    PhylomeDBi P36895.
    TreeFami TF314724.

    Enzyme and pathway databases

    Reactomei REACT_220505. Signaling by BMP.

    Miscellaneous databases

    NextBioi 280531.
    PROi P36895.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P36895.
    Bgeei P36895.
    CleanExi MM_BMPR1A.
    Genevestigatori P36895.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis."
      Dewulf N., Verschueren K., Lonnoy O., Moren A., Grimsby S., Spiegle K., Miyazono K., Huylebroeck D., ten Dijke P.
      Endocrinology 136:2652-2663(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss.
      Tissue: Embryo.
    2. "A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo."
      Suzuki A., Thies R.S., Yamaji N., Song J.J., Wozney J., Murakami K., Kung H.
      Proc. Natl. Acad. Sci. U.S.A. 91:10255-10259(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Retina.

    Entry informationi

    Entry nameiBMR1A_MOUSE
    AccessioniPrimary (citable) accession number: P36895
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 148 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3