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Protein

Ras-related protein Ral-B

Gene

Ralb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis (By similarity). Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells.By similarity2 Publications

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 29GTPBy similarity9
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi128 – 131GTPBy similarity4
Nucleotide bindingi158 – 160GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cytokinesis Source: UniProtKB
  • Ras protein signal transduction Source: Reactome
  • regulation of exocyst assembly Source: UniProtKB
  • regulation of exocyst localization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-171007. p38MAPK events.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Ral-B
Gene namesi
Name:Ralb
Synonyms:Ral-b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619852. Ralb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827001 – 203Ras-related protein Ral-BAdd BLAST203
PropeptideiPRO_0000281353204 – 206Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203Cysteine methyl esterBy similarity1
Lipidationi203S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Prenylation is essential for membrane localization.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP36860.
PRIDEiP36860.

PTM databases

iPTMnetiP36860.
PhosphoSitePlusiP36860.
SwissPalmiP36860.

Interactioni

Subunit structurei

Interacts with EXOC8. Interacts with RALBP1 via its effector domain (By similarity).By similarity

Protein-protein interaction databases

BioGridi250481. 1 interactor.
STRINGi10116.ENSRNOP00000003413.

Structurei

3D structure databases

ProteinModelPortaliP36860.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 51Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiP36860.
KOiK07835.
PhylomeDBiP36860.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR028412. Ral.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PTHR24070:SF199. PTHR24070:SF199. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANKGKSQG SLVLHKVIMV GSGGVGKSAL TLQFMYDEFV EDYEPTKADS
60 70 80 90 100
YRKKVVLDGE EVQIDILDTA GQEDYAAIRD NYFRSGEGFL LVFSITEHES
110 120 130 140 150
FTATAEFREQ ILRVKAEEDK IPLLVVGNKS DLEERRQVPV EEARGKAEEW
160 170 180 190 200
GVQYVETSAK TRANVDKVFF DLMREIRAKK MSENKDKNGR KSGKSKKSFK

ERCCLL
Length:206
Mass (Da):23,317
Last modified:June 1, 1994 - v1
Checksum:i42C43BCE66A3D421
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19699 mRNA. Translation: AAA42004.1.
BC072505 mRNA. Translation: AAH72505.1.
PIRiJN0623.
RefSeqiNP_446273.1. NM_053821.2.
XP_017454125.1. XM_017598636.1.
UniGeneiRn.4586.

Genome annotation databases

GeneIDi116546.
KEGGirno:116546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19699 mRNA. Translation: AAA42004.1.
BC072505 mRNA. Translation: AAH72505.1.
PIRiJN0623.
RefSeqiNP_446273.1. NM_053821.2.
XP_017454125.1. XM_017598636.1.
UniGeneiRn.4586.

3D structure databases

ProteinModelPortaliP36860.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250481. 1 interactor.
STRINGi10116.ENSRNOP00000003413.

PTM databases

iPTMnetiP36860.
PhosphoSitePlusiP36860.
SwissPalmiP36860.

Proteomic databases

PaxDbiP36860.
PRIDEiP36860.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116546.
KEGGirno:116546.

Organism-specific databases

CTDi5899.
RGDi619852. Ralb.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiP36860.
KOiK07835.
PhylomeDBiP36860.

Enzyme and pathway databases

ReactomeiR-RNO-171007. p38MAPK events.

Miscellaneous databases

PROiP36860.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR028412. Ral.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PTHR24070:SF199. PTHR24070:SF199. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRALB_RAT
AccessioniPrimary (citable) accession number: P36860
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.