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Reviewed, UniProtKB/Swiss-Prot P36876 (2ABA_RAT)

Last modified February 9, 2010. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Alternative name(s):
    PP2A subunit B isoform alpha
    PP2A subunit B isoform B55-alpha
    PP2A subunit B isoform PR55-alpha
    PP2A subunit B isoform R2-alpha
    PP2A subunit B isoform BRA
Gene names
Name: Ppp2r2a
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Subunit structure

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TP53 By similarity.

Tissue specificity

Brain.

Sequence similarities

Belongs to the phosphatase 2A regulatory subunit B family.

Contains 7 WD repeats.

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Ontologies

Keywords
   DomainRepeat
WD repeat
   PTMAcetylation
Gene Ontology (GO)
   Biological processsignal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentprotein phosphatase type 2A complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionprotein phosphatase type 2A regulator activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 447446Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
PRO_0000071420

Regions

Repeat26 – 6540WD 1
Repeat91 – 13242WD 2
Repeat175 – 21339WD 3
Repeat224 – 26441WD 4
Repeat283 – 32139WD 5
Repeat338 – 37942WD 6
Repeat414 – 44633WD 7

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Natural variations

Natural variant601E → ESFKVHAALREASNLSMQ

Experimental info

Sequence conflict1051K → E in AAA41909. Ref.1
Sequence conflict1051K → R in BAA21904. Ref.3
Sequence conflict2131N → S in BAA21904. Ref.3
Sequence conflict2221M → V in BAA21904. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
P36876-1 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 180AC837D9DA4ECE

FASTA44751,678
        10         20         30         40         50         60 
MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG RVVIFQQEQE 

        70         80         90        100        110        120 
NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQKNAAQF LLSTNDKTIK 

       130        140        150        160        170        180 
LWKISERDKR PEGYNLKEED GRYRDPTTVT TLRVPVFRPM DLMVEASPRR IFANAHTYHI 

       190        200        210        220        230        240 
NSISINSDYE TYLSADDLRI NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN 

       250        260        270        280        290        300 
TFVYSSSKGT IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM 

       310        320        330        340        350        360 
MTRDYLSVKV WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW NGSDSVVMTG 

       370        380        390        400        410        420 
SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS GKRKKDEISV DSLDFNKKIL 

       430        440 
HTAWHPKENI IAVATTNNLY IFQDKVN

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References

« Hide 'large scale' references
[1]"The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigens."
Pallas D.C., Weller W., Jaspers S., Miller T.B. Jr., Lane W.S., Roberts T.M.
J. Virol. 66:886-893(1992) [PubMed: 1370560] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[3]"Expression of PP2A B regulatory subunit beta isotype in rat testis."
Hatano Y., Shima H., Haneji T., Miura A.B., Sugimura T., Nagao M.
FEBS Lett. 324:71-75(1993) [PubMed: 8389301] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-272.
Strain: Fischer 344.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M83298 mRNA. Translation: AAA41910.1.
M83297 mRNA. Translation: AAA41909.1.
BC128731 mRNA. Translation: AAI28732.1.
D14419 mRNA. Translation: BAA21904.1.
IPIIPI00326486.
PIRA41805.
RefSeqNP_446451.1.
UniGeneRn.81155

3D structure databases

SMRP36876. Positions 26-373, 77-443.
ModBaseSearch...

Protein-protein interaction databases

STRINGP36876.

Proteomic databases

PRIDEP36876.

Genome annotation databases

EnsemblENSRNOT00000015318; ENSRNOP00000015318; ENSRNOG00000011158; Rattus norvegicus. [Genome view]
GeneID117104.
KEGGrno:117104.
UCSCM83297. rat.

Organism-specific databases

CTD117104.
RGD620919. Ppp2r2a.

Phylogenomic databases

eggNOGroNOG04944.
HOVERGENP36876.
InParanoidP36876.
PhylomeDBP36876.

Gene expression databases

ArrayExpressP36876.
GenevestigatorP36876.
GermOnlineENSRNOG00000011158. Rattus norvegicus.

Family and domain databases

InterProIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR011046. WD40_repeat-like_dom.
IPR019781. WD40_repeat_sg.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PANTHERPTHR11871. Pp2A_PR55. 1 hit.
PfamPF00400. WD40. 2 hits.
[Graphical view]
PIRSFPIRSF037309. PP2A_PR55. 1 hit.
PRINTSPR00600. PP2APR55.
SMARTSM00320. WD40. 7 hits.
[Graphical view]
PROSITEPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
PS00678. WD_REPEATS_1. False negative.
PS50082. WD_REPEATS_2. False negative.
PS50294. WD_REPEATS_REGION. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio619996.

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Entry information

Entry name2ABA_RAT
AccessionPrimary (citable) accession number: P36876
Secondary accession number(s): A1A5M9, O35512, P36878
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 9, 2010
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents