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Protein

Putative phosphotransferase enzyme IIA component YadI

Gene

yadI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.By similarity

Catalytic activityi

Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91Tele-phosphohistidine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:AGAX-MONOMER.
ECOL316407:JW0125-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphotransferase enzyme IIA component YadI (EC:2.7.1.-)
Alternative name(s):
Putative PTS system EIIA component
Gene namesi
Name:yadI
Ordered Locus Names:b0129, JW0125
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12322. yadI.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 146146Putative phosphotransferase enzyme IIA component YadIPRO_0000186708Add
BLAST

Proteomic databases

PaxDbiP36881.

Interactioni

Protein-protein interaction databases

STRINGi511145.b0129.

Structurei

3D structure databases

ProteinModelPortaliP36881.
SMRiP36881. Positions 5-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 124124PTS EIIA type-4PROSITE-ProRule annotationAdd
BLAST

Domaini

The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.

Sequence similaritiesi

Contains 1 PTS EIIA type-4 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108YTN. Bacteria.
COG2893. LUCA.
HOGENOMiHOG000095324.
InParanoidiP36881.
OMAiLPLRESM.
OrthoDBiEOG6FJNGT.
PhylomeDBiP36881.

Family and domain databases

Gene3Di3.40.50.510. 1 hit.
InterProiIPR004701. PTS_EIIA_man-typ.
[Graphical view]
PfamiPF03610. EIIA-man. 1 hit.
[Graphical view]
SUPFAMiSSF53062. SSF53062. 1 hit.
PROSITEiPS51096. PTS_EIIA_TYPE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGWVITCHD DRAQEILDAL EKKHGALLQC RAVNFWRGLS SNMLSRMMCD
60 70 80 90 100
ALHEADSGEG VIFLTDIAGA PPYRVASLLS HKHSRCEVIS GVTLPLIEQM
110 120 130 140
MACRETMTSS EFRERIVELG APEVSSLWHQ QQKNPPFVLK HNLYEY
Length:146
Mass (Da):16,540
Last modified:November 1, 1997 - v2
Checksum:i9534A95A41130CE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73240.1.
AP009048 Genomic DNA. Translation: BAB96706.2.
PIRiA64736.
RefSeqiNP_414671.1. NC_000913.3.
WP_000901987.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73240; AAC73240; b0129.
BAB96706; BAB96706; BAB96706.
GeneIDi947397.
KEGGiecj:JW0125.
eco:b0129.
PATRICi32115361. VBIEscCol129921_0132.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73240.1.
AP009048 Genomic DNA. Translation: BAB96706.2.
PIRiA64736.
RefSeqiNP_414671.1. NC_000913.3.
WP_000901987.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP36881.
SMRiP36881. Positions 5-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511145.b0129.

Proteomic databases

PaxDbiP36881.

Protocols and materials databases

DNASUi947397.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73240; AAC73240; b0129.
BAB96706; BAB96706; BAB96706.
GeneIDi947397.
KEGGiecj:JW0125.
eco:b0129.
PATRICi32115361. VBIEscCol129921_0132.

Organism-specific databases

EchoBASEiEB2227.
EcoGeneiEG12322. yadI.

Phylogenomic databases

eggNOGiENOG4108YTN. Bacteria.
COG2893. LUCA.
HOGENOMiHOG000095324.
InParanoidiP36881.
OMAiLPLRESM.
OrthoDBiEOG6FJNGT.
PhylomeDBiP36881.

Enzyme and pathway databases

BioCyciEcoCyc:AGAX-MONOMER.
ECOL316407:JW0125-MONOMER.

Miscellaneous databases

PROiP36881.

Family and domain databases

Gene3Di3.40.50.510. 1 hit.
InterProiIPR004701. PTS_EIIA_man-typ.
[Graphical view]
PfamiPF03610. EIIA-man. 1 hit.
[Graphical view]
SUPFAMiSSF53062. SSF53062. 1 hit.
PROSITEiPS51096. PTS_EIIA_TYPE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region."
    Fujita N., Mori H., Yura T., Ishihama A.
    Nucleic Acids Res. 22:1637-1639(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiYADI_ECOLI
AccessioniPrimary (citable) accession number: P36881
Secondary accession number(s): P75658
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.