P36894 (BMR1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein receptor type-1A
Short name=BMP type-1A receptor
Short name=BMPR-1A
EC=2.7.11.30

Alternative name(s):
Activin receptor-like kinase 3
Short name=ALK-3
Serine/threonine-protein kinase receptor R5
Short name=SKR5
CD_antigen=CD292

Gene names

Name:	BMPR1A
Synonyms:	ACVRLK3, ALK3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	532 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Highly expressed in skeletal muscle.
Involvement in disease	Juvenile polyposis syndrome (JPS) [MIM:174900]: Autosomal dominant gastrointestinal hamartomatous polyposis syndrome in which patients are at risk for developing gastrointestinal cancers. The lesions are typified by a smooth histological appearance, predominant stroma, cystic spaces and lack of a smooth muscle core. Multiple juvenile polyps usually occur in a number of Mendelian disorders. Sometimes, these polyps occur without associated features as in JPS; here, polyps tend to occur in the large bowel and are associated with an increased risk of colon and other gastrointestinal cancers. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Cowden disease (CD) [MIM:158350]: Autosomal dominant cancer predisposition syndrome associated with elevated risk for tumors of the breast, thyroid and skin. The predominant phenotype for CD is multiple hamartoma syndrome, in many organ systems including the breast (70% of CD patients), thyroid (40-60%), skin, CNS (40%), gastrointestinal tract. Affected individuals are at an increased risk of both breast and thyroid cancers. Trichilemmomas (benign tumors of the hair follicle infundibulum), and mucocutaneous papillomatosis (99%) are hallmarks of CD. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6 Ref.7 Polyposis syndrome, mixed hereditary 2 (HMPS2) [MIM:610069]: A disease is characterized by atypical juvenile polyps, colonic adenomas, and colorectal carcinomas. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6 A microdeletion of chromosome 10q23 involving BMPR1A and PTEN is a cause of chromosome 10q23 deletion syndrome, which shows overlapping features of the following three disorders: Bannayan-Zonana syndrome, Cowden disease and juvenile polyposis syndrome. Ref.6
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Disease	Disease mutation
Domain	Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from direct assay PubMed 18436533PubMed 9389648. Source: BHF-UCL Mullerian duct regression Inferred from electronic annotation. Source: Compara cartilage development Inferred from electronic annotation. Source: Compara developmental growth Inferred from electronic annotation. Source: Compara dorsal/ventral axis specification Inferred from electronic annotation. Source: Compara ectoderm development Inferred from electronic annotation. Source: Compara embryonic digit morphogenesis Inferred from electronic annotation. Source: Compara embryonic organ development Inferred from electronic annotation. Source: Compara endocardial cushion formation Inferred from sequence or structural similarity. Source: BHF-UCL heart formation Inferred from electronic annotation. Source: Compara hindlimb morphogenesis Inferred from electronic annotation. Source: Compara immune response Inferred from mutant phenotype PubMed 16886151. Source: BHF-UCL in utero embryonic development Inferred from electronic annotation. Source: Compara lateral mesoderm development Inferred from electronic annotation. Source: Compara lung development Inferred from electronic annotation. Source: Compara mesendoderm development Inferred from electronic annotation. Source: Compara mesoderm formation Inferred from electronic annotation. Source: Compara negative regulation of neurogenesis Inferred from electronic annotation. Source: Compara neural crest cell development Inferred from electronic annotation. Source: Compara neural plate mediolateral regionalization Inferred from electronic annotation. Source: Compara odontogenesis of dentin-containing tooth Inferred from electronic annotation. Source: Compara palate development Inferred from electronic annotation. Source: Compara paraxial mesoderm structural organization Inferred from electronic annotation. Source: Compara pituitary gland development Inferred from electronic annotation. Source: Compara positive regulation of SMAD protein import into nucleus Inferred from direct assay PubMed 9389648. Source: BHF-UCL positive regulation of bone mineralization Inferred from mutant phenotype PubMed 18436533. Source: BHF-UCL positive regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of mesenchymal cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of osteoblast differentiation Inferred from mutant phenotype PubMed 18436533. Source: BHF-UCL positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from direct assay PubMed 9389648. Source: BHF-UCL positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara regulation of lateral mesodermal cell fate specification Inferred from electronic annotation. Source: Compara somitogenesis Inferred from electronic annotation. Source: Compara stem cell maintenance Inferred from electronic annotation. Source: Compara transforming growth factor beta receptor signaling pathway Traceable author statement Ref.1. Source: ProtInc
Cellular_component	dendrite Inferred from electronic annotation. Source: Compara integral to membrane Traceable author statement Ref.1. Source: ProtInc neuronal cell body Inferred from electronic annotation. Source: Compara plasma membrane Inferred from direct assay PubMed 15657086. Source: BHF-UCL
Molecular_function	ATP binding Inferred from direct assay PubMed 12065756. Source: HGNC SMAD binding Inferred from direct assay PubMed 12065756. Source: HGNC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein homodimerization activity Inferred from direct assay PubMed 18436533. Source: BHF-UCL sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from electronic annotation. Source: Compara transforming growth factor beta-activated receptor activity Inferred from electronic annotation. Source: InterPro transmembrane receptor protein serine/threonine kinase activity Traceable author statement. Source: Reactome
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BMP2	P12643	2	EBI-1029237,EBI-1029262

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

23

Potential

Chain

24 – 532

509

Bone morphogenetic protein receptor type-1A

PRO_0000024410

Regions

Topological domain

24 – 152

129

Extracellular Potential

Transmembrane

153 – 176

24

Helical; Potential

Topological domain

177 – 532

356

Cytoplasmic Potential

Domain

204 – 233

30

GS

Domain

234 – 525

292

Protein kinase

Nucleotide binding

240 – 248

9

ATP By similarity

Region

107 – 109

3

Mediates specificity for BMP ligand

Sites

Active site

362

1

Proton acceptor By similarity

Binding site

261

1

ATP By similarity

Amino acid modifications

Glycosylation

73

1

N-linked (GlcNAc...) Potential

Disulfide bond

61 ↔ 82

Disulfide bond

63 ↔ 67

Disulfide bond

76 ↔ 100

Disulfide bond

110 ↔ 124

Disulfide bond

125 ↔ 130

Natural variations

Natural variant

2

1

P → T. Ref.1 Ref.2 Ref.13
Corresponds to variant rs11528010 [ dbSNP | Ensembl ].

VAR_041397

Natural variant

58

1

F → Y in a renal clear cell carcinoma sample; somatic mutation. Ref.13

VAR_041398

Natural variant

62

1

Y → D in JPS. Ref.8

VAR_022828

Natural variant

82

1

C → Y in JPS. Ref.8

VAR_022829

Natural variant

124

1

C → R in JPS. Ref.7

VAR_015533

Natural variant

130

1

C → R in JPS. Ref.9

VAR_022830

Natural variant

338

1

A → D in CD. Ref.7

VAR_015534

Natural variant

376

1

C → Y in JPS. Ref.7

VAR_015535

Natural variant

443

1

R → C in JPS. Ref.8 Ref.13
Corresponds to variant rs35619497 [ dbSNP | Ensembl ].

VAR_022831

Natural variant

450

1

V → M. Ref.13
Corresponds to variant rs55932635 [ dbSNP | Ensembl ].

VAR_041399

Natural variant

470

1

M → T in JPS. Ref.10

VAR_022832

Natural variant

486

1

R → Q in a gastric adenocarcinoma sample; somatic mutation. Ref.13

VAR_041400

Experimental info

Mutagenesis

107 – 109

3

DFQ → REL: Affinity for BMP2 decreased by over 200-fold. Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

532

Helix Strand Turn

Details...

Beta strand

59 – 62

4

Beta strand

64 – 66

3

Beta strand

75 – 88

14

Beta strand

90 – 92

3

Beta strand

94 – 101

8

Helix

106 – 111

6

Beta strand

116 – 118

3

Beta strand

120 – 125

6

Helix

130 – 133

4

Sequences

	Sequence		Length	Mass (Da)
	P36894 [UniParc]. Last modified March 15, 2005. Version 2. Checksum: 00CE2DDDA3A44170	FASTA	532	60,198
	10 20 30 40 50 60 MPQLYIYIRL LGAYLFIISR VQGQNLDSML HGTGMKSDSD QKKSENGVTL APEDTLPFLK 70 80 90 100 110 120 CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC MKYEGSDFQC KDSPKAQLRR 130 140 150 160 170 180 TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLVLLISM AVCIIAMIIF SSCFCYKHYC 190 200 210 220 230 240 KSISSRRRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 250 260 270 280 290 300 GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 310 320 330 340 350 360 SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 370 380 390 400 410 420 RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDVPLNT RVGTKRYMAP EVLDESLNKN 430 440 450 460 470 480 HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 490 500 510 520 530 PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity." ten Dijke P., Ichijo H., Franzen P., Schulz P., Saras J., Toyoshima H., Heldin C.-H., Miyazono K. Oncogene 8:2879-2887(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-2. Tissue: Placenta.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-2. Tissue: Placenta.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"Structure of the Alk1 extracellular domain and characterization of its bone morphogenetic protein (BMP) binding properties." Mahlawat P., Ilangovan U., Biswas T., Sun L.Z., Hinck A.P. Biochemistry 51:6328-6341(2012) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH BMP2, MUTAGENESIS OF 107-ASP--GLN-109.
[5]	"Crystal structure of the BMP-2-BRIA ectodomain complex." Kirsch T., Sebald W., Dreyer M.K. Nat. Struct. Biol. 7:492-496(2000) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 55-143 IN COMPLEX WITH BMP-2.
[6]	"Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis." Howe J.R., Bair J.L., Sayed M.G., Anderson M.E., Mitros F.A., Petersen G.M., Velculescu V.E., Traverso G., Vogelstein B. Nat. Genet. 28:184-187(2001) [PubMed] [Europe PMC] [Abstract] Cited for: DISEASE.
[7]	"Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes." Zhou X.-P., Woodford-Richens K., Lehtonen R., Kurose K., Aldred M., Hampel H., Launonen V., Virta S., Pilarski R., Salovaara R., Bodmer W.F., Conrad B.A., Dunlop M., Hodgson S.V., Iwama T., Jaervinen H., Kellokumpu I., Kim J.C. , Leggett B., Markie D., Mecklin J.-P., Neale K., Phillips R., Piris J., Rozen P., Houlston R.S., Aaltonen L.A., Tomlinson I.P.M., Eng C. Am. J. Hum. Genet. 69:704-711(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS JPS ARG-124 AND TYR-376, VARIANT CD ASP-338.
[8]	"Germline SMAD4 or BMPR1A mutations and phenotype of juvenile polyposis." Sayed M.G., Ahmed A.F., Ringold J.R., Anderson M.E., Bair J.L., Mitros F.A., Lynch H.T., Tinley S.T., Petersen G.M., Giardiello F.M., Vogelstein B., Howe J.R. Ann. Surg. Oncol. 9:901-906(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS JPS ASP-62; TYR-82 AND CYS-443.
[9]	"Juvenile polyposis: massive gastric polyposis is more common in MADH4 mutation carriers than in BMPR1A mutation carriers." Friedl W., Uhlhaas S., Schulmann K., Stolte M., Loff S., Back W., Mangold E., Stern M., Knaebel H.P., Sutter C., Weber R.G., Pistorius S., Burger B., Propping P. Hum. Genet. 111:108-111(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT JPS ARG-130.
[10]	"Identification of a novel BMPR1A germline mutation in a Korean juvenile polyposis patient without SMAD4 mutation." Kim I.J., Park J.H., Kang H.C., Kim K.H., Kim J.H., Ku J.L., Kang S.B., Park S.Y., Lee J.S., Park J.G. Clin. Genet. 63:126-130(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT JPS THR-470.
[11]	"Contiguous gene deletion within chromosome arm 10q is associated with juvenile polyposis of infancy, reflecting cooperation between the BMPR1A and PTEN tumor-suppressor genes." Delnatte C., Sanlaville D., Mougenot J.-F., Vermeesch J.-R., Houdayer C., Blois M.-C., Genevieve D., Goulet O., Fryns J.-P., Jaubert F., Vekemans M., Lyonnet S., Romana S., Eng C., Stoppa-Lyonnet D. Am. J. Hum. Genet. 78:1066-1074(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN JUVENILE POLYPOSIS OF INFANCY.
[12]	"Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function." Cao X., Eu K.W., Kumarasinghe M.P., Li H.H., Loi C., Cheah P.Y. J. Med. Genet. 43:E13-E13(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN HEREDITARY MIXED POLYPOSIS SYNDROME 2.
[13]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-2; TYR-58; CYS-443; MET-450 AND GLN-486.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z22535 mRNA. Translation: CAA80257.1.
AK291764 mRNA. Translation: BAF84453.1.
BC028383 mRNA. Translation: AAH28383.1.

IPI

IPI00005731.

PIR

I37163.

RefSeq

NP_004320.2. NM_004329.2.

UniGene

Hs.524477.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ES7	X-ray	2.90	B/D	55-143	[»]
1REW	X-ray	1.86	C/D	24-152	[»]
2GOO	X-ray	2.20	B/E	24-152	[»]
2H62	X-ray	1.85	C	24-152	[»]
2H64	X-ray	1.92	B	24-152	[»]
2K3G	NMR	-	A	52-152	[»]
2QJ9	X-ray	2.44	C/D	24-152	[»]
2QJA	X-ray	2.60	C/D	24-152	[»]
2QJB	X-ray	2.50	C/D	24-152	[»]
3NH7	X-ray	2.70	A/B/C/D	24-152	[»]
3QB4	X-ray	2.28	B/D	24-152	[»]

ProteinModelPortal

P36894.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-5793N.

IntAct

P36894. 4 interactions.

MINT

MINT-124304.

STRING

9606.ENSP00000224764.

PTM databases

PhosphoSite

P36894.

Polymorphism databases

DMDM

61252444.

Proteomic databases

PaxDb

P36894.

PRIDE

P36894.

Protocols and materials databases

DNASU

657.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000224764; ENSP00000224764; ENSG00000107779.
ENST00000372037; ENSP00000361107; ENSG00000107779.

GeneID

657.

KEGG

hsa:657.

UCSC

uc001kdy.3. human.

Organism-specific databases

CTD

657.

GeneCards

GC10P088506.

HGNC

HGNC:1076. BMPR1A.

HPA

CAB019398.

MIM

158350. phenotype.
174900. phenotype.
601299. gene.
610069. phenotype.
612242. phenotype.

neXtProt

NX_P36894.

Orphanet

157794. Hereditary mixed polyposis syndrome.
144. Hereditary nonpolyposis colon cancer.
2929. Juvenile gastrointestinal polyposis.
79076. Juvenile polyposis of infancy.

PharmGKB

PA25386.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0515.

HOGENOM

HOG000230587.

HOVERGEN

HBG054502.

InParanoid

P36894.

KO

K04673.

OMA

LEVVCVK.

OrthoDB

EOG4F1X2X.

PhylomeDB

P36894.

Enzyme and pathway databases

BRENDA

2.7.10.2. 2681.

Pathway_Interaction_DB

bmppathway. BMP receptor signaling.

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

Bgee

P36894.

CleanEx

HS_BMPR1A.

Genevestigator

P36894.

Family and domain databases

InterPro

IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
[Graphical view]

Pfam

PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]

SMART

SM00467. GS. 1 hit.
[Graphical view]

SUPFAM

SSF56112. Kinase_like. 1 hit.

PROSITE

PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P36894.

ChEMBL

CHEMBL5275.

EvolutionaryTrace

P36894.

GenomeRNAi

657.

NextBio

2672.

SOURCE

Search...

Entry information

Entry name

BMR1A_HUMAN

Accession

Primary (citable) accession number: P36894
Secondary accession number(s): A8K6U9, Q8NEN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	March 15, 2005
Last modified:	May 1, 2013
This is version 162 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.