P36895 (BMR1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein receptor type-1A
Short name=BMP type-1A receptor
Short name=BMPR-1A
EC=2.7.11.30

Alternative name(s):
Activin receptor-like kinase 3
Short name=ALK-3
BMP-2/BMP-4 receptor
Serine/threonine-protein kinase receptor R5
Short name=SKR5
CD_antigen=CD292

Gene names

Name:	Bmpr1a
Synonyms:	Acvrlk3, Bmpr

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	532 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Widely expressed.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from direct assay PubMed 9268344. Source: MGI Mullerian duct regression Inferred from mutant phenotype PubMed 12368913. Source: MGI cartilage development Inferred from mutant phenotype PubMed 15492776. Source: MGI developmental growth Inferred from mutant phenotype PubMed 17359964. Source: MGI dorsal/ventral axis specification Inferred from mutant phenotype PubMed 12923052. Source: MGI ectoderm development Inferred from mutant phenotype PubMed 15136139. Source: MGI embryonic digit morphogenesis Inferred from genetic interaction PubMed 20043884. Source: MGI embryonic organ development Inferred from mutant phenotype PubMed 17359964. Source: MGI endocardial cushion formation Inferred from mutant phenotype PubMed 16314491. Source: MGI heart formation Inferred from mutant phenotype PubMed 16943278. Source: MGI hindlimb morphogenesis Inferred from mutant phenotype PubMed 16556916. Source: MGI immune response Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from mutant phenotype PubMed 17359964. Source: MGI lateral mesoderm development Inferred from mutant phenotype PubMed 16943278. Source: MGI lung development Inferred from mutant phenotype PubMed 16414041. Source: MGI mesendoderm development Inferred from mutant phenotype PubMed 15136140. Source: MGI mesoderm formation Inferred from mutant phenotype PubMed 17699604. Source: MGI negative regulation of neurogenesis Inferred from mutant phenotype PubMed 17699604. Source: MGI neural crest cell development Inferred from mutant phenotype PubMed 19793887. Source: MGI neural plate mediolateral regionalization Inferred from mutant phenotype PubMed 16943278. Source: MGI odontogenesis of dentin-containing tooth Inferred from mutant phenotype PubMed 15716346. Source: MGI palate development Inferred from mutant phenotype PubMed 15716346. Source: MGI paraxial mesoderm structural organization Inferred from mutant phenotype PubMed 16943278. Source: MGI pituitary gland development Inferred from mutant phenotype PubMed 17359964. Source: MGI positive regulation of SMAD protein import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of bone mineralization Inferred from electronic annotation. Source: Compara positive regulation of epithelial cell proliferation Inferred from mutant phenotype PubMed 16414041. Source: MGI positive regulation of mesenchymal cell proliferation Inferred from mutant phenotype PubMed 15716346. Source: MGI positive regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from direct assay PubMed 19416967. Source: MGI regulation of lateral mesodermal cell fate specification Inferred from genetic interaction PubMed 16943278. Source: MGI somitogenesis Inferred from mutant phenotype PubMed 16943278. Source: MGI stem cell maintenance Inferred from mutant phenotype PubMed 17699604. Source: MGI
Cellular_component	caveola Inferred from electronic annotation. Source: Compara dendrite Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW neuronal cell body Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from direct assay PubMed 19416967. Source: MGI transforming growth factor beta-activated receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 532	509	Bone morphogenetic protein receptor type-1A		PRO_0000024411
Regions
	Topological domain	24 – 152	129	Extracellular Potential
	Transmembrane	153 – 176	24	Helical; Potential
	Topological domain	177 – 532	356	Cytoplasmic Potential
	Domain	204 – 233	30	GS
	Domain	234 – 525	292	Protein kinase
	Nucleotide binding	240 – 248	9	ATP By similarity
	Region	107 – 109	3	Mediates specificity for BMP ligand By similarity
Sites
	Active site	362	1	Proton acceptor By similarity
	Binding site	261	1	ATP By similarity
Amino acid modifications
	Glycosylation	73	1	N-linked (GlcNAc...) Potential
	Disulfide bond	61 ↔ 82		By similarity
	Disulfide bond	63 ↔ 67		By similarity
	Disulfide bond	76 ↔ 100		By similarity
	Disulfide bond	110 ↔ 124		By similarity
	Disulfide bond	125 ↔ 130		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P36895 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 70CC83CFB07CE9D5	FASTA	532	60,063
	10 20 30 40 50 60 MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDLD QKKPENGVTL APEDTLPFLK 70 80 90 100 110 120 CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC MKYEGSDFQC KDSPKAQLRR 130 140 150 160 170 180 TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLVVLISM AVCIVAMIIF SSCFCYKHYC 190 200 210 220 230 240 KSISSRGRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 250 260 270 280 290 300 GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 310 320 330 340 350 360 SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 370 380 390 400 410 420 RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT RVGTKRYMAP EVLDESLNKN 430 440 450 460 470 480 HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 490 500 510 520 530 PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis." Dewulf N., Verschueren K., Lonnoy O., Moren A., Grimsby S., Spiegle K., Miyazono K., Huylebroeck D., ten Dijke P. Endocrinology 136:2652-2663(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Swiss. Tissue: Embryo.
[2]	"A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo." Suzuki A., Thies R.S., Yamaji N., Song J.J., Wozney J., Murakami K., Kung H. Proc. Natl. Acad. Sci. U.S.A. 91:10255-10259(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells." Koenig B.B., Cook J.S., Wolsing D.H., Ting J., Tiesman J.P., Correa P.E., Olson C.A., Pecquet A.L., Ventura F., Grant R.A., Chen G., Wrana J.L., Massague J., Rosenbaum J.S. Mol. Cell. Biol. 14:5961-5974(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Retina.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z23154 mRNA. Translation: CAA80678.1. D16250 mRNA. Translation: BAA03769.1. U04672 mRNA. Translation: AAA21514.1. BC042611 mRNA. Translation: AAH42611.1.
IPI	IPI00128193.
PIR	A56238.
RefSeq	NP_033888.2. NM_009758.4.
UniGene	Mm.237825.
3D structure databases
ProteinModelPortal	P36895.
SMR	P36895. Positions 55-143, 204-530.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5796N.
IntAct	P36895. 1 interaction.
PTM databases
PhosphoSite	P36895.
Proteomic databases
PaxDb	P36895.
PRIDE	P36895.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000049005; ENSMUSP00000035900; ENSMUSG00000021796.
GeneID	12166.
KEGG	mmu:12166.
UCSC	uc007taw.1. mouse.
Organism-specific databases
CTD	657.
MGI	MGI:1338938. Bmpr1a.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000230587.
HOVERGEN	HBG054502.
InParanoid	P36895.
KO	K04673.
OMA	LEVVCVK.
OrthoDB	EOG4F1X2X.
Gene expression databases
ArrayExpress	P36895.
Bgee	P36895.
CleanEx	MM_BMPR1A.
Genevestigator	P36895.
GermOnline	ENSMUSG00000021796. Mus musculus.
Family and domain databases
InterPro	IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
SMART	SM00467. GS. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	280531.
SOURCE	Search...

Entry information

Entry name

BMR1A_MOUSE

Accession

Primary (citable) accession number: P36895

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 29, 2013
This is version 135 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program