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P36895 (BMR1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein receptor type-1A

Short name=BMP type-1A receptor
Short name=BMPR-1A
EC=2.7.11.30
Alternative name(s):
Activin receptor-like kinase 3
Short name=ALK-3
BMP-2/BMP-4 receptor
Serine/threonine-protein kinase receptor R5
Short name=SKR5
CD_antigen=CD292
Gene names
Name:Bmpr1a
Synonyms:Acvrlk3, Bmpr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Widely expressed.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 GS domain.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   LigandATP-binding
Magnesium
Manganese
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Receptor
Serine/threonine-protein kinase
Transferase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from direct assay PubMed 9268344. Source: MGI

Mullerian duct regression

Inferred from mutant phenotype PubMed 12368913. Source: MGI

anterior/posterior pattern specification

Inferred from mutant phenotype PubMed 15136140. Source: MGI

cartilage development

Inferred from mutant phenotype PubMed 15492776. Source: MGI

cell differentiation

Inferred from genetic interaction PubMed 15469980. Source: MGI

developmental growth

Inferred from mutant phenotype PubMed 17359964. Source: MGI

dorsal/ventral axis specification

Inferred from mutant phenotype PubMed 12923052. Source: MGI

dorsal/ventral pattern formation

Inferred from genetic interaction PubMed 15673568. Source: MGI

ectoderm development

Inferred from mutant phenotype PubMed 15136139. Source: MGI

embryonic digit morphogenesis

Inferred from genetic interaction PubMed 20043884. Source: MGI

embryonic morphogenesis

Inferred from mutant phenotype PubMed 15716346. Source: MGI

embryonic organ development

Inferred from mutant phenotype PubMed 17359964. Source: MGI

endocardial cushion formation

Inferred from mutant phenotype PubMed 16314491. Source: MGI

endoderm development

Inferred from mutant phenotype PubMed 15136140. Source: MGI

heart development

Inferred from mutant phenotype PubMed 16556916. Source: MGI

heart formation

Inferred from mutant phenotype PubMed 16943278. Source: MGI

heart morphogenesis

Inferred from mutant phenotype PubMed 17359964. Source: MGI

hindlimb morphogenesis

Inferred from mutant phenotype PubMed 16556916. Source: MGI

immune response

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from mutant phenotype PubMed 17359964. Source: MGI

lateral mesoderm development

Inferred from mutant phenotype PubMed 16943278. Source: MGI

lung development

Inferred from mutant phenotype PubMed 16414041. Source: MGI

mesendoderm development

Inferred from mutant phenotype PubMed 15136140. Source: MGI

mesoderm formation

Inferred from mutant phenotype PubMed 17699604. Source: MGI

negative regulation of neurogenesis

Inferred from mutant phenotype PubMed 17699604. Source: MGI

nervous system development

Inferred from mutant phenotype PubMed 17359964. Source: MGI

neural crest cell development

Inferred from mutant phenotype PubMed 19793887. Source: MGI

neural plate mediolateral regionalization

Inferred from mutant phenotype PubMed 16943278. Source: MGI

neural plate pattern specification

Inferred from mutant phenotype PubMed 16943278. Source: MGI

odontogenesis of dentin-containing tooth

Inferred from mutant phenotype PubMed 15716346. Source: MGI

palate development

Inferred from mutant phenotype PubMed 15716346. Source: MGI

paraxial mesoderm development

Inferred from mutant phenotype PubMed 16943278. Source: MGI

paraxial mesoderm structural organization

Inferred from mutant phenotype PubMed 16943278. Source: MGI

pattern specification process

Inferred from mutant phenotype PubMed 15716346. Source: MGI

pituitary gland development

Inferred from mutant phenotype PubMed 17359964. Source: MGI

positive regulation of SMAD protein import into nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of bone mineralization

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 16414041. Source: MGI

positive regulation of mesenchymal cell proliferation

Inferred from mutant phenotype PubMed 15716346. Source: MGI

positive regulation of osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 19416967. Source: MGI

regulation of lateral mesodermal cell fate specification

Inferred from genetic interaction PubMed 16943278. Source: MGI

somitogenesis

Inferred from mutant phenotype PubMed 16943278. Source: MGI

stem cell maintenance

Inferred from mutant phenotype PubMed 17699604. Source: MGI

transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 19416967. Source: GOC

   Cellular_componentcaveola

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from direct assay PubMed 19416967. Source: MGI

transforming growth factor beta-activated receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 532509Bone morphogenetic protein receptor type-1A
PRO_0000024411

Regions

Topological domain24 – 152129Extracellular Potential
Transmembrane153 – 17624Helical; Potential
Topological domain177 – 532356Cytoplasmic Potential
Domain204 – 23330GS
Domain234 – 525292Protein kinase
Nucleotide binding240 – 2489ATP By similarity
Region107 – 1093Mediates specificity for BMP ligand By similarity

Sites

Active site3621Proton acceptor By similarity
Binding site2611ATP By similarity

Amino acid modifications

Glycosylation731N-linked (GlcNAc...) Potential
Disulfide bond61 ↔ 82 By similarity
Disulfide bond63 ↔ 67 By similarity
Disulfide bond76 ↔ 100 By similarity
Disulfide bond110 ↔ 124 By similarity
Disulfide bond125 ↔ 130 By similarity

Sequences

Sequence LengthMass (Da)Tools
P36895 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 70CC83CFB07CE9D5

FASTA53260,063
        10         20         30         40         50         60 
MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDLD QKKPENGVTL APEDTLPFLK 

        70         80         90        100        110        120 
CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC MKYEGSDFQC KDSPKAQLRR 

       130        140        150        160        170        180 
TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLVVLISM AVCIVAMIIF SSCFCYKHYC 

       190        200        210        220        230        240 
KSISSRGRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 

       250        260        270        280        290        300 
GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 

       310        320        330        340        350        360 
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 

       370        380        390        400        410        420 
RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT RVGTKRYMAP EVLDESLNKN 

       430        440        450        460        470        480 
HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 

       490        500        510        520        530 
PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 

« Hide

References

« Hide 'large scale' references
[1]"Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis."
Dewulf N., Verschueren K., Lonnoy O., Moren A., Grimsby S., Spiegle K., Miyazono K., Huylebroeck D., ten Dijke P.
Endocrinology 136:2652-2663(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Swiss.
Tissue: Embryo.
[2]"A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo."
Suzuki A., Thies R.S., Yamaji N., Song J.J., Wozney J., Murakami K., Kung H.
Proc. Natl. Acad. Sci. U.S.A. 91:10255-10259(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells."
Koenig B.B., Cook J.S., Wolsing D.H., Ting J., Tiesman J.P., Correa P.E., Olson C.A., Pecquet A.L., Ventura F., Grant R.A., Chen G., Wrana J.L., Massague J., Rosenbaum J.S.
Mol. Cell. Biol. 14:5961-5974(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Retina.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z23154 mRNA. Translation: CAA80678.1.
D16250 mRNA. Translation: BAA03769.1.
U04672 mRNA. Translation: AAA21514.1.
BC042611 mRNA. Translation: AAH42611.1.
CCDSCCDS26938.1.
PIRA56238.
RefSeqNP_033888.2. NM_009758.4.
XP_006518532.1. XM_006518469.1.
XP_006518533.1. XM_006518470.1.
UniGeneMm.237825.

3D structure databases

ProteinModelPortalP36895.
SMRP36895. Positions 55-143, 204-530.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198371. 4 interactions.
DIPDIP-5796N.
IntActP36895. 1 interaction.

Chemistry

GuidetoPHARMACOLOGY1786.

PTM databases

PhosphoSiteP36895.

Proteomic databases

PaxDbP36895.
PRIDEP36895.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049005; ENSMUSP00000035900; ENSMUSG00000021796.
GeneID12166.
KEGGmmu:12166.
UCSCuc007taw.1. mouse.

Organism-specific databases

CTD657.
MGIMGI:1338938. Bmpr1a.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000230587.
HOVERGENHBG054502.
InParanoidP36895.
KOK04673.
OMACYNRDLE.
OrthoDBEOG7Q8CN3.
PhylomeDBP36895.
TreeFamTF314724.

Gene expression databases

ArrayExpressP36895.
BgeeP36895.
CleanExMM_BMPR1A.
GenevestigatorP36895.

Family and domain databases

InterProIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERPTHR23255. PTHR23255. 1 hit.
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTSM00467. GS. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280531.
PROP36895.
SOURCESearch...

Entry information

Entry nameBMR1A_MOUSE
AccessionPrimary (citable) accession number: P36895
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot