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Reviewed, UniProtKB/Swiss-Prot P36888 (FLT3_HUMAN)

Last modified June 16, 2009. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (8) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    FL cytokine receptor
    EC=2.7.10.1
Alternative name(s):
    Tyrosine-protein kinase receptor FLT3
    Stem cell tyrosine kinase 1
      Short name=STK-1
    CD_antigen=CD135
Gene names
Name: FLT3
Synonyms: STK1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length993 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Receptor for the FL cytokine. Has a tyrosine-protein kinase activity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Interacts with FIZ1 following ligand activation By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Bone marrow cells.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 protein kinase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 993967FL cytokine receptor
PRO_0000016778

Regions

Topological domain27 – 543517Extracellular Potential
Transmembrane544 – 56320 Potential
Topological domain564 – 993430Cytoplasmic Potential
Domain253 – 34391Ig-like C2-type
Domain610 – 943334Protein kinase
Nucleotide binding616 – 6249ATP By similarity

Sites

Active site8111Proton acceptor By similarity
Binding site6441ATP By similarity

Amino acid modifications

Glycosylation431N-linked (GlcNAc...) Potential
Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation1511N-linked (GlcNAc...) Potential
Glycosylation3061N-linked (GlcNAc...) Potential
Glycosylation3231N-linked (GlcNAc...) Potential
Glycosylation3511N-linked (GlcNAc...) Potential
Glycosylation3541N-linked (GlcNAc...) Potential
Glycosylation4731N-linked (GlcNAc...) Potential
Glycosylation5021N-linked (GlcNAc...) Potential
Glycosylation5411N-linked (GlcNAc...) Potential

Natural variations

Natural variant71D → G: dbSNP rs12872889.
VAR_034677
Natural variant1581V → A Ref.5
VAR_042069
Natural variant1941V → M Ref.6
VAR_054149
Natural variant2271T → M: dbSNP rs1933437. Ref.5 Ref.2 Ref.3
VAR_034678
Natural variant3241D → N: dbSNP rs35602083. Ref.5
VAR_042070
Natural variant3581D → V Ref.5
VAR_042071
Natural variant5571V → I: dbSNP rs35958982. Ref.5
VAR_042072

Experimental info

Sequence conflict81G → A in AAA18947. Ref.1
Sequence conflict10 – 112QL → TV in AAA18947. Ref.1
Sequence conflict781A → R in CAA81393. Ref.2
Sequence conflict3461E → G in AAA18947. Ref.1
Sequence conflict9401T → H in AAA35487. Ref.4

Secondary structure

1 ............................................................... 993
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P36888-1 [UniParc].

Last modified August 21, 2007. Version 2.
Checksum: 6C1995718F352ECE

FASTA993112,903
        10         20         30         40         50         60 
MPALARDGGQ LPLLVVFSAM IFGTITNQDL PVIKCVLINH KNNDSSVGKS SSYPMVSESP 

        70         80         90        100        110        120 
EDLGCALRPQ SSGTVYEAAA VEVDVSASIT LQVLVDAPGN ISCLWVFKHS SLNCQPHFDL 

       130        140        150        160        170        180 
QNRGVVSMVI LKMTETQAGE YLLFIQSEAT NYTILFTVSI RNTLLYTLRR PYFRKMENQD 

       190        200        210        220        230        240 
ALVCISESVP EPIVEWVLCD SQGESCKEES PAVVKKEEKV LHELFGTDIR CCARNELGRE 

       250        260        270        280        290        300 
CTRLFTIDLN QTPQTTLPQL FLKVGEPLWI RCKAVHVNHG FGLTWELENK ALEEGNYFEM 

       310        320        330        340        350        360 
STYSTNRTMI RILFAFVSSV ARNDTGYYTC SSSKHPSQSA LVTIVEKGFI NATNSSEDYE 

       370        380        390        400        410        420 
IDQYEEFCFS VRFKAYPQIR CTWTFSRKSF PCEQKGLDNG YSISKFCNHK HQPGEYIFHA 

       430        440        450        460        470        480 
ENDDAQFTKM FTLNIRRKPQ VLAEASASQA SCFSDGYPLP SWTWKKCSDK SPNCTEEITE 

       490        500        510        520        530        540 
GVWNRKANRK VFGQWVSSST LNMSEAIKGF LVKCCAYNSL GTSCETILLN SPGPFPFIQD 

       550        560        570        580        590        600 
NISFYATIGV CLLFIVVLTL LICHKYKKQF RYESQLQMVQ VTGSSDNEYF YVDFREYEYD 

       610        620        630        640        650        660 
LKWEFPRENL EFGKVLGSGA FGKVMNATAY GISKTGVSIQ VAVKMLKEKA DSSEREALMS 

       670        680        690        700        710        720 
ELKMMTQLGS HENIVNLLGA CTLSGPIYLI FEYCCYGDLL NYLRSKREKF HRTWTEIFKE 

       730        740        750        760        770        780 
HNFSFYPTFQ SHPNSSMPGS REVQIHPDSD QISGLHGNSF HSEDEIEYEN QKRLEEEEDL 

       790        800        810        820        830        840 
NVLTFEDLLC FAYQVAKGME FLEFKSCVHR DLAARNVLVT HGKVVKICDF GLARDIMSDS 

       850        860        870        880        890        900 
NYVVRGNARL PVKWMAPESL FEGIYTIKSD VWSYGILLWE IFSLGVNPYP GIPVDANFYK 

       910        920        930        940        950        960 
LIQNGFKMDQ PFYATEEIYI IMQSCWAFDS RKRPSFPNLT SFLGCQLADA EEAMYQNVDG 

       970        980        990 
RVSECPHTYQ NRRPFSREMD LGLLSPQAQV EDS

« Hide

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References

« Hide 'large scale' references
[1]"STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells."
Small D., Levenstein M., Kim E., Carow C., Amin S., Rockwell P., Witte L., Burrow C., Ratajczak M.Z., Gewirtz A.M., Civin C.I.
Proc. Natl. Acad. Sci. U.S.A. 91:459-463(1994) [PubMed: 7507245] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells."
Rosnet O., Schiff C., Pebusque M.J., Marchetto S., Tonnelle C., Toiron Y., Birg F., Birnbaum D.
Blood 82:1110-1119(1993) [PubMed: 8394751] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-227.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-227.
[4]"Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene."
Rosnet O., Mattei M.-G., Marchetto S., Birnbaum D.
Genomics 9:380-385(1991) [PubMed: 2004790] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 783-942.
Tissue: Testis.
[5]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed: 17344846] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-158; MET-227; ASN-324; VAL-358 AND ILE-557.
[6]"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Ley T.J., Mardis E.R., Ding L., Fulton B., McLellan M.D., Chen K., Dooling D., Dunford-Shore B.H., McGrath S., Hickenbotham M., Cook L., Abbott R., Larson D.E., Koboldt D.C., Pohl C., Smith S., Hawkins A., Abbott S. expand/collapse author list , Locke D., Hillier L.W., Miner T., Fulton L., Magrini V., Wylie T., Glasscock J., Conyers J., Sander N., Shi X., Osborne J.R., Minx P., Gordon D., Chinwalla A., Zhao Y., Ries R.E., Payton J.E., Westervelt P., Tomasson M.H., Watson M., Baty J., Ivanovich J., Heath S., Shannon W.D., Nagarajan R., Walter M.J., Link D.C., Graubert T.A., DiPersio J.F., Wilson R.K.
Nature 456:66-72(2008) [PubMed: 18987736] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-194.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U02687 mRNA. Translation: AAA18947.1.
Z26652 mRNA. Translation: CAA81393.1.
BC126350 mRNA. Translation: AAI26351.1.
L36162 mRNA. Translation: AAA35487.1.
IPIIPI00005722.
PIRA36873.
A39061.
RefSeqNP_004110.2.
UniGeneHs.507590

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1RJBX-ray2.10A564-958[»]
DisProtDP00312.
ModBaseSearch...

PTM databases

PhosphoSiteP36888.

Proteomic databases

PRIDEP36888.

Genome annotation databases

EnsemblENSG00000122025. Homo sapiens. [Contig view]
GeneID2322.
KEGGhsa:2322.
NMPDRfig|9606.3.peg.8675.

Organism-specific databases

GeneCardsGC13M027475.
H-InvDBHIX0037338.
HGNCHGNC:3765. FLT3.
HPACAB018358.
MIM136351. gene.
Orphanet519. Leukemia, myeloid, acute.
PharmGKBPA28181.
GenAtlasSearch...

Phylogenomic databases

HOVERGENP36888.

Enzyme and pathway databases

BRENDA2.7.10.1. 247.

Gene expression databases

ArrayExpressP36888.
BgeeP36888.
CleanExHS_FLT3.
GermOnlineENSG00000122025. Homo sapiens.

Family and domain databases

InterProIPR013151. Ig.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR001824. Recept_tyr_kinase-III_CS.
IPR001245. Tyr_pkinase.
IPR008266. Tyr_pkinase_AS.
IPR016243. TyrPK_CSF1-R.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 2 hits.
PfamPF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFPIRSF000615. TyrPK_CSF1-R. 1 hit.
ProDomPD000001. Prot_kinase. 2 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00398. Sorafenib.
DB01268. Sunitinib.
NextBio9425.
SOURCESearch...

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Entry information

Entry nameFLT3_HUMAN
AccessionPrimary (citable) accession number: P36888
Secondary accession number(s): A0AVG9, Q13414
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: August 21, 2007
Last modified: June 16, 2009
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

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SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents