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Protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Gene

Ppp2r2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

GO - Molecular functioni

  • protein complex binding Source: RGD
  • protein phosphatase 2A binding Source: RGD
  • protein phosphatase type 2A regulator activity Source: InterPro
  • protein serine/threonine phosphatase activity Source: Ensembl
  • tau protein binding Source: RGD

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-2995383. Initiation of Nuclear Envelope Reformation.
R-RNO-69231. Cyclin D associated events in G1.
R-RNO-69273. Cyclin A/B1 associated events during G2/M transition.
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Alternative name(s):
PP2A subunit B isoform B55-alpha
PP2A subunit B isoform BRA
PP2A subunit B isoform PR55-alpha
PP2A subunit B isoform R2-alpha
PP2A subunit B isoform alpha
Gene namesi
Name:Ppp2r2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi620919. Ppp2r2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 447446Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformPRO_0000071420Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP36876.
PRIDEiP36876.

PTM databases

iPTMnetiP36876.
PhosphoSiteiP36876.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

GenevisibleiP36876. RN.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TP53. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity).By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD
  • protein phosphatase 2A binding Source: RGD
  • tau protein binding Source: RGD

Protein-protein interaction databases

DIPiDIP-40819N.
MINTiMINT-121997.
STRINGi10116.ENSRNOP00000015318.

Structurei

3D structure databases

ProteinModelPortaliP36876.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 6540WD 1Add
BLAST
Repeati91 – 13242WD 2Add
BLAST
Repeati175 – 21339WD 3Add
BLAST
Repeati224 – 26441WD 4Add
BLAST
Repeati283 – 32139WD 5Add
BLAST
Repeati338 – 37942WD 6Add
BLAST
Repeati414 – 44633WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1354. Eukaryota.
COG5170. LUCA.
GeneTreeiENSGT00390000006311.
HOGENOMiHOG000089745.
HOVERGENiHBG000012.
InParanoidiP36876.
KOiK04354.
OMAiFLKFSLR.
OrthoDBiEOG7Q5HCZ.
PhylomeDBiP36876.
TreeFamiTF105553.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG
60 70 80 90 100
RVVIFQQEQE NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR
110 120 130 140 150
WLPQKNAAQF LLSTNDKTIK LWKISERDKR PEGYNLKEED GRYRDPTTVT
160 170 180 190 200
TLRVPVFRPM DLMVEASPRR IFANAHTYHI NSISINSDYE TYLSADDLRI
210 220 230 240 250
NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN TFVYSSSKGT
260 270 280 290 300
IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM
310 320 330 340 350
MTRDYLSVKV WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW
360 370 380 390 400
NGSDSVVMTG SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS
410 420 430 440
GKRKKDEISV DSLDFNKKIL HTAWHPKENI IAVATTNNLY IFQDKVN
Length:447
Mass (Da):51,678
Last modified:June 1, 1994 - v1
Checksum:i180AC837D9DA4ECE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051K → E in AAA41909 (PubMed:1370560).Curated
Sequence conflicti105 – 1051K → R in BAA21904 (PubMed:8389301).Curated
Sequence conflicti213 – 2131N → S in BAA21904 (PubMed:8389301).Curated
Sequence conflicti222 – 2221M → V in BAA21904 (PubMed:8389301).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601E → ESFKVHAALREASNLSMQ.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83298 mRNA. Translation: AAA41910.1.
M83297 mRNA. Translation: AAA41909.1.
BC128731 mRNA. Translation: AAI28732.1.
D14419 mRNA. Translation: BAA21904.1.
PIRiA41805.
RefSeqiNP_446451.1. NM_053999.2.
UniGeneiRn.81155.

Genome annotation databases

EnsembliENSRNOT00000015318; ENSRNOP00000015318; ENSRNOG00000011158.
GeneIDi117104.
KEGGirno:117104.
UCSCiRGD:620919. rat.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83298 mRNA. Translation: AAA41910.1.
M83297 mRNA. Translation: AAA41909.1.
BC128731 mRNA. Translation: AAI28732.1.
D14419 mRNA. Translation: BAA21904.1.
PIRiA41805.
RefSeqiNP_446451.1. NM_053999.2.
UniGeneiRn.81155.

3D structure databases

ProteinModelPortaliP36876.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-40819N.
MINTiMINT-121997.
STRINGi10116.ENSRNOP00000015318.

PTM databases

iPTMnetiP36876.
PhosphoSiteiP36876.

Proteomic databases

PaxDbiP36876.
PRIDEiP36876.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015318; ENSRNOP00000015318; ENSRNOG00000011158.
GeneIDi117104.
KEGGirno:117104.
UCSCiRGD:620919. rat.

Organism-specific databases

CTDi5520.
RGDi620919. Ppp2r2a.

Phylogenomic databases

eggNOGiKOG1354. Eukaryota.
COG5170. LUCA.
GeneTreeiENSGT00390000006311.
HOGENOMiHOG000089745.
HOVERGENiHBG000012.
InParanoidiP36876.
KOiK04354.
OMAiFLKFSLR.
OrthoDBiEOG7Q5HCZ.
PhylomeDBiP36876.
TreeFamiTF105553.

Enzyme and pathway databases

ReactomeiR-RNO-2995383. Initiation of Nuclear Envelope Reformation.
R-RNO-69231. Cyclin D associated events in G1.
R-RNO-69273. Cyclin A/B1 associated events during G2/M transition.
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

NextBioi619996.
PROiP36876.

Gene expression databases

GenevisibleiP36876. RN.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigens."
    Pallas D.C., Weller W., Jaspers S., Miller T.B. Jr., Lane W.S., Roberts T.M.
    J. Virol. 66:886-893(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  3. "Expression of PP2A B regulatory subunit beta isotype in rat testis."
    Hatano Y., Shima H., Haneji T., Miura A.B., Sugimura T., Nagao M.
    FEBS Lett. 324:71-75(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-272.
    Strain: Fischer 344.

Entry informationi

Entry namei2ABA_RAT
AccessioniPrimary (citable) accession number: P36876
Secondary accession number(s): A1A5M9, O35512, P36878
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 11, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.