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P36874

- PP1GA_XENLA

UniProt

P36874 - PP1GA_XENLA

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Protein

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit A

Gene

ppp1cc-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (By similarity). Promotes nuclear envelope reassembly by targeting nuclear membrane vesicles to chromatin at the end of mitosis. Acts by dephosphorylating membrane proteins such as lamin B receptor (lbr) to regulate the binding of membrane proteins to chromatin.By similarity1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

Cofactori

Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Manganese 1By similarity
Metal bindingi66 – 661Manganese 1By similarity
Metal bindingi92 – 921Manganese 1By similarity
Metal bindingi92 – 921Manganese 2By similarity
Metal bindingi124 – 1241Manganese 2By similarity
Active sitei125 – 1251Proton donorBy similarity
Metal bindingi173 – 1731Manganese 2By similarity
Metal bindingi248 – 2481Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. glycogen metabolic process Source: UniProtKB-KW
  2. mitotic nuclear division Source: UniProtKB-KW
  3. mitotic nuclear envelope reassembly Source: UniProtKB
  4. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Carbohydrate metabolism, Cell cycle, Cell division, Glycogen metabolism, Mitosis

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit A (EC:3.1.3.16)
Short name:
PP-1G-A
Short name:
xPP1-gamma1
Gene namesi
Name:ppp1cc-a
Synonyms:ppp1cc
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-967940. ppp1cc.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus By similarity. Nucleusnucleolus By similarity. Cleavage furrow By similarity. Nucleusnucleoplasm By similarity. Chromosomecentromerekinetochore By similarity. Nucleus speckle By similarity. Midbody By similarity. Mitochondrion By similarity. Membrane 1 Publication

GO - Cellular componenti

  1. kinetochore Source: UniProtKB-KW
  2. membrane Source: UniProtKB
  3. mitochondrion Source: UniProtKB
  4. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Serine/threonine-protein phosphatase PP1-gamma catalytic subunit APRO_0000058790Add
BLAST

Proteomic databases

PRIDEiP36874.

Interactioni

Subunit structurei

PP1 comprises a catalytic subunit, ppp1c1, ppp1cb or ppp1cc, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then is complexed to one or several targeting or regulatory subunits.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
casp2Q9IB672EBI-2908704,EBI-7207360
cenpeO422632EBI-2908704,EBI-2607221

Protein-protein interaction databases

IntActiP36874. 2 interactions.
MINTiMINT-7978751.

Structurei

3D structure databases

ProteinModelPortaliP36874.
SMRiP36874. Positions 6-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

HOVERGENiHBG000216.
KOiK06269.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36874-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADVDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP
60 70 80 90 100
ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS
110 120 130 140 150
LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK
160 170 180 190 200
TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL
210 220 230 240 250
LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV
260 270 280 290 300
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE
310 320
KKKPNASRPV TPPRGMITKQ AKK
Length:323
Mass (Da):36,956
Last modified:March 3, 2009 - v2
Checksum:i8CD4C5DE036A8C2B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti213 – 2131V → I in AAA49934. 1 PublicationCurated
Sequence conflicti220 – 2201D → Y in AAA49934. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB106881 mRNA. Translation: BAF51554.1.
L17039 mRNA. Translation: AAA49934.1.
BC090213 mRNA. Translation: AAH90213.1.
RefSeqiNP_001081308.1. NM_001087839.1.
UniGeneiXl.6679.

Genome annotation databases

GeneIDi397767.
KEGGixla:397767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB106881 mRNA. Translation: BAF51554.1 .
L17039 mRNA. Translation: AAA49934.1 .
BC090213 mRNA. Translation: AAH90213.1 .
RefSeqi NP_001081308.1. NM_001087839.1.
UniGenei Xl.6679.

3D structure databases

ProteinModelPortali P36874.
SMRi P36874. Positions 6-300.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P36874. 2 interactions.
MINTi MINT-7978751.

Proteomic databases

PRIDEi P36874.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397767.
KEGGi xla:397767.

Organism-specific databases

Xenbasei XB-GENE-967940. ppp1cc.

Phylogenomic databases

HOVERGENi HBG000216.
KOi K06269.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nuclear envelope precursor vesicle targeting to chromatin is stimulated by protein phosphatase 1 in Xenopus egg extracts."
    Ito H., Koyama Y., Takano M., Ishii K., Maeno M., Furukawa K., Horigome T.
    Exp. Cell Res. 313:1897-1910(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
    Tissue: Oocyte.
  2. "The C-terminus of Xenopus protein phosphatase 1-gamma1 determines its cell cycle-dependent regulation and phosphorylation."
    Walker D.H., Rempel R., Maller J.L.
    Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. NIH - Xenopus Gene Collection (XGC) project
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.

Entry informationi

Entry nameiPP1GA_XENLA
AccessioniPrimary (citable) accession number: P36874
Secondary accession number(s): Q5EAX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3