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Protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Gene

Ppp2r2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-69231 Cyclin D associated events in G1
R-RNO-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-RNO-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Alternative name(s):
PP2A subunit B isoform B55-alpha
PP2A subunit B isoform BRA
PP2A subunit B isoform PR55-alpha
PP2A subunit B isoform R2-alpha
PP2A subunit B isoform alpha
Gene namesi
Name:Ppp2r2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi620919 Ppp2r2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000714202 – 447Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP36876
PRIDEiP36876

PTM databases

iPTMnetiP36876
PhosphoSitePlusiP36876

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSRNOG00000011158
GenevisibleiP36876 RN

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). Interacts with TP53 (By similarity). Interacts with IER5 (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-40819N
IntActiP36876, 4 interactors
STRINGi10116.ENSRNOP00000015318

Structurei

3D structure databases

ProteinModelPortaliP36876
SMRiP36876
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 65WD 1Add BLAST40
Repeati91 – 132WD 2Add BLAST42
Repeati175 – 213WD 3Add BLAST39
Repeati224 – 264WD 4Add BLAST41
Repeati283 – 321WD 5Add BLAST39
Repeati338 – 379WD 6Add BLAST42
Repeati414 – 446WD 7Add BLAST33

Sequence similaritiesi

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1354 Eukaryota
COG5170 LUCA
GeneTreeiENSGT00390000006311
HOGENOMiHOG000089745
HOVERGENiHBG000012
InParanoidiP36876
KOiK04354
OMAiPGGCTSL
OrthoDBiEOG091G09BB
PhylomeDBiP36876
TreeFamiTF105553

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR000009 PP2A_PR55
IPR018067 PP2A_PR55_CS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11871 PTHR11871, 1 hit
PIRSFiPIRSF037309 PP2A_PR55, 1 hit
PRINTSiPR00600 PP2APR55
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS01024 PR55_1, 1 hit
PS01025 PR55_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG
60 70 80 90 100
RVVIFQQEQE NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR
110 120 130 140 150
WLPQKNAAQF LLSTNDKTIK LWKISERDKR PEGYNLKEED GRYRDPTTVT
160 170 180 190 200
TLRVPVFRPM DLMVEASPRR IFANAHTYHI NSISINSDYE TYLSADDLRI
210 220 230 240 250
NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN TFVYSSSKGT
260 270 280 290 300
IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM
310 320 330 340 350
MTRDYLSVKV WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW
360 370 380 390 400
NGSDSVVMTG SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS
410 420 430 440
GKRKKDEISV DSLDFNKKIL HTAWHPKENI IAVATTNNLY IFQDKVN
Length:447
Mass (Da):51,678
Last modified:June 1, 1994 - v1
Checksum:i180AC837D9DA4ECE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105K → E in AAA41909 (PubMed:1370560).Curated1
Sequence conflicti105K → R in BAA21904 (PubMed:8389301).Curated1
Sequence conflicti213N → S in BAA21904 (PubMed:8389301).Curated1
Sequence conflicti222M → V in BAA21904 (PubMed:8389301).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti60E → ESFKVHAALREASNLSMQ. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83298 mRNA Translation: AAA41910.1
M83297 mRNA Translation: AAA41909.1
BC128731 mRNA Translation: AAI28732.1
D14419 mRNA Translation: BAA21904.1
PIRiA41805
RefSeqiNP_446451.1, NM_053999.2
UniGeneiRn.81155

Genome annotation databases

EnsembliENSRNOT00000015318; ENSRNOP00000015318; ENSRNOG00000011158
GeneIDi117104
KEGGirno:117104
UCSCiRGD:620919 rat

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry namei2ABA_RAT
AccessioniPrimary (citable) accession number: P36876
Secondary accession number(s): A1A5M9, O35512, P36878
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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