Reviewed, UniProtKB/Swiss-Prot P36895 (BMR1A_MOUSE)

Names and origin

Protein names

Recommended name:
    Bone morphogenetic protein receptor type-1A
    EC=2.7.11.30
Alternative name(s):
    Serine/threonine-protein kinase receptor R5
      Short name=SKR5
    Activin receptor-like kinase 3
      Short name=ALK-3
    BMP-2/BMP-4 receptor
    CD_antigen=CD292

Gene names

Name:	Bmpr1a
Synonyms:	Acvrlk3, Bmpr

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	532 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Widely expressed.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	BMP signaling pathway Inferred from mutant phenotype. Source: MGI Mullerian duct regression Inferred from mutant phenotype. Source: MGI anterior/posterior pattern formation Inferred from mutant phenotype. Source: MGI cartilage development Inferred from mutant phenotype. Source: MGI developmental growth Inferred from mutant phenotype. Source: MGI dorsal/ventral axis specification Inferred from mutant phenotype. Source: MGI ectoderm development Inferred from mutant phenotype. Source: MGI embryonic organ development Inferred from mutant phenotype. Source: MGI heart morphogenesis Inferred from mutant phenotype. Source: MGI hindlimb morphogenesis Inferred from mutant phenotype. Source: MGI in utero embryonic development Inferred from mutant phenotype. Source: MGI lung development Inferred from mutant phenotype. Source: MGI mesendoderm development Inferred from mutant phenotype. Source: MGI mesoderm formation Inferred from mutant phenotype. Source: MGI negative regulation of neurogenesis Inferred from mutant phenotype. Source: MGI odontogenesis of dentine-containing tooth Inferred from mutant phenotype. Source: MGI palate development Inferred from mutant phenotype. Source: MGI pituitary gland development Inferred from mutant phenotype. Source: MGI positive regulation of epithelial cell proliferation Inferred from mutant phenotype. Source: MGI positive regulation of mesenchymal cell proliferation Inferred from mutant phenotype. Source: MGI protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro stem cell maintenance Inferred from mutant phenotype. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW transforming growth factor beta receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 532	509	Bone morphogenetic protein receptor type-1A		PRO_0000024411
Regions
	Topological domain	24 – 152	129	Extracellular Potential
	Transmembrane	153 – 176	24	Potential
	Topological domain	177 – 532	356	Cytoplasmic Potential
	Domain	204 – 233	30	GS
	Domain	234 – 525	292	Protein kinase
	Nucleotide binding	240 – 248	9	ATP By similarity
Sites
	Active site	362	1	Proton acceptor By similarity
	Binding site	261	1	ATP By similarity
Amino acid modifications
	Modified residue	215	1	Phosphoserine By similarity
	Modified residue	216	1	Phosphoserine By similarity
	Modified residue	218	1	Phosphoserine By similarity
	Modified residue	220	1	Phosphoserine By similarity
	Glycosylation	73	1	N-linked (GlcNAc...) Potential
	Disulfide bond	61 ↔ 82		By similarity
	Disulfide bond	63 ↔ 67		By similarity
	Disulfide bond	76 ↔ 100		By similarity
	Disulfide bond	110 ↔ 124		By similarity
	Disulfide bond	125 ↔ 130		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P36895-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 70CC83CFB07CE9D5	FASTA	532	60,063
	10 20 30 40 50 60 MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDLD QKKPENGVTL APEDTLPFLK 70 80 90 100 110 120 CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC MKYEGSDFQC KDSPKAQLRR 130 140 150 160 170 180 TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLVVLISM AVCIVAMIIF SSCFCYKHYC 190 200 210 220 230 240 KSISSRGRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 250 260 270 280 290 300 GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 310 320 330 340 350 360 SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 370 380 390 400 410 420 RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT RVGTKRYMAP EVLDESLNKN 430 440 450 460 470 480 HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 490 500 510 520 530 PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis." Dewulf N., Verschueren K., Lonnoy O., Moren A., Grimsby S., Spiegle K., Miyazono K., Huylebroeck D., ten Dijke P. Endocrinology 136:2652-2663(1995) [PubMed: 7750489] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Swiss. Tissue: Embryo.
[2]	"A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo." Suzuki A., Thies R.S., Yamaji N., Song J.J., Wozney J., Murakami K., Kung H. Proc. Natl. Acad. Sci. U.S.A. 91:10255-10259(1994) [PubMed: 7937936] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells." Koenig B.B., Cook J.S., Wolsing D.H., Ting J., Tiesman J.P., Correa P.E., Olson C.A., Pecquet A.L., Ventura F., Grant R.A., Chen G., Wrana J.L., Massague J., Rosenbaum J.S. Mol. Cell. Biol. 14:5961-5974(1994) [PubMed: 8065329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Retina.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z23154 mRNA. Translation: CAA80678.1. D16250 mRNA. Translation: BAA03769.1. U04672 mRNA. Translation: AAA21514.1. BC042611 mRNA. Translation: AAH42611.1.
IPI	IPI00128193.
PIR	A56238.
RefSeq	NP_033888.2.
UniGene	Mm.237825
3D structure databases
HSSP	HSSP built from PDB template 1ES7 based on UniProtKB P36894.
SMR	P36895. Positions 55-146.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5796N.
STRING	P36895.
Proteomic databases
PRIDE	P36895.
Genome annotation databases
Ensembl	ENSMUST00000049005; ENSMUSP00000035900; ENSMUSG00000021796; Mus musculus. [Genome view]
GeneID	12166.
KEGG	mmu:12166.
UCSC	uc007taw.1. mouse.
Organism-specific databases
CTD	12166.
MGI	MGI:1338938. Bmpr1a.
Phylogenomic databases
HOGENOM	P36895.
HOVERGEN	P36895.
OMA	DECLRAM.
Enzyme and pathway databases
BRENDA	2.7.10.2. 244. 2.7.11.30. 244.
Gene expression databases
ArrayExpress	P36895.
Bgee	P36895.
CleanEx	MM_BMPR1A.
Genevestigator	P36895.
GermOnline	ENSMUSG00000021796. Mus musculus.
Family and domain databases
InterPro	IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00467. GS. 1 hit. [Graphical view]
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	280531.
SOURCE	Search...

Entry information

Entry name

BMR1A_MOUSE

Accession

Primary (citable) accession number: P36895

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	November 3, 2009
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)