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P36895

- BMR1A_MOUSE

UniProt

P36895 - BMR1A_MOUSE

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Protein

Bone morphogenetic protein receptor type-1A

Gene
Bmpr1a, Acvrlk3, Bmpr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei261 – 2611ATP By similarity
Active sitei362 – 3621Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi240 – 2489ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. receptor signaling protein serine/threonine kinase activity Source: InterPro
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  5. transforming growth factor beta-activated receptor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. BMP signaling pathway Source: MGI
  3. cartilage development Source: MGI
  4. cell differentiation Source: MGI
  5. developmental growth Source: MGI
  6. dorsal/ventral axis specification Source: MGI
  7. dorsal/ventral pattern formation Source: MGI
  8. ectoderm development Source: MGI
  9. embryonic digit morphogenesis Source: MGI
  10. embryonic morphogenesis Source: MGI
  11. embryonic organ development Source: MGI
  12. endocardial cushion formation Source: MGI
  13. endoderm development Source: MGI
  14. heart development Source: MGI
  15. heart formation Source: MGI
  16. heart morphogenesis Source: MGI
  17. hindlimb morphogenesis Source: MGI
  18. immune response Source: Ensembl
  19. in utero embryonic development Source: MGI
  20. lateral mesoderm development Source: MGI
  21. lung development Source: MGI
  22. mesendoderm development Source: MGI
  23. mesoderm formation Source: MGI
  24. Mullerian duct regression Source: MGI
  25. negative regulation of neurogenesis Source: MGI
  26. nervous system development Source: MGI
  27. neural crest cell development Source: MGI
  28. neural plate mediolateral regionalization Source: MGI
  29. neural plate pattern specification Source: MGI
  30. odontogenesis of dentin-containing tooth Source: MGI
  31. palate development Source: MGI
  32. paraxial mesoderm development Source: MGI
  33. paraxial mesoderm structural organization Source: MGI
  34. pattern specification process Source: MGI
  35. pituitary gland development Source: MGI
  36. positive regulation of bone mineralization Source: Ensembl
  37. positive regulation of epithelial cell proliferation Source: MGI
  38. positive regulation of mesenchymal cell proliferation Source: MGI
  39. positive regulation of osteoblast differentiation Source: Ensembl
  40. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  41. positive regulation of SMAD protein import into nucleus Source: Ensembl
  42. positive regulation of transcription, DNA-templated Source: MGI
  43. regulation of lateral mesodermal cell fate specification Source: MGI
  44. somitogenesis Source: MGI
  45. stem cell maintenance Source: MGI
  46. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_220505. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein receptor type-1A (EC:2.7.11.30)
Short name:
BMP type-1A receptor
Short name:
BMPR-1A
Alternative name(s):
Activin receptor-like kinase 3
Short name:
ALK-3
BMP-2/BMP-4 receptor
Serine/threonine-protein kinase receptor R5
Short name:
SKR5
CD_antigen: CD292
Gene namesi
Name:Bmpr1a
Synonyms:Acvrlk3, Bmpr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1338938. Bmpr1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 152129Extracellular Reviewed predictionAdd
BLAST
Transmembranei153 – 17624Helical; Reviewed predictionAdd
BLAST
Topological domaini177 – 532356Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. caveola Source: Ensembl
  2. dendrite Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 532509Bone morphogenetic protein receptor type-1APRO_0000024411Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi61 ↔ 82 By similarity
Disulfide bondi63 ↔ 67 By similarity
Glycosylationi73 – 731N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi76 ↔ 100 By similarity
Disulfide bondi110 ↔ 124 By similarity
Disulfide bondi125 ↔ 130 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP36895.
PRIDEiP36895.

PTM databases

PhosphoSiteiP36895.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

ArrayExpressiP36895.
BgeeiP36895.
CleanExiMM_BMPR1A.
GenevestigatoriP36895.

Interactioni

Protein-protein interaction databases

BioGridi198371. 4 interactions.
DIPiDIP-5796N.
IntActiP36895. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP36895.
SMRiP36895. Positions 55-143, 204-530.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 23330GSAdd
BLAST
Domaini234 – 525292Protein kinaseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni107 – 1093Mediates specificity for BMP ligand By similarity

Sequence similaritiesi

Contains 1 GS domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiP36895.
KOiK04673.
OMAiCYNRDLE.
OrthoDBiEOG7Q8CN3.
PhylomeDBiP36895.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36895-1 [UniParc]FASTAAdd to Basket

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MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDLD QKKPENGVTL    50
APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC 100
MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS 150
IRWLVVLISM AVCIVAMIIF SSCFCYKHYC KSISSRGRYN RDLEQDEAFI 200
PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV GKGRYGEVWM 250
GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY 350
GTQGKPAIAH RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT 400
RVGTKRYMAP EVLDESLNKN HFQPYIMADI YSFGLIIWEM ARRCITGGIV 450
EEYQLPYYNM VPSDPSYEDM REVVCVKRLR PIVSNRWNSD ECLRAVLKLM 500
SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532
Length:532
Mass (Da):60,063
Last modified:June 1, 1994 - v1
Checksum:i70CC83CFB07CE9D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z23154 mRNA. Translation: CAA80678.1.
D16250 mRNA. Translation: BAA03769.1.
U04672 mRNA. Translation: AAA21514.1.
BC042611 mRNA. Translation: AAH42611.1.
CCDSiCCDS26938.1.
PIRiA56238.
RefSeqiNP_033888.2. NM_009758.4.
XP_006518532.1. XM_006518469.1.
XP_006518533.1. XM_006518470.1.
UniGeneiMm.237825.

Genome annotation databases

EnsembliENSMUST00000049005; ENSMUSP00000035900; ENSMUSG00000021796.
GeneIDi12166.
KEGGimmu:12166.
UCSCiuc007taw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z23154 mRNA. Translation: CAA80678.1 .
D16250 mRNA. Translation: BAA03769.1 .
U04672 mRNA. Translation: AAA21514.1 .
BC042611 mRNA. Translation: AAH42611.1 .
CCDSi CCDS26938.1.
PIRi A56238.
RefSeqi NP_033888.2. NM_009758.4.
XP_006518532.1. XM_006518469.1.
XP_006518533.1. XM_006518470.1.
UniGenei Mm.237825.

3D structure databases

ProteinModelPortali P36895.
SMRi P36895. Positions 55-143, 204-530.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198371. 4 interactions.
DIPi DIP-5796N.
IntActi P36895. 1 interaction.

Chemistry

GuidetoPHARMACOLOGYi 1786.

PTM databases

PhosphoSitei P36895.

Proteomic databases

PaxDbi P36895.
PRIDEi P36895.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049005 ; ENSMUSP00000035900 ; ENSMUSG00000021796 .
GeneIDi 12166.
KEGGi mmu:12166.
UCSCi uc007taw.1. mouse.

Organism-specific databases

CTDi 657.
MGIi MGI:1338938. Bmpr1a.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000230587.
HOVERGENi HBG054502.
InParanoidi P36895.
KOi K04673.
OMAi CYNRDLE.
OrthoDBi EOG7Q8CN3.
PhylomeDBi P36895.
TreeFami TF314724.

Enzyme and pathway databases

Reactomei REACT_220505. Signaling by BMP.

Miscellaneous databases

NextBioi 280531.
PROi P36895.
SOURCEi Search...

Gene expression databases

ArrayExpressi P36895.
Bgeei P36895.
CleanExi MM_BMPR1A.
Genevestigatori P36895.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis."
    Dewulf N., Verschueren K., Lonnoy O., Moren A., Grimsby S., Spiegle K., Miyazono K., Huylebroeck D., ten Dijke P.
    Endocrinology 136:2652-2663(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss.
    Tissue: Embryo.
  2. "A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo."
    Suzuki A., Thies R.S., Yamaji N., Song J.J., Wozney J., Murakami K., Kung H.
    Proc. Natl. Acad. Sci. U.S.A. 91:10255-10259(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.

Entry informationi

Entry nameiBMR1A_MOUSE
AccessioniPrimary (citable) accession number: P36895
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 3, 2014
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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