P36849 (HEX_ADE03) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hexon protein

Alternative name(s):
Late protein 2

Gene names

Name:

PII

Organism

Human adenovirus B serotype 3 (HAdV-3) (Human adenovirus 3)

Taxonomic identifier

45659 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Human adenovirus B

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	944 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is one of the structural proteins of the viral capsid and is synthesized during late infection. It is involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of viral capsid to the nucleus By similarity.
Subunit structure	Homotrimer By similarity.
Subcellular location	Virion Potential.
Sequence similarities	Belongs to the adenoviridae hexon protein family.

Ontologies

Keywords
Biological process	Cytoplasmic active transport of viral material Host-virus interaction Initiation of viral infection Microtubule-dependent active transport of viral material
Cellular component	Virion
Developmental stage	Late protein
Molecular function	Capsid protein
Gene Ontology (GO)
Biological process	interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 944	944	Hexon protein		PRO_0000221814

Sequences

	Sequence		Length	Mass (Da)
	P36849 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: B779C679417F49D9	FASTA	944	106,088
	10 20 30 40 50 60 MATPSMMPQW AYMHIAGQDA SGYLSPGLVQ FARATDTYFS MGNKFRNPTV APTHDVTTDR 70 80 90 100 110 120 SQRLMLRFVP VDREDNTYSY KVRYTLAVGD NRVLDMASTF FDIRGVLDRG PSFKPYSGTA 130 140 150 160 170 180 YNSLAPKGAP NTSQWIVTTN GDNAVTTTTN TFGIASMKGG NITKEGLQIG KDITTTEGEE 190 200 210 220 230 240 KPIYADKTYQ PEPQVGEESW TDTDGTNEKF GGRALKPATN MKPCYGSFAR PTNIKGGQAK 250 260 270 280 290 300 NRKVKPTTEG GVETEEPDID MEFFDGRDAV AGALAPEIVL YTENVNLETP DSHVVYKPET 310 320 330 340 350 360 SNNSHANLGQ QAMPNRPNYI GFRDNFVGLM YYNSTGNMGV LAGQASQLNA VVDLQDRNTE 370 380 390 400 410 420 LSYQLLLDSL GDRTRYFSMW NQAVDSYDPD VRIIENHGIE DELPNYCFPL NGIGPGHTYQ 430 440 450 460 470 480 GIKVKTDDTN GWEKDANVAP ANEITIGNNL AMEINIQANL WRSFLYSNVA LYLPDVYKYT 490 500 510 520 530 540 PPNITLPTNT NTYEYMNGRV VSPSLVDSYI NIGARWSLDP MDNVNPFNHH RNAGLRYRSM 550 560 570 580 590 600 LLGNGRYVPF HIQVPQKFFA VKNLLLLPGS YTYEWNFRKD VNMVLQSSLG NDLRTDGATI 610 620 630 640 650 660 SFTSINLYAT FFPMAHNTAS TLEAMLRNDT NDQSFNDYLS AANMLYPIPA NATNIPISIP 670 680 690 700 710 720 SRNWAAFRGW SFTRLKTKET PSLGSGFDPY FVYSGSIPYL DGTFYLNHTF KKVAIMFDSS 730 740 750 760 770 780 VSWPGNDRLL SPNEFEIKRT VDGEGYNVAQ CNMTKDWFLV QMLANYNIGY QGFYIPEGYK 790 800 810 820 830 840 DRMYSFFRNF QPMSRQVVDE VNYTDYKAVT LPYQHNNSGF VGYLAPTMRQ GEPYPANYPY 850 860 870 880 890 900 PLIGTTAVKS VTQKKFLCDR TMWRIPFSSN FMSMGALTDL GQNMLYANSA HALDMTFEVD 910 920 930 940 PMDEPTLLYL LFEVFDVVRV HQPHRGVIEA VYLRTPFSAG NATT

References

[1]	"Sequence characterization and comparison of human adenovirus subgenus B and E hexons." Pring-Akerblom P., Trijssenaar J., Adrian T. Virology 212:232-236(1995) [PubMed: 7676636] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Isolate GB.
[2]	Pring-Akerblom P. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X76549 Genomic DNA. Translation: CAA54051.1.
PIR	S39298.
3D structure databases
ProteinModelPortal	P36849.
SMR	P36849. Positions 6-941.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR016108. Adenovirus_Pll_hexon_C. IPR016107. Adenovirus_Pll_hexon_N. IPR016110. Adenovirus_Pll_hexon_sub3. IPR016111. Adenovirus_Pll_hexon_sub4. IPR016112. Virus_hexon. [Graphical view]
Gene3D	G3DSA:2.70.9.10. Coat_hexon/vp54_sub4_dsDNA-vir. 2 hits. G3DSA:3.90.249.10. Coat_hexon_sub3_Adenovir. 3 hits.
Pfam	PF01065. Adeno_hexon. 1 hit. PF03678. Adeno_hexon_C. 1 hit. [Graphical view]
SUPFAM	SSF49749. Coat_hexon/vp54/p3_dsDNA-vir. 2 hits.
ProtoNet	Search...

Entry information

Entry name

HEX_ADE03

Accession

Primary (citable) accession number: P36849

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	December 15, 1998
Last modified:	October 19, 2011
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program